Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within IL23-mediated signaling events 52.0 3151.0 60.0 -0.694 0.018 1000.0 -1000.0 -0.127 -1000.0 HIF-1-alpha transcription factor network 41.0 3140.0 76.0 -0.426 0.026 1000.0 -1000.0 -0.07 -1000.0 Syndecan-1-mediated signaling events 37.0 1272.0 34.0 -0.242 0.017 1000.0 -1000.0 -0.04 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 35.0 2411.0 68.0 -0.681 0.246 1000.0 -1000.0 -0.097 -1000.0 IL4-mediated signaling events 33.0 3093.0 91.0 -0.649 0.543 1000.0 -1000.0 -0.122 -1000.0 Ephrin B reverse signaling 33.0 1621.0 48.0 -0.326 0.081 1000.0 -1000.0 -0.068 -1000.0 Endothelins 32.0 3117.0 96.0 -0.297 0.017 1000.0 -1000.0 -0.061 -1000.0 Signaling mediated by p38-alpha and p38-beta 31.0 1399.0 44.0 -0.221 0.017 1000.0 -1000.0 -0.021 -1000.0 Wnt signaling 31.0 218.0 7.0 -0.167 0.007 1000.0 -1000.0 -0.023 -1000.0 IL12-mediated signaling events 29.0 2565.0 87.0 -0.369 0.043 1000.0 -1000.0 -0.103 -1000.0 Calcium signaling in the CD4+ TCR pathway 28.0 872.0 31.0 -0.387 0.014 1000.0 -1000.0 -0.069 -1000.0 Glypican 1 network 27.0 1341.0 48.0 -0.227 0.019 1000.0 -1000.0 -0.039 -1000.0 Fc-epsilon receptor I signaling in mast cells 27.0 2651.0 97.0 -0.262 0.049 1000.0 -1000.0 -0.085 -1000.0 TCGA08_p53 27.0 195.0 7.0 -0.085 0.044 1000.0 -1000.0 -0.007 -1000.0 TCGA08_retinoblastoma 27.0 218.0 8.0 -0.09 0.034 1000.0 -1000.0 -0.015 -1000.0 Noncanonical Wnt signaling pathway 24.0 647.0 26.0 -0.167 0.017 1000.0 -1000.0 -0.042 -1000.0 Glucocorticoid receptor regulatory network 24.0 2775.0 114.0 -0.517 0.28 1000.0 -1000.0 -0.065 -1000.0 amb2 Integrin signaling 23.0 1899.0 82.0 -0.278 0.021 1000.0 -1000.0 -0.08 -1000.0 EGFR-dependent Endothelin signaling events 23.0 488.0 21.0 -0.194 0.026 1000.0 -1000.0 -0.078 -1000.0 PLK2 and PLK4 events 22.0 67.0 3.0 -0.058 0.01 1000.0 -1000.0 -0.007 -1000.0 Osteopontin-mediated events 22.0 855.0 38.0 -0.278 0.017 1000.0 -1000.0 -0.107 -1000.0 BMP receptor signaling 22.0 1858.0 81.0 -0.385 0.047 1000.0 -1000.0 -0.098 -1000.0 IL27-mediated signaling events 22.0 1153.0 51.0 -0.288 0.16 1000.0 -1000.0 -0.072 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 22.0 1730.0 78.0 -0.186 0.072 1000.0 -1000.0 -0.055 -1000.0 Thromboxane A2 receptor signaling 21.0 2239.0 105.0 -0.194 0.054 1000.0 -1000.0 -0.066 -1000.0 FAS signaling pathway (CD95) 21.0 996.0 47.0 -0.386 0.025 1000.0 -1000.0 -0.042 -1000.0 Syndecan-2-mediated signaling events 20.0 1413.0 69.0 -0.229 0.017 1000.0 -1000.0 -0.023 -1000.0 TCR signaling in naïve CD8+ T cells 20.0 1889.0 93.0 -0.142 0.026 1000.0 -1000.0 -0.074 -1000.0 IL1-mediated signaling events 19.0 1205.0 62.0 -0.244 0.064 1000.0 -1000.0 -0.091 -1000.0 IL6-mediated signaling events 19.0 1472.0 75.0 -0.23 0.05 1000.0 -1000.0 -0.069 -1000.0 Cellular roles of Anthrax toxin 18.0 738.0 39.0 -0.081 0.017 1000.0 -1000.0 -0.027 -1000.0 FOXA2 and FOXA3 transcription factor networks 18.0 854.0 46.0 -0.331 0.059 1000.0 -1000.0 -0.056 -1000.0 Glypican 2 network 18.0 75.0 