IL23-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CCL2 -0.509 0.611 -9999.0 0.0 -1.285 69.0 69.0 IL23A -0.564 0.626 -9999.0 0.0 -1.305 76.0 76.0 NF kappa B1 p50/RelA/I kappa B alpha -0.483 0.587 -9999.0 0.0 -1.178 73.0 73.0 positive regulation of T cell mediated cytotoxicity -0.526 0.652 -9999.0 0.0 -1.33 69.0 69.0 ITGA3 -0.485 0.568 -9999.0 0.0 -1.217 65.0 65.0 IL17F -0.303 0.353 -9999.0 0.0 -0.743 63.0 63.0 IL12B -0.018 0.074 -9999.0 0.0 -0.371 4.0 4.0 STAT1 (dimer) -0.505 0.623 -9999.0 0.0 -1.276 69.0 69.0 CD4 -0.442 0.529 -9999.0 0.0 -1.155 59.0 59.0 IL23 -0.542 0.594 -9999.0 0.0 -1.242 76.0 76.0 IL23R -0.123 0.362 -9999.0 0.0 -1.466 13.0 13.0 IL1B -0.555 0.64 -9999.0 0.0 -1.353 69.0 69.0 T-helper cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL24 -0.451 0.535 -9999.0 0.0 -1.178 58.0 58.0 TYK2 -0.009 0.041 -9999.0 0.0 -9999.0 0.0 0.0 STAT4 0.02 0.079 -9999.0 0.0 -0.328 9.0 9.0 STAT3 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IL18RAP -0.067 0.186 -9999.0 0.0 -0.373 50.0 50.0 IL12RB1 -0.011 0.044 -9999.0 0.0 -0.242 1.0 1.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IL12Rbeta1/TYK2 -0.008 0.055 -9999.0 0.0 -0.182 1.0 1.0 IL23R/JAK2 -0.133 0.349 -9999.0 0.0 -1.384 13.0 13.0 positive regulation of chronic inflammatory response -0.526 0.652 -9999.0 0.0 -1.33 69.0 69.0 natural killer cell activation 0.01 0.019 0.081 11.0 -9999.0 0.0 11.0 JAK2 -0.026 0.089 -9999.0 0.0 -0.312 11.0 11.0 PIK3R1 0.028 0.062 -9999.0 0.0 -0.483 3.0 3.0 NFKB1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of dendritic cell antigen processing and presentation -0.507 0.551 -9999.0 0.0 -1.154 76.0 76.0 ALOX12B -0.446 0.534 -9999.0 0.0 -1.169 59.0 59.0 CXCL1 -0.545 0.616 -9999.0 0.0 -1.27 76.0 76.0 T cell proliferation -0.526 0.652 -9999.0 0.0 -1.33 69.0 69.0 NFKBIA 0.025 0.044 -9999.0 0.0 -0.306 3.0 3.0 IL17A -0.236 0.275 -9999.0 0.0 -0.564 63.0 63.0 PI3K -0.473 0.597 -9999.0 0.0 -1.22 68.0 68.0 IFNG -0.03 0.06 0.129 7.0 -0.13 37.0 44.0 STAT3 (dimer) -0.441 0.566 -9999.0 0.0 -1.174 64.0 64.0 IL18R1 0.003 0.097 -9999.0 0.0 -0.284 18.0 18.0 IL23/IL23R/JAK2/TYK2/SOCS3 -0.244 0.325 -9999.0 0.0 -0.746 37.0 37.0 IL18/IL18R -0.072 0.189 -9999.0 0.0 -0.357 51.0 51.0 macrophage activation -0.024 0.022 -9999.0 0.0 -0.047 68.0 68.0 TNF -0.511 0.58 -9999.0 0.0 -1.221 70.0 70.0 STAT3/STAT4 -0.472 0.597 -9999.0 0.0 -1.212 69.0 69.0 STAT4 (dimer) -0.504 0.627 -9999.0 0.0 -1.282 69.0 69.0 IL18 -0.027 0.156 -9999.0 0.0 -0.422 26.0 26.0 IL19 -0.446 0.529 -9999.0 0.0 -1.158 59.0 59.0 STAT5A (dimer) -0.498 0.623 -9999.0 0.0 -1.268 69.0 69.0 STAT1 0.015 0.067 -9999.0 0.0 -0.204 18.0 18.0 SOCS3 0.013 0.091 -9999.0 0.0 -0.311 13.0 13.0 CXCL9 -0.62 0.662 -9999.0 0.0 -1.325 90.0 90.0 MPO -0.444 0.533 -9999.0 0.0 -1.149 61.0 61.0 positive regulation of humoral immune response -0.526 0.652 -9999.0 0.0 -1.33 69.0 69.0 IL23/IL23R/JAK2/TYK2 -0.573 0.742 -9999.0 0.0 -1.465 69.0 69.0 IL6 -0.56 0.638 -9999.0 0.0 -1.313 76.0 76.0 STAT5A 0.027 0.049 -9999.0 0.0 -0.259 5.0 5.0 IL2 0.026 0.028 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of tyrosine phosphorylation of STAT protein 0.01 0.019 0.081 11.0 -9999.0 0.0 11.0 CD3E -0.445 0.53 -9999.0 0.0 -1.155 60.0 60.0 keratinocyte proliferation -0.526 0.652 -9999.0 0.0 -1.33 69.0 69.0 NOS2 -0.445 0.532 -9999.0 0.0 -1.104 69.0 69.0