rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(3), CD14(2), CD19(2), CD1B(1), CD1D(2), CD1E(1), CD22(5), CD33(3), CD34(2), CD36(2), CD38(2), CD3E(1), CD3G(1), CD4(3), CD44(4), CD5(2), CD55(2), CD7(2), CD8A(1), CD8B(1), CD9(2), CR1(5), CR2(6), CSF1R(3), CSF3R(2), DNTT(2), EPO(1), EPOR(1), FLT3(7), FLT3LG(1), GP9(1), GYPA(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL1R1(2), IL2RA(3), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), ITGA1(1), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGAM(8), ITGB3(1), KIT(3), KITLG(2), MS4A1(2), TFRC(2), THPO(1), TPO(4) 31730473 140 79 136 52 54 23 28 23 12 0 0.00054 0.23 2 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(4), NR0B2(3), NR1H3(1), NR1H4(3), RXRA(3) 2161711 14 14 14 3 3 2 4 3 2 0 0.00076 0.23 3 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), LPA(6), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1), SERPINF2(1), VWF(10) 14027949 58 43 58 22 21 10 11 5 11 0 0.0011 0.23 4 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), COMT(2), DBH(6), DDC(1), FAH(1), GOT1(1), HPD(1), MAOB(1), PNMT(1), TAT(3), TPO(4), TYR(5) 12332970 66 42 64 14 35 9 9 13 0 0 0.0019 0.29 5 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 130 ACTB(1), CHAD(1), COL11A1(8), COL11A2(9), COL17A1(3), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DES(3), DSC1(5), DSC2(2), DSC3(2), DSG1(4), DSG2(1), DSG4(10), FN1(3), GJA1(1), GJA10(1), GJA8(1), GJA9(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJC2(1), GJC3(1), GJD4(3), INA(2), ITGA6(2), ITGB4(5), KRT1(2), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(4), KRT17(3), KRT18(3), KRT2(3), KRT20(1), KRT24(1), KRT25(3), KRT28(3), KRT3(1), KRT31(3), KRT32(2), KRT33A(3), KRT33B(2), KRT34(3), KRT36(4), KRT37(2), KRT38(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(3), KRT72(1), KRT73(1), KRT74(3), KRT75(2), KRT76(2), KRT77(2), KRT78(1), KRT79(2), KRT8(3), KRT81(1), KRT82(1), KRT83(2), KRT84(2), KRT85(2), KRT9(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), LMNB1(1), LMNB2(3), NES(3), RELN(20), SPP1(1), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VIM(1), VWF(10) 92368007 406 151 395 169 150 79 74 49 52 2 0.0028 0.34 6 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CANX(4), CD4(3), CD8A(1), CD8B(1), CIITA(7), CTSS(2), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), HSP90AA1(1), HSP90AB1(2), HSPA5(2), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), LGMN(1), NFYB(1), NFYC(3), PDIA3(1), PSME1(1), PSME2(1), TAP1(4), TAP2(2) 18456357 74 49 71 27 16 11 17 15 15 0 0.0050 0.41 7 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(2), CD3E(1), CD3G(1), CD4(3), CD58(1), CD8A(1), IL6(2), KITLG(2) 2527581 13 12 11 3 4 0 3 4 2 0 0.0052 0.41 8 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(1), GZMB(3), HLA-A(1), ITGAL(4), ITGB2(5), PRF1(3) 3417489 20 15 20 14 6 1 4 1 8 0 0.0054 0.41 9 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(3), CD5(2), CD7(2), IFNB1(1), IFNG(1), IL12B(1), IL4(1), ITGAX(7), TLR2(4), TLR4(1), TLR7(5), TLR9(2) 7416008 33 24 33 13 13 6 9 3 2 0 0.0060 0.41 10 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(4), HDC(3), PNMT(1), TPH1(3) 2333567 17 13 17 6 10 4 2 1 0 0 0.0070 0.43 11 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD28(1), CD3E(1), CD3G(1), CD4(3) 1034755 6 6 4 2 1 0 1 3 1 0 0.0077 0.43 12 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), ETNK1(1), GNPAT(4), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH2(2), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB2(5), PLCG1(3), PLCG2(11), PPAP2C(1) 19614435 86 52 84 23 35 10 12 16 11 2 0.0096 0.46 13 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPX1(2), PRKCE(1) 2387423 14 11 13 9 2 2 4 5 1 0 0.0097 0.46 14 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), F10(1), F2(1), F5(9), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), PROC(2), SERPINC1(2), SERPING1(5) 17935830 70 45 68 18 20 17 13 10 10 0 0.013 0.52 15 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 DNM1(5), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GPHN(1), NSF(1), SRC(2), UBQLN1(2) 3977986 22 16 21 8 6 3 6 5 2 0 0.016 0.52 16 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 63 AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CX3CR1(2), CXCR3(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GRPR(1), LHCGR(1), MC2R(1), MC3R(6), MC4R(3), MC5R(2), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR1(1), TACR3(4), TRHR(2), TSHR(1) 19571591 94 54 94 38 42 19 18 11 4 0 0.016 0.52 17 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(5), BDKRB1(1), BDKRB2(3), C1QB(1), C1QC(1), C1R(1), C1S(1), C2(2), C3(8), C3AR1(1), C5(1), C5AR1(1), C6(4), C7(6), C8A(3), C8B(5), C9(1), CD55(2), CFB(1), CFH(3), CFI(1), CPB2(1), CR1(5), CR2(6), F10(1), F13A1(5), F13B(2), F2(1), F5(9), F7(1), F8(8), F9(4), FGA(3), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(2), MBL2(1), PLAU(2), PLAUR(1), PLG(2), PROC(2), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(5), THBD(3), VWF(10) 35749445 145 75 142 68 48 23 33 19 20 2 0.018 0.52 18 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 50 ADORA3(1), CCKBR(2), CCR3(2), CELSR1(10), CELSR2(9), CELSR3(8), CHRM2(4), CHRM3(3), CXCR3(2), EDNRA(1), EMR2(4), EMR3(2), FSHR(1), GHRHR(3), GPR116(9), GPR132(3), GPR133(7), GPR135(3), GPR143(1), GPR17(1), GPR18(1), GPR56(2), GPR61(2), GPR84(1), GPR88(1), GRM1(1), GRPR(1), HRH4(1), LGR6(3), LPHN2(4), LPHN3(2), LTB4R2(2), NTSR1(2), OR2M4(2), OR8G2(1), P2RY13(3), PTGFR(2), SMO(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(1) 24966910 113 60 111 45 40 15 21 23 14 0 0.018 0.52 19 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(7), AGT(3), AGTR1(2), AGTR2(1), BDKRB2(3), KNG1(4), NOS3(5), REN(2) 3816834 27 16 27 9 11 5 5 3 3 0 0.019 0.52 20 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(1), EPO(1), FLT3(7), IL6(2), KITLG(2), TGFB1(1), TGFB2(1) 3311320 15 13 15 1 2 3 4 2 4 0 0.020 0.52 21 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 238 ACVR1(3), ACVR2B(1), AMHR2(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CCL13(1), CCL15(1), CCL19(1), CCL2(2), CCL20(1), CCL22(1), CCL24(1), CCL26(1), CCL3(1), CCL5(1), CCL7(1), CCR1(2), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CD70(1), CLCF1(1), CNTF(1), CSF1R(3), CSF2RB(4), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL13(1), CXCL6(3), CXCR3(2), CXCR6(1), EDA(3), EGF(3), EPO(1), EPOR(1), FLT1(2), FLT3(7), FLT3LG(1), FLT4(3), GDF5(2), GH1(1), GH2(2), GHR(3), HGF(4), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL17RB(1), IL18R1(1), IL18RAP(4), IL1R1(2), IL1RAP(2), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), INHBA(3), INHBB(2), INHBE(1), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(1), MET(5), MPL(2), NGFR(1), OSM(1), OSMR(2), PDGFC(3), PDGFRB(5), PPBP(2), PRL(3), RELT(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF10A(2), TNFRSF11A(3), TNFRSF12A(2), TNFRSF13B(2), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFRSF6B(2), TNFRSF8(3), TNFSF10(5), TNFSF11(4), TNFSF13B(2), TNFSF14(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFC(2), XCL1(2), XCL2(2), XCR1(1) 64994140 263 112 261 79 90 37 62 43 31 0 0.020 0.52 22 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 22 GUSB(3), RPE(1), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B4(5), UGT2B7(3), XYLB(4) 8964603 33 24 33 16 10 5 7 8 3 0 0.022 0.52 23 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 2753369 12 12 12 5 7 2 1 1 1 0 0.022 0.52 24 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 293806 3 3 3 1 2 1 0 0 0 0 0.023 0.52 25 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1), SELP(2) 6700687 33 21 32 17 13 2 7 6 5 0 0.024 0.52 26 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ABP1(9), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), SDS(4), UPB1(1) 11727333 58 33 58 12 19 13 10 11 5 0 0.024 0.52 27 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), CHAT(3), COMT(2), DBH(6), DDC(1), GAD1(4), GAD2(3), HDC(3), PAH(1), PNMT(1), TPH1(3) 5608230 28 21 28 9 13 5 3 7 0 0 0.025 0.52 28 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(5), F2(1), FGA(3), FGB(1), FGG(4), PLAU(2), PLG(2), SERPINB2(2), SERPINE1(1) 5404654 22 20 22 8 9 5 4 2 2 0 0.026 0.52 29 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(2), CD44(4), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A6(7), DAG1(2), FN1(3), FNDC1(1), FNDC3A(2), GP9(1), HMMR(1), HSPG2(16), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), RELN(20), SDC1(1), SDC2(2), SDC4(1), SPP1(1), SV2B(1), SV2C(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TNC(7), TNN(5), TNR(2), TNXB(6), VWF(10) 85028972 335 135 327 124 118 68 55 47 45 2 0.027 0.52 30 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(3), HLA-DRA(1), HLA-DRB1(2) 979062 7 6 5 1 1 2 0 4 0 0 0.027 0.52 31 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(3), SP1(6), SP3(1) 1979947 11 9 11 3 2 1 2 3 3 0 0.028 0.52 32 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(9), AGMAT(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH4A1(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), DAO(3), GAMT(1), GATM(2), GOT1(1), MAOB(1), NOS1(9), NOS3(5), OAT(1), ODC1(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1) 17401829 77 46 75 19 31 17 11 17 1 0 0.028 0.52 33 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(1), CADM1(2), CADM3(1), CD22(5), CD226(2), CD274(1), CD276(3), CD28(1), CD34(2), CD4(3), CD58(1), CD6(2), CD8A(1), CD8B(1), CDH1(3), CDH15(3), CDH3(1), CDH4(3), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CNTN1(5), CNTN2(5), CNTNAP1(3), ESAM(1), F11R(1), GLG1(4), HLA-A(1), HLA-B(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(3), HLA-DOB(2), HLA-DPA1(1), HLA-DQA2(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-F(2), ICAM3(1), ICOSLG(1), ITGA4(7), ITGA6(2), ITGA8(7), ITGA9(1), ITGAL(4), ITGAM(8), ITGAV(1), ITGB2(5), ITGB7(2), ITGB8(3), JAM2(1), JAM3(1), L1CAM(7), MAG(5), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(5), NFASC(4), NLGN1(3), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(3), NRXN3(3), OCLN(1), PDCD1(1), PECAM1(2), PTPRC(4), PTPRF(4), PTPRM(3), PVR(2), PVRL1(2), PVRL2(1), SDC1(1), SDC2(2), SDC4(1), SELE(1), SELP(2), SELPLG(2), SIGLEC1(1), VCAN(7) 57897988 213 109 210 98 81 29 35 35 31 2 0.028 0.52 34 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(1), TAT(3), TYR(5) 1908974 10 9 10 1 1 3 2 4 0 0 0.029 0.53 35 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F5(9), F7(1), FGA(3), FGB(1), FGG(4), PROC(2), SERPINC1(2) 6457793 24 19 24 9 7 5 6 1 5 0 0.037 0.64 36 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ITGAL(4), ITGAM(8), ITGB2(5), PECAM1(2), SELE(1) 4433802 24 15 23 13 8 2 7 2 5 0 0.038 0.64 37 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 155 ADORA1(2), ADORA2B(1), ADORA3(1), ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), CCBP2(1), CCKAR(3), CCKBR(2), CCR1(2), CCR10(1), CCR3(2), CCR4(1), CCR6(2), CCR7(2), CCR8(1), CCR9(2), CHML(2), CHRM2(4), CHRM3(3), CMKLR1(1), CNR1(2), CNR2(3), CX3CR1(2), CXCR3(2), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(3), GALR2(1), GALT(1), GHSR(4), GNB2L1(1), GPR17(1), GPR174(1), GPR27(3), GPR3(1), GPR37(3), GPR4(1), GPR50(3), GPR83(4), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LHCGR(1), MC3R(6), MC4R(3), MC5R(2), MLNR(1), NMUR1(2), NTSR1(2), OPN1SW(2), OPRK1(1), OPRL1(2), OPRM1(4), OR1F1(2), OR1Q1(1), OR2H1(4), OR7A5(1), OR7C1(1), OXTR(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY6(2), PPYR1(2), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), RHO(1), RRH(1), SSTR2(1), SSTR3(2), SSTR4(4), TRHR(2) 45797096 205 98 204 84 91 26 36 37 15 0 0.038 0.64 38 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 66 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C1(3), AKR1C4(2), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1B1(4), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP2S1(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHDH(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B4(5), UGT2B7(3) 21117095 88 49 88 32 36 7 20 23 2 0 0.046 0.73 