Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within IL23-mediated signaling events 43.0 2599.0 60.0 -0.62 0.035 1000.0 -1000.0 -0.066 -1000.0 HIF-1-alpha transcription factor network 34.0 2590.0 76.0 -0.294 0.041 1000.0 -1000.0 -0.031 -1000.0 TCGA08_p53 34.0 238.0 7.0 -0.082 0.029 1000.0 -1000.0 -0.004 -1000.0 Ephrin B reverse signaling 32.0 1557.0 48.0 -0.246 0.05 1000.0 -1000.0 -0.029 -1000.0 IL4-mediated signaling events 27.0 2510.0 91.0 -0.612 0.487 1000.0 -1000.0 -0.092 -1000.0 Fc-epsilon receptor I signaling in mast cells 27.0 2651.0 97.0 -0.182 0.036 1000.0 -1000.0 -0.058 -1000.0 Wnt signaling 27.0 192.0 7.0 -0.118 0.031 1000.0 -1000.0 -0.019 -1000.0 Endothelins 24.0 2399.0 96.0 -0.226 0.04 1000.0 -1000.0 -0.049 -1000.0 Signaling mediated by p38-alpha and p38-beta 24.0 1096.0 44.0 -0.155 0.035 1000.0 -1000.0 -0.028 -1000.0 Syndecan-1-mediated signaling events 23.0 810.0 34.0 -0.134 0.042 1000.0 -1000.0 -0.033 -1000.0 EGFR-dependent Endothelin signaling events 22.0 473.0 21.0 -0.088 0.051 1000.0 -1000.0 -0.001 -1000.0 IL12-mediated signaling events 21.0 1879.0 87.0 -0.327 0.039 1000.0 -1000.0 -0.045 -1000.0 Osteopontin-mediated events 21.0 822.0 38.0 -0.172 0.04 1000.0 -1000.0 -0.041 -1000.0 Thromboxane A2 receptor signaling 21.0 2251.0 105.0 -0.171 0.051 1000.0 -1000.0 -0.04 -1000.0 Glypican 1 network 21.0 1012.0 48.0 -0.129 0.044 1000.0 -1000.0 -0.017 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 21.0 1451.0 68.0 -0.378 0.174 1000.0 -1000.0 -0.058 -1000.0 TCGA08_retinoblastoma 21.0 170.0 8.0 -0.03 0.036 1000.0 -1000.0 -0.004 -1000.0 Noncanonical Wnt signaling pathway 20.0 527.0 26.0 -0.118 0.035 1000.0 -1000.0 -0.055 -1000.0 IL27-mediated signaling events 20.0 1058.0 51.0 -0.188 0.125 1000.0 -1000.0 -0.061 -1000.0 FOXA2 and FOXA3 transcription factor networks 19.0 881.0 46.0 -0.248 0.04 1000.0 -1000.0 -0.054 -1000.0 Calcium signaling in the CD4+ TCR pathway 19.0 592.0 31.0 -0.199 0.032 1000.0 -1000.0 -0.039 -1000.0 Glypican 2 network 18.0 75.0 4.0 -0.01 -0.0 1000.0 -1000.0 -0.0 -1000.0 Glucocorticoid receptor regulatory network 17.0 2018.0 114.0 -0.389 0.212 1000.0 -1000.0 -0.054 -1000.0 IL1-mediated signaling events 17.0 1081.0 62.0 -0.153 0.082 1000.0 -1000.0 -0.041 -1000.0 FAS signaling pathway (CD95) 17.0 820.0 47.0 -0.311 0.057 1000.0 -1000.0 -0.027 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 17.0 1357.0 78.0 -0.238 0.052 1000.0 -1000.0 -0.052 -1000.0 Presenilin action in Notch and Wnt signaling 16.0 1018.0 61.0 -0.144 0.099 1000.0 -1000.0 -0.045 -1000.0 BMP receptor signaling 16.0 1351.0 81.0 -0.155 0.064 1000.0 -1000.0 -0.044 -1000.0 amb2 Integrin signaling 16.0 1382.0 82.0 -0.163 0.045 1000.0 -1000.0 -0.026 -1000.0 TCR signaling in naïve CD8+ T cells 15.0 1427.0 93.0 -0.084 0.051 1000.0 -1000.0 -0.042 -1000.0 Canonical Wnt signaling pathway 15.0 787.0 51.0 -0.263 0.112 1000.0 -1000.0 -0.043 -1000.0 Visual signal transduction: Rods 15.0 822.0 52.0 -0.17 0.052 1000.0 -1000.0 -0.031 -1000.0 PLK2 and PLK4 