Canonical Wnt signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations HDAC1 0.05 0.041 0.213 5.0 -9999.0 0.0 5.0 AES 0.044 0.051 0.2 1.0 -0.487 1.0 2.0 FBXW11 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LRP6/FZD1 0.049 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SMAD4 0.017 0.063 -9999.0 0.0 -0.483 3.0 3.0 DKK2 -0.031 0.148 -9999.0 0.0 -0.308 40.0 40.0 TLE1 0.019 0.126 0.198 2.0 -0.471 12.0 14.0 MACF1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.037 0.092 0.324 3.0 -0.29 1.0 4.0 WIF1 -0.023 0.103 -9999.0 0.0 -0.204 51.0 51.0 beta catenin/RanBP3 0.085 0.183 0.416 42.0 -9999.0 0.0 42.0 KREMEN2 -0.071 0.175 -9999.0 0.0 -0.308 64.0 64.0 DKK1 -0.099 0.19 -9999.0 0.0 -0.317 79.0 79.0 beta catenin/beta TrCP1 0.053 0.094 0.327 3.0 -9999.0 0.0 3.0 FZD1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AXIN2 -0.263 0.629 0.644 8.0 -1.521 40.0 48.0 AXIN1 0.031 0.051 -9999.0 0.0 -0.481 2.0 2.0 RAN 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/GSK3/beta catenin 0.04 0.088 -9999.0 0.0 -0.556 3.0 3.0 beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 -0.053 0.192 0.289 1.0 -0.58 11.0 12.0 Axin1/APC/GSK3 0.062 0.079 0.268 2.0 -0.37 1.0 3.0 Axin1/APC/GSK3/beta catenin/Macf1 0.024 0.087 -9999.0 0.0 -0.365 3.0 3.0 HNF1A 0.014 0.036 0.16 6.0 -9999.0 0.0 6.0 CTBP1 0.048 0.037 0.206 4.0 -9999.0 0.0 4.0 MYC 0.011 0.437 0.626 29.0 -1.595 10.0 39.0 RANBP3 0.033 0.036 -9999.0 0.0 -0.473 1.0 1.0 DKK2/LRP6/Kremen 2 -0.052 0.154 -9999.0 0.0 -0.308 44.0 44.0 NKD1 -0.144 0.215 -9999.0 0.0 -0.351 97.0 97.0 TCF4 0.033 0.048 0.197 4.0 -0.194 2.0 6.0 TCF3 0.04 0.069 0.213 1.0 -0.442 3.0 4.0 WNT1/LRP6/FZD1/Axin1 0.08 0.047 -9999.0 0.0 -0.267 2.0 2.0 Ran/GTP 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CtBP/CBP/TCF/TLE1/AES 0.049 0.244 0.486 39.0 -0.51 3.0 42.0 LEF1 0.016 0.115 0.212 1.0 -0.305 19.0 20.0 DVL1 0.029 0.08 0.234 1.0 -0.518 2.0 3.0 CSNK2A1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 beta catenin/TCF/CtBP/CBP/TLE1/AES -0.039 0.152 0.306 1.0 -0.603 6.0 7.0 DKK1/LRP6/Kremen 2 -0.093 0.175 -9999.0 0.0 -0.333 57.0 57.0 LRP6 0.034 0.018 -9999.0 0.0 -0.203 1.0 1.0 CSNK1A1 0.051 0.04 0.21 5.0 -9999.0 0.0 5.0 NLK 0.029 0.021 -9999.0 0.0 -0.203 1.0 1.0 CCND1 -0.057 0.214 -9999.0 0.0 -1.31 4.0 4.0 WNT1 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GSK3A 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.033 0.036 -9999.0 0.0 -0.483 1.0 1.0 FRAT1 0.029 0.051 -9999.0 0.0 -0.483 2.0 2.0 PPP2R5D 0.112 0.114 0.291 48.0 -9999.0 0.0 48.0 APC 0.015 0.08 0.544 1.0 -0.258 10.0 11.0 WNT1/LRP6/FZD1 0.044 0.04 -9999.0 0.0 -0.228 1.0 1.0 CREBBP 0.046 0.053 0.213 2.0 -0.486 1.0 3.0