E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.01 0.15 -9999.0 0.0 -0.509 16.0 16.0 KLHL20 0.027 0.119 0.217 9.0 -0.26 15.0 24.0 CYFIP2 0.009 0.112 -9999.0 0.0 -0.458 11.0 11.0 Rac1/GDP 0.051 0.139 0.281 3.0 -0.398 8.0 11.0 ENAH -0.022 0.157 -9999.0 0.0 -0.523 16.0 16.0 AP1M1 0.033 0.036 -9999.0 0.0 -0.483 1.0 1.0 RAP1B 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.011 0.093 -9999.0 0.0 -0.297 15.0 15.0 CDC42/GTP 0.039 0.103 -9999.0 0.0 -0.363 6.0 6.0 ABI1/Sra1/Nap1 -0.029 0.058 -9999.0 0.0 -0.182 19.0 19.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.014 0.126 -9999.0 0.0 -0.273 28.0 28.0 RAPGEF1 0.037 0.158 0.305 2.0 -0.487 11.0 13.0 CTNND1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.004 0.155 -9999.0 0.0 -0.522 16.0 16.0 CRK 0.033 0.168 -9999.0 0.0 -0.546 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.049 0.081 -9999.0 0.0 -0.298 10.0 10.0 alphaE/beta7 Integrin 0.014 0.101 -9999.0 0.0 -0.346 14.0 14.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.068 -9999.0 0.0 -0.259 10.0 10.0 Rap1/GTP/I-afadin 0.054 0.06 -9999.0 0.0 -0.27 6.0 6.0 DLG1 -0.01 0.147 -9999.0 0.0 -0.5 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.055 -9999.0 0.0 -0.281 5.0 5.0 MLLT4 0.02 0.087 -9999.0 0.0 -0.483 6.0 6.0 ARF6/GTP/NME1/Tiam1 0.048 0.06 -9999.0 0.0 -0.282 5.0 5.0 PI3K -0.011 0.074 -9999.0 0.0 -0.377 5.0 5.0 ARF6 0.028 0.051 -9999.0 0.0 -0.483 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.087 -9999.0 0.0 -0.349 10.0 10.0 TIAM1 0.028 0.054 -9999.0 0.0 -0.39 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.048 0.096 -9999.0 0.0 -0.261 15.0 15.0 AKT1 0.03 0.068 0.177 3.0 -0.206 5.0 8.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 CDH1 0.011 0.111 -9999.0 0.0 -0.483 10.0 10.0 RhoA/GDP 0.062 0.142 0.273 4.0 -0.361 11.0 15.0 actin cytoskeleton organization 0.026 0.092 0.182 10.0 -0.187 15.0 25.0 CDC42/GDP 0.057 0.142 0.273 4.0 -0.361 11.0 15.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.056 -9999.0 0.0 -0.233 10.0 10.0 ITGB7 0.0 0.13 -9999.0 0.0 -0.483 14.0 14.0 RAC1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.052 0.102 -9999.0 0.0 -0.278 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.031 0.088 -9999.0 0.0 -0.259 15.0 15.0 mol:GDP 0.047 0.155 0.274 4.0 -0.426 11.0 15.0 CDC42/GTP/IQGAP1 0.042 0.019 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 p120 catenin/RhoA/GDP 0.071 0.147 0.286 3.0 -0.406 8.0 11.0 RAC1/GTP/IQGAP1 0.042 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.03 -9999.0 0.0 -0.349 1.0 1.0 RHOA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.019 -9999.0 0.0 -0.204 1.0 1.0 CTNNA1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.025 0.074 0.156 13.0 -0.195 5.0 18.0 NME1 0.031 0.037 -9999.0 0.0 -0.483 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.011 0.149 -9999.0 0.0 -0.509 16.0 16.0 regulation of cell-cell adhesion -0.002 0.069 -9999.0 0.0 -0.314 6.0 6.0 WASF2 0.01 0.053 0.107 9.0 -0.15 3.0 12.0 Rap1/GTP 0.073 0.127 0.287 2.0 -0.413 6.0 8.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.117 -9999.0 0.0 -0.255 24.0 24.0 CCND1 0.028 0.088 0.181 12.0 -0.244 5.0 17.0 VAV2 -0.0 0.288 -9999.0 0.0 -0.702 23.0 23.0 RAP1/GDP 0.075 0.136 0.297 2.0 -0.427 6.0 8.0 adherens junction assembly -0.011 0.144 -9999.0 0.0 -0.491 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.014 0.117 -9999.0 0.0 -0.251 27.0 27.0 E-cadherin/beta catenin -0.004 0.081 -9999.0 0.0 -0.336 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.022 0.145 -9999.0 0.0 -0.584 11.0 11.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.047 0.137 -9999.0 0.0 -0.397 22.0 22.0 E-cadherin/beta catenin/alpha catenin 0.034 0.103 -9999.0 0.0 -0.304 15.0 15.0 ITGAE 0.026 0.031 -9999.0 0.0 -0.204 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.159 -9999.0 0.0 -0.535 16.0 16.0