IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.026 0.034 -9999.0 0.0 -0.452 1.0 1.0 CD4-positive alpha-beta T cell lineage commitment -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.16 0.223 0.623 25.0 -9999.0 0.0 25.0 IL27/IL27R/JAK1 -0.194 0.311 -9999.0 0.0 -1.061 19.0 19.0 TBX21 -0.232 0.311 -9999.0 0.0 -0.67 61.0 61.0 IL12B -0.005 0.095 -9999.0 0.0 -0.53 7.0 7.0 IL12A -0.039 0.134 -9999.0 0.0 -0.388 28.0 28.0 IL6ST 0.009 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IL27RA/JAK1 -0.103 0.326 -9999.0 0.0 -1.286 15.0 15.0 IL27 -0.153 0.266 -9999.0 0.0 -0.579 62.0 62.0 TYK2 0.01 0.009 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.069 0.145 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 2 cell differentiation 0.16 0.223 0.623 25.0 -9999.0 0.0 25.0 T cell proliferation during immune response 0.16 0.223 0.623 25.0 -9999.0 0.0 25.0 MAPKKK cascade -0.16 0.223 -9999.0 0.0 -0.623 25.0 25.0 STAT3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 0.012 0.053 -9999.0 0.0 -0.537 2.0 2.0 STAT1 -0.025 0.136 -9999.0 0.0 -0.472 19.0 19.0 IL12RB1 0.011 0.033 -9999.0 0.0 -0.468 1.0 1.0 positive regulation of tyrosine phosphorylation of STAT protein -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.201 0.277 -9999.0 0.0 -0.658 41.0 41.0 IL27/IL27R/JAK2/TYK2 -0.162 0.227 -9999.0 0.0 -0.633 25.0 25.0 positive regulation of T cell mediated cytotoxicity -0.16 0.223 -9999.0 0.0 -0.623 25.0 25.0 STAT1 (dimer) -0.288 0.352 -9999.0 0.0 -0.912 39.0 39.0 JAK2 -0.028 0.137 -9999.0 0.0 -0.519 16.0 16.0 JAK1 0.014 0.042 -9999.0 0.0 -0.608 1.0 1.0 STAT2 (dimer) -0.148 0.218 -9999.0 0.0 -0.619 23.0 23.0 T cell proliferation -0.266 0.246 -9999.0 0.0 -0.597 56.0 56.0 IL12/IL12R/TYK2/JAK2 -0.095 0.187 -9999.0 0.0 -0.593 13.0 13.0 IL17A -0.077 0.14 -9999.0 0.0 -9999.0 0.0 0.0 mast cell activation 0.16 0.223 0.623 25.0 -9999.0 0.0 25.0 IFNG -0.046 0.057 -9999.0 0.0 -0.115 70.0 70.0 T cell differentiation -0.012 0.011 -9999.0 0.0 -0.025 66.0 66.0 STAT3 (dimer) -0.145 0.215 -9999.0 0.0 -0.61 23.0 23.0 STAT5A (dimer) -0.151 0.223 -9999.0 0.0 -0.61 26.0 26.0 STAT4 (dimer) -0.156 0.23 -9999.0 0.0 -0.613 29.0 29.0 STAT4 -0.005 0.108 -9999.0 0.0 -0.529 9.0 9.0 T cell activation -0.0 0.037 0.108 22.0 -9999.0 0.0 22.0 IL27R/JAK2/TYK2 -0.12 0.32 -9999.0 0.0 -1.185 16.0 16.0 GATA3 0.042 0.146 -9999.0 0.0 -1.37 2.0 2.0 IL18 -0.044 0.148 -9999.0 0.0 -0.425 29.0 29.0 positive regulation of mast cell cytokine production -0.143 0.21 -9999.0 0.0 -0.58 25.0 25.0 IL27/EBI3 -0.107 0.196 -9999.0 0.0 -0.422 61.0 61.0 IL27RA -0.125 0.344 -9999.0 0.0 -1.378 15.0 15.0 IL6 -0.222 0.281 -9999.0 0.0 -0.53 100.0 100.0 STAT5A 0.006 0.076 -9999.0 0.0 -0.495 5.0 5.0 monocyte differentiation -0.002 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.056 0.127 0.494 15.0 -9999.0 0.0 15.0 IL1B -0.083 0.179 -9999.0 0.0 -0.409 51.0 51.0 EBI3 0.009 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.004 0.077 -9999.0 0.0 -0.359 10.0 10.0