39 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(2), LRP8(2), RELN(20), VLDLR(2) 5680593 27 18 27 18 10 8 1 3 5 0 0.047 0.73 40 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 37 AKT1(1), ASAH1(1), CREB3(1), CREB5(1), CREBBP(8), DAG1(2), EGR1(2), EGR2(3), EGR3(4), ELK1(1), GNAQ(1), MAP1B(9), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2), NTRK1(4), OPN1LW(3), PIK3CD(2), PTPN11(6), RPS6KA3(5), SRC(2), TERF2IP(3) 16686834 75 43 75 19 21 13 20 16 5 0 0.049 0.73 41 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 68 CALM1(1), CDS1(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(6), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), OCRL(1), PI4KA(1), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PRKCA(3), PRKCG(1), SYNJ1(1), SYNJ2(7) 45439822 172 86 170 40 62 26 31 24 27 2 0.049 0.73 42 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), CREBBP(8), DFFA(1), DFFB(3), GZMA(1), GZMB(3), PRF1(3) 4170990 21 15 21 5 4 3 6 4 4 0 0.050 0.73 43 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), RPS6KB1(1), STAT6(3) 5883058 23 18 22 6 8 3 3 7 2 0 0.052 0.75 44 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(1), CD3G(1), CD4(3), ITGAL(4), ITGB2(5), PTPRC(4) 4539789 19 14 17 13 4 2 3 3 7 0 0.055 0.77 45 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1) 2311758 13 9 13 2 8 0 3 2 0 0 0.058 0.78 46 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(4), GOT1(1), NOS1(9), NOS3(5), OAT(1), OTC(2), P4HA1(1), P4HA2(3), P4HA3(1), PARS2(2), PRODH(1), RARS2(1) 14085749 55 36 53 16 23 8 11 12 1 0 0.058 0.78 47 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 10 CREBBP(8), DAXX(4), PAX3(3), PML(2), SIRT1(2), SP100(3), TNFRSF1A(2), TNFRSF1B(2) 6197133 26 18 26 8 6 5 7 4 4 0 0.061 0.79 48 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), KERA(2), LUM(3) 1446169 7 7 6 4 2 2 1 0 2 0 0.062 0.79 49 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(4), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(5), NFATC1(3), NFATC2(1), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SYT1(1), VIP(1), VIPR2(2) 10901738 36 28 35 16 7 4 4 12 9 0 0.063 0.79 50 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1) 4933029 23 16 22 14 7 2 6 4 2 2 0.070 0.81 51 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 224 ADORA1(2), ADORA2B(1), ADORA3(1), ADRA2C(4), ADRB1(1), ADRB2(1), AGTR1(2), AGTR2(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), BRS3(2), C3AR1(1), C5AR1(1), CALCRL(2), CCKAR(3), CCKBR(2), CGA(1), CHRM2(4), CHRM3(3), CNR1(2), CNR2(3), CRHR1(2), CTSG(4), CYSLTR1(1), CYSLTR2(1), DRD1(2), DRD2(1), DRD3(1), DRD5(4), EDNRA(1), EDNRB(1), F2(1), F2RL3(1), FPR1(1), FSHR(1), GABBR1(1), GABBR2(6), GABRA2(2), GABRA3(2), GABRA4(4), GABRA5(3), GABRB1(3), GABRB3(2), GABRD(2), GABRG1(2), GABRG2(6), GABRP(4), GABRQ(2), GABRR2(1), GALR1(3), GALR2(1), GH1(1), GH2(2), GHR(3), GHRHR(3), GHSR(4), GIPR(1), GLP1R(1), GLP2R(1), GLRA2(1), GLRA3(3), GLRB(1), GPR156(3), GPR50(3), GPR83(4), GRIA1(4), GRIA3(5), GRIA4(2), GRID1(3), GRID2(1), GRIK1(1), GRIK2(2), GRIK3(3), GRIK4(1), GRIK5(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRIN3A(1), GRIN3B(1), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM6(6), GRM7(3), GRM8(8), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(5), HRH3(1), HRH4(1), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R2(2), MC2R(1), MC3R(6), MC4R(3), MC5R(2), MCHR1(2), MCHR2(3), MLNR(1), NMUR1(2), NPBWR1(2), NPFFR1(2), NPFFR2(2), NR3C1(1), NTSR1(2), OPRK1(1), OPRL1(2), OPRM1(4), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), P2RY1(1), P2RY10(1), P2RY13(3), P2RY14(1), P2RY2(2), P2RY4(2), P2RY6(2), PARD3(2), PPYR1(2), PRL(3), PRSS1(1), PTAFR(2), PTGDR(1), PTGER2(2), PTGER3(2), PTGER4(2), PTGFR(2), PTGIR(1), PTH2R(2), RXFP1(3), RXFP2(1), SCTR(2), SSTR2(1), SSTR3(2), SSTR4(4), SSTR5(2), TAAR2(1), TAAR5(1), TACR1(1), TACR3(4), THRA(1), TRHR(2), TSHB(1), TSHR(1), TSPO(1), UTS2R(1), VIPR2(2) 83041066 368 140 367 165 164 47 62 63 32 0 0.070 0.81 52 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(3), CD8A(1), EPO(1), IL2(1), IL4(1), IL6(2), IL7(1) 2405698 10 9 8 2 3 1 0 5 1 0 0.071 0.81 53 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(1), AKT2(1), AKT3(1), ANKRD6(3), APC(7), AXIN1(2), AXIN2(1), DACT1(5), DKK1(1), DKK2(3), FSTL1(2), GSK3B(1), LRP1(15), MVP(2), NKD2(2), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2) 15524662 58 37 52 11 18 3 15 14 8 0 0.071 0.81 54 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), IL6(2), LDLR(4) 2160204 8 8 8 3 1 1 3 2 1 0 0.071 0.81 55 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 37 ALAS1(2), ALAS2(1), BLVRA(1), BLVRB(1), COX10(1), COX15(1), CP(4), CPOX(1), EARS2(2), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B4(5), UGT2B7(3), UROD(1), UROS(1) 14867181 56 34 56 21 14 5 11 18 8 0 0.077 0.85 56 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MAX(2), SP1(6), SP3(1), WT1(3) 2504554 13 10 13 1 4 2 2 1 4 0 0.078 0.85 57 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(4), ADCY4(2), ADCY6(2), ADCY8(4), CACNA1A(4), CACNA1B(7), GNAS(3), GNAT3(3), GNB1(1), GNB3(1), GRM4(5), ITPR3(11), KCNB1(3), PDE1A(1), PLCB2(5), PRKACG(1), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(4), TAS1R1(1), TAS1R2(2), TAS2R1(1), TAS2R10(2), TAS2R14(2), TAS2R16(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R41(3), TAS2R42(1), TAS2R60(1), TAS2R8(1), TRPM5(1) 21727627 89 52 88 45 39 11 16 14 9 0 0.079 0.85 58 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(2), ENPP3(1), NADSYN1(4), NMNAT2(1), NNMT(1), QPRT(3) 5902823 19 17 16 2 8 2 2 6 1 0 0.080 0.85 59 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD3G(1), CD4(3), HLA-DRA(1), HLA-DRB1(2), PTPRC(4), ZAP70(5) 3681922 17 12 15 6 4 4 2 4 3 0 0.083 0.85 60 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(2), ACADS(4), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), SDS(4) 10403076 48 27 48 14 13 12 7 9 7 0 0.084 0.85 61 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(4), JAK3(4), MAPK1(3), MAPK3(2), STAT3(2), TYK2(3) 4692033 21 16 19 3 9 3 3 5 1 0 0.084 0.85 62 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG2(2), CKB(1), CKM(1), CKMT1A(3), CKMT1B(2), CPS1(6), GAMT(1), GATM(2), OAT(1), ODC1(1), OTC(2) 6769060 24 19 23 5 7 5 4 7 1 0 0.085 0.85 63 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD3E(1), CD3G(1), CD4(3), CXCR3(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(4), STAT4(1), TYK2(3) 5635956 25 17 22 9 11 1 5 4 4 0 0.088 0.87 64 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(1) 1952432 8 8 6 1 6 0 1 1 0 0 0.090 0.87 65 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(9), AOC2(2), AOC3(2), CES1(2) 2419051 15 10 15 1 8 3 1 3 0 0 0.093 0.88 66 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 5 CCL2(2), MST1R(6) 2032362 8 8 8 5 4 0 0 3 1 0 0.094 0.88 67 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), CD4(3), HLA-DRA(1), HLA-DRB1(2), IL4(1), IL5RA(1), IL6(2) 2187762 12 8 10 2 2 3 0 5 2 0 0.10 0.92 68 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), LPO(1), MPO(3), PRDX2(2), TPO(4), TYR(5) 3807130 21 14 21 8 11 1 2 4 3 0 0.10 0.92 69 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 26 CCL3(1), CCR1(2), CCR3(2), CCR4(1), CCR7(2), CD28(1), CD4(3), CXCR3(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL4(1), IL4R(6), TGFB1(1), TGFB2(1) 7533077 37 21 35 7 12 3 8 8 6 0 0.10 0.92 70 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(1), CD3E(1), CD3G(1), HLA-DRA(1), HLA-DRB1(2), IL2(1), ITK(3), PTPN11(6) 3682662 16 12 16 6 2 3 4 6 1 0 0.11 0.93 71 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(2), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), NOS1(9), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SYT1(1) 9871541 44 29 42 19 20 3 8 11 2 0 0.12 0.94 72 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ABP1(9), ACADM(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DPYD(2), DPYS(2), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), MLYCD(1), UPB1(1) 10880045 46 28 46 9 17 7 8 11 3 0 0.12 0.94 73 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 1940571 9 7 9 2 0 4 1 1 3 0 0.12 0.94 74 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(1), C6(4), C7(6), IL6(2), ITGA4(7), ITGAL(4), ITGB2(5), SELP(2), SELPLG(2) 9840865 41 25 40 26 13 3 7 8 8 2 0.12 0.94 75 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(8), CD3E(1), CD3G(1), CD4(3), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8965084 41 26 39 12 14 8 7 7 5 0 0.12 0.94 76 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(8), CD3E(1), CD3G(1), CD4(3), CREBBP(8), GNAS(3), GNB1(1), GNGT1(1), HLA-DRA(1), HLA-DRB1(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8965084 41 26 39 12 14 8 7 7 5 0 0.12 0.94 77 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(2), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CLCA1(3), CLCA2(2), CLCA4(2), CNGA3(2), CNGA4(2), CNGB1(5), GNAL(1), GUCA1B(1), GUCA1C(3), PDE1C(4), PRKACG(1), PRKG2(5), PRKX(2) 12240769 45 30 44 22 13 7 11 11 3 0 0.12 0.94 78 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(2), ABCB4(8), ABCC1(3), ABCC3(5), GSTP1(1) 5751848 23 18 23 12 9 4 2 4 4 0 0.12 0.94 79 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), GK(1), GLA(1), GLB1(1), LCT(8), LIPC(1), LIPG(5), PNLIP(2), PNLIPRP1(2), PPAP2C(1) 18858900 84 44 83 21 34 14 17 12 7 0 0.12 0.94 80 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(1) 468602 2 2 2 1 0 0 1 0 1 0 0.12 0.94 81 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 ALOX15(2), ALOX5(1), CBR1(1), CBR3(2), CYP4F2(5), CYP4F3(5), EPX(6), GGT1(2), LPO(1), LTA4H(1), MPO(3), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PRDX2(2), PTGIS(1), PTGS1(2), TBXAS1(3), TPO(4) 10927491 52 31 52 18 28 5 6 5 6 2 0.13 0.94 82 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(8), ACACB(9), FASN(7), MCAT(1), OXSM(3) 5930850 28 17 28 7 11 1 8 5 3 0 0.13 0.94 83 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ITGA4(7), ITGAL(4), ITGB2(5), PECAM1(2), SELE(1) 5304269 23 14 23 13 7 1 4 6 5 0 0.13 0.94 84 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR109B(3), GPR161(2), GPR18(1), GPR34(1), GPR45(2), GPR65(1), GPR68(2), GPR81(2) 3922283 16 12 16 5 6 2 2 4 2 0 0.13 0.94 85 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), PIAS3(4), PTPRU(3), SRC(2), STAT3(2) 6157097 26 19 23 4 12 4 3 5 2 0 0.14 0.94 86 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP5(2), ACP6(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CMBL(1), CYP3A4(3), CYP3A43(2), CYP3A7(3), DHRS7(1), PON1(4), PON3(2) 6896273 31 19 31 7 12 3 7 8 1 0 0.14 0.94 87 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(9), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(2), CNDP1(4), DDC(1), HAL(2), HARS(3), HDC(3), HNMT(1), MAOB(1), PRPS2(2) 9896289 48 27 48 9 24 9 5 8 2 0 0.14 0.94 88 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(9), AGXT2(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PISD(3), PLCB2(5), PLCG1(3), PLCG2(11), PSPH(2), SARDH(6), SHMT2(1), TARS(2) 16846339 74 40 71 18 29 14 16 8 7 0 0.14 0.94 89 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), JAK1(3), STAT1(1), STAT2(5), TYK2(3) 4326909 14 12 14 3 4 2 5 1 2 0 0.14 0.94 90 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(1), AKT2(1), AKT3(1), BLNK(2), BTK(1), CARD11(6), CD19(2), CD22(5), CD72(2), CHUK(4), CR2(6), FOS(1), GSK3B(1), IFITM1(1), IKBKB(2), INPP5D(6), KRAS(1), LILRB3(1), LYN(1), MALT1(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(2), SYK(2), VAV1(6), VAV2(3), VAV3(2) 26863909 109 57 107 37 40 12 22 21 14 0 0.15 0.94 91 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), AKT2(1), AKT3(1), BCR(1), BTK(1), CD19(2), CDKN2A(3), FLOT1(2), GAB1(1), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), NR0B2(3), PLCG2(11), PREX1(9), PTPRC(4), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SYK(2), TEC(5), VAV1(6) 20753223 91 48 91 29 32 17 18 12 12 0 0.15 0.94 92 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), MAPK1(3), MAPK3(2), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), NTRK1(4), PLCG1(3) 5981265 19 18 19 10 5 5 4 5 0 0 0.15 0.94 