VEGFR1 specific signals Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR1 homodimer/VEGFB homodimer 0.006 0.101 -9999.0 0.0 -0.517 5.0 5.0 VEGFR1 homodimer/NRP1 -0.007 0.091 -9999.0 0.0 -0.505 5.0 5.0 mol:DAG 0.007 0.101 -9999.0 0.0 -0.545 4.0 4.0 VEGFR1 homodimer/NRP1/VEGFR 121 -0.006 0.084 -9999.0 0.0 -0.467 5.0 5.0 CaM/Ca2+ 0.015 0.1 -9999.0 0.0 -0.521 4.0 4.0 HIF1A 0.023 0.071 -9999.0 0.0 -0.326 5.0 5.0 GAB1 0.028 0.054 -9999.0 0.0 -0.39 3.0 3.0 AKT1 0.031 0.119 0.303 2.0 -0.518 4.0 6.0 PLCG1 0.007 0.102 -9999.0 0.0 -0.55 4.0 4.0 NOS3 0.082 0.14 0.305 27.0 -0.518 4.0 31.0 CBL 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:NO 0.086 0.139 0.303 30.0 -0.498 4.0 34.0 FLT1 -0.006 0.105 -9999.0 0.0 -0.577 5.0 5.0 PGF 0.025 0.044 -9999.0 0.0 -0.204 7.0 7.0 VEGFR1 homodimer/NRP2/VEGFR121 0.006 0.093 -9999.0 0.0 -0.494 5.0 5.0 CALM1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 eNOS/Hsp90 0.072 0.135 0.284 28.0 -0.483 4.0 32.0 endothelial cell proliferation 0.082 0.154 0.336 28.0 -0.548 4.0 32.0 mol:Ca2+ 0.007 0.101 -9999.0 0.0 -0.54 4.0 4.0 MAPK3 -0.008 0.093 0.257 1.0 -0.447 4.0 5.0 MAPK1 -0.004 0.093 0.257 1.0 -0.486 4.0 5.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 PLGF homodimer 0.025 0.044 -9999.0 0.0 -0.203 7.0 7.0 PRKACA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RP11-342D11.1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CAV1 0.023 0.064 -9999.0 0.0 -0.273 8.0 8.0 VEGFA homodimer -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR1 homodimer/VEGFA homodimer -0.007 0.091 -9999.0 0.0 -0.505 5.0 5.0 platelet activating factor biosynthetic process 0.065 0.149 0.332 24.0 -0.489 3.0 27.0 PI3K 0.067 0.125 -9999.0 0.0 -0.525 4.0 4.0 PRKCA 0.001 0.097 -9999.0 0.0 -0.508 4.0 4.0 PRKCB 0.001 0.094 -9999.0 0.0 -0.51 4.0 4.0 VEGFR1 homodimer/PLGF homodimer 0.006 0.1 -9999.0 0.0 -0.526 5.0 5.0 VEGFA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFB 0.031 0.051 -9999.0 0.0 -0.483 2.0 2.0 mol:IP3 0.007 0.101 -9999.0 0.0 -0.545 4.0 4.0 RASA1 0.034 0.134 -9999.0 0.0 -0.563 4.0 4.0 NRP2 0.03 0.046 -9999.0 0.0 -0.273 4.0 4.0 VEGFR1 homodimer -0.005 0.104 -9999.0 0.0 -0.575 5.0 5.0 VEGFB homodimer 0.031 0.051 -9999.0 0.0 -0.482 2.0 2.0 NCK1 0.026 0.071 -9999.0 0.0 -0.483 4.0 4.0 eNOS/Caveolin-1 0.09 0.145 0.309 24.0 -0.503 4.0 28.0 PTPN11 0.029 0.053 -9999.0 0.0 -0.39 3.0 3.0 mol:PI-3-4-5-P3 0.065 0.123 -9999.0 0.0 -0.518 4.0 4.0 mol:L-citrulline 0.086 0.139 0.303 30.0 -0.498 4.0 34.0 VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.021 0.092 -9999.0 0.0 -0.597 3.0 3.0 VEGFR1 homodimer/VEGFA homodimer/NCK1 0.005 0.095 -9999.0 0.0 -0.504 5.0 5.0 CD2AP 0.033 0.036 -9999.0 0.0 -0.483 1.0 1.0 PI3K/GAB1 0.071 0.129 -9999.0 0.0 -0.559 4.0 4.0 PDPK1 0.034 0.12 0.351 1.0 -0.565 3.0 4.0 VEGFR1 homodimer/VEGFA homodimer/SHP2 0.005 0.093 -9999.0 0.0 -0.483 5.0 5.0 mol:NADP 0.086 0.139 0.303 30.0 -0.498 4.0 34.0 HSP90AA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ubiquitin-dependent protein catabolic process 0.019 0.09 -9999.0 0.0 -0.589 3.0 3.0 VEGFR1 homodimer/NRP2 0.006 0.101 -9999.0 0.0 -0.533 5.0 5.0