EPHB forward signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Ephrin A5/EPHB2 0.019 0.088 -9999.0 0.0 -0.302 14.0 14.0 cell-cell adhesion 0.054 0.11 0.389 12.0 -9999.0 0.0 12.0 Ephrin B/EPHB2/RasGAP 0.014 0.132 -9999.0 0.0 -0.294 26.0 26.0 ITSN1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B1/EPHB3 -0.007 0.131 -9999.0 0.0 -0.315 30.0 30.0 Ephrin B1/EPHB1 -0.022 0.113 -9999.0 0.0 -0.31 18.0 18.0 HRAS/GDP -0.031 0.127 -9999.0 0.0 -0.356 15.0 15.0 Ephrin B/EPHB1/GRB7 -0.011 0.124 -9999.0 0.0 -0.272 26.0 26.0 Endophilin/SYNJ1 0.02 0.124 -9999.0 0.0 -0.263 20.0 20.0 KRAS 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 Ephrin B/EPHB1/Src -0.011 0.112 -9999.0 0.0 -0.308 16.0 16.0 endothelial cell migration 0.025 0.093 -9999.0 0.0 -0.268 15.0 15.0 GRB2 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GRB7 0.028 0.051 -9999.0 0.0 -0.483 2.0 2.0 PAK1 0.023 0.132 0.363 1.0 -0.47 2.0 3.0 HRAS 0.032 0.04 -9999.0 0.0 -0.343 2.0 2.0 RRAS 0.023 0.127 -9999.0 0.0 -0.267 20.0 20.0 DNM1 0.029 0.037 -9999.0 0.0 -0.204 5.0 5.0 cell-cell signaling 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.013 0.119 -9999.0 0.0 -0.272 22.0 22.0 lamellipodium assembly -0.054 0.11 -9999.0 0.0 -0.389 12.0 12.0 Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.004 0.111 -9999.0 0.0 -0.503 4.0 4.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 EPHB2 0.004 0.121 -9999.0 0.0 -0.483 12.0 12.0 EPHB3 -0.043 0.183 -9999.0 0.0 -0.458 33.0 33.0 EPHB1 -0.064 0.158 -9999.0 0.0 -0.269 68.0 68.0 EPHB4 0.022 0.07 -9999.0 0.0 -0.323 7.0 7.0 mol:GDP -0.012 0.132 0.26 7.0 -0.377 15.0 22.0 Ephrin B/EPHB2 0.011 0.113 -9999.0 0.0 -0.273 24.0 24.0 Ephrin B/EPHB3 -0.008 0.127 -9999.0 0.0 -0.267 34.0 34.0 JNK cascade -0.056 0.129 0.312 2.0 -0.309 32.0 34.0 Ephrin B/EPHB1 -0.016 0.118 -9999.0 0.0 -0.279 24.0 24.0 RAP1/GDP -0.002 0.143 0.308 6.0 -0.351 13.0 19.0 EFNB2 -0.004 0.121 -9999.0 0.0 -0.462 13.0 13.0 EFNB3 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EFNB1 0.027 0.058 -9999.0 0.0 -0.315 5.0 5.0 Ephrin B2/EPHB1-2 -0.04 0.133 -9999.0 0.0 -0.308 32.0 32.0 RAP1B 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.042 0.144 -9999.0 0.0 -0.436 13.0 13.0 Rap1/GTP -0.047 0.12 -9999.0 0.0 -0.398 12.0 12.0 axon guidance 0.019 0.088 -9999.0 0.0 -0.301 14.0 14.0 MAPK3 -0.001 0.108 -9999.0 0.0 -0.444 5.0 5.0 MAPK1 0.003 0.104 -9999.0 0.0 -0.459 4.0 4.0 Rac1/GDP -0.015 0.134 0.278 5.0 -0.369 12.0 17.0 actin cytoskeleton reorganization -0.055 0.099 -9999.0 0.0 -0.341 12.0 12.0 CDC42/GDP -0.008 0.145 0.311 8.0 -0.363 13.0 21.0 PI3K 0.029 0.096 -9999.0 0.0 -0.27 15.0 15.0 EFNA5 0.028 0.054 -9999.0 0.0 -0.39 3.0 3.0 Ephrin B2/EPHB4 0.01 0.085 -9999.0 0.0 -0.295 13.0 13.0 Ephrin B/EPHB2/Intersectin/N-WASP -0.014 0.106 -9999.0 0.0 -0.42 6.0 6.0 CDC42 0.032 0.019 -9999.0 0.0 -0.204 1.0 1.0 RAS family/GTP -0.055 0.119 -9999.0 0.0 -0.382 14.0 14.0 PTK2 0.095 0.21 0.588 31.0 -9999.0 0.0 31.0 MAP4K4 -0.057 0.13 0.313 2.0 -0.312 32.0 34.0 SRC 0.011 0.062 -9999.0 0.0 -0.483 3.0 3.0 KALRN 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Intersectin/N-WASP 0.047 0.031 -9999.0 0.0 -0.349 1.0 1.0 neuron projection morphogenesis -0.02 0.148 0.389 7.0 -0.404 8.0 15.0 MAP2K1 -0.005 0.103 -9999.0 0.0 -0.479 4.0 4.0 WASL 0.032 0.036 -9999.0 0.0 -0.483 1.0 1.0 Ephrin B1/EPHB1-2/NCK1 -0.02 0.148 -9999.0 0.0 -0.31 30.0 30.0 cell migration 0.022 0.14 0.259 9.0 -0.586 3.0 12.0 NRAS 0.019 0.079 -9999.0 0.0 -0.328 9.0 9.0 SYNJ1 0.02 0.125 -9999.0 0.0 -0.266 20.0 20.0 PXN 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TF 0.001 0.125 0.196 1.0 -0.448 3.0 4.0 HRAS/GTP -0.037 0.133 -9999.0 0.0 -0.414 12.0 12.0 Ephrin B1/EPHB1-2 -0.025 0.134 -9999.0 0.0 -0.309 27.0 27.0 cell adhesion mediated by integrin -0.011 0.12 0.263 13.0 -0.198 40.0 53.0 RAC1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.037 0.139 -9999.0 0.0 -0.316 30.0 30.0 RAC1-CDC42/GTP -0.078 0.144 -9999.0 0.0 -0.401 24.0 24.0 RASA1 0.024 0.073 -9999.0 0.0 -0.427 5.0 5.0 RAC1-CDC42/GDP -0.008 0.134 0.281 5.0 -0.405 7.0 12.0 ruffle organization -0.025 0.157 0.334 11.0 -0.459 8.0 19.0 NCK1 0.026 0.071 -9999.0 0.0 -0.483 4.0 4.0 receptor internalization 0.002 0.12 0.196 1.0 -0.443 2.0 3.0 Ephrin B/EPHB2/KALRN 0.022 0.121 -9999.0 0.0 -0.275 24.0 24.0 ROCK1 -0.028 0.11 -9999.0 0.0 -0.286 30.0 30.0 RAS family/GDP -0.056 0.099 -9999.0 0.0 -0.366 10.0 10.0 Rac1/GTP -0.053 0.12 -9999.0 0.0 -0.413 12.0 12.0 Ephrin B/EPHB1/Src/Paxillin -0.018 0.105 -9999.0 0.0 -0.312 16.0 16.0