IL27-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB1 0.034 0.017 -9999.0 0.0 -0.204 1.0 1.0 CD4-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cytokine production during immune response 0.125 0.21 0.609 22.0 -9999.0 0.0 22.0 IL27/IL27R/JAK1 -0.144 0.33 -9999.0 0.0 -1.144 16.0 16.0 TBX21 -0.188 0.249 0.378 1.0 -0.598 42.0 43.0 IL12B 0.018 0.06 -9999.0 0.0 -0.317 5.0 5.0 IL12A -0.027 0.088 -9999.0 0.0 -0.231 27.0 27.0 IL6ST 0.017 0.028 -9999.0 0.0 -9999.0 0.0 0.0 IL27RA/JAK1 -0.098 0.339 -9999.0 0.0 -1.296 15.0 15.0 IL27 -0.098 0.201 -9999.0 0.0 -0.411 55.0 55.0 TYK2 0.013 0.031 -9999.0 0.0 -9999.0 0.0 0.0 T-helper cell lineage commitment -0.041 0.125 0.198 15.0 -0.268 39.0 54.0 T-helper 2 cell differentiation 0.125 0.21 0.609 22.0 -9999.0 0.0 22.0 T cell proliferation during immune response 0.125 0.21 0.609 22.0 -9999.0 0.0 22.0 MAPKKK cascade -0.125 0.21 -9999.0 0.0 -0.609 22.0 22.0 STAT3 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STAT2 0.032 0.04 -9999.0 0.0 -0.343 2.0 2.0 STAT1 0.014 0.068 -9999.0 0.0 -0.207 18.0 18.0 IL12RB1 0.032 0.018 -9999.0 0.0 -0.206 1.0 1.0 positive regulation of tyrosine phosphorylation of STAT protein 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB2 -0.17 0.232 0.379 1.0 -0.574 35.0 36.0 IL27/IL27R/JAK2/TYK2 -0.126 0.214 -9999.0 0.0 -0.619 22.0 22.0 positive regulation of T cell mediated cytotoxicity -0.125 0.21 -9999.0 0.0 -0.609 22.0 22.0 STAT1 (dimer) -0.186 0.348 0.518 1.0 -0.945 24.0 25.0 JAK2 -0.002 0.081 -9999.0 0.0 -0.285 12.0 12.0 JAK1 0.032 0.036 -9999.0 0.0 -0.482 1.0 1.0 STAT2 (dimer) -0.114 0.212 -9999.0 0.0 -0.593 22.0 22.0 T cell proliferation -0.177 0.227 -9999.0 0.0 -0.542 40.0 40.0 IL12/IL12R/TYK2/JAK2 -0.061 0.199 -9999.0 0.0 -0.864 7.0 7.0 IL17A -0.042 0.124 0.199 14.0 -0.268 39.0 53.0 mast cell activation 0.125 0.21 0.609 22.0 -9999.0 0.0 22.0 IFNG -0.033 0.056 -9999.0 0.0 -0.126 42.0 42.0 T cell differentiation -0.01 0.01 -9999.0 0.0 -0.024 58.0 58.0 STAT3 (dimer) -0.107 0.21 -9999.0 0.0 -0.588 21.0 21.0 STAT5A (dimer) -0.11 0.213 -9999.0 0.0 -0.602 21.0 21.0 STAT4 (dimer) -0.118 0.219 -9999.0 0.0 -0.597 24.0 24.0 STAT4 0.02 0.079 -9999.0 0.0 -0.328 9.0 9.0 T cell activation 0.001 0.034 0.121 15.0 -9999.0 0.0 15.0 IL27R/JAK2/TYK2 -0.1 0.33 -9999.0 0.0 -1.228 15.0 15.0 GATA3 0.015 0.151 0.565 1.0 -1.393 2.0 3.0 IL18 -0.031 0.106 -9999.0 0.0 -0.299 26.0 26.0 positive regulation of mast cell cytokine production -0.105 0.205 -9999.0 0.0 -0.574 21.0 21.0 IL27/EBI3 -0.062 0.152 -9999.0 0.0 -0.337 43.0 43.0 IL27RA -0.113 0.356 -9999.0 0.0 -1.38 15.0 15.0 IL6 -0.117 0.203 -9999.0 0.0 -0.343 82.0 82.0 STAT5A 0.027 0.049 -9999.0 0.0 -0.259 5.0 5.0 monocyte differentiation -0.002 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IL2 0.036 0.122 0.465 15.0 -9999.0 0.0 15.0 IL1B -0.055 0.126 -9999.0 0.0 -0.271 47.0 47.0 EBI3 0.017 0.027 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.001 0.043 -9999.0 0.0 -0.182 9.0 9.0