IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.069 0.253 -9999.0 0.0 -0.712 9.0 9.0 CRP -0.068 0.253 -9999.0 0.0 -0.687 11.0 11.0 cell cycle arrest -0.094 0.283 -9999.0 0.0 -0.692 23.0 23.0 TIMP1 -0.076 0.254 -9999.0 0.0 -0.67 17.0 17.0 IL6ST 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.097 0.214 -9999.0 0.0 -0.527 27.0 27.0 AP1 -0.076 0.175 -9999.0 0.0 -0.488 10.0 10.0 GAB2 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.176 0.419 -9999.0 0.0 -1.038 34.0 34.0 HSP90B1 0.016 0.103 -9999.0 0.0 -0.951 1.0 1.0 GAB1 0.009 0.075 -9999.0 0.0 -0.543 4.0 4.0 MAPK14 -0.102 0.228 -9999.0 0.0 -0.539 33.0 33.0 AKT1 0.05 0.082 -9999.0 0.0 -0.481 3.0 3.0 FOXO1 0.033 0.113 -9999.0 0.0 -0.456 5.0 5.0 MAP2K6 -0.109 0.22 -9999.0 0.0 -0.49 38.0 38.0 mol:GTP -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.089 0.233 -9999.0 0.0 -0.558 25.0 25.0 MITF -0.101 0.207 -9999.0 0.0 -0.474 33.0 33.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.022 0.246 -9999.0 0.0 -1.436 6.0 6.0 CEBPB 0.025 0.043 -9999.0 0.0 -0.608 1.0 1.0 GRB2/SOS1/GAB family/SHP2 -0.019 0.101 -9999.0 0.0 -0.384 5.0 5.0 STAT3 -0.1 0.296 -9999.0 0.0 -0.733 23.0 23.0 STAT1 -0.025 0.072 -9999.0 0.0 -0.281 6.0 6.0 CEBPD -0.073 0.257 -9999.0 0.0 -0.7 11.0 11.0 PIK3CA 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.023 0.054 -9999.0 0.0 -0.44 3.0 3.0 JUN -0.053 0.193 -9999.0 0.0 -0.572 27.0 27.0 PIAS3/MITF -0.09 0.199 -9999.0 0.0 -0.477 28.0 28.0 MAPK11 -0.103 0.23 -9999.0 0.0 -0.544 33.0 33.0 STAT3 (dimer)/FOXO1 -0.05 0.259 -9999.0 0.0 -0.625 15.0 15.0 GRB2/SOS1/GAB family -0.123 0.181 -9999.0 0.0 -0.534 26.0 26.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.144 0.227 -9999.0 0.0 -0.519 40.0 40.0 GRB2 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 -0.02 0.135 -9999.0 0.0 -0.502 16.0 16.0 LBP -0.046 0.221 -9999.0 0.0 -0.631 8.0 8.0 PIK3R1 0.01 0.072 -9999.0 0.0 -0.608 3.0 3.0 JAK1 0.016 0.041 -9999.0 0.0 -0.59 1.0 1.0 MYC -0.1 0.319 -9999.0 0.0 -0.883 19.0 19.0 FGG -0.079 0.277 -9999.0 0.0 -0.738 16.0 16.0 macrophage differentiation -0.094 0.283 -9999.0 0.0 -0.692 23.0 23.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.168 0.204 -9999.0 0.0 -0.45 55.0 55.0 JUNB -0.082 0.271 -9999.0 0.0 -0.735 15.0 15.0 FOS -0.16 0.26 -9999.0 0.0 -0.533 72.0 72.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.104 0.202 -9999.0 0.0 -0.441 36.0 36.0 STAT1/PIAS1 -0.086 0.192 -9999.0 0.0 -0.446 28.0 28.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.042 0.067 -9999.0 0.0 -0.459 2.0 2.0 STAT3 (dimer) -0.099 0.294 -9999.0 0.0 -0.734 22.0 22.0 PRKCD -0.077 0.252 -9999.0 0.0 -0.615 20.0 20.0 IL6R -0.004 0.112 -9999.0 0.0 -0.544 9.0 9.0 SOCS3 -0.114 0.281 -9999.0 0.0 -0.795 21.0 21.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.003 0.126 -9999.0 0.0 -0.325 24.0 24.0 Rac1/GTP -0.096 0.223 -9999.0 0.0 -0.536 28.0 28.0 HCK -0.091 0.23 -9999.0 0.0 -0.574 41.0 41.0 MAPKKK cascade 0.012 0.093 -9999.0 0.0 -0.472 3.0 3.0 bone resorption -0.16 0.388 -9999.0 0.0 -0.947 34.0 34.0 IRF1 -0.102 0.321 -9999.0 0.0 -0.814 24.0 24.0 mol:GDP -0.112 0.22 -9999.0 0.0 -0.499 35.0 35.0 SOS1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.114 0.223 -9999.0 0.0 -0.502 36.0 36.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.108 0.216 -9999.0 0.0 -0.543 28.0 28.0 PTPN11 -0.013 0.092 -9999.0 0.0 -0.935 2.0 2.0 IL6/IL6RA -0.169 0.225 -9999.0 0.0 -0.402 103.0 103.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.007 0.121 -9999.0 0.0 -0.339 18.0 18.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.029 0.158 -9999.0 0.0 -0.384 32.0 32.0 IL6 -0.23 0.283 -9999.0 0.0 -0.541 100.0 100.0 PIAS3 0.013 0.045 -9999.0 0.0 -0.466 2.0 2.0 PTPRE -0.004 0.099 -9999.0 0.0 -0.541 7.0 7.0 PIAS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.1 0.167 0.293 1.0 -0.361 37.0 38.0 LMO4 -0.052 0.188 -9999.0 0.0 -0.524 30.0 30.0 STAT3 (dimer)/PIAS3 -0.094 0.283 -9999.0 0.0 -0.7 22.0 22.0 MCL1 0.049 0.134 -9999.0 0.0 -1.161 2.0 2.0