4.0 -0.044 -0.0 1000.0 -1000.0 -0.008 -1000.0 Syndecan-4-mediated signaling events 18.0 1267.0 67.0 -0.119 0.021 1000.0 -1000.0 -0.089 -1000.0 Visual signal transduction: Rods 18.0 952.0 52.0 -0.285 0.017 1000.0 -1000.0 -0.075 -1000.0 Presenilin action in Notch and Wnt signaling 17.0 1055.0 61.0 -0.247 0.126 1000.0 -1000.0 -0.067 -1000.0 Signaling events mediated by PRL 17.0 579.0 34.0 -0.112 0.043 1000.0 -1000.0 -0.039 -1000.0 IFN-gamma pathway 16.0 1136.0 68.0 -0.2 0.019 1000.0 -1000.0 -0.081 -1000.0 S1P1 pathway 16.0 593.0 36.0 -0.205 0.017 1000.0 -1000.0 -0.065 -1000.0 Canonical Wnt signaling pathway 16.0 831.0 51.0 -0.275 0.148 1000.0 -1000.0 -0.053 -1000.0 Caspase cascade in apoptosis 15.0 1157.0 74.0 -0.163 0.075 1000.0 -1000.0 -0.041 -1000.0 Signaling events mediated by the Hedgehog family 15.0 826.0 52.0 -0.222 0.142 1000.0 -1000.0 -0.042 -1000.0 Nectin adhesion pathway 15.0 967.0 63.0 -0.079 0.024 1000.0 -1000.0 -0.075 -1000.0 EPHB forward signaling 15.0 1299.0 85.0 -0.168 0.108 1000.0 -1000.0 -0.085 -1000.0 BCR signaling pathway 15.0 1554.0 99.0 -0.233 0.034 1000.0 -1000.0 -0.09 -1000.0 FOXM1 transcription factor network 15.0 781.0 51.0 -0.24 0.042 1000.0 -1000.0 -0.141 -1000.0 Ras signaling in the CD4+ TCR pathway 15.0 258.0 17.0 -0.07 0.012 1000.0 -1000.0 -0.043 -1000.0 E-cadherin signaling events 14.0 71.0 5.0 -0.025 0.015 1000.0 -1000.0 -0.021 -1000.0 a4b1 and a4b7 Integrin signaling 13.0 65.0 5.0 -0.027 -0.0 1000.0 -1000.0 -0.016 -1000.0 Arf6 signaling events 13.0 852.0 62.0 -0.194 0.043 1000.0 -1000.0 -0.028 -1000.0 PDGFR-alpha signaling pathway 13.0 583.0 44.0 -0.263 0.027 1000.0 -1000.0 -0.063 -1000.0 Syndecan-3-mediated signaling events 13.0 487.0 35.0 -0.229 0.018 1000.0 -1000.0 -0.039 -1000.0 Signaling events mediated by PTP1B 12.0 926.0 76.0 -0.196 0.049 1000.0 -1000.0 -0.078 -1000.0 Nongenotropic Androgen signaling 12.0 671.0 52.0 -0.141 0.053 1000.0 -1000.0 -0.063 -1000.0 LPA receptor mediated events 12.0 1324.0 102.0 -0.23 0.038 1000.0 -1000.0 -0.074 -1000.0 IL2 signaling events mediated by STAT5 12.0 283.0 22.0 -0.104 0.018 1000.0 -1000.0 -0.039 -1000.0 Sphingosine 1-phosphate (S1P) pathway 11.0 334.0 28.0 -0.092 0.026 1000.0 -1000.0 -0.019 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 11.0 521.0 45.0 -0.113 0.046 1000.0 -1000.0 -0.088 -1000.0 Visual signal transduction: Cones 10.0 396.0 38.0 -0.071 0.018 1000.0 -1000.0 -0.057 -1000.0 p75(NTR)-mediated signaling 10.0 1264.0 125.0 -0.238 0.034 1000.0 -1000.0 -0.089 -1000.0 TRAIL signaling pathway 10.0 488.0 48.0 -0.081 0.03 1000.0 -1000.0 -0.074 -1000.0 Class I PI3K signaling events 10.0 789.0 73.0 -0.091 0.026 1000.0 -1000.0 -0.054 -1000.0 Regulation of Telomerase 10.0 1025.0 102.0 -0.317 0.056 1000.0 -1000.0 -0.114 -1000.0 JNK signaling in the CD4+ TCR pathway 9.0 158.0 17.0 -0.069 0.015 1000.0 -1000.0 -0.028 -1000.0 Signaling events mediated by HDAC Class III 9.0 395.0 40.0 -0.097 0.03 1000.0 -1000.0 -0.029 -1000.0 Regulation of nuclear SMAD2/3 signaling 8.0 1186.0 136.0 -0.164 0.066 1000.0 -1000.0 -0.065 -1000.0 ErbB4 signaling events 8.0 555.0 69.0 -0.285 0.058 1000.0 -1000.0 -0.09 -1000.0 Hedgehog signaling events mediated by Gli proteins 8.0 543.0 65.0 -0.155 0.044 1000.0 -1000.0 -0.059 -1000.0 Ceramide signaling pathway 8.0 644.0 76.0 -0.194 0.076 1000.0 -1000.0 -0.042 -1000.0 Reelin signaling pathway 8.0 492.0 56.0 -0.153 0.04 1000.0 -1000.0 -0.079 -1000.0 Signaling mediated by p38-gamma and p38-delta 8.0 121.0 15.0 -0.022 0.024 1000.0 -1000.0 -0.023 -1000.0 IL2 signaling events mediated by PI3K 8.0 466.0 58.0 -0.087 0.034 1000.0 -1000.0 -0.084 -1000.0 Integrins in angiogenesis 8.0 718.0 84.0 -0.282 0.043 1000.0 -1000.0 -0.09 -1000.0 Effects of Botulinum toxin 8.0 217.0 26.0 -0.181 0.026 1000.0 -1000.0 -0.063 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 8.0 611.0 74.0 -0.194 0.027 1000.0 -1000.0 -0.082 -1000.0 E-cadherin signaling in the nascent adherens junction 8.0 616.0 76.0 -0.067 0.024 1000.0 -1000.0 -0.085 -1000.0 Arf6 downstream pathway 7.0 323.0 43.0 -0.028 0.022 1000.0 -1000.0 -0.035 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 7.0 281.0 37.0 -0.027 0.025 1000.0 -1000.0 -0.052 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 7.0 393.0 52.0 -0.156 0.057 1000.0 -1000.0 -0.036 -1000.0 Insulin Pathway 7.0 553.0 74.0 -0.275 0.044 1000.0 -1000.0 -0.093 -1000.0 VEGFR1 specific signals 7.0 394.0 56.0 -0.009 0.035 1000.0 -1000.0 -0.042 -1000.0 PDGFR-beta signaling pathway 7.0 721.0 97.0 -0.105 0.04 1000.0 -1000.0 -0.08 -1000.0 Regulation of Androgen receptor activity 7.0 558.0 70.0 -0.197 0.065 1000.0 -1000.0 -0.06 -1000.0 Aurora B signaling 7.0 475.0 67.0 -0.195 0.02 1000.0 -1000.0 -0.067 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 6.0 565.0 85.0 -0.177 0.055 1000.0 -1000.0 -0.067 -1000.0 HIF-2-alpha transcription factor network 6.0 300.0 43.0 -0.096 0.043 1000.0 -1000.0 -0.064 -1000.0 Retinoic acid receptors-mediated signaling 6.0 369.0 58.0 -0.198 0.089 1000.0 -1000.0 -0.081 -1000.0 Regulation of p38-alpha and p38-beta 6.0 333.0 54.0 -0.091 0.044 1000.0 -1000.0 -0.057 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 6.0 763.0 125.0 -0.068 0.067 1000.0 -1000.0 -0.105 -1000.0 Plasma membrane estrogen receptor signaling 6.0 580.0 86.0 -0.082 0.038 1000.0 -1000.0 -0.087 -1000.0 S1P3 pathway 6.0 291.0 42.0 -0.061 0.026 1000.0 -1000.0 -0.031 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 6.0 205.0 33.0 -0.102 0.041 1000.0 -1000.0 -0.028 -1000.0 LPA4-mediated signaling events 5.0 68.0 12.0 -0.006 0.02 1000.0 -1000.0 -0.012 -1000.0 Coregulation of Androgen receptor activity 5.0 454.0 76.0 -0.133 0.035 1000.0 -1000.0 -0.039 -1000.0 BARD1 signaling events 5.0 292.0 57.0 -0.099 0.04 1000.0 -1000.0 -0.045 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 5.0 294.0 54.0 -0.153 0.062 1000.0 -1000.0 -0.092 -1000.0 Ephrin A reverse signaling 5.0 38.0 7.0 -0.001 0.013 1000.0 -1000.0 -0.016 -1000.0 Aurora A signaling 5.0 306.0 60.0 -0.033 0.032 1000.0 -1000.0 -0.029 -1000.0 mTOR