IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 0.002 0.278 -9999.0 0.0 -0.799 10.0 10.0 CRP -0.057 0.255 -9999.0 0.0 -0.786 12.0 12.0 cell cycle arrest -0.08 0.29 -9999.0 0.0 -0.833 17.0 17.0 TIMP1 -0.046 0.241 -9999.0 0.0 -0.721 13.0 13.0 IL6ST 0.032 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.063 0.183 -9999.0 0.0 -0.537 16.0 16.0 AP1 0.008 0.149 -9999.0 0.0 -0.508 3.0 3.0 GAB2 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.108 0.41 -9999.0 0.0 -1.013 30.0 30.0 HSP90B1 -0.001 0.087 -9999.0 0.0 -1.04 1.0 1.0 GAB1 0.029 0.054 -9999.0 0.0 -0.398 3.0 3.0 MAPK14 -0.07 0.19 -9999.0 0.0 -0.66 12.0 12.0 AKT1 0.029 0.081 -9999.0 0.0 -0.421 4.0 4.0 FOXO1 0.031 0.079 -9999.0 0.0 -0.401 4.0 4.0 MAP2K6 -0.067 0.178 -9999.0 0.0 -0.502 17.0 17.0 mol:GTP -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.078 0.187 -9999.0 0.0 -0.548 17.0 17.0 MITF -0.06 0.167 -9999.0 0.0 -0.443 19.0 19.0 positive regulation of NF-kappaB transcription factor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.029 0.28 -9999.0 0.0 -1.33 9.0 9.0 CEBPB 0.016 0.039 -9999.0 0.0 -0.483 1.0 1.0 GRB2/SOS1/GAB family/SHP2 0.018 0.101 -9999.0 0.0 -0.411 4.0 4.0 STAT3 -0.087 0.31 -9999.0 0.0 -0.929 16.0 16.0 STAT1 0.016 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CEBPD -0.047 0.255 -9999.0 0.0 -0.783 11.0 11.0 PIK3CA 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.047 0.05 -9999.0 0.0 -0.349 3.0 3.0 JUN -0.017 0.15 -9999.0 0.0 -0.405 25.0 25.0 PIAS3/MITF -0.049 0.169 -9999.0 0.0 -0.464 16.0 16.0 MAPK11 -0.068 0.187 -9999.0 0.0 -0.647 12.0 12.0 STAT3 (dimer)/FOXO1 -0.04 0.24 -9999.0 0.0 -0.689 13.0 13.0 GRB2/SOS1/GAB family 0.004 0.173 -9999.0 0.0 -0.447 13.0 13.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.067 0.145 -9999.0 0.0 -0.449 16.0 16.0 GRB2 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.015 0.078 -9999.0 0.0 -0.273 12.0 12.0 LBP 0.042 0.23 -9999.0 0.0 -0.566 10.0 10.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 JAK1 0.031 0.038 -9999.0 0.0 -0.47 1.0 1.0 MYC -0.068 0.33 -9999.0 0.0 -0.96 18.0 18.0 FGG -0.073 0.267 -9999.0 0.0 -0.833 14.0 14.0 macrophage differentiation -0.08 0.29 -9999.0 0.0 -0.833 17.0 17.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.048 0.172 -9999.0 0.0 -0.29 53.0 53.0 JUNB -0.07 0.263 -9999.0 0.0 -0.795 15.0 15.0 FOS -0.063 0.171 -9999.0 0.0 -0.318 56.0 56.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.061 0.164 -9999.0 0.0 -0.483 15.0 15.0 STAT1/PIAS1 -0.033 0.166 -9999.0 0.0 -0.472 11.0 11.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.038 0.075 -9999.0 0.0 -0.387 3.0 3.0 STAT3 (dimer) -0.084 0.307 -9999.0 0.0 -0.914 16.0 16.0 PRKCD -0.07 0.229 0.363 9.0 -0.609 18.0 27.0 IL6R 0.019 0.08 -9999.0 0.0 -0.345 8.0 8.0 SOCS3 -0.078 0.256 -9999.0 0.0 -1.034 10.0 10.0 gp130 (dimer)/JAK1/JAK1/LMO4 0.03 0.106 -9999.0 0.0 -0.291 13.0 13.0 Rac1/GTP -0.064 0.191 -9999.0 0.0 -0.554 16.0 16.0 HCK -0.013 0.11 -9999.0 0.0 -0.352 17.0 17.0 MAPKKK cascade 0.043 0.11 -9999.0 0.0 -0.539 3.0 3.0 bone resorption -0.094 0.382 -9999.0 0.0 -0.928 30.0 30.0 IRF1 -0.088 0.302 -9999.0 0.0 -0.957 15.0 15.0 mol:GDP -0.071 0.185 -9999.0 0.0 -0.497 20.0 20.0 SOS1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.073 0.187 -9999.0 0.0 -0.506 20.0 20.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.069 0.209 -9999.0 0.0 -0.724 13.0 13.0 PTPN11 0.009 0.116 -9999.0 0.0 -0.92 3.0 3.0 IL6/IL6RA -0.077 0.166 -9999.0 0.0 -0.336 50.0 50.0 gp130 (dimer)/TYK2/TYK2/LMO4 0.035 0.098 -9999.0 0.0 -0.294 12.0 12.0 gp130 (dimer)/JAK2/JAK2/LMO4 0.023 0.109 -9999.0 0.0 -0.274 19.0 19.0 IL6 -0.119 0.203 -9999.0 0.0 -0.345 82.0 82.0 PIAS3 0.033 0.024 -9999.0 0.0 -0.204 2.0 2.0 PTPRE 0.019 0.069 -9999.0 0.0 -0.336 6.0 6.0 PIAS1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.057 0.133 -9999.0 0.0 -0.328 22.0 22.0 LMO4 -0.017 0.133 -9999.0 0.0 -0.323 28.0 28.0 STAT3 (dimer)/PIAS3 -0.077 0.293 -9999.0 0.0 -0.853 16.0 16.0 MCL1 0.034 0.136 -9999.0 0.0 -0.901 3.0 3.0