Osteopontin-mediated events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IKK alpha homodimer -0.083 0.144 -9999.0 0.0 -0.386 12.0 12.0 NF kappa B1 p50/RelA/I kappa B alpha -0.084 0.151 0.33 2.0 -0.45 9.0 11.0 alphaV/beta3 Integrin/Osteopontin/Src -0.117 0.179 -9999.0 0.0 -0.354 65.0 65.0 AP1 -0.149 0.18 -9999.0 0.0 -0.451 26.0 26.0 ILK -0.092 0.136 -9999.0 0.0 -0.355 11.0 11.0 bone resorption -0.093 0.134 -9999.0 0.0 -0.353 13.0 13.0 PTK2B 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PYK2/p130Cas -0.067 0.149 -9999.0 0.0 -0.344 11.0 11.0 ITGAV 0.02 0.083 -9999.0 0.0 -0.403 7.0 7.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD44/Rho Family GTPase/ROCK2 0.026 0.098 -9999.0 0.0 -0.349 13.0 13.0 alphaV/beta3 Integrin/Osteopontin -0.087 0.164 -9999.0 0.0 -0.298 65.0 65.0 MAP3K1 -0.095 0.138 -9999.0 0.0 -0.276 63.0 63.0 JUN -0.018 0.15 -9999.0 0.0 -0.405 25.0 25.0 MAPK3 -0.101 0.133 -9999.0 0.0 -0.41 10.0 10.0 MAPK1 -0.096 0.132 -9999.0 0.0 -0.384 12.0 12.0 Rac1/GDP 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.094 0.126 -9999.0 0.0 -0.348 12.0 12.0 ITGB3 0.032 0.024 -9999.0 0.0 -0.212 1.0 1.0 NFKBIA -0.101 0.143 0.339 1.0 -0.424 14.0 15.0 FOS -0.063 0.171 -9999.0 0.0 -0.319 56.0 56.0 CD44 0.03 0.051 -9999.0 0.0 -0.483 2.0 2.0 CHUK 0.027 0.062 -9999.0 0.0 -0.483 3.0 3.0 PLAU -0.153 0.303 -9999.0 0.0 -1.142 15.0 15.0 NF kappa B1 p50/RelA -0.084 0.163 -9999.0 0.0 -0.454 13.0 13.0 BCAR1 0.034 0.017 -9999.0 0.0 -0.204 1.0 1.0 RELA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin 0.04 0.064 -9999.0 0.0 -0.344 4.0 4.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SYK -0.095 0.139 -9999.0 0.0 -0.277 64.0 64.0 VAV3 -0.145 0.155 0.198 1.0 -0.335 54.0 55.0 MAP3K14 -0.093 0.136 -9999.0 0.0 -0.277 58.0 58.0 ROCK2 0.007 0.117 -9999.0 0.0 -0.46 12.0 12.0 SPP1 -0.172 0.219 -9999.0 0.0 -0.357 109.0 109.0 RAC1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.124 0.145 -9999.0 0.0 -0.344 35.0 35.0 MMP2 -0.147 0.161 -9999.0 0.0 -0.448 23.0 23.0