events 14.0 44.0 3.0 -0.016 0.029 1000.0 -1000.0 -0.002 -1000.0 Syndecan-2-mediated signaling events 14.0 984.0 69.0 -0.135 0.043 1000.0 -1000.0 -0.04 -1000.0 Arf6 signaling events 14.0 875.0 62.0 -0.088 0.083 1000.0 -1000.0 -0.018 -1000.0 FOXM1 transcription factor network 14.0 745.0 51.0 -0.24 0.033 1000.0 -1000.0 -0.095 -1000.0 Signaling events mediated by the Hedgehog family 13.0 706.0 52.0 -0.12 0.072 1000.0 -1000.0 -0.032 -1000.0 Cellular roles of Anthrax toxin 13.0 522.0 39.0 -0.062 0.032 1000.0 -1000.0 -0.019 -1000.0 IFN-gamma pathway 13.0 901.0 68.0 -0.108 0.046 1000.0 -1000.0 -0.051 -1000.0 S1P1 pathway 13.0 494.0 36.0 -0.149 0.035 1000.0 -1000.0 -0.034 -1000.0 EPHB forward signaling 13.0 1188.0 85.0 -0.078 0.095 1000.0 -1000.0 -0.063 -1000.0 IL6-mediated signaling events 13.0 996.0 75.0 -0.119 0.047 1000.0 -1000.0 -0.045 -1000.0 Nectin adhesion pathway 12.0 817.0 63.0 -0.052 0.054 1000.0 -1000.0 -0.043 -1000.0 Syndecan-3-mediated signaling events 12.0 430.0 35.0 -0.135 0.05 1000.0 -1000.0 -0.028 -1000.0 BCR signaling pathway 12.0 1218.0 99.0 -0.187 0.04 1000.0 -1000.0 -0.056 -1000.0 Ras signaling in the CD4+ TCR pathway 12.0 207.0 17.0 -0.028 0.046 1000.0 -1000.0 -0.023 -1000.0 Caspase cascade in apoptosis 11.0 841.0 74.0 -0.125 0.063 1000.0 -1000.0 -0.042 -1000.0 a4b1 and a4b7 Integrin signaling 11.0 58.0 5.0 0.0 0.033 1000.0 -1000.0 0.014 -1000.0 Reelin signaling pathway 11.0 620.0 56.0 -0.084 0.092 1000.0 -1000.0 -0.035 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 11.0 846.0 74.0 -0.088 0.048 1000.0 -1000.0 -0.065 -1000.0 Syndecan-4-mediated signaling events 11.0 742.0 67.0 -0.058 0.064 1000.0 -1000.0 -0.031 -1000.0 E-cadherin signaling events 11.0 56.0 5.0 0.011 0.033 1000.0 -1000.0 0.016 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 10.0 450.0 45.0 -0.053 0.05 1000.0 -1000.0 -0.042 -1000.0 LPA receptor mediated events 10.0 1043.0 102.0 -0.142 0.035 1000.0 -1000.0 -0.08 -1000.0 IL2 signaling events mediated by STAT5 10.0 223.0 22.0 -0.088 0.036 1000.0 -1000.0 -0.035 -1000.0 Signaling events mediated by PRL 10.0 342.0 34.0 -0.051 0.054 1000.0 -1000.0 -0.033 -1000.0 Sphingosine 1-phosphate (S1P) pathway 9.0 275.0 28.0 -0.039 0.046 1000.0 -1000.0 -0.014 -1000.0 JNK signaling in the CD4+ TCR pathway 9.0 159.0 17.0 -0.035 0.034 1000.0 -1000.0 -0.024 -1000.0 Arf6 downstream pathway 9.0 429.0 43.0 -0.034 0.041 1000.0 -1000.0 -0.026 -1000.0 Ceramide signaling pathway 9.0 726.0 76.0 -0.088 0.069 1000.0 -1000.0 -0.028 -1000.0 Nongenotropic Androgen signaling 9.0 498.0 52.0 -0.093 0.061 1000.0 -1000.0 -0.031 -1000.0 E-cadherin signaling in the nascent adherens junction 9.0 707.0 76.0 -0.047 0.075 1000.0 -1000.0 -0.053 -1000.0 Visual signal transduction: Cones 8.0 327.0 38.0 -0.004 0.043 1000.0 -1000.0 -0.001 -1000.0 Signaling events mediated by PTP1B 8.0 642.0 76.0 -0.087 0.059 1000.0 -1000.0 -0.04 -1000.0 p75(NTR)-mediated signaling 8.0 1050.0 125.0 -0.139 0.077 1000.0 -1000.0 -0.043 -1000.0 PDGFR-alpha signaling pathway 