93 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1D(1), ADRA2C(4), ADRB1(1), ADRB2(1), CHRM2(4), CHRM3(3), DRD1(2), DRD2(1), DRD3(1), DRD5(4), HRH1(1), HRH2(5), HTR1A(2), HTR1B(3), HTR1D(1), HTR1E(2), HTR1F(2), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1) 9718968 48 29 48 18 23 5 8 8 4 0 0.15 0.94 94 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 3532572 12 11 12 7 6 3 2 0 1 0 0.15 0.94 95 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(1), CYP11B2(4), CYP17A1(1), HSD11B1(2), HSD3B2(2) 3532572 12 11 12 7 6 3 2 0 1 0 0.15 0.94 96 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 8 EGF(3), MAP2K1(1), MAP3K1(5), MAPK14(1), NCOR2(5), RXRA(3), THRA(1) 5254910 19 14 19 7 4 3 2 5 5 0 0.15 0.94 97 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(1), CD3G(1), CD8A(1), ITGAL(4), ITGB2(5), PTPRC(4) 4298928 17 12 17 12 5 2 3 0 7 0 0.15 0.94 98 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 12 CASR(5), GABBR1(1), GPRC5A(1), GPRC5C(1), GPRC5D(2), GRM1(1), GRM2(1), GRM4(5), GRM5(1), GRM7(3), GRM8(8) 7588700 29 21 29 26 14 1 6 4 4 0 0.15 0.94 99 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(3), HLA-DRA(1), HLA-DRB1(2), IL2(1), IL4(1) 1633088 9 6 7 1 2 2 0 5 0 0 0.16 0.94 100 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), TAT(3) 1070053 4 4 4 0 1 2 1 0 0 0 0.16 0.94 101 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NFKB1(1), SP1(6) 5623970 22 16 22 5 4 5 2 5 6 0 0.16 0.94 102 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CEL(3), DGAT2(2), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), GK(1), GK2(2), GLA(1), GLB1(1), GPAM(2), LCT(8), LIPC(1), LIPG(5), MGLL(2), PNLIP(2), PNLIPRP1(2), PNPLA3(1), PPAP2C(1) 23080983 89 50 88 25 37 11 17 16 8 0 0.16 0.94 103 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), IKBKB(2), IL1R1(2), IRAK1(2), MAP3K1(5), MAP3K14(2), MAP3K7(2), NFKB1(1), NFKBIA(2), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2) 9716920 29 22 28 14 4 5 6 10 4 0 0.16 0.94 104 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA(1), LPO(1), MPO(3), TPO(4) 3329226 15 12 15 7 11 0 0 1 3 0 0.16 0.94 105 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(1), CDKN1B(3), CUL1(5), UBE2M(3) 2741691 12 10 12 3 2 2 4 0 4 0 0.16 0.94 106 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), DHFR(1), FPGS(2) 2450112 11 9 11 4 4 0 4 2 1 0 0.17 0.94 107 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(7), ACE2(2), AGT(3), AGTR1(2), AGTR2(1), ANPEP(3), CTSA(2), CTSG(4), ENPEP(9), LNPEP(2), NLN(1), REN(2), THOP1(1) 8431879 39 22 39 13 17 5 8 3 6 0 0.17 0.94 108 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 ARSB(2), FUCA1(1), GALNS(1), GBA(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NAGLU(1), NEU1(1), NEU2(4) 12923965 42 30 42 15 15 2 9 7 9 0 0.17 0.94 109 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 GUSB(3), RPE(1), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5) 6320515 18 16 18 11 4 5 3 3 3 0 0.17 0.94 110 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(1), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), IL2(1), IL2RA(3), IL4(1), IL4R(6) 5130651 28 15 28 4 12 5 4 5 2 0 0.17 0.94 111 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), PRDX2(2), TAT(3), TPO(4) 8803849 43 26 43 10 23 5 4 8 3 0 0.17 0.95 112 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 BLVRA(1), BLVRB(1), CP(4), CPOX(1), EPRS(2), FECH(3), GUSB(3), HCCS(3), HMBS(1), HMOX1(2), PPOX(2), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UROD(1), UROS(1) 10330169 38 24 38 16 10 4 6 12 6 0 0.18 0.99 113 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(2), GSR(1), GSS(1), NFKB1(1), NOX1(2), XDH(8) 4061497 15 11 14 5 2 3 7 1 2 0 0.18 0.99 114 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1), NTAN1(1), SIRT1(2), SIRT2(2), VNN2(1) 4653069 13 11 13 1 2 2 1 2 6 0 0.19 1.00 115 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(8), ACADM(2), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SDS(4), SUCLA2(1), SUCLG1(2) 13418593 50 29 50 11 12 13 10 6 9 0 0.19 1.00 116 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME3(3), PGK2(3), PKLR(4), RPE(1), TKT(2), TKTL1(2), TKTL2(2) 7845277 34 21 34 8 11 5 7 8 3 0 0.20 1.00 117 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), NR3C1(1), RETN(1), RXRA(3) 2319283 7 7 7 4 1 2 0 1 3 0 0.20 1.00 118 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3) 9003646 30 21 29 12 6 3 6 11 4 0 0.20 1.00 119 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), C9orf95(1), CD38(2), ENPP3(1), NADK(3), NADSYN1(4), NMNAT2(1), NNMT(1), NT5C1B(3), NT5C2(2), QPRT(3) 8700021 28 21 25 8 10 2 5 9 2 0 0.20 1.00 120 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE1(1), CCNE2(1), CDKN1B(3), CDKN2A(3), E2F2(3) 3378480 12 11 12 8 3 3 1 1 4 0 0.20 1.00 121 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3) 4182675 17 12 16 5 10 2 3 1 1 0 0.21 1.00 122 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(6), JAK1(3), JAK2(4), TYK2(3) 4182675 17 12 16 5 10 2 3 1 1 0 0.21 1.00 123 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 44 FN3K(1), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(4), ITGB1BP3(2), ITPKB(2), MINPP1(1), MIOX(1), OCRL(1), PI4KA(1), PI4KB(3), PIK3C3(1), PIK3CB(2), PIK3CD(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), SYNJ1(1), SYNJ2(7) 27083580 95 53 94 24 34 14 17 12 16 2 0.21 1.00 124 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(2), HLA-A(1), KLRC1(1), KLRC3(3), MAP2K1(1), MAPK3(2), PAK1(2), PTK2B(1), PTPN6(4), SYK(2), VAV1(6) 5990598 25 15 25 12 7 1 12 2 3 0 0.21 1.00 125 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(7), CD44(4), FCGR3A(1), IL6R(2), TGFB1(1), TGFB2(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(3), TNFSF8(1) 5271297 24 14 24 7 6 4 6 3 5 0 0.22 1.00 126 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), CDS1(1), CHAT(3), CHKA(1), CHKB(1), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKI(3), DGKQ(1), DGKZ(5), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(4), GPAM(2), GPD1(2), GPD2(1), LCAT(1), MYST3(4), MYST4(4), PCYT1A(1), PCYT1B(2), PISD(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLD2(1), PNPLA3(1), PPAP2C(1), PTDSS1(1), PTDSS2(1), SH3GLB1(2) 25960462 90 52 88 26 30 11 15 18 14 2 0.22 1.00 127 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), CHUK(4), ELK1(1), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(1), RALA(1), RALBP1(3), RALGDS(3), RHOA(1) 6100778 19 15 18 5 4 1 3 6 5 0 0.22 1.00 128 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNB1(1), IKBKB(2), IL1R1(2), IL1RAP(2), IL1RN(1), IL6(2), IRAK1(2), IRAK2(3), IRAK3(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), TGFB1(1), TGFB2(1) 11783783 37 26 36 16 5 5 5 13 9 0 0.22 1.00 129 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 APH1A(3), CREBBP(8), CTBP1(3), CTBP2(4), DLL3(1), DTX1(1), DTX3L(1), DVL2(2), EP300(6), HDAC1(1), HDAC2(3), HES1(1), JAG1(3), JAG2(5), LFNG(1), MAML1(3), MAML2(2), MAML3(1), MFNG(2), NCOR2(5), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMB(1), NUMBL(2), PSEN2(1), RBPJ(1), RBPJL(4), SNW1(1) 25862211 88 52 85 29 27 12 20 15 12 2 0.23 1.00 130 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), SLC23A1(1), SLC23A2(3), SLC2A1(4), SLC2A3(2) 10143840 39 26 37 13 15 10 4 4 6 0 0.23 1.00 131 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ABP1(9), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), COMT(2), DBH(6), DDC(1), ESCO1(2), FAH(1), GOT1(1), HPD(1), LCMT1(1), MAOB(1), MYST3(4), MYST4(4), PNMT(1), PNPLA3(1), PRMT7(2), PRMT8(1), SH3GLB1(2), TAT(3), TPO(4), TYR(5), TYRP1(2) 23154003 86 51 84 23 40 11 12 18 5 0 0.24 1.00 132 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(1), FOS(1), IL6(2), IL6R(2), JAK1(3), JAK2(4), JAK3(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2), STAT3(2) 9560632 34 23 32 6 11 5 6 8 4 0 0.24 1.00 133 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(1), IL12B(1), IL2(1) 1206627 7 4 7 0 1 2 0 2 2 0 0.24 1.00 134 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(3), SCAP(5), SREBF1(2), SREBF2(3) 4554029 18 12 18 6 7 2 4 0 5 0 0.24 1.00 135 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 239 ACVR1C(2), AKT1(1), AKT2(1), AKT3(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(1), CACNB2(1), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(4), CACNG6(1), CACNG7(1), CACNG8(1), CD14(2), CDC25B(1), CHUK(4), DAXX(4), DDIT3(1), DUSP10(1), DUSP14(1), DUSP16(1), DUSP2(2), DUSP4(3), DUSP8(1), DUSP9(1), EGF(3), ELK1(1), ELK4(1), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FLNA(14), FLNB(4), FLNC(6), FOS(1), GADD45B(1), GNA12(2), IKBKB(2), IL1R1(2), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(1), MKNK1(1), NFATC2(1), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(3), NRAS(1), NTF3(1), NTRK1(4), NTRK2(1), PAK1(2), PDGFRB(5), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PPM1B(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PPP5C(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTPRR(2), RAP1B(2), RAPGEF2(4), RASA2(1), RASGRF1(5), RASGRF2(6), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA2(2), RPS6KA3(5), RRAS2(3), SOS1(1), SOS2(4), SRF(2), STK3(2), STK4(1), STMN1(1), TAOK1(1), TAOK2(2), TAOK3(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TNFRSF1A(2), TRAF2(2), ZAK(1) 105901986 385 144 380 140 150 43 62 69 59 2 0.24 1.00 136 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(3), PTPRU(3), STAT1(1), STAT2(5), TYK2(3) 5024612 16 14 16 4 7 1 5 1 2 0 0.24 1.00 137 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX1(2), ACOX3(1), FADS2(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3) 3962896 20 12 20 6 7 1 2 4 4 2 0.24 1.00 138 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(2), ACPT(3), ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), PON1(4) 11601263 49 29 49 17 21 2 14 11 1 0 0.25 1.00 139 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(1), CDKN1B(3), CDKN2A(3), E2F2(3), MDM2(1) 2835188 11 10 11 7 2 5 0 0 4 0 0.26 1.00 140 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(1), NAT2(1), XDH(8) 3252534 12 10 12 4 3 2 4 1 2 0 0.26 1.00 141 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(9), AGXT2(2), AKR1B10(2), ALAS1(2), ALAS2(1), AMT(2), AOC2(2), AOC3(2), BHMT(3), CBS(1), CHKA(1), CHKB(1), CTH(1), DAO(3), DLD(1), DMGDH(3), GAMT(1), GATM(2), GCAT(1), GLDC(2), MAOB(1), PHGDH(1), PIPOX(2), PISD(3), PSPH(2), RDH13(1), SARDH(6), SARS2(2), SDS(4), SHMT2(1), TARS(2), TARS2(1) 17182900 68 38 64 15 23 14 17 7 7 0 0.26 1.00 142 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), CHST1(2), CHST2(3), CHST6(1), FUT8(1), ST3GAL1(2), ST3GAL3(1) 4837895 20 14 20 5 6 6 2 5 1 0 0.26 1.00 143 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CAMKK1(3), CAMKK2(1), SYT1(1) 4626443 15 13 15 6 3 1 2 6 3 0 0.26 1.00 144 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4) 19416741 88 44 87 15 42 14 13 13 6 0 0.26 1.00 145 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGM3(2), PKLR(4) 19416741 88 44 87 15 42 14 13 13 6 0 0.26 1.00 146 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(12), CALM1(1), CAPN2(1), CAPNS1(1), EP300(6), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(3), NFATC2(1), PPP3CB(1), PRKCA(3), SYT1(1) 9559706 35 22 35 10 9 3 8 9 4 2 0.27 1.00 147 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 23 B4GALT2(1), FBP2(4), G6PC(2), GAA(3), GALE(2), GALK1(3), GALT(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2) 12393398 53 30 51 16 28 6 7 8 4 0 0.27 1.00 148 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(5), CACNA1D(9), CACNA1F(10), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CGA(1), ELK1(1), GNA11(2), GNAQ(1), GNAS(3), GNRH1(1), GNRH2(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK7(3), MAPK9(2), MMP14(4), MMP2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLD2(1), PRKACG(1), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(1), SOS1(1), SOS2(4), SRC(2) 49572904 204 89 202 63 81 28 34 36 21 4 0.27 1.00 149 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 207423 1 1 1 0 1 0 0 0 0 0 0.27 1.00 150 