Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.024 0.028 -9999.0 0.0 -0.347 1.0 1.0 alphaV beta3 Integrin 0.032 0.094 -9999.0 0.0 -0.288 11.0 11.0 PTK2 0.038 0.106 0.355 3.0 -0.344 4.0 7.0 IGF1R 0.03 0.04 -9999.0 0.0 -0.343 2.0 2.0 PI4KB 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MFGE8 0.017 0.085 -9999.0 0.0 -0.359 9.0 9.0 SRC 0.011 0.062 -9999.0 0.0 -0.483 3.0 3.0 CDKN1B 0.014 0.061 -9999.0 0.0 -0.393 3.0 3.0 VEGFA -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ILK 0.021 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.012 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PTK2B 0.01 0.049 -9999.0 0.0 -0.249 5.0 5.0 alphaV/beta3 Integrin/JAM-A 0.038 0.1 -9999.0 0.0 -0.268 14.0 14.0 CBL 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 0.048 0.08 -9999.0 0.0 -0.309 8.0 8.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.045 0.103 -9999.0 0.0 -0.292 12.0 12.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin 0.017 0.043 -9999.0 0.0 -0.258 4.0 4.0 alphaV/beta3 Integrin/Syndecan-1 0.056 0.065 -9999.0 0.0 -0.316 5.0 5.0 PI4KA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.012 0.141 -9999.0 0.0 -0.381 12.0 12.0 PI4 Kinase 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Osteopontin -0.091 0.162 -9999.0 0.0 -0.303 65.0 65.0 RPS6KB1 -0.063 0.103 -9999.0 0.0 -0.424 8.0 8.0 TLN1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 -0.026 0.143 -9999.0 0.0 -0.506 12.0 12.0 GPR124 0.02 0.064 -9999.0 0.0 -0.273 8.0 8.0 MAPK1 -0.024 0.145 -9999.0 0.0 -0.504 13.0 13.0 PXN 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 alphaV/beta3 Integrin/Tumstatin 0.055 0.062 -9999.0 0.0 -0.298 4.0 4.0 cell adhesion 0.024 0.103 -9999.0 0.0 -0.283 17.0 17.0 ANGPTL3 0.022 0.076 -9999.0 0.0 -0.363 7.0 7.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.02 0.046 -9999.0 0.0 -0.295 3.0 3.0 IGF-1R heterotetramer 0.03 0.04 -9999.0 0.0 -0.343 2.0 2.0 Rac1/GDP 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TGFBR2 0.03 0.051 -9999.0 0.0 -0.483 2.0 2.0 ITGB3 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 IGF1 0.015 0.081 -9999.0 0.0 -0.263 14.0 14.0 RAC1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion 0.042 0.075 -9999.0 0.0 -0.309 6.0 6.0 apoptosis 0.021 0.082 -9999.0 0.0 -0.402 7.0 7.0 CD47 0.022 0.081 -9999.0 0.0 -0.437 6.0 6.0 alphaV/beta3 Integrin/CD47 0.049 0.084 -9999.0 0.0 -0.33 8.0 8.0 VCL 0.032 0.036 -9999.0 0.0 -0.483 1.0 1.0 alphaV/beta3 Integrin/Del1 0.008 0.133 -9999.0 0.0 -0.31 27.0 27.0 CSF1 0.034 0.018 -9999.0 0.0 -0.204 1.0 1.0 PIK3C2A 0.014 0.067 -9999.0 0.0 -0.465 3.0 3.0 PI4 Kinase/Pyk2 0.006 0.065 -9999.0 0.0 -0.223 9.0 9.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.053 0.059 -9999.0 0.0 -0.27 5.0 5.0 FAK1/Vinculin 0.055 0.103 0.313 2.0 -0.308 2.0 4.0 alphaV beta3/Integrin/ppsTEM5 0.042 0.075 -9999.0 0.0 -0.31 6.0 6.0 RHOA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VTN 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.034 0.017 -9999.0 0.0 -0.204 1.0 1.0 FGF2 -0.003 0.115 -9999.0 0.0 -0.297 24.0 24.0 F11R -0.013 0.091 -9999.0 0.0 -0.359 11.0 11.0 alphaV/beta3 Integrin/Lactadherin 0.043 0.083 -9999.0 0.0 -0.289 10.0 10.0 alphaV/beta3 Integrin/TGFBR2 0.054 0.068 -9999.0 0.0 -0.298 6.0 6.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.073 0.065 -9999.0 0.0 -0.272 5.0 5.0 HSP90AA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin 0.054 0.054 -9999.0 0.0 -0.27 4.0 4.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 -0.016 0.132 -9999.0 0.0 -0.3 32.0 32.0 alphaV/beta3 Integrin/Pyk2 0.038 0.056 -9999.0 0.0 -0.25 5.0 5.0 SDC1 0.033 0.036 -9999.0 0.0 -0.483 1.0 1.0 VAV3 -0.047 0.115 -9999.0 0.0 -0.265 43.0 43.0 PTPN11 0.029 0.053 -9999.0 0.0 -0.39 3.0 3.0 IRS1 0.013 0.098 -9999.0 0.0 -0.382 11.0 11.0 FAK1/Paxillin 0.058 0.102 0.288 3.0 -0.308 2.0 5.0 cell migration 0.049 0.097 0.263 4.0 -0.283 2.0 6.0 ITGAV 0.021 0.083 -9999.0 0.0 -0.403 7.0 7.0 PI3K 0.045 0.106 -9999.0 0.0 -0.318 2.0 2.0 SPP1 -0.172 0.221 -9999.0 0.0 -0.36 109.0 109.0 KDR 0.032 0.04 -9999.0 0.0 -0.343 2.0 2.0 mol:PI-4-5-P2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.021 0.082 -9999.0 0.0 -0.403 7.0 7.0 COL4A3 0.031 0.033 -9999.0 0.0 -0.204 4.0 4.0 angiogenesis -0.022 0.148 -9999.0 0.0 -0.529 12.0 12.0 Rac1/GTP -0.029 0.112 -9999.0 0.0 -0.248 37.0 37.0 EDIL3 -0.035 0.167 -9999.0 0.0 -0.393 34.0 34.0 cell proliferation 0.053 0.067 -9999.0 0.0 -0.297 6.0 6.0