Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.015 0.116 -9999.0 0.0 -0.552 6.0 6.0 IHH 0.025 0.095 -9999.0 0.0 -0.528 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.072 0.14 -9999.0 0.0 -0.302 46.0 46.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.072 0.139 0.3 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.003 0.123 -9999.0 0.0 -0.391 10.0 10.0 SMO -0.007 0.117 -9999.0 0.0 -0.395 11.0 11.0 AKT1 -0.013 0.151 -9999.0 0.0 -0.56 8.0 8.0 ARRB2 0.027 0.038 -9999.0 0.0 -0.483 1.0 1.0 BOC 0.026 0.054 -9999.0 0.0 -0.243 7.0 7.0 ADRBK1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.008 0.119 -9999.0 0.0 -0.387 12.0 12.0 STIL -0.004 0.102 -9999.0 0.0 -0.281 10.0 10.0 DHH N/PTCH2 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.028 0.076 -9999.0 0.0 -0.296 9.0 9.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.004 0.167 -9999.0 0.0 -0.864 6.0 6.0 determination of left/right symmetry -0.008 0.119 -9999.0 0.0 -0.387 12.0 12.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 skeletal system development 0.004 0.165 -9999.0 0.0 -0.852 6.0 6.0 IHH N/Hhip -0.017 0.161 -9999.0 0.0 -0.402 28.0 28.0 DHH N/Hhip -0.008 0.134 -9999.0 0.0 -0.349 25.0 25.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.008 0.119 -9999.0 0.0 -0.387 12.0 12.0 pancreas development -0.039 0.172 -9999.0 0.0 -0.403 35.0 35.0 HHAT -0.001 0.125 -9999.0 0.0 -0.401 17.0 17.0 PI3K 0.045 0.049 -9999.0 0.0 -0.349 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.12 0.202 -9999.0 0.0 -0.331 88.0 88.0 somite specification -0.008 0.119 -9999.0 0.0 -0.387 12.0 12.0 SHH Np/Cholesterol/PTCH1 -0.004 0.091 -9999.0 0.0 -0.249 22.0 22.0 SHH Np/Cholesterol/PTCH2 0.01 0.079 -9999.0 0.0 -0.275 13.0 13.0 SHH Np/Cholesterol/Megalin 0.009 0.08 -9999.0 0.0 -0.276 13.0 13.0 SHH -0.01 0.094 -9999.0 0.0 -0.357 13.0 13.0 catabolic process 0.008 0.079 -9999.0 0.0 -0.332 9.0 9.0 SMO/Vitamin D3 -0.012 0.112 -9999.0 0.0 -0.333 13.0 13.0 SHH Np/Cholesterol/Hhip -0.032 0.131 -9999.0 0.0 -0.308 33.0 33.0 LRP2 0.033 0.024 -9999.0 0.0 -0.204 2.0 2.0 receptor-mediated endocytosis -0.011 0.108 -9999.0 0.0 -0.321 13.0 13.0 SHH Np/Cholesterol/BOC 0.005 0.081 -9999.0 0.0 -0.276 13.0 13.0 SHH Np/Cholesterol/CDO 0.008 0.079 -9999.0 0.0 -0.276 13.0 13.0 mesenchymal cell differentiation 0.032 0.13 0.307 33.0 -9999.0 0.0 33.0 mol:Vitamin D3 0.005 0.101 0.206 3.0 -0.249 22.0 25.0 IHH N/PTCH2 0.044 0.063 -9999.0 0.0 -0.318 5.0 5.0 CDON 0.033 0.024 -9999.0 0.0 -0.204 2.0 2.0 IHH N/PTCH1 0.027 0.084 -9999.0 0.0 -0.334 9.0 9.0 Megalin/LRPAP1 0.049 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.035 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.074 -9999.0 0.0 -0.274 13.0 13.0 PTCH1 0.008 0.079 -9999.0 0.0 -0.333 9.0 9.0 HHIP -0.039 0.172 -9999.0 0.0 -0.403 35.0 35.0