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(2), ADORA2B(1), ADORA3(1), P2RY1(1), P2RY2(2), P2RY6(2) 2363953 9 8 9 1 3 0 2 2 2 0 0.27 1.00 151 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), GOT1(1), MDH2(1), ME1(4), ME2(2), ME3(3), PKLR(4), RPE(1), TKT(2) 6979042 29 18 29 6 10 3 6 8 2 0 0.28 1.00 152 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(8), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4) 14781438 56 32 56 14 17 10 12 10 7 0 0.28 1.00 153 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(1) 620625 2 2 2 0 0 0 1 1 0 0 0.28 1.00 154 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(12), CALM1(1), CAMK1(2), HDAC5(4), IGF1R(2), INSR(5), MAPK14(1), MAPK7(3), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2), NFATC1(3), NFATC2(1), PPP3CB(1), SYT1(1) 12060348 42 29 42 14 11 8 9 9 5 0 0.28 1.00 155 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1) 6877628 28 17 27 20 9 3 7 5 2 2 0.28 1.00 156 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(4), IKBKAP(4), IKBKB(2), MAP3K1(5), MAP3K14(2), NFKB1(1), NFKBIA(2), TNFAIP3(1), TRAF3(3) 7318170 24 16 23 9 3 3 4 10 4 0 0.28 1.00 157 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C8B(5), C9(1), MASP1(2) 8218368 35 20 34 21 10 5 9 7 2 2 0.28 1.00 158 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 18 CALCRL(2), CRHR1(2), ELTD1(5), EMR1(4), EMR2(4), GHRHR(3), GIPR(1), GLP1R(1), GLP2R(1), GPR64(2), LPHN2(4), LPHN3(2), SCTR(2), VIPR2(2) 9176718 35 20 35 16 10 4 8 7 6 0 0.29 1.00 159 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 26 ACTA1(1), AKT1(1), BDKRB2(3), CALM1(1), CAV1(1), FLT1(2), FLT4(3), NOS3(5), PDE2A(3), PDE3A(1), PDE3B(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKG2(5), SLC7A1(2), SYT1(1), TNNI1(2) 11031321 38 26 38 15 13 6 4 10 5 0 0.29 1.00 160 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2B1(4), MAN2B2(2), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4) 7860819 25 19 25 9 13 1 4 4 3 0 0.29 1.00 161 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(3), TNFSF11(4) 4476253 12 11 12 7 4 3 2 0 3 0 0.30 1.00 162 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), JAK2(4), JAK3(4), PIAS1(2), PIAS3(4), PTPRU(3), SOAT1(2) 5522242 22 15 19 4 12 1 4 4 1 0 0.30 1.00 163 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(2), ARSB(2), ARSD(1), ARSE(1), CYP11B2(4), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B2(2), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5) 10343168 33 23 33 22 10 6 7 6 4 0 0.31 1.00 164 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.31 1.00 165 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.31 1.00 166 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6141389 27 16 27 8 9 6 8 1 3 0 0.31 1.00 167 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(3), BCMO1(2), RDH5(1) 1582419 10 5 10 1 3 5 1 0 1 0 0.31 1.00 168 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(8), GNA12(2), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1) 4103160 15 11 15 5 4 1 3 5 2 0 0.31 1.00 169 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(1), GNAQ(1), MARCKS(1), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SP1(6), SP3(1), SYT1(1) 8245499 26 19 26 11 4 4 4 8 6 0 0.32 1.00 170 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2) 2695597 11 7 11 1 2 3 2 2 2 0 0.32 1.00 171 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(1), PDE1A(1), PLCB1(4), PLCB2(5), PRL(3), TRH(1), VIP(1) 4434609 19 11 19 5 10 3 2 1 1 2 0.33 1.00 172 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ABP1(9), ACY3(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AMDHD1(3), AOC2(2), AOC3(2), CARM1(1), CNDP1(4), DDC(1), FTCD(3), HAL(2), HARS(3), HARS2(1), HDC(3), HNMT(1), LCMT1(1), MAOB(1), PRMT7(2), PRMT8(1), PRPS2(2), UROC1(2) 15524197 56 36 56 17 29 5 6 14 2 0 0.33 1.00 173 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), HDAC9(5), MEF2A(1), MEF2C(1), MEF2D(1), MYOD1(2) 3035540 12 8 12 4 1 4 4 1 2 0 0.33 1.00 174 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS2(3), CTH(1), GOT1(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MPST(1), SDS(4), SULT1C2(2), SULT1C4(1), SULT4A1(1) 4798084 20 12 20 3 3 4 6 3 4 0 0.33 1.00 175 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 4899111 23 13 23 5 5 8 4 3 3 0 0.33 1.00 176 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 5388913 21 14 21 5 11 1 5 4 0 0 0.33 1.00 177 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(6), ESR1(3), MAPK1(3), MAPK3(2), PELP1(2), SRC(2) 5861877 26 14 26 4 6 5 8 4 1 2 0.33 1.00 178 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), MAPK1(3), MAPK3(2), MYT1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SRC(2) 7939238 31 19 31 7 14 3 5 6 3 0 0.33 1.00 179 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 106 ACTN1(1), ACTN3(1), ACTN4(4), ARHGAP5(2), CDH5(2), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CTNNA1(1), CTNNA2(2), CTNNA3(1), CYBB(2), ESAM(1), EZR(3), F11R(1), GNAI2(1), GRLF1(4), ITGA4(7), ITGAL(4), ITGAM(8), ITGB2(5), ITK(3), JAM2(1), JAM3(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(1), MMP9(2), MSN(1), MYL2(2), MYLPF(1), NCF1(2), NCF4(1), NOX1(2), NOX3(5), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), RAPGEF3(1), RAPGEF4(2), RASSF5(2), RHOA(1), RHOH(2), ROCK1(3), ROCK2(4), SIPA1(3), TXK(1), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2) 46542184 170 80 168 72 61 16 41 28 24 0 0.34 1.00 180 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 IFNG(1), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(4), NFKB1(1), NFKBIA(2), TNFRSF1A(2), TNFRSF1B(2), USH1C(1), WT1(3) 6173227 20 14 19 8 7 1 4 5 3 0 0.34 1.00 181 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 24 AKT1(1), AKT2(1), AKT3(1), BCL2(3), GSK3B(1), IL4R(6), IRS1(4), JAK1(3), JAK3(4), MAP4K1(1), MAPK1(3), MAPK3(2), PIK3CD(2), SOCS1(1), SOS1(1), SOS2(4), STAT6(3) 12602564 41 27 40 11 14 4 9 11 3 0 0.34 1.00 182 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(6), APOE(1), CETP(2), HMGCR(1), LCAT(1), LDLR(4), LIPC(1), LRP1(15), SCARB1(1), SOAT1(2) 10040960 34 21 31 9 5 5 12 5 4 3 0.35 1.00 183 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(2), TAX1BP3(1), UBE2A(1), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2M(3), UBE3A(5) 4137499 16 10 16 1 3 2 5 1 3 2 0.35 1.00 184 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 27 CD4(3), HLA-DRA(1), HLA-DRB1(2), IFNB1(1), IFNG(1), IL12B(1), IL2(1), IL4(1), IL6(2), IL7(1), TGFB1(1), TGFB2(1) 5198747 16 12 14 5 2 3 1 6 4 0 0.35 1.00 185 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(8), DVL2(2), EDNRB(1), EP300(6), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GSK3B(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MITF(2), NRAS(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), TCF7(3), TCF7L2(3), TYR(5), TYRP1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4) 42059694 172 77 168 50 56 20 39 31 22 4 0.35 1.00 186 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(3), GREB1(2), MTA1(4), MTA3(2), PDZK1(1), TUBA8(4) 4036321 18 10 18 7 7 2 5 1 3 0 0.35 1.00 187 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ACADVL(3), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CPT1A(1), CPT1C(2), CPT2(1), CYP4A11(3), CYP4A22(4), ECHS1(1), EHHADH(2), HADHA(1), HSD17B10(1), HSD17B4(1) 19720139 63 39 61 16 23 4 14 12 10 0 0.36 1.00 188 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), CALM1(1), ELK1(1), FCER1A(3), FCER1G(1), FOS(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLA2G4A(5), PLCG1(3), PPP3CB(1), SOS1(1), SYK(2), SYT1(1), VAV1(6) 15627890 47 30 47 23 9 10 8 12 6 2 0.36 1.00 189 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TAL1(1), TALDO1(1), TKT(2) 8108679 38 20 38 7 16 7 3 8 4 0 0.36 1.00 190 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(1), IFNGR2(1), JAK1(3), JAK2(4), STAT1(1) 3343293 11 8 10 0 6 0 1 2 2 0 0.36 1.00 191 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLUD2(4) 1683449 7 5 7 2 3 0 3 0 1 0 0.36 1.00 192 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(2), GOT1(1), PAH(1), TAT(3), YARS(2) 3374325 10 9 10 4 4 2 2 2 0 0 0.37 1.00 193 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 120 ARAF(1), CD244(1), FCER1G(1), FCGR3A(1), GZMB(3), HCST(1), HLA-A(1), HLA-B(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), ITGAL(4), ITGB2(5), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KLRC1(1), KLRC3(3), KLRK1(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MICB(1), NCR1(2), NCR2(3), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), PAK1(2), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRF1(3), PRKCA(3), PRKCG(1), PTK2B(1), PTPN11(6), PTPN6(4), SH2D1B(1), SH3BP2(2), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SYK(2), TNFRSF10A(2), TNFSF10(5), ULBP1(1), VAV1(6), VAV2(3), VAV3(2), ZAP70(5) 41401531 149 72 149 69 46 15 35 29 24 0 0.37 1.00 194 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(3), INSR(5), IRS1(4), JAK2(4), MAP2K1(1), MAPK1(3), MAPK3(2), PLCG1(3), PRKCA(3), PTPN6(4), SLC2A4(3), SOCS1(1), SOS1(1), SRF(2), STAT5A(2), STAT5B(2) 11643369 44 26 43 13 16 7 8 10 3 0 0.38 1.00 195 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(8), GNAS(3), GNB1(1), GNGT1(1) 2556429 13 10 13 4 7 1 3 1 1 0 0.38 1.00 196 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(6), GLS(3), GOT1(1) 3019519 10 7 10 2 2 2 4 1 1 0 0.38 1.00 197 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(3), AGTR1(2), AGTR2(1), COL4A1(4), COL4A2(8), COL4A3(3), COL4A4(4), COL4A5(5), COL4A6(5), REN(2) 10340714 39 23 37 11 13 11 6 5 4 0 0.38 1.00 198 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 CD3E(1), CD3G(1), CXCR3(2), ETV5(2), IFNG(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(1), JAK2(4), MAPK14(1), STAT4(1), TYK2(3) 7214838 26 17 25 11 11 1 7 2 5 0 0.38 1.00 199 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(3), KARS(4) 1930467 7 5 7 2 0 1 1 4 1 0 0.38 1.00 200 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ADC(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EARS2(2), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GFPT2(3), GLS(3), GLUD2(4), GLUL(1), GMPS(1), GOT1(1), GSR(1), GSS(1), NADSYN1(4), NAGK(2), QARS(3) 15751750 60 32 60 13 14 9 15 17 3 2 0.38 1.00 201 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(1) 2728774 9 7 9 6 2 1 3 2 1 0 0.39 1.00 202 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), DFFB(3), GZMB(3), TOP2A(1), TOP2B(1) 3551959 9 8 9 2 2 0 2 3 2 0 0.39 1.00 203 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1) 6464244 27 16 27 8 9 6 8 1 3 0 0.39 1.00 204 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(6), LPO(1), MPO(3), MTHFR(3), SHMT2(1), TPO(4) 4632196 18 13 18 9 12 0 2 1 3 0 0.39 1.00 205 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1C1(3), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(7) 12995770 54 29 54 22 27 5 9 3 10 0 0.40 1.00 206 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(3), GALNT2(4), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), ST3GAL1(2), WBSCR17(7) 5757903 29 15 29 14 15 4 6 1 3 0 0.40 1.00 207 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2), TOB1(2), TOB2(1) 4320259 22 10 22 3 5 3 4 3 7 0 0.40 1.00 208 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 16 ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(1), HYAL2(1), LCT(8), NAGLU(1) 7676047 26 17 26 9 9 1 6 4 6 0 0.40 1.00 209 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 163 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY7(3), ADCY8(4), ADCY9(5), ADORA2B(1), ADRA1D(1), ADRB1(1), ADRB2(1), AGTR1(2), ATP2A1(4), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), ATP2B4(1), AVPR1A(3), AVPR1B(1), BDKRB1(1), BDKRB2(3), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1F(10), CACNA1G(6), CACNA1H(9), CACNA1I(5), CACNA1S(12), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CCKAR(3), CCKBR(2), CD38(2), CHRM2(4), CHRM3(3), CHRNA7(2), CYSLTR1(1), CYSLTR2(1), DRD1(2), EDNRA(1), EDNRB(1), ERBB2(7), ERBB3(4), ERBB4(1), GNA11(2), GNA15(4), GNAL(1), GNAQ(1), GNAS(3), GRIN1(3), GRIN2A(13), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), GRPR(1), HRH1(1), HRH2(5), HTR2A(1), HTR2C(2), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), LHCGR(1), LTB4R2(2), MYLK(7), MYLK2(1), NOS1(9), NOS3(5), NTSR1(2), OXTR(2), P2RX1(1), P2RX2(3), P2RX4(2), P2RX5(3), P2RX7(2), PDE1A(1), PDE1C(4), PDGFRB(5), PHKA1(3), PHKA2(4), PHKB(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(3), PLCG2(11), PLCZ1(1), PPID(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(2), PTK2B(1), RYR1(14), RYR3(17), SLC25A5(2), SLC8A1(2), SLC8A3(2), SPHK1(1), SPHK2(2), TACR1(1), TACR3(4), TNNC1(1), TRHR(2), TRPC1(1), VDAC1(1), VDAC2(1) 99839322 438 141 430 141 193 52 79 64 48 2 0.41 1.00 210 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(4), PC(3), PDHA1(1), SLC25A11(3) 3635305 13 9 13 5 3 1 4 4 1 0 0.41 1.00 211 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), AKT2(1), AKT3(1), CDKN1A(1), ELK1(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(2), SOS1(1) 5448617 15 12 15 6 6 3 1 3 2 0 0.41 1.00 212 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(1), ALDH5A1(2), CAD(6), CPS1(6), EPRS(2), GAD1(4), GAD2(3), GCLC(1), GFPT1(5), GLS(3), GLUL(1), GMPS(1), GOT1(1), GSS(1), NADSYN1(4), QARS(3) 13204749 46 26 46 9 10 9 11 13 3 0 0.41 1.00 213 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 64 AKT1(1), AKT2(1), AKT3(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NOS3(5), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), SH2D2A(2), SPHK1(1), SPHK2(2), SRC(2), VEGFA(2) 24478401 91 47 89 29 32 11 14 20 12 2 0.43 1.00 214 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), BIRC3(1), DFFA(1), DFFB(3), GZMB(3), PRF1(3), SCAP(5), SREBF1(2), SREBF2(3) 7117067 23 16 23 9 8 1 4 4 6 0 0.43 1.00 215 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(1), ALDOC(3), DERA(2), FBP1(2), FBP2(4), G6PD(2), GPI(4), PFKM(3), PFKP(6), PGLS(2), PGM3(2), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKT(2), TKTL1(2), TKTL2(2) 9580655 43 22 43 7 18 6 6 8 5 0 0.43 1.00 216 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(2), ALAS2(1), CPOX(1), FECH(3), HMBS(1), PPOX(2), UROD(1), UROS(1) 3096938 12 8 12 1 2 1 3 3 3 0 0.43 1.00 217 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(3), CHKA(1), PCYT1A(1), PDHA1(1), PDHA2(3) 2740861 9 8 9 4 5 0 0 1 3 0 0.43 1.00 218 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 20 IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MIOX(1), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11) 15031846 53 30 52 11 17 8 13 4 9 2 0.43 1.00 219 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(4), PLCG1(3), PRKCA(3), VAV1(6) 3662901 17 9 17 7 5 4 4 2 0 2 0.43 1.00 220 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(2), ACP6(2), ACPT(3), ENPP3(1), LHPP(1), MTMR1(2), MTMR2(3), RFK(1), TYR(5) 6011045 20 12 20 5 4 4 4 6 2 0 0.43 1.00 221 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(1), GOT1(1), PAH(1), TAT(3), YARS(2), YARS2(2) 3538569 11 9 11 2 2 4 3 2 0 0 0.44 1.00 222 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDPS(2), HMGCR(1), LSS(1), MVD(1), MVK(1), NQO2(1), PMVK(1), SC5DL(2), SQLE(1) 4352042 15 10 14 1 6 0 3 3 3 0 0.44 1.00 223 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(1), ABP1(9), ACMSD(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CYP19A1(3), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2D6(3), CYP2E1(4), CYP3A4(3), CYP3A7(3), CYP4B1(3), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), KYNU(3), MAOB(1), SDS(4), TDO2(2), TPH1(3) 21968333 88 44 86 22 36 13 20 14 5 0 0.44 1.00 224 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(6), ABCA10(2), ABCA12(2), ABCA13(6), ABCA2(3), ABCA3(3), ABCA4(6), ABCA5(4), ABCA6(2), ABCA7(3), ABCA8(1), ABCA9(4), ABCB1(4), ABCB10(2), ABCB11(2), ABCB4(8), ABCB5(7), ABCB6(4), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(2), ABCC11(3), ABCC12(1), ABCC2(3), ABCC3(5), ABCC4(4), ABCC5(7), ABCC6(5), ABCC8(6), ABCD1(4), ABCD2(4), ABCD3(3), ABCG1(2), ABCG2(2), ABCG4(6), ABCG5(3), ABCG8(3), CFTR(7), TAP1(4), TAP2(2) 45266297 155 71 154 58 53 18 34 20 23 7 0.44 1.00 225 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(1), AGT(3), AKT1(1), CALM1(1), CAMK1(2), CAMK4(1), CREBBP(8), ELSPBP1(1), F2(1), FGF2(1), FKBP1A(1), GATA4(2), GSK3B(1), MAP2K1(1), MAPK1(3), MAPK14(1), MAPK3(2), MEF2C(1), MYH2(13), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RPS6KB1(1), SYT1(1) 18412548 58 35 58 24 14 9 12 14 9 0 0.44 1.00 226 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(8), ACACB(9), ACOT12(1), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), LDHD(1), MDH2(1), ME1(4), ME2(2), ME3(3), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(3), PDHB(1), PKLR(4) 18815701 65 37 65 20 22 6 16 13 8 0 0.44 1.00 227 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(8), ADRB2(1), CFTR(7), GNAS(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5000185 22 13 22 6 11 3 4 2 2 0 0.44 1.00 228 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 25 ERBB2(7), ERBB4(1), ETV7(1), FMN2(2), KRAS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NOTCH1(4), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(3), PIWIL3(4), PIWIL4(1), SOS1(1), SOS2(4), SPIRE1(3) 18469803 56 35 52 19 15 5 10 14 12 0 0.44 1.00 229 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 39 AGL(5), AMY2B(1), ENPP3(1), G6PC(2), GAA(3), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), MGAM(7), PGM3(2), PYGB(4), PYGL(1), PYGM(2), SI(3), UCHL1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2B4(5), UXS1(1) 21856473 66 42 64 30 30 8 12 9 7 0 0.44 1.00 230 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(2), GAD1(4), GAD2(3), GGT1(2) 2278836 12 6 12 2 4 3 2 3 0 0 0.45 1.00 231 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(1), CCND2(1), CCNE1(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), RBL1(3) 5489046 17 12 17 8 1 4 5 2 5 0 0.45 1.00 232 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(9), ALDH1A3(1), ALDH3A1(3), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(2), DDC(1), EPX(6), ESCO1(2), GOT1(1), HPD(1), LPO(1), MAOB(1), MPO(3), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), TAT(3), TPO(4) 13787304 54 32 54 11 25 7 5 11 6 0 0.45 1.00 233 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSS(1), GSTA1(2), GSTA4(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1) 6880063 26 15 25 6 11 2 6 6 1 0 0.45 1.00 234 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), CHUK(4), GH1(1), GHR(3), NFKB1(1), NFKBIA(2), PPP2CA(1) 4158788 13 10 12 4 3 2 2 4 2 0 0.45 1.00 235 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 196 ABI2(2), ACTN1(1), ACTN3(1), ACTN4(4), APC(7), APC2(2), ARAF(1), ARHGEF1(2), ARHGEF4(2), ARHGEF7(1), ARPC1B(1), ARPC2(1), ARPC4(1), ARPC5L(1), BDKRB1(1), BDKRB2(3), CD14(2), CFL2(1), CHRM2(4), CHRM3(3), CYFIP1(2), CYFIP2(1), DIAPH1(2), DIAPH2(3), DIAPH3(4), DOCK1(9), EGF(3), EZR(3), F2(1), FGD1(2), FGD3(2), FGF10(1), FGF13(1), FGF14(2), FGF18(1), FGF2(1), FGF20(2), FGF21(1), FGF23(3), FGF3(1), FGF6(3), FGF9(1), FGFR1(3), FGFR2(3), FGFR3(2), FGFR4(3), FN1(3), GIT1(2), GNA12(2), GRLF1(4), GSN(2), IQGAP1(2), IQGAP2(4), IQGAP3(5), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), KRAS(1), LIMK1(1), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MSN(1), MYH10(3), MYH14(6), MYH9(8), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), NCKAP1(2), NCKAP1L(4), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PIP4K2A(3), PIP4K2B(1), PIP4K2C(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(6), PTK2(2), PXN(1), RHOA(1), ROCK1(3), ROCK2(4), RRAS2(3), SLC9A1(3), SOS1(1), SOS2(4), SSH1(1), SSH2(4), SSH3(2), TIAM1(2), TIAM2(8), TMSL3(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), WASF1(1), WASF2(1) 103362878 362 134 358 128 131 40 79 54 58 0 0.45 1.00 236 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NGFR(1) 3196853 11 8 11 2 4 1 2 3 1 0 0.46 1.00 237 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 50 AKR1C4(2), ARSD(1), ARSE(1), CARM1(1), CYP11B2(4), CYP19A1(3), HSD11B1(2), HSD17B3(1), HSD17B7(1), HSD17B8(1), HSD3B2(2), LCMT1(1), PRMT7(2), PRMT8(1), STS(2), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B4(5), UGT2B7(3) 17940786 51 34 51 32 17 7 13 11 3 0 0.46 1.00 238 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG2(2), ACTR3(2), AKT1(1), ANGPTL2(2), CFL2(1), FLNA(14), FLNC(6), FSCN3(2), LIMK1(1), MYH2(13), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), VASP(2), WASF1(1) 18440072 72 39 72 23 29 8 16 9 10 0 0.46 1.00 239 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C1R(1), C1S(1), C2(2), C3(8), C5(1), C6(4), C7(6), C8A(3), C9(1), MASP1(2), MBL2(1) 8383457 31 18 30 23 9 3 8 7 2 2 0.46 1.00 240 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2), GNAQ(1), ITPKB(2) 2334197 6 6 6 1 2 0 0 2 2 0 0.46 1.00 241 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(3), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), NFKB1(1), NSMAF(3), RIPK1(1), TNFRSF1A(2), TRAF2(2) 8274482 23 18 23 7 5 4 4 5 5 0 0.46 1.00 242 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAS1(2), ALAS2(1), CPO(3), FECH(3), GATA1(1), HMBS(1), UROD(1), UROS(1) 3207720 13 7 13 2 2 3 2 4 2 0 0.47 1.00 243 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(2), ACADS(4), ECHS1(1), HADHA(1) 2142674 8 5 8 2 3 1 2 1 1 0 0.47 1.00 244 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(1), CDK5R1(1), LIMK1(1), MAP3K1(5), MYL2(2), MYLK(7), PAK1(2), PPP1R12B(6), RALBP1(3), RPS6KB1(1), TRIO(8), VAV1(6), WASF1(1) 11688440 44 24 44 16 13 6 13 7 5 0 0.47 1.00 245 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(2), ACADS(4), ACADVL(3), ACSL3(3), ACSL4(2), CPT1A(1), CPT2(1), EHHADH(2), HADHA(1), PECR(1) 6771058 20 13 20 4 6 3 4 5 2 0 0.47 1.00 246 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 ALOX12B(1), ALOX15(2), ALOX15B(1), ALOX5(1), CBR1(1), CBR3(2), CYP2B6(2), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP4A11(3), CYP4A22(4), CYP4F2(5), CYP4F3(5), EPHX2(2), GGT1(2), GPX1(2), GPX2(1), GPX5(2), LTA4H(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3) 15372562 68 33 67 28 31 6 15 9 5 2 0.48 1.00 247 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(3), ADCY9(5), AK1(1), ARF4(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), GNAS(3), PLCG1(3), PLCG2(11), PRKCA(3), SEC61A1(1), TRIM23(1) 14879216 59 32 59 22 24 11 12 5 7 0 0.48 1.00 248 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(9), ACY1(1), ADC(2), AGMAT(1), ALDH18A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(2), AOC3(2), ARG2(2), CPS1(6), GATM(2), MAOB(1), ODC1(1), OTC(2), SAT1(1), SAT2(1) 11918551 43 25 43 9 13 10 8 12 0 0 0.48 1.00 249 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 30 CD14(2), CHUK(4), ELK1(1), FOS(1), IKBKB(2), IRAK1(2), LY96(1), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), PPARA(1), TLR10(1), TLR2(4), TLR4(1), TLR7(5), TLR9(2) 13907536 41 27 40 23 8 12 6 11 4 0 0.48 1.00 250 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS2(2), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1A1(1), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(1), ALDOC(3), BPGM(1), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PGM3(2), PKLR(4) 22858971 92 46 91 21 41 12 15 16 8 0 0.49 1.00 251 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(1), AKT2(1), AKT3(1), BTK(1), FCER1A(3), FCER1G(1), GAB2(3), IL4(1), INPP5D(6), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NRAS(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCG1(3), PLCG2(11), PRKCA(3), PRKCD(5), PRKCE(1), SOS1(1), SOS2(4), SYK(2), VAV1(6), VAV2(3), VAV3(2) 25977261 102 49 102 38 43 13 15 16 13 2 0.50 1.00 252 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(4), B3GALNT1(1), B3GALT5(2), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2) 4233734 15 10 15 9 5 1 4 2 3 0 0.50 1.00 253 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), ARHGDIB(4), CASP1(4), GZMB(3), PRF1(3) 5217895 17 11 17 7 3 4 2 4 4 0 0.50 1.00 254 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), SQLE(1) 1248932 3 3 3 0 1 0 0 2 0 0 0.50 1.00 255 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 FUCA1(1), GLB1(1), HEXA(1), LCT(8), MAN2C1(2), MANBA(1), NEU1(1), NEU2(4) 6339425 19 13 19 7 