8.0 378.0 44.0 -0.13 0.068 1000.0 -1000.0 -0.038 -1000.0 IL2 signaling events mediated by PI3K 8.0 507.0 58.0 -0.066 0.051 1000.0 -1000.0 -0.049 -1000.0 Integrins in angiogenesis 8.0 725.0 84.0 -0.172 0.073 1000.0 -1000.0 -0.036 -1000.0 Regulation of Androgen receptor activity 8.0 568.0 70.0 -0.104 0.083 1000.0 -1000.0 -0.049 -1000.0 Aurora B signaling 8.0 598.0 67.0 -0.141 0.054 1000.0 -1000.0 -0.039 -1000.0 Hedgehog signaling events mediated by Gli proteins 7.0 495.0 65.0 -0.112 0.058 1000.0 -1000.0 -0.044 -1000.0 Signaling mediated by p38-gamma and p38-delta 7.0 116.0 15.0 -0.022 0.03 1000.0 -1000.0 -0.032 -1000.0 Regulation of p38-alpha and p38-beta 7.0 406.0 54.0 -0.031 0.067 1000.0 -1000.0 -0.028 -1000.0 Effects of Botulinum toxin 7.0 189.0 26.0 -0.094 0.06 1000.0 -1000.0 -0.003 -1000.0 Class I PI3K signaling events 7.0 534.0 73.0 -0.061 0.049 1000.0 -1000.0 -0.035 -1000.0 Regulation of Telomerase 7.0 745.0 102.0 -0.2 0.077 1000.0 -1000.0 -0.04 -1000.0 VEGFR1 specific signals 7.0 426.0 56.0 -0.008 0.09 1000.0 -1000.0 -0.041 -1000.0 Regulation of nuclear SMAD2/3 signaling 6.0 900.0 136.0 -0.073 0.05 1000.0 -1000.0 -0.046 -1000.0 ErbB4 signaling events 6.0 462.0 69.0 -0.179 0.064 1000.0 -1000.0 -0.031 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 6.0 351.0 54.0 -0.084 0.047 1000.0 -1000.0 -0.037 -1000.0 mTOR signaling pathway 6.0 352.0 53.0 -0.052 0.039 1000.0 -1000.0 -0.041 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 6.0 241.0 37.0 -0.017 0.068 1000.0 -1000.0 -0.033 -1000.0 Signaling events mediated by HDAC Class III 6.0 251.0 40.0 -0.056 0.061 1000.0 -1000.0 -0.032 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 6.0 352.0 52.0 -0.07 0.092 1000.0 -1000.0 -0.035 -1000.0 HIF-2-alpha transcription factor network 6.0 263.0 43.0 -0.038 0.053 1000.0 -1000.0 -0.04 -1000.0 Arf6 trafficking events 6.0 460.0 71.0 -0.049 0.037 1000.0 -1000.0 -0.021 -1000.0 Insulin Pathway 6.0 501.0 74.0 -0.167 0.104 1000.0 -1000.0 -0.037 -1000.0 Plasma membrane estrogen receptor signaling 6.0 558.0 86.0 -0.051 0.098 1000.0 -1000.0 -0.059 -1000.0 S1P3 pathway 6.0 274.0 42.0 -0.033 0.046 1000.0 -1000.0 -0.031 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 6.0 208.0 33.0 -0.048 0.075 1000.0 -1000.0 -0.034 -1000.0 PDGFR-beta signaling pathway 6.0 600.0 97.0 -0.05 0.096 1000.0 -1000.0 -0.053 -1000.0 S1P4 pathway 6.0 150.0 25.0 -0.016 0.046 1000.0 -1000.0 -0.02 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 5.0 427.0 85.0 -0.18 0.075 1000.0 -1000.0 -0.045 -1000.0 EPO signaling pathway 5.0 300.0 55.0 -0.019 0.055 1000.0 -1000.0 -0.04 -1000.0 TRAIL signaling pathway 5.0 270.0 48.0 -0.02 0.061 1000.0 -1000.0 -0.032 -1000.0 Signaling events regulated by Ret tyrosine kinase 5.0 439.0 82.0 -0.026 0.063 1000.0 -1000.0 -0.061 -1000.0 S1P5 pathway 5.0 98.0 17.0 -0.013 0.036 1000.0 -1000.0 -0.008 -1000.0 FoxO family signaling 5.0 337.0 64.0 -0.081 0.05 1000.0 -1000.0 -0.043 -1000.0 Retinoic acid receptors-mediated signaling 5.0 342.0 58.0 -0.107 