IFN-gamma pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.094 0.169 -9999.0 0.0 -0.336 56.0 56.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CRKL 0.01 0.067 -9999.0 0.0 -0.561 3.0 3.0 STAT1 (dimer)/Cbp/p300 -0.099 0.246 -9999.0 0.0 -0.581 35.0 35.0 IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.017 0.103 -9999.0 0.0 -0.347 18.0 18.0 antigen processing and presentation of peptide antigen via MHC class I -0.099 0.124 -9999.0 0.0 -0.338 34.0 34.0 CaM/Ca2+ -0.087 0.155 -9999.0 0.0 -0.409 19.0 19.0 RAP1A 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 STAT1 (dimer)/SHP2 -0.102 0.208 -9999.0 0.0 -0.57 23.0 23.0 AKT1 -0.064 0.157 -9999.0 0.0 -0.412 15.0 15.0 MAP2K1 -0.072 0.158 -9999.0 0.0 -0.394 19.0 19.0 MAP3K11 -0.08 0.163 -9999.0 0.0 -0.416 19.0 19.0 IFNGR1 0.004 0.044 -9999.0 0.0 -0.604 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CaM/Ca2+/CAMKII -0.034 0.075 -9999.0 0.0 -0.429 2.0 2.0 Rap1/GTP -0.08 0.11 -9999.0 0.0 -0.449 5.0 5.0 CRKL/C3G 0.019 0.055 -9999.0 0.0 -0.381 4.0 4.0 IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP -0.087 0.173 -9999.0 0.0 -0.39 26.0 26.0 CEBPB -0.062 0.196 -9999.0 0.0 -0.495 20.0 20.0 STAT3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.085 0.227 -9999.0 0.0 -1.027 6.0 6.0 STAT1 -0.103 0.208 -9999.0 0.0 -0.572 23.0 23.0 CALM1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IFN-gamma (dimer) -0.2 0.272 -9999.0 0.0 -0.53 89.0 89.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer)/PIAS1 -0.088 0.199 -9999.0 0.0 -0.534 23.0 23.0 CEBPB/PTGES2/Cbp/p300 -0.091 0.138 -9999.0 0.0 -0.417 22.0 22.0 mol:Ca2+ -0.096 0.165 -9999.0 0.0 -0.333 56.0 56.0 MAPK3 -0.07 0.188 -9999.0 0.0 -0.892 4.0 4.0 STAT1 (dimer) -0.135 0.177 -9999.0 0.0 -0.486 34.0 34.0 MAPK1 -0.058 0.164 -9999.0 0.0 -0.533 5.0 5.0 JAK2 -0.029 0.14 -9999.0 0.0 -0.529 16.0 16.0 PIK3R1 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 JAK1 0.004 0.044 -9999.0 0.0 -0.605 1.0 1.0 CAMK2D 0.014 0.042 -9999.0 0.0 -0.609 1.0 1.0 DAPK1 -0.045 0.179 -9999.0 0.0 -0.462 22.0 22.0 SMAD7 -0.019 0.089 -9999.0 0.0 -0.241 2.0 2.0 CBL/CRKL/C3G -0.06 0.161 -9999.0 0.0 -0.426 15.0 15.0 PI3K -0.105 0.141 -9999.0 0.0 -0.419 20.0 20.0 IFNG -0.2 0.272 -9999.0 0.0 -0.531 89.0 89.0 apoptosis -0.048 0.139 -9999.0 0.0 -0.365 18.0 18.0 CAMK2G 0.014 0.042 -9999.0 0.0 -0.609 1.0 1.0 STAT3 (dimer) 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CAMK2A 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 CAMK2B 0.004 0.082 -9999.0 0.0 -0.49 6.0 6.0 FRAP1 -0.052 0.151 -9999.0 0.0 -0.466 6.0 6.0 PRKCD -0.062 0.158 -9999.0 0.0 -0.421 14.0 14.0 RAP1B 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 negative regulation of cell growth -0.099 0.124 -9999.0 0.0 -0.338 34.0 34.0 PTPN2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EP300 -0.007 0.12 -9999.0 0.0 -0.594 9.0 9.0 IRF1 -0.086 0.256 -9999.0 0.0 -0.635 31.0 31.0 STAT1 (dimer)/PIASy -0.095 0.198 -9999.0 0.0 -0.536 23.0 23.0 SOCS1 -0.007 0.173 -9999.0 0.0 -1.439 3.0 3.0 mol:GDP -0.082 0.138 -9999.0 0.0 -0.407 15.0 15.0 CASP1 -0.072 0.157 -9999.0 0.0 -0.289 70.0 70.0 PTGES2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRF9 -0.009 0.11 -9999.0 0.0 -0.338 14.0 14.0 mol:PI-3-4-5-P3 -0.103 0.137 -9999.0 0.0 -0.407 20.0 20.0 RAP1/GDP -0.081 0.111 -9999.0 0.0 -0.454 5.0 5.0 CBL -0.078 0.162 -9999.0 0.0 -0.413 19.0 19.0 MAP3K1 -0.084 0.163 -9999.0 0.0 -0.417 19.0 19.0 PIAS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIAS4 0.01 0.062 -9999.0 0.0 -0.514 3.0 3.0 antigen processing and presentation of peptide antigen via MHC class II -0.099 0.124 -9999.0 0.0 -0.338 34.0 34.0 PTPN11 -0.091 0.169 -9999.0 0.0 -0.334 56.0 56.0 CREBBP 0.013 0.053 -9999.0 0.0 -0.537 2.0 2.0 RAPGEF1 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0