p75(NTR)-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Sortilin/TRAF6 0.049 0.032 -9999.0 0.0 -0.349 1.0 1.0 Necdin/E2F1 -0.004 0.091 -9999.0 0.0 -0.349 10.0 10.0 proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.009 0.126 -9999.0 0.0 -0.252 35.0 35.0 NGF (dimer)/p75(NTR)/BEX1 0.044 0.019 -9999.0 0.0 -9999.0 0.0 0.0 NT-4/5 (dimer)/p75(NTR) 0.024 0.012 -9999.0 0.0 -0.133 1.0 1.0 IKBKB 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.017 0.047 -9999.0 0.0 -0.254 3.0 3.0 IKBKG 0.035 0.017 -9999.0 0.0 -0.204 1.0 1.0 BDNF 0.017 0.084 -9999.0 0.0 -0.297 12.0 12.0 MGDIs/NGR/p75(NTR)/LINGO1 0.032 0.052 -9999.0 0.0 -0.295 3.0 3.0 FURIN 0.027 0.049 -9999.0 0.0 -0.259 5.0 5.0 proBDNF (dimer)/p75(NTR)/Sortilin 0.051 0.074 -9999.0 0.0 -0.332 5.0 5.0 LINGO1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Sortilin/TRAF6/NRIF 0.006 0.084 -9999.0 0.0 -0.291 1.0 1.0 proBDNF (dimer) 0.017 0.084 -9999.0 0.0 -0.296 12.0 12.0 NTRK1 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 RTN4R 0.019 0.073 -9999.0 0.0 -0.297 9.0 9.0 neuron apoptosis -0.031 0.13 -9999.0 0.0 -0.485 7.0 7.0 IRAK1 0.034 0.023 -9999.0 0.0 -0.204 2.0 2.0 SHC1 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.05 0.099 -9999.0 0.0 -0.262 10.0 10.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.022 0.1 -9999.0 0.0 -0.264 18.0 18.0 MAGEH1 -0.026 0.151 -9999.0 0.0 -0.343 34.0 34.0 proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.02 0.104 -9999.0 0.0 -0.279 18.0 18.0 Mammalian IAPs/DIABLO 0.035 0.085 -9999.0 0.0 -0.262 11.0 11.0 proNGF (dimer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.024 0.075 -9999.0 0.0 -0.39 6.0 6.0 APP 0.013 0.093 -9999.0 0.0 -0.356 11.0 11.0 NT-4/5 (dimer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZNF274 0.023 0.075 -9999.0 0.0 -0.39 6.0 6.0 RhoA/GDP/RHOGDI 0.05 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NGF 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell cycle arrest -0.009 0.04 0.205 5.0 -0.268 1.0 6.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.025 0.04 -9999.0 0.0 -0.275 3.0 3.0 NT-4/5 (dimer)/p75(NTR)/TRAF6 0.045 0.016 -9999.0 0.0 -9999.0 0.0 0.0 NCSTN 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.001 0.11 -9999.0 0.0 -0.298 23.0 23.0 PSENEN 0.031 0.04 -9999.0 0.0 -0.343 2.0 2.0 mol:ceramide 0.022 0.036 -9999.0 0.0 -0.267 1.0 1.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.02 0.037 -9999.0 0.0 -0.222 4.0 4.0 p75(NTR)/beta APP 0.032 0.071 -9999.0 0.0 -0.349 5.0 5.0 BEX1 0.035 0.017 -9999.0 0.0 -0.204 1.0 1.0 mol:GDP 0.003 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer) -0.046 0.144 -9999.0 0.0 -0.275 51.0 51.0 MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.051 0.055 -9999.0 0.0 -0.27 3.0 3.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 RAC1/GTP 0.036 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MYD88 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CHUK 0.027 0.062 -9999.0 0.0 -0.483 3.0 3.0 NGF (dimer)/p75(NTR)/PKA -0.0 0.111 -9999.0 0.0 -0.299 23.0 23.0 RHOB 0.019 0.081 -9999.0 0.0 -0.315 10.0 10.0 RHOA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAGE-G1/E2F1 0.021 0.047 -9999.0 0.0 -0.349 2.0 2.0 NT3 (dimer) 0.01 0.097 -9999.0 0.0 -0.323 14.0 14.0 TP53 -0.04 0.113 -9999.0 0.0 -0.42 4.0 4.0 PRDM4 0.022 0.036 0.189 5.0 -0.229 2.0 7.0 BDNF (dimer) -0.139 0.209 -9999.0 0.0 -0.35 87.0 87.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SORT1 0.032 0.04 -9999.0 0.0 -0.343 2.0 2.0 activation of caspase activity 0.004 0.122 -9999.0 0.0 -0.25 35.0 35.