Arf6 trafficking events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SLC2A4 0.005 0.096 -9999.0 0.0 -0.323 14.0 14.0 CLTC -0.007 0.133 -9999.0 0.0 -0.436 17.0 17.0 calcium ion-dependent exocytosis 0.001 0.073 -9999.0 0.0 -0.279 5.0 5.0 Dynamin 2/GTP 0.026 0.04 -9999.0 0.0 -0.269 3.0 3.0 EXOC4 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CD59 -0.009 0.113 -9999.0 0.0 -0.385 16.0 16.0 CPE -0.049 0.112 -9999.0 0.0 -0.297 30.0 30.0 CTNNB1 0.011 0.093 -9999.0 0.0 -0.297 15.0 15.0 membrane fusion 0.018 0.033 -9999.0 0.0 -0.181 1.0 1.0 CTNND1 0.014 0.042 0.188 4.0 -0.253 3.0 7.0 DNM2 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.002 0.084 -9999.0 0.0 -0.258 16.0 16.0 TSHR 0.013 0.038 -9999.0 0.0 -0.295 3.0 3.0 INS 0.02 0.027 -9999.0 0.0 -9999.0 0.0 0.0 BIN1 0.016 0.1 -9999.0 0.0 -0.483 8.0 8.0 mol:Choline 0.018 0.033 -9999.0 0.0 -0.181 1.0 1.0 growth hormone secretagogue receptor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.012 0.039 -9999.0 0.0 -0.294 3.0 3.0 membrane depolarization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.051 -9999.0 0.0 -0.483 2.0 2.0 mol:Ca2+ 0.026 0.04 -9999.0 0.0 -0.267 3.0 3.0 JUP -0.008 0.114 -9999.0 0.0 -0.385 16.0 16.0 ASAP2/amphiphysin II 0.025 0.068 -9999.0 0.0 -0.267 10.0 10.0 ARF6/GTP 0.021 0.037 -9999.0 0.0 -0.347 2.0 2.0 CDH1 -0.019 0.119 -9999.0 0.0 -0.37 18.0 18.0 clathrin-independent pinocytosis 0.02 0.037 -9999.0 0.0 -0.346 2.0 2.0 MAPK8IP3 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 positive regulation of endocytosis 0.02 0.037 -9999.0 0.0 -0.346 2.0 2.0 EXOC2 0.033 0.036 -9999.0 0.0 -0.483 1.0 1.0 substrate adhesion-dependent cell spreading 0.022 0.059 -9999.0 0.0 -0.422 1.0 1.0 insulin receptor binding -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SPAG9 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.003 0.133 0.362 18.0 -9999.0 0.0 18.0 positive regulation of phagocytosis 0.013 0.033 -9999.0 0.0 -0.293 2.0 2.0 ARF6/GTP/JIP3 0.035 0.051 -9999.0 0.0 -0.295 4.0 4.0 ACAP1 0.017 0.035 -9999.0 0.0 -0.163 3.0 3.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CHRM2 -0.036 0.138 -9999.0 0.0 -0.407 18.0 18.0 clathrin heavy chain/ACAP1 -0.006 0.114 -9999.0 0.0 -0.358 17.0 17.0 JIP4/KLC1 0.036 0.037 -9999.0 0.0 -0.267 2.0 2.0 EXOC1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 exocyst 0.025 0.056 -9999.0 0.0 -0.428 1.0 1.0 RALA/GTP 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.037 0.04 -9999.0 0.0 -0.295 2.0 2.0 receptor recycling 0.02 0.037 -9999.0 0.0 -0.346 2.0 2.0 CTNNA1 0.014 0.042 0.188 4.0 -0.253 3.0 7.0 NME1 0.012 0.04 -9999.0 0.0 -0.295 3.0 3.0 clathrin coat assembly -0.01 0.136 -9999.0 0.0 -0.423 18.0 18.0 IL2RA -0.032 0.131 -9999.0 0.0 -0.406 17.0 17.0 VAMP3 0.013 0.033 -9999.0 0.0 -0.294 2.0 2.0 GLUT4/clathrin heavy chain/ACAP1 -0.004 0.118 -9999.0 0.0 -0.33 18.0 18.0 EXOC6 0.03 0.051 -9999.0 0.0 -0.483 2.0 2.0 PLD1 0.011 0.034 -9999.0 0.0 -0.261 2.0 2.0 PLD2 0.015 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC5 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.082 -9999.0 0.0 -0.262 16.0 16.0 SDC1 -0.01 0.114 -9999.0 0.0 -0.385 16.0 16.0 ARF6/GDP 0.025 0.04 -9999.0 0.0 -0.295 3.0 3.0 EXOC7 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin -0.002 0.137 -9999.0 0.0 -0.373 18.0 18.0 mol:Phosphatidic acid 0.018 0.033 -9999.0 0.0 -0.181 1.0 1.0 endocytosis -0.024 0.068 0.266 10.0 -9999.0 0.0 10.0 SCAMP2 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ADRB2 -0.025 0.142 0.341 2.0 -0.425 17.0 19.0 EXOC3 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ASAP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Dynamin 2/GDP 0.031 0.042 -9999.0 0.0 -0.267 3.0 3.0 KLC1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AVPR2 -0.014 0.133 0.385 1.0 -0.406 18.0 19.0 RALA 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.13 -9999.0 0.0 -0.356 18.0 18.0