10 1 2 4 2 0 0.50 1.00 256 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(1), ARSB(2), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), PPAP2C(1), SPTLC1(3), SPTLC2(1), UGCG(1) 9346687 32 20 32 15 11 5 3 4 7 2 0.50 1.00 257 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(5), ESR1(3), ESR2(1), ESRRA(2), NPM1(1), NR1D1(3), NR1H2(1), NR1H3(1), NR1I3(2), NR2F2(2), NR2F6(1), NR3C1(1), NR4A1(3), NR4A2(2), NR5A1(1), NR5A2(1), PGR(4), PPARA(1), RARG(2), ROR1(2), RORA(1), RORC(3), RXRA(3), RXRB(1), RXRG(1), THRA(1), VDR(2) 15986444 51 33 49 27 16 2 10 12 11 0 0.51 1.00 258 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(1), ANXA5(1), CYP11A1(1), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(5), PRL(3), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1), PTGIS(1), PTGS1(2), SCGB1A1(1), TBXAS1(3) 8177226 32 16 32 9 9 6 3 8 4 2 0.51 1.00 259 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 19 ADCY1(8), AKT1(1), BCL2(3), CSF2RB(4), IGF1R(2), KIT(3), KITLG(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 6807436 26 17 26 5 11 3 6 4 2 0 0.51 1.00 260 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PAK1(2) 5856060 16 13 16 5 1 4 4 4 3 0 0.52 1.00 261 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 18 AP2A1(2), AP2M1(4), BIN1(1), CALM1(1), DNM1(5), EPN1(1), EPS15(1), PICALM(2), PPP3CB(1), SYNJ1(1), SYNJ2(7), SYT1(1) 8043241 27 15 26 7 7 6 7 3 4 0 0.52 1.00 262 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(1), IL12B(1), IL16(4), IL2(1), IL4(1), IL6(2) 3964825 11 8 11 5 2 1 2 4 2 0 0.52 1.00 263 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(8), CPT1A(1), LEPR(1), PRKAA2(1), PRKAG1(2), PRKAG2(5) 5919449 18 12 18 3 8 1 5 1 3 0 0.53 1.00 264 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1) 4061066 14 9 14 4 5 4 1 0 4 0 0.53 1.00 265 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), IMPDH1(2), OAZ1(1), POLD1(3), POLG(4), PRPS2(2), RRM1(2) 4959256 15 10 14 6 4 2 3 3 3 0 0.53 1.00 266 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ABAT(2), ACADS(4), ACSM1(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH5A1(2), ALDH9A1(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(4), GAD2(3), HADHA(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(1), RDH13(1) 16399088 52 31 52 20 18 7 10 9 8 0 0.53 1.00 267 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CUL1(5), FBXW7(2) 2642751 8 7 8 4 3 1 2 0 2 0 0.53 1.00 268 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(3), IL22RA1(1), JAK1(3), JAK2(4), JAK3(4), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), TYK2(3) 7302229 26 16 24 6 12 2 6 5 1 0 0.53 1.00 269 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 16 CALM1(1), CCL2(2), FOS(1), GNAQ(1), MAPK14(1), PLCG1(3), PRKCA(3), PTK2B(1), SYT1(1) 5281234 14 11 14 9 3 2 2 6 1 0 0.54 1.00 270 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(3), DHCR7(4), FDPS(2), GGCX(1), HMGCR(1), HSD17B7(1), IDI2(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1), TM7SF2(2) 7681268 26 16 25 7 8 2 7 3 6 0 0.54 1.00 271 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1) 4066968 13 10 12 1 7 1 2 3 0 0 0.54 1.00 272 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(4), IFNG(1), IKBKB(2), IL2(1), IL4(1), MAP3K1(5), MAP3K5(1), MAPK14(1), NFKB1(1), NFKBIA(2), TNFSF9(3), TRAF2(2) 7816794 25 15 24 13 8 2 3 7 5 0 0.55 1.00 273 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(4), MAP3K14(2), MAPK14(1), NFKB1(1), TNFRSF13B(2), TNFSF13B(2), TRAF2(2), TRAF3(3), TRAF5(1) 5745691 18 12 17 6 4 0 4 7 3 0 0.55 1.00 274 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), AKT2(1), AKT3(1), BCL2(3), BCR(1), BLNK(2), BTK(1), CD19(2), CD22(5), CR2(6), DAG1(2), FLOT1(2), GSK3B(1), INPP5D(6), ITPR1(7), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), MAPK3(2), NFATC1(3), NFATC2(1), NR0B2(3), PIK3CD(2), PLCG2(11), PPP3CB(1), PTPRC(4), SOS1(1), SOS2(4), SYK(2), VAV1(6) 27675255 108 53 107 32 43 14 20 16 15 0 0.55 1.00 275 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(8), ACACB(9), ACADM(2), ACSS2(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHC(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLA2(1), SUCLG1(2) 16123336 52 29 52 13 16 7 13 8 8 0 0.55 1.00 276 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), AKT2(1), AKT3(1), BPNT1(1), ILK(2), MAPK1(3), MAPK3(2), PIK3CD(2), PTK2B(1), RBL2(1), SOS1(1) 6879113 16 13 16 6 4 2 3 6 1 0 0.55 1.00 277 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3), ERBB3(4), NRG1(4) 3105556 11 7 11 2 4 0 3 3 1 0 0.56 1.00 278 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(4), DNAJC3(3), EIF2S2(1), MAP3K14(2), NFKB1(1), NFKBIA(2) 3587258 13 7 12 4 1 1 3 5 3 0 0.56 1.00 279 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(1), B4GALT2(1), DDOST(2), DPAGT1(1), FUT8(1), MAN1A1(3), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), RPN1(1), ST6GAL1(4) 7750835 24 15 24 5 6 5 3 5 5 0 0.57 1.00 280 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(8), GNAS(3), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAR2A(1), PRKAR2B(1) 5958974 25 15 25 6 12 1 6 4 2 0 0.57 1.00 281 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT4(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GCNT2(1), ST3GAL6(2) 6100494 22 13 22 9 8 3 4 6 1 0 0.57 1.00 282 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(2), CHIT1(1), CMAS(1), CTBS(3), GFPT1(5), GFPT2(3), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), LHPP(1), MTMR1(2), MTMR2(3), NAGK(2), NPL(3), PGM3(2), UAP1(1) 11395607 43 23 40 9 12 3 12 8 6 2 0.57 1.00 283 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(3), CHUK(4), DAXX(4), EGF(3), FOS(1), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(1), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), NFKB1(1), NFKBIA(2), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), RIPK1(1), SP1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 18655627 67 36 66 25 16 10 16 15 10 0 0.57 1.00 284 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(1), ELOVL2(2), ELOVL5(1), FADS1(1), FADS2(1), FASN(7), HADHA(1), PECR(1), SCD(2) 5319808 20 12 20 3 6 3 4 4 3 0 0.57 1.00 285 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), BLVRB(1), HMOX1(2), IL10RA(1), IL6(2), JAK1(3), STAT1(1), STAT3(2), STAT5A(2) 4931464 15 10 15 4 4 2 2 3 4 0 0.57 1.00 286 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(8), CALM1(1), ELK1(1), FOS(1), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), MAP2K1(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RPS6KA3(5), SYT1(1) 13613042 43 27 43 15 12 6 8 12 5 0 0.58 1.00 287 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 3235255 15 8 15 3 5 5 3 2 0 0 0.58 1.00 288 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1) 3235255 15 8 15 3 5 5 3 2 0 0 0.58 1.00 289 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 ACTR3(2), AKT1(1), ANGPTL2(2), DAG1(2), GCA(1), ITGA9(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), MAP2K1(1), MAPK1(3), MAPK3(2), NR1I3(2), PAK1(2), PDE3A(1), PDE3B(4), PIK3CD(2), PLDN(1), PSME1(1), RIPK3(2), RPS4X(1), VASP(2) 16749545 64 34 64 17 18 11 14 10 11 0 0.58 1.00 290 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(2), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK1(3), MAPK3(2), MAPK8IP3(5), PAPPA(6), RPS6KA3(5), SOS1(1), SYK(2), VAV1(6), VAV2(3), VAV3(2) 12633746 48 26 48 14 18 9 9 8 4 0 0.58 1.00 291 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(6), HLA-DRA(1), HLA-DRB1(2), ITGAL(4), ITGB2(5), PTPRC(4) 5799042 27 11 26 13 6 6 7 1 7 0 0.58 1.00 292 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4) 2470997 8 5 8 5 2 1 1 3 1 0 0.58 1.00 293 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(8), ADCY8(4), ARAF(1), ATF4(1), CACNA1C(5), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CREBBP(8), EP300(6), GNAQ(1), GRIA1(4), GRIN1(3), GRIN2A(13), GRIN2B(4), GRIN2C(2), GRIN2D(2), GRM1(1), GRM5(1), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NRAS(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RAP1B(2), RAPGEF3(1), RPS6KA2(2), RPS6KA3(5) 38930540 151 68 148 54 52 23 34 25 13 4 0.59 1.00 294 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(1), ALDOC(3), DLAT(1), DLD(1), ENO2(1), ENO3(2), FBP1(2), FBP2(4), G6PC(2), GAPDH(1), GAPDHS(2), GCK(2), GOT1(1), GPI(4), HK2(3), HK3(4), LDHA(2), LDHAL6B(1), LDHC(1), MDH2(1), PC(3), PCK1(4), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(6), PGK2(3), PKLR(4) 16619362 68 32 67 20 26 11 11 13 7 0 0.59 1.00 295 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(1), EPHA4(3), ITGA1(1), L1CAM(7), LYN(1), RAP1B(2), SELP(2) 5541318 17 12 17 3 9 3 2 2 1 0 0.59 1.00 296 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 653274 2 2 2 0 0 1 1 0 0 0 0.60 1.00 297 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 IFNG(1), IFNGR1(1), JAK1(3), JAK2(4), PTPRU(3), STAT1(1) 4512928 13 10 12 1 9 0 1 1 2 0 0.60 1.00 298 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(7), CDC25B(1), MYT1(7) 5167848 15 9 15 0 5 3 2 2 3 0 0.60 1.00 299 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRB1(1), DRD1(2), DRD2(1), EGF(3), GJA1(1), GNA11(2), GNAI2(1), GNAQ(1), GNAS(3), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), HTR2A(1), HTR2C(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K5(1), MAP3K2(1), MAPK1(3), MAPK3(2), MAPK7(3), NPR1(6), NPR2(1), NRAS(1), PDGFC(3), PDGFD(2), PDGFRB(5), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKG2(5), PRKX(2), SOS1(1), SOS2(4), SRC(2), TJP1(2), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 50342281 184 85 176 70 70 22 33 31 26 2 0.60 1.00 300 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), ESRRA(2), HDAC5(4), MEF2A(1), MEF2C(1), MEF2D(1), PPARA(1), PPP3CB(1), SLC2A4(3), SYT1(1) 8008658 25 16 25 7 4 4 6 7 4 0 0.61 1.00 301 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(1), UXS1(1) 1560555 5 3 5 0 2 2 0 1 0 0 0.61 1.00 302 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT1(2), AGPAT2(2), AGPAT3(2), AGPAT4(1), AGPS(1), ENPP2(5), PAFAH2(2), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLD2(1), PPAP2C(1) 9229215 33 19 33 17 13 3 4 5 6 2 0.62 1.00 303 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 58 ATP12A(5), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(5), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), ATP7B(3), COX10(1), COX8A(1), NDUFA10(2), NDUFA4(2), NDUFA8(1), NDUFB7(1), NDUFS2(1), NDUFV1(2), NDUFV2(2), PPA2(1), UQCRC1(3) 14093507 52 27 52 15 14 11 13 7 7 0 0.62 1.00 304 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL5(1), CCR3(2), HLA-DRA(1), HLA-DRB1(2) 1233437 6 3 6 0 0 3 0 2 1 0 0.62 1.00 305 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX1(2), GPX2(1), GPX5(2), GSR(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(2), GSTM1(1), GSTM3(1), GSTP1(1), GSTT1(1), IDH2(2), MGST1(1), MGST3(1) 8192219 30 16 29 7 14 2 7 6 1 0 0.62 1.00 306 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(2) 827895 2 2 2 2 1 0 1 0 0 0 0.63 1.00 307 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(3), ELK1(1), FOS(1), INSR(5), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SLC2A4(3), SOS1(1), SRF(2) 8615025 29 17 29 8 8 6 5 6 4 0 0.63 1.00 308 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1C4(2), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), SOAT2(2) 9397592 38 19 38 9 16 10 8 4 0 0 0.63 1.00 309 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(2), VAMP2(1) 1301392 3 3 3 1 2 0 0 0 1 0 0.63 1.00 310 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(2), ACPT(3), ENPP3(1), RFK(1), TYR(5) 3874593 12 7 12 4 2 2 2 5 1 0 0.63 1.00 311 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP2E1(4), NR1I3(2), PTGS1(2) 2149083 8 5 8 5 3 0 3 1 1 0 0.64 1.00 312 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(1), CACNA1A(4), CRHR1(2), GNA11(2), GNA12(2), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(3), GRIA1(4), GRIA3(5), GRID2(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IGF1R(2), ITPR1(7), ITPR2(11), ITPR3(11), KRAS(1), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), NOS1(9), NOS3(5), NPR1(6), NPR2(1), NRAS(1), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(3), PRKCG(1), PRKG2(5), RYR1(14) 