0.067 1000.0 -1000.0 -0.036 -1000.0 Paxillin-dependent events mediated by a4b1 5.0 204.0 36.0 -0.06 0.062 1000.0 -1000.0 -0.047 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 5.0 741.0 125.0 -0.05 0.095 1000.0 -1000.0 -0.043 -1000.0 Class IB PI3K non-lipid kinase events 5.0 15.0 3.0 -0.025 0.025 1000.0 -1000.0 -0.018 -1000.0 LPA4-mediated signaling events 4.0 49.0 12.0 -0.023 0.016 1000.0 -1000.0 -0.025 -1000.0 ErbB2/ErbB3 signaling events 4.0 273.0 65.0 -0.087 0.05 1000.0 -1000.0 -0.056 -1000.0 Coregulation of Androgen receptor activity 4.0 306.0 76.0 -0.076 0.056 1000.0 -1000.0 -0.035 -1000.0 BARD1 signaling events 4.0 250.0 57.0 -0.048 0.073 1000.0 -1000.0 -0.032 -1000.0 Aurora A signaling 4.0 247.0 60.0 -0.055 0.054 1000.0 -1000.0 -0.015 -1000.0 Aurora C signaling 4.0 30.0 7.0 -0.0 0.036 1000.0 -1000.0 -0.014 -1000.0 PLK1 signaling events 4.0 405.0 85.0 -0.026 0.055 1000.0 -1000.0 -0.028 -1000.0 Class I PI3K signaling events mediated by Akt 4.0 289.0 68.0 -0.054 0.071 1000.0 -1000.0 -0.031 -1000.0 ceramide signaling pathway 4.0 213.0 49.0 -0.011 0.05 1000.0 -1000.0 -0.034 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 4.0 365.0 83.0 -0.04 0.07 1000.0 -1000.0 -0.021 -1000.0 Angiopoietin receptor Tie2-mediated signaling 4.0 354.0 88.0 -0.167 0.099 1000.0 -1000.0 -0.067 -1000.0 E-cadherin signaling in keratinocytes 4.0 212.0 43.0 -0.044 0.091 1000.0 -1000.0 -0.029 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 3.0 75.0 23.0 0.003 0.038 1000.0 -1000.0 -0.021 -1000.0 Ephrin A reverse signaling 3.0 26.0 7.0 -0.002 0.037 1000.0 -1000.0 0.0 -1000.0 TCGA08_rtk_signaling 3.0 103.0 26.0 -0.027 0.058 1000.0 -1000.0 -0.005 -1000.0 IGF1 pathway 3.0 198.0 57.0 -0.025 0.083 1000.0 -1000.0 -0.044 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 3.0 464.0 120.0 -0.016 0.092 1000.0 -1000.0 -0.049 -1000.0 p38 MAPK signaling pathway 3.0 141.0 44.0 -0.0 0.059 1000.0 -1000.0 -0.017 -1000.0 Signaling events mediated by HDAC Class II 2.0 170.0 75.0 -0.017 0.066 1000.0 -1000.0 -0.019 -1000.0 Insulin-mediated glucose transport 2.0 79.0 32.0 -0.013 0.044 1000.0 -1000.0 -0.019 -1000.0 Signaling events mediated by HDAC Class I 2.0 243.0 104.0 -0.047 0.079 1000.0 -1000.0 -0.025 -1000.0 Atypical NF-kappaB pathway 2.0 76.0 31.0 -0.015 0.045 1000.0 -1000.0 -0.022 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 1.0 55.0 34.0 -0.043 0.085 1000.0 -1000.0 -0.025 -1000.0 Canonical NF-kappaB pathway 1.0 40.0 39.0 -0.0 0.076 1000.0 -1000.0 -0.029 -1000.0 Circadian rhythm pathway 1.0 26.0 22.0 -0.012 0.073 1000.0 -1000.0 -0.021 -1000.0 Alternative NF-kappaB pathway 1.0 15.0 13.0 -0.0 0.09 1000.0 -1000.0 -0.0 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 26.0 27.0 -0.0 0.049 1000.0 -1000.0 -0.03 -1000.0 Rapid glucocorticoid signaling 0.0 15.0 20.0 -0.0 0.041 1000.0 -1000.0 -0.003 -1000.0 Arf1 pathway 0.0 45.0 54.0 -0.001 0.065 1000.0 -1000.0 -0.017 -1000.0 Total 1373 79630 7203 -13.1081180961 8.16318506141 131000 -131000 -4.46482776267 -131000