Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.07 -9999.0 0.0 -0.236 15.0 15.0 epithelial cell differentiation 0.041 0.093 -9999.0 0.0 -0.259 15.0 15.0 CYFIP2 0.009 0.112 -9999.0 0.0 -0.458 11.0 11.0 ENAH -0.042 0.089 0.279 1.0 -0.358 5.0 6.0 EGFR 0.016 0.09 -9999.0 0.0 -0.413 8.0 8.0 EPHA2 0.011 0.088 -9999.0 0.0 -0.278 15.0 15.0 MYO6 -0.009 0.083 -9999.0 0.0 -0.249 19.0 19.0 CTNNB1 0.011 0.093 -9999.0 0.0 -0.297 15.0 15.0 ABI1/Sra1/Nap1 0.044 0.089 -9999.0 0.0 -0.307 10.0 10.0 AQP5 -0.023 0.093 -9999.0 0.0 -0.471 4.0 4.0 CTNND1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.074 -9999.0 0.0 -0.246 15.0 15.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.101 -9999.0 0.0 -0.247 33.0 33.0 EGF -0.088 0.187 -9999.0 0.0 -0.32 72.0 72.0 NCKAP1 0.021 0.068 -9999.0 0.0 -0.259 10.0 10.0 AQP3 -0.037 0.108 -9999.0 0.0 -0.419 10.0 10.0 cortical microtubule organization 0.041 0.093 -9999.0 0.0 -0.259 15.0 15.0 GO:0000145 -0.026 0.064 -9999.0 0.0 -0.235 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.048 0.096 -9999.0 0.0 -0.261 15.0 15.0 MLLT4 0.02 0.087 -9999.0 0.0 -0.483 6.0 6.0 ARF6/GDP -0.051 0.089 -9999.0 0.0 -0.383 7.0 7.0 ARF6 0.028 0.051 -9999.0 0.0 -0.483 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.047 0.097 -9999.0 0.0 -0.287 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.015 0.076 -9999.0 0.0 -0.304 2.0 2.0 PVRL2 0.03 0.043 -9999.0 0.0 -0.297 3.0 3.0 ZYX -0.006 0.08 -9999.0 0.0 -0.249 17.0 17.0 ARF6/GTP 0.046 0.103 -9999.0 0.0 -0.272 13.0 13.0 CDH1 0.011 0.111 -9999.0 0.0 -0.483 10.0 10.0 EGFR/EGFR/EGF/EGF -0.043 0.139 -9999.0 0.0 -0.271 44.0 44.0 RhoA/GDP 0.044 0.091 -9999.0 0.0 -0.248 15.0 15.0 actin cytoskeleton organization -0.016 0.078 -9999.0 0.0 -0.246 15.0 15.0 IGF-1R heterotetramer 0.03 0.04 -9999.0 0.0 -0.343 2.0 2.0 GIT1 0.033 0.018 -9999.0 0.0 -0.204 1.0 1.0 IGF1R 0.03 0.04 -9999.0 0.0 -0.343 2.0 2.0 IGF1 0.015 0.081 -9999.0 0.0 -0.263 14.0 14.0 DIAPH1 0.021 0.185 -9999.0 0.0 -0.64 10.0 10.0 Wnt receptor signaling pathway -0.041 0.093 0.259 15.0 -9999.0 0.0 15.0 RHOA 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.05 0.087 -9999.0 0.0 -0.401 6.0 6.0 CTNNA1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.079 -9999.0 0.0 -0.251 15.0 15.0 EFNA1 0.021 0.076 -9999.0 0.0 -0.363 7.0 7.0 LPP -0.026 0.067 -9999.0 0.0 -0.241 15.0 15.0 Ephrin A1/EPHA2 0.014 0.118 -9999.0 0.0 -0.302 19.0 19.0 SEC6/SEC8 -0.014 0.093 -9999.0 0.0 -0.4 7.0 7.0 MGAT3 -0.04 0.102 -9999.0 0.0 -0.251 33.0 33.0 HGF/MET 0.028 0.098 -9999.0 0.0 -0.261 17.0 17.0 HGF 0.03 0.043 -9999.0 0.0 -0.297 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.07 -9999.0 0.0 -0.238 15.0 15.0 actin cable formation -0.02 0.101 0.249 5.0 -0.318 5.0 10.0 KIAA1543 -0.035 0.08 -9999.0 0.0 -0.325 6.0 6.0 KIFC3 -0.007 0.08 -9999.0 0.0 -0.25 16.0 16.0 NCK1 0.026 0.071 -9999.0 0.0 -0.483 4.0 4.0 EXOC3 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.004 0.076 -9999.0 0.0 -0.25 15.0 15.0 NCK1/GIT1 0.042 0.058 -9999.0 0.0 -0.349 4.0 4.0 mol:GDP 0.041 0.093 -9999.0 0.0 -0.259 15.0 15.0 EXOC4 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.064 -9999.0 0.0 -0.248 15.0 15.0 PIP5K1C -0.005 0.075 -9999.0 0.0 -0.25 15.0 15.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.033 0.093 0.3 1.0 -0.399 4.0 5.0 adherens junction assembly -0.013 0.095 0.38 1.0 -0.418 3.0 4.0 IGF-1R heterotetramer/IGF1 0.019 0.099 -9999.0 0.0 -0.252 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.076 -9999.0 0.0 -0.349 7.0 7.0 MET 0.027 0.056 -9999.0 0.0 -0.343 4.0 4.0 PLEKHA7 -0.003 0.076 -9999.0 0.0 -0.25 15.0 15.0 mol:GTP 0.045 0.096 -9999.0 0.0 -0.286 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.026 0.096 -9999.0 0.0 -0.385 7.0 7.0 cortical actin cytoskeleton stabilization 0.005 0.07 -9999.0 0.0 -0.236 15.0 15.0 regulation of cell-cell adhesion -0.016 0.078 -9999.0 0.0 -0.246 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.07 -9999.0 0.0 -0.238 15.0 15.0