43149797 166 74 158 63 67 21 27 26 21 4 0.64 1.00 313 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(1), BCL2(3), IGF1R(2), POLR2A(2), PPP2CA(1), PRKCA(3), TEP1(4), TERT(8), TNKS(4), XRCC5(1) 9171493 29 19 27 4 12 3 6 4 4 0 0.64 1.00 314 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(1), EIF4E(2), FBL(1), LDHA(2), LDHC(1), MAPK14(1), NCL(3) 3536753 14 7 14 3 4 1 1 5 3 0 0.64 1.00 315 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK1(3), MAPK3(2), SOS1(1) 5980178 14 12 14 3 4 3 1 5 1 0 0.65 1.00 316 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(6), LPO(1), MPO(3), PRDX2(2), SHMT2(1), TPO(4) 4676705 17 11 17 9 11 0 2 1 3 0 0.65 1.00 317 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), NTRK1(4), PLCG1(3), PRKCA(3), SOS1(1) 4715254 12 10 12 7 3 3 2 4 0 0 0.65 1.00 318 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(1), AFMID(3), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1) 5436982 14 11 14 7 7 1 4 2 0 0 0.65 1.00 319 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(1), ABLIM2(1), ABLIM3(2), CFL2(1), DCC(9), DPYSL2(2), DPYSL5(2), EFNA3(2), EFNA5(2), EFNB1(2), EFNB2(2), EFNB3(1), EPHA1(6), EPHA2(2), EPHA3(2), EPHA4(3), EPHA5(4), EPHA6(2), EPHA7(6), EPHA8(6), EPHB2(6), EPHB3(1), EPHB4(2), EPHB6(5), FES(3), GNAI2(1), GSK3B(1), KRAS(1), L1CAM(7), LIMK1(1), LIMK2(1), LRRC4C(3), MAPK1(3), MAPK3(2), MET(5), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NRAS(1), NRP1(5), NTN1(3), NTN4(2), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLXNA1(3), PLXNA2(8), PLXNA3(3), PLXNB1(3), PLXNB2(7), PLXNC1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PTK2(2), RGS3(2), RHOA(1), RHOD(1), RND1(1), ROBO1(3), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(4), SEMA3A(1), SEMA3B(1), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(3), SEMA4G(3), SEMA5A(2), SEMA5B(2), SEMA6B(1), SEMA6C(1), SEMA7A(1), SLIT1(4), SLIT2(5), SRGAP1(5), SRGAP2(2), SRGAP3(4), UNC5A(4), UNC5D(2) 72176922 230 106 223 76 61 40 48 47 34 0 0.65 1.00 320 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(8), FSHR(1), GNAS(3), XPO1(2) 3767123 14 10 14 3 8 1 3 1 1 0 0.66 1.00 321 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 3135228 8 6 8 4 0 3 1 1 3 0 0.66 1.00 322 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(2), AGXT2(2), ASNS(1), CAD(6), GAD1(4), GAD2(3), GOT1(1), NARS(1), PC(3) 10342147 26 19 26 13 5 5 7 6 3 0 0.66 1.00 323 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), AKT2(1), AKT3(1), IARS(4), IL13RA1(1), IL4(1), IL4R(6), INPP5D(6), JAK1(3), JAK2(4), JAK3(4), NR0B2(3), RPS6KB1(1), SOS1(1), SOS2(4), SRC(2), STAT6(3), TYK2(3) 13804452 49 27 47 15 22 10 6 7 4 0 0.66 1.00 324 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(1), MMP9(2), RECK(1), TIMP3(2) 3004129 10 7 10 1 5 1 2 1 1 0 0.66 1.00 325 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASS(3), KARS(4) 2839594 9 5 9 3 0 2 1 4 2 0 0.66 1.00 326 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 28 MAP2K7(1), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(2), SYT1(1), TRAF2(2), TRAF3(3), TRAF5(1) 10233819 34 20 34 10 12 2 8 9 3 0 0.66 1.00 327 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(3), CREBBP(8), EP300(6), IL7(1), IL7R(1), JAK1(3), JAK3(4), PTK2B(1), STAT5A(2), STAT5B(2) 9753607 31 18 30 12 6 5 11 4 3 2 0.66 1.00 328 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(1), CREBBP(8), EP300(6), ERCC3(2), ESR1(3), GRIP1(6), GTF2E1(1), GTF2F1(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), MEF2C(1), NCOR2(5), NRIP1(3), PELP1(2), POLR2A(2), TBP(2) 18281204 60 34 60 14 19 7 18 6 8 2 0.67 1.00 329 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(1), BCL2(3), CABIN1(12), CALM1(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(2), CREBBP(8), CSNK2A1(3), EGR2(3), EGR3(4), EP300(6), FCER1A(3), FCGR3A(1), FOS(1), GATA3(2), GATA4(2), GRLF1(4), GSK3B(1), IFNB1(1), IFNG(1), IL2(1), IL2RA(3), IL4(1), IL6(2), ITK(3), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(3), P2RX7(2), PAK1(2), PPP3CB(1), PPP3R1(1), PTPRC(4), SLA(1), SP1(6), SP3(1), TGFB1(1), TRAF2(2), VAV1(6), VAV2(3), VAV3(2), XPO5(1) 35016704 131 57 131 38 33 21 32 20 23 2 0.67 1.00 330 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(1), ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(1), ENPP7(3), GAL3ST1(2), GALC(2), GBA(1), GLA(1), GLB1(1), LCT(8), NEU1(1), NEU2(4), PPAP2C(1), SGMS1(1), SGMS2(1), SMPD3(1), SPHK1(1), SPHK2(2), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(2) 13679523 43 26 42 18 15 8 5 5 8 2 0.67 1.00 331 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 182 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ARHGAP5(2), BCL2(3), BIRC2(1), BIRC3(1), CAPN2(1), CAV1(1), CAV3(1), CCND2(1), CHAD(1), COL11A1(8), COL11A2(9), COL1A1(4), COL1A2(9), COL2A1(2), COL3A1(5), COL4A1(4), COL4A2(8), COL4A4(4), COL4A6(5), COL5A1(3), COL5A2(5), COL5A3(11), COL6A1(5), COL6A2(3), COL6A6(7), COMP(1), DIAPH1(2), DOCK1(9), EGF(3), ELK1(1), ERBB2(7), FARP2(2), FIGF(1), FLNA(14), FLNB(4), FLNC(6), FLT1(2), FN1(3), GRLF1(4), GSK3B(1), HGF(4), IGF1R(2), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAV(1), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), LAMA1(17), LAMA2(12), LAMA3(7), LAMA4(4), LAMA5(9), LAMB1(4), LAMB2(3), LAMB3(4), LAMB4(11), LAMC1(2), LAMC2(6), LAMC3(5), MAP2K1(1), MAPK1(3), MAPK3(2), MAPK9(2), MET(5), MYL2(2), MYLK(7), MYLK2(1), MYLPF(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARVB(1), PARVG(2), PDGFC(3), PDGFD(2), PDGFRB(5), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PIP5K1C(4), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(3), PRKCG(1), PTK2(2), PXN(1), RAP1B(2), RELN(20), RHOA(1), ROCK1(3), ROCK2(4), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), SRC(2), THBS1(3), THBS2(5), THBS3(1), THBS4(2), TLN1(6), TLN2(5), TNC(7), TNN(5), TNR(2), TNXB(6), VASP(2), VAV1(6), VAV2(3), VAV3(2), VCL(2), VEGFA(2), VEGFC(2), VWF(10), ZYX(2) 135942059 504 155 493 172 172 85 95 77 73 2 0.67 1.00 332 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(2) 1249454 4 3 4 2 1 1 0 0 2 0 0.67 1.00 333 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(4), BIRC2(1), BIRC3(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), DFFA(1), DFFB(3), GZMB(3), LMNB1(1), LMNB2(3), PRF1(3) 7723788 28 16 28 7 4 5 5 8 6 0 0.67 1.00 334 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B2(2) 3278617 8 6 8 6 2 0 4 0 2 0 0.68 1.00 335 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(2), FOS(1), MAPK14(1), THBS1(3) 2982491 7 6 7 4 1 2 0 3 1 0 0.68 1.00 336 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), B3GNT1(2), FUT1(1), FUT9(1), GCNT2(1) 2428650 7 5 7 3 3 1 1 1 1 0 0.68 1.00 337 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADM(2), ACADS(4), ACADSB(1), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2), SDS(4) 14547809 54 26 52 15 17 12 11 7 7 0 0.68 1.00 338 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 142 AKT1(1), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND2(1), CLCF1(1), CNTF(1), CREBBP(8), CSF2RB(4), CSF3R(2), EP300(6), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(3), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(1), IFNGR2(1), IFNW1(1), IL10RA(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL13RA1(1), IL15RA(1), IL2(1), IL21(1), IL21R(4), IL22(3), IL22RA1(1), IL23R(2), IL24(1), IL26(1), IL28A(1), IL28B(1), IL28RA(1), IL2RA(3), IL2RB(1), IL4(1), IL4R(6), IL5RA(1), IL6(2), IL6R(2), IL7(1), IL7R(1), IRF9(2), JAK1(3), JAK2(4), JAK3(4), LEPR(1), LIFR(1), MPL(2), OSM(1), OSMR(2), PIAS1(2), PIAS2(1), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PRL(3), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(1), SOCS4(2), SOS1(1), SOS2(4), SPRED1(1), SPRED2(1), SPRY1(1), SPRY2(2), STAM2(2), STAT1(1), STAT2(5), STAT3(2), STAT4(1), STAT5A(2), STAT5B(2), STAT6(3), TPO(4), TYK2(3) 54128747 188 81 185 64 65 25 45 33 18 2 0.68 1.00 339 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 40 AKT1(1), AKT2(1), AKT3(1), CAB39(2), DDIT4(1), EIF4B(3), FIGF(1), HIF1A(1), MAPK1(3), MAPK3(2), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PRKAA2(1), RICTOR(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TSC1(4), TSC2(2), ULK1(1), ULK2(6), ULK3(1), VEGFA(2), VEGFC(2) 17594022 56 31 56 14 16 9 8 10 13 0 0.68 1.00 340 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ECHS1(1), EHHADH(2), HADHA(1), SDS(4) 3366834 9 6 9 3 1 3 1 1 3 0 0.68 1.00 341 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), CCL5(1), CHUK(4), CXCL1(1), F11R(1), GIT1(2), IKBKB(2), JAM2(1), JAM3(1), LYN(1), MAP3K14(2), MAPK13(1), MAPK14(1), MAPK9(2), MET(5), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(11), PTPN11(6), PTPRZ1(3), SRC(2), TCIRG1(2), TJP1(2) 26992127 94 46 93 39 30 14 20 19 11 0 0.68 1.00 342 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(8), CDR1(2), DGKI(3), FAU(1), PIGK(3), RPL10(1), RPL11(1), RPL14(1), RPL15(1), RPL18A(2), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL39(1), RPL5(2), RPL8(1), RPLP0(2), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(2), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), RPSA(1), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(1) 20833415 61 34 60 25 20 10 14 5 12 0 0.69 1.00 343 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CD3E(1), CD3G(1), ELK1(1), FOS(1), MAP2K1(1), MAP3K1(5), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYT1(1), VAV1(6), ZAP70(5) 17550822 43 30 43 25 11 7 9 9 7 0 0.69 1.00 344 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI2(1), SQLE(1) 1690221 4 3 4 0 1 0 0 2 1 0 0.69 1.00 345 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), PAK1(2), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), SRC(2), SYT1(1) 11397828 29 20 29 13 6 5 4 10 4 0 0.69 1.00 346 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB3(1), CREB5(1), MAPK1(3), SNX13(1), SRC(2), TERF2IP(3) 3828054 12 7 12 1 2 2 3 5 0 0 0.69 1.00 347 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR2(2), SNAP23(1), SNAP25(2), SNAP29(1), STX11(1), STX19(1), STX2(1), STX3(1), STX4(1), STX5(2), STX7(1), STX8(1), TSNARE1(2), USE1(1), VAMP2(1), VAMP5(1) 6371131 20 12 20 7 6 3 1 5 5 0 0.70 1.00 348 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK2(3), HK3(4), IMPA1(1), PGM3(2), TGDS(1) 4578927 13 10 12 2 7 1 2 3 0 0 0.70 1.00 349 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 22 ARNT(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), ELAVL1(1), FLT1(2), FLT4(3), HIF1A(1), NOS3(5), PLCG1(3), PRKCA(3), PTK2(2), PXN(1), VHL(1) 10727019 31 20 31 11 9 4 6 9 3 0 0.70 1.00 350 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(3), CREBBP(8), EP300(6), MAP2K1(1), MAP3K7(2), MAPK3(2), SKIL(2), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5) 10432659 39 18 39 9 9 6 11 6 5 2 0.70 1.00 351 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), CALM1(1), ELK1(1), FOS(1), LYN(1), MAP2K1(1), MAP3K1(5), MAPK14(1), MAPK3(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), PLCG1(3), PPP3CB(1), PRKCA(3), SOS1(1), SYK(2), SYT1(1), VAV1(6) 15272232 40 26 40 23 9 7 8 11 5 0 0.70 1.00 352 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CAMK1(2), ELK1(1), FPR1(1), GNA15(4), GNB1(1), GNGT1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(5), MAPK1(3), MAPK14(1), MAPK3(2), NCF1(2), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKBIA(2), PAK1(2), PLCB1(4), PPP3CB(1), SYT1(1) 14267583 45 24 45 18 7 7 10 11 8 2 0.70 1.00 353 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(2), EGF(3), HGS(3), TFRC(2) 4056839 10 7 10 4 0 2 2 3 3 0 0.70 1.00 354 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(1), GRHPR(1), HAO1(1), HAO2(2), HYI(2), MDH2(1), MTHFD1L(1) 5187062 11 10 11 7 5 1 4 1 0 0 0.71 1.00 355 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), BCL2(3), DAXX(4), MAPKAPK2(1), MAPKAPK3(1) 4559228 11 9 11 4 2 1 4 2 2 0 0.71 1.00 356 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(1), SRPR(4) 3024644 6 5 6 2 2 0 2 0 2 0 0.71 1.00 357 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(4), FDPS(2), HMGCR(1), HMGCS1(1), LSS(1), MVD(1), MVK(1), PMVK(1), SC5DL(2), SQLE(1) 