signaling pathway 5.0 280.0 53.0 -0.011 0.046 1000.0 -1000.0 -0.069 -1000.0 Signaling events regulated by Ret tyrosine kinase 5.0 491.0 82.0 -0.055 0.032 1000.0 -1000.0 -0.087 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 5.0 425.0 83.0 -0.056 0.056 1000.0 -1000.0 -0.071 -1000.0 TCGA08_rtk_signaling 5.0 146.0 26.0 -0.031 0.042 1000.0 -1000.0 -0.017 -1000.0 Arf6 trafficking events 5.0 377.0 71.0 -0.091 0.044 1000.0 -1000.0 -0.068 -1000.0 Class IB PI3K non-lipid kinase events 5.0 15.0 3.0 -0.004 0.004 1000.0 -1000.0 -0.011 -1000.0 ErbB2/ErbB3 signaling events 4.0 304.0 65.0 -0.079 0.045 1000.0 -1000.0 -0.067 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 4.0 100.0 23.0 -0.009 0.028 1000.0 -1000.0 -0.051 -1000.0 Canonical NF-kappaB pathway 4.0 156.0 39.0 -0.086 0.064 1000.0 -1000.0 -0.084 -1000.0 Aurora C signaling 4.0 33.0 7.0 -0.013 0.01 1000.0 -1000.0 -0.027 -1000.0 PLK1 signaling events 4.0 409.0 85.0 -0.057 0.038 1000.0 -1000.0 -0.05 -1000.0 FoxO family signaling 4.0 304.0 64.0 -0.11 0.079 1000.0 -1000.0 -0.067 -1000.0 Paxillin-dependent events mediated by a4b1 4.0 159.0 36.0 -0.03 0.032 1000.0 -1000.0 -0.075 -1000.0 Angiopoietin receptor Tie2-mediated signaling 4.0 415.0 88.0 -0.275 0.075 1000.0 -1000.0 -0.103 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 4.0 566.0 120.0 -0.062 0.064 1000.0 -1000.0 -0.067 -1000.0 p38 MAPK signaling pathway 4.0 201.0 44.0 -0.015 0.034 1000.0 -1000.0 -0.063 -1000.0 EPO signaling pathway 3.0 218.0 55.0 -0.051 0.046 1000.0 -1000.0 -0.086 -1000.0 S1P5 pathway 3.0 63.0 17.0 -0.05 0.017 1000.0 -1000.0 -0.019 -1000.0 ceramide signaling pathway 3.0 177.0 49.0 -0.061 0.041 1000.0 -1000.0 -0.04 -1000.0 IGF1 pathway 3.0 219.0 57.0 -0.042 0.036 1000.0 -1000.0 -0.093 -1000.0 E-cadherin signaling in keratinocytes 3.0 154.0 43.0 -0.033 0.032 1000.0 -1000.0 -0.069 -1000.0 S1P4 pathway 3.0 86.0 25.0 -0.05 0.03 1000.0 -1000.0 -0.025 -1000.0 Signaling events mediated by HDAC Class II 2.0 217.0 75.0 -0.037 0.038 1000.0 -1000.0 -0.053 -1000.0 Class I PI3K signaling events mediated by Akt 2.0 140.0 68.0 -0.039 0.055 1000.0 -1000.0 -0.062 -1000.0 Atypical NF-kappaB pathway 2.0 87.0 31.0 -0.058 0.032 1000.0 -1000.0 -0.039 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 1.0 56.0 34.0 -0.013 0.038 1000.0 -1000.0 -0.04 -1000.0 Circadian rhythm pathway 1.0 34.0 22.0 -0.017 0.058 1000.0 -1000.0 -0.035 -1000.0 Insulin-mediated glucose transport 1.0 53.0 32.0 -0.007 0.036 1000.0 -1000.0 -0.028 -1000.0 Signaling events mediated by HDAC Class I 1.0 196.0 104.0 -0.034 0.059 1000.0 -1000.0 -0.074 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 1.0 30.0 27.0 -0.006 0.037 1000.0 -1000.0 -0.062 -1000.0 Rapid glucocorticoid signaling 1.0 20.0 20.0 -0.0 0.024 1000.0 -1000.0 -0.017 -1000.0 Alternative NF-kappaB pathway 1.0 13.0 13.0 -0.0 0.044 1000.0 -1000.0 -0.03 -1000.0 Arf1 pathway 0.0 34.0 54.0 -0.006 0.041 1000.0 -1000.0 -0.038 -1000.0 Total 1618 94407 7203 -20.1140955414 6.23421369704 131000 -131000 -7.73380072079 -131000