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.061 0.034 -9999.0 0.0 -0.23 2.0 2.0 RHOC 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 XIAP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.004 0.093 0.255 3.0 -0.348 3.0 6.0 DIABLO 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SMPD2 0.022 0.036 -9999.0 0.0 -0.269 1.0 1.0 APH1B 0.02 0.073 -9999.0 0.0 -0.297 9.0 9.0 APH1A 0.003 0.107 -9999.0 0.0 -0.307 19.0 19.0 proNGF (dimer)/p75(NTR)/Sortilin 0.042 0.032 -9999.0 0.0 -0.252 2.0 2.0 PSEN1 0.032 0.019 -9999.0 0.0 -0.204 1.0 1.0 APAF-1/Pro-Caspase 9 0.026 0.085 -9999.0 0.0 -0.335 9.0 9.0 NT3 (dimer)/p75(NTR) 0.029 0.077 -9999.0 0.0 -0.335 7.0 7.0 MAPK8 0.006 0.084 0.255 3.0 -0.337 3.0 6.0 MAPK9 0.005 0.082 0.267 2.0 -0.344 2.0 4.0 APAF1 0.008 0.107 -9999.0 0.0 -0.353 15.0 15.0 NTF3 0.01 0.097 -9999.0 0.0 -0.323 14.0 14.0 NTF4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDN -0.023 0.148 -9999.0 0.0 -0.367 29.0 29.0 RAC1/GDP 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA-B-C/GDP 0.019 0.11 -9999.0 0.0 -0.244 26.0 26.0 p75 CTF/Sortilin/TRAF6/NRIF 0.077 0.063 -9999.0 0.0 -0.272 5.0 5.0 RhoA-B-C/GTP -0.001 0.11 -9999.0 0.0 -0.297 23.0 23.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.072 0.091 -9999.0 0.0 -0.287 8.0 8.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.068 0.075 -9999.0 0.0 -0.333 4.0 4.0 PRKACB -0.032 0.166 -9999.0 0.0 -0.411 31.0 31.0 proBDNF (dimer)/p75 ECD 0.037 0.066 -9999.0 0.0 -0.349 4.0 4.0 ChemicalAbstracts:86-01-1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.011 0.126 -9999.0 0.0 -0.303 28.0 28.0 BIRC2 0.034 0.018 -9999.0 0.0 -0.204 1.0 1.0 neuron projection morphogenesis -0.063 0.102 -9999.0 0.0 -0.333 16.0 16.0 BAD -0.003 0.088 0.304 1.0 -0.355 2.0 3.0 RIPK2 0.022 0.063 -9999.0 0.0 -0.483 3.0 3.0 NGFR 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 CYCS 0.009 0.057 -9999.0 0.0 -0.253 7.0 7.0 ADAM17 0.036 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.049 0.05 -9999.0 0.0 -0.293 3.0 3.0 BCL2L11 -0.003 0.087 0.304 1.0 -0.355 2.0 3.0 BDNF (dimer)/p75(NTR) 0.035 0.067 -9999.0 0.0 -0.349 4.0 4.0 PI3K 0.057 0.046 -9999.0 0.0 -0.27 3.0 3.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.056 0.039 -9999.0 0.0 -0.23 2.0 2.0 NDNL2 0.032 0.019 -9999.0 0.0 -0.204 1.0 1.0 YWHAE 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI 0.028 0.056 -9999.0 0.0 -0.343 4.0 4.0 NGF (dimer)/p75(NTR) 0.024 0.012 -9999.0 0.0 -0.133 1.0 1.0 ChemicalAbstracts:146-91-8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.053 0.059 -9999.0 0.0 -0.256 6.0 6.0 TRAF6 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.032 0.036 -9999.0 0.0 -0.483 1.0 1.0 oligodendrocyte cell fate commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 0.014 0.063 -9999.0 0.0 -0.307 6.0 6.0 SQSTM1 0.034 0.017 -9999.0 0.0 -0.204 1.0 1.0 NGFRAP1 -0.063 0.199 -9999.0 0.0 -0.444 43.0 43.0 CASP3 -0.004 0.083 0.242 1.0 -0.329 2.0 3.0 E2F1 0.014 0.052 -9999.0 0.0 -0.483 2.0 2.0 CASP9 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex 0.058 0.059 -9999.0 0.0 -0.427 1.0 1.0 NGF (dimer)/TRKA 0.025 0.012 -9999.0 0.0 -0.133 1.0 1.0 MMP7 -0.122 0.22 -9999.0 0.0 -0.389 77.0 77.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.067 0.061 -9999.0 0.0 -0.255 5.0 5.0 MMP3 -0.133 0.221 -9999.0 0.0 -0.38 84.0 84.0 APAF-1/Caspase 9 -0.021 0.086 -9999.0 0.0 -0.369 4.0 4.0