5222852 16 9 15 3 5 0 5 3 3 0 0.71 1.00 358 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 89 AKT1(1), AKT2(1), AKT3(1), CARD11(6), CBL(1), CBLB(1), CBLC(1), CD28(1), CD3E(1), CD3G(1), CD4(3), CD8A(1), CD8B(1), CHUK(4), FOS(1), GRAP2(1), IFNG(1), IKBKB(2), IL2(1), IL4(1), ITK(3), KRAS(1), MALT1(3), MAP3K14(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PDCD1(1), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLCG1(3), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKCQ(1), PTPN6(4), PTPRC(4), RASGRP1(1), RHOA(1), SOS1(1), SOS2(4), TEC(5), VAV1(6), VAV2(3), VAV3(2), ZAP70(5) 37674807 120 59 117 49 36 14 25 29 16 0 0.71 1.00 359 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), DOCK1(9), ELK1(1), FOS(1), GAB1(1), HGF(4), ITGA1(1), MAP2K1(1), MAP2K2(1), MAP4K1(1), MAPK1(3), MAPK3(2), MET(5), PAK1(2), PTK2(2), PTK2B(1), PTPN11(6), PXN(1), RAP1B(2), SOS1(1), SRC(2), STAT3(2) 15909130 50 28 50 10 15 8 10 13 4 0 0.72 1.00 360 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL14(1), RPL18A(2), RPL22L1(1), RPL3(1), RPL31(1), RPL32(1), RPL35A(1), RPL36A(1), RPL36AL(1), RPL39(1), RPL8(1), RPS10(2), RPS12(1), RPS2(1), RPS25(1), RPS28(1), RPS3(1), RPS3A(2), RPS4Y1(1), RPS5(2), RPSA(1) 8850132 29 18 28 11 9 4 6 4 6 0 0.72 1.00 361 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 9 ATM(7), CDC25B(1), MYT1(7) 5677758 15 9 15 1 5 3 2 2 3 0 0.72 1.00 362 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(1), AKT2(1), AKT3(1), BTK(1), CDKN2A(3), GSK3B(1), IARS(4), IGFBP1(1), INPP5D(6), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SOS1(1), SOS2(4), TEC(5), YWHAB(1), YWHAE(2) 13074307 42 23 42 16 13 11 5 5 8 0 0.72 1.00 363 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 AKR1B10(2), B4GALT2(1), G6PC(2), GAA(3), GALE(2), GALK1(3), GALT(1), GANC(1), GCK(2), GLA(1), GLB1(1), HK2(3), HK3(4), LCT(8), MGAM(7), PFKM(3), PFKP(6), PGM3(2), RDH13(1), UGP2(1) 14712833 54 29 52 14 30 5 8 6 5 0 0.72 1.00 364 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(1), CAPN1(5), CAPN2(1), CAPNS1(1), CXCR3(2), EGF(3), ITGA1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(6) 11849096 40 21 40 11 13 3 9 12 3 0 0.72 1.00 365 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(1), EGF(3), MAP2K1(1), MAPK1(3), MAPK3(2), PTPRB(4), SOS1(1), SPRY1(1), SPRY2(2), SRC(2) 8602278 20 14 19 9 5 2 3 7 3 0 0.72 1.00 366 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), NDST1(2), NDST2(2), NDST3(2), NDST4(5) 8299249 37 17 37 7 10 5 10 5 7 0 0.72 1.00 367 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(3), ELK1(1), FOS(1), IGF1R(2), IRS1(4), MAP2K1(1), MAPK3(2), PTPN11(6), SOS1(1), SRF(2) 8341991 23 16 23 7 8 4 4 5 2 0 0.73 1.00 368 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(3), AGTR1(2), ATF2(1), CALM1(1), ELK1(1), GNAQ(1), MAP2K1(1), MAP2K2(1), MAP3K1(5), MAPK1(3), MAPK3(2), MEF2A(1), MEF2C(1), MEF2D(1), PAK1(2), PRKCA(3), PTK2(2), PTK2B(1), SOS1(1), SRC(2), SYT1(1) 12443946 36 21 36 14 8 6 9 10 3 0 0.73 1.00 369 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1) 2558268 9 7 9 1 5 1 2 1 0 0 0.73 1.00 370 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B4GALT7(1), HS3ST1(1), HS3ST3A1(3), XYLT1(3), XYLT2(1) 2558268 9 7 9 1 5 1 2 1 0 0 0.73 1.00 371 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(3), IRS1(4), MAPK1(3), MAPK14(1), MAPK3(2), MKNK1(1), PRKCA(3), RPS6KB1(1) 9454304 30 15 30 6 9 2 5 10 4 0 0.73 1.00 372 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(3), ACVR1C(2), ACVR2B(1), ACVRL1(2), AMHR2(3), BMP5(3), BMP6(3), BMPR1A(2), BMPR1B(1), BMPR2(2), CDKN2B(1), COMP(1), CREBBP(8), CUL1(5), DCN(2), EP300(6), FST(2), GDF5(2), GDF6(1), GDF7(1), ID1(1), IFNG(1), INHBA(3), INHBB(2), INHBE(1), LEFTY1(5), LEFTY2(2), LTBP1(1), MAPK1(3), MAPK3(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(3), RBL2(1), RHOA(1), ROCK1(3), ROCK2(4), RPS6KB1(1), SMAD3(1), SMAD4(1), SMAD7(1), SMAD9(1), SMURF1(6), SP1(6), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), THBS1(3), THBS2(5), THBS3(1), THBS4(2), ZFYVE16(2), ZFYVE9(2) 38984308 132 61 131 36 32 26 31 23 18 2 0.73 1.00 373 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(5) 7433431 23 14 23 7 7 4 3 4 5 0 0.73 1.00 374 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(7), ASAH1(1), CERK(1), CREB3(1), CREB5(1), DAG1(2), EPHB2(6), FOS(1), GNAQ(1), ITPKB(2), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2) 10853794 37 21 37 11 12 4 9 8 4 0 0.73 1.00 375 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 AKR1B10(2), ALOX15(2), ALOX5(1), CYP2C18(1), CYP2C8(2), CYP2C9(2), CYP2E1(4), CYP3A4(3), CYP3A43(2), CYP3A7(3), PLA2G12A(3), PLA2G2F(2), PLA2G3(2), PLA2G4A(5), PLA2G5(1), PLA2G6(3), RDH13(1) 9501740 39 17 39 13 15 2 8 8 4 2 0.73 1.00 376 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 30 GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2F1(1), GTF2H4(1), GTF2IRD1(2), TAF1(4), TAF1L(14), TAF2(2), TAF4(2), TAF4B(1), TAF5(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(2), TAF9(1), TBPL2(2) 14193225 45 22 43 14 13 4 14 6 8 0 0.73 1.00 377 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(3), ABCG2(2), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1) 9335101 25 17 25 16 7 5 4 4 5 0 0.74 1.00 378 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(2), EP300(6), EPO(1), HIF1A(1), LDHA(2), NOS3(5), VHL(1) 6659170 19 11 19 9 4 0 5 6 2 2 0.74 1.00 379 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(4), FUT1(1), FUT9(1), GBGT1(2), GLA(1), HEXA(1), ST3GAL1(2) 3976029 12 8 12 9 5 1 2 1 3 0 0.74 1.00 380 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUD2(4), GLUL(1), HAL(2) 8479240 33 16 33 7 14 4 7 4 4 0 0.74 1.00 381 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(1), UGP2(1), UXS1(1) 1991565 6 3 6 0 2 2 1 1 0 0 0.74 1.00 382 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(2), EPHB2(6), F2(1), F2RL3(1), MAP2K5(1), MAPK1(3), MAPK7(3), PLD2(1), PTK2(2), RASAL1(3), SRC(2), TEC(5), VAV1(6) 10846676 37 21 37 12 12 8 9 6 2 0 0.75 1.00 383 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(3), EGF(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2) 12542902 33 21 33 12 10 7 5 7 4 0 0.75 1.00 384 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 44 ACOX1(2), APOA2(1), CD36(2), CREBBP(8), EHHADH(2), EP300(6), HSD17B4(1), MAPK1(3), MAPK3(2), ME1(4), MRPL11(1), NCOA1(3), NCOR1(6), NCOR2(5), NFKBIA(2), NR0B2(3), NR1H3(1), NRIP1(3), PPARA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), RXRA(3), SP1(6), STAT5A(2), STAT5B(2) 22308002 75 38 75 24 18 7 19 17 10 4 0.75 1.00 385 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(1), APOBEC1(2), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1) 2977124 7 5 7 2 3 1 2 0 1 0 0.75 1.00 386 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(4), CREBBP(8), EP300(6), IKBKB(2), MAP2K3(1), MAP3K14(2), MAP3K7(2), MAPK14(1), NFKB1(1), NFKBIA(2), NR3C1(1), TGFBR1(1), TGFBR2(5), TLR2(4) 11876729 40 20 39 13 6 7 10 9 6 2 0.75 1.00 387 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADRA1D(1), ADRB1(1), ADRB2(1), ATP1A4(1), ATP2A2(2), ATP2A3(4), ATP2B1(2), ATP2B2(4), ATP2B3(8), CACNA1A(4), CACNA1B(7), CACNA1C(5), CACNA1D(9), CACNA1E(9), CACNA1S(12), CACNB3(1), CALM1(1), CAMK1(2), CAMK2B(1), CAMK2D(1), CAMK2G(4), CAMK4(1), CASQ2(1), CHRM2(4), CHRM3(3), GJA1(1), GJB1(4), GJB3(2), GJB5(2), GJB6(1), GNA11(2), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNB1(3), KCNJ3(2), KCNJ5(3), MIB1(2), NME7(3), PLCB3(5), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SLC8A3(2), USP5(5), YWHAB(1) 70176176 266 106 262 102 115 35 44 44 28 0 0.75 1.00 388 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(1), CREBBP(8), EP300(6), NCOA3(4), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RXRA(3) 7782844 25 13 25 6 5 4 7 4 3 2 0.75 1.00 389 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ARHGEF2(6), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 20832705 69 38 65 27 21 9 14 19 6 0 0.75 1.00 390 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTB(1), ARHGEF2(6), ARPC5L(1), CD14(2), CDH1(3), CTTN(1), EZR(3), HCLS1(5), KRT18(3), LY96(1), NCL(3), OCLN(1), PRKCA(3), RHOA(1), ROCK1(3), ROCK2(4), TLR4(1), TLR5(4), TUBA1A(2), TUBA1C(1), TUBA3C(3), TUBA4A(1), TUBA8(4), TUBB1(1), TUBB2A(1), TUBB2C(1), TUBB3(1), TUBB4(2), TUBB4Q(4), TUBB8(1) 20832705 69 38 65 27 21 9 14 19 6 0 0.75 1.00 391 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(8), ADRB2(1), GNAS(3), PLCE1(7), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5703176 22 12 22 3 9 3 4 3 3 0 0.76 1.00 392 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(7), BMPR1B(1), CCND2(1), CDKN1B(3), EGR1(2), ESR2(1), FSHR(1), LHCGR(1), MSH5(3), NCOR1(6), NR5A1(1), NRIP1(3), PGR(4), PTGER2(2), VDR(2), ZP2(2) 14056328 40 23 40 12 11 5 12 4 6 2 0.76 1.00 393 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(8), EP300(6), HDAC3(1), IKBKB(2), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2) 9036928 29 15 28 12 4 4 9 6 4 2 0.76 1.00 394 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(7), ATR(9) 5823225 16 9 16 3 4 4 2 4 2 0 0.76 1.00 395 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 SLPI(1) 661770 1 1 1 1 1 0 0 0 0 0 0.76 1.00 396 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(9), AOC2(2), AOC3(2), CES1(2), DDHD1(1), ESCO1(2), MYST3(4), MYST4(4), PLA1A(1), PNPLA3(1), SH3GLB1(2) 10220356 31 19 31 6 11 5 5 6 4 0 0.76 1.00 397 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(3), THTPA(1) 2569519 7 4 7 1 2 1 2 1 1 0 0.77 1.00 398 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(2), CNR2(3), DNMT1(5), PTAFR(2), PTGDR(1), PTGER2(2), PTGER4(2), PTGFR(2), PTGIR(1) 4337739 20 9 20 8 6 2 1 8 3 0 0.77 1.00 399 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(1), CSF1R(3), EGF(3), MET(5), PRKCA(3), SH3GLB1(2), SH3GLB2(4), SH3KBP1(3), SRC(2) 5899232 26 11 26 7 8 4 5 5 4 0 0.77 1.00 400 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 36 AKT1(1), AKT2(1), AKT3(1), BCR(1), BLNK(2), BTK(1), CD19(2), DAG1(2), EPHB2(6), ITPKB(2), LYN(1), MAP2K1(1), MAP2K2(1), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(2), PLCG2(11), SOS1(1), SOS2(4), SYK(2), VAV1(6) 18418967 61 32 61 25 24 9 11 11 6 0 0.77 1.00 401 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), MIOX(1) 3423771 9 7 9 3 4 1 2 2 0 0 0.77 1.00 402 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(1), AKT2(1), AKT3(1), CCL3(1), CCL5(1), CD14(2), CHUK(4), FOS(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNAR2(1), IFNB1(1), IKBKB(2), IL12B(1), IL6(2), IRAK1(2), IRAK4(2), LBP(2), LY96(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K7(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), RIPK1(1), SPP1(1), STAT1(1), TBK1(2), TLR1(2), TLR2(4), TLR4(1), TLR5(4), TLR7(5), TLR8(3), TLR9(2), TRAF3(3) 32124634 92 49 91 42 22 17 14 25 14 0 0.77 1.00 403 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(1), CA1(1), CA12(2), CA3(1), CA5A(3), CA5B(1), CA6(1), CA7(2), CA8(2), CPS1(6), CTH(1), GLS(3), GLUL(1), HAL(2) 7581930 29 14 29 6 12 4 5 4 4 0 0.77 1.00 404 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), DUSP14(1), EIF4E(2), IFNG(1), IL1R1(2), NR4A3(1), WDR1(2) 4340112 11 7 11 6 1 2 0 5 3 0 0.77 1.00 405 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 18 ADCY1(8), AKT1(1), ASAH1(1), GNB1(1), GNGT1(1), ITGAV(1), ITGB3(1), MAPK1(3), MAPK3(2), PLCB1(4), PRKCA(3), PTK2(2), SPHK1(1), SRC(2) 8431125 31 17 31 6 13 5 5 4 2 2 0.77 1.00 406 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(8), ARHGEF1(2), F2(1), F2RL3(1), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MAP3K7(2), PLCB1(4), PPP1R12B(6), PRKCA(3), PTK2B(1), ROCK1(3) 8809860 36 17 36 8 13 3 8 8 2 2 0.78 1.00 407 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(1), GABARAPL1(1), IFNA13(1), IFNA14(1), IFNA17(1), IFNA21(1), IFNA5(1), IFNA7(2), IFNG(1), PIK3C3(1), PIK3R4(2), PRKAA2(1), ULK1(1), ULK2(6), ULK3(1) 8181741 23 13 23 5 4 2 7 5 5 0 0.78 1.00 408 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 77 AGL(5), AMY2B(1), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHX58(2), ENPP3(1), EP400(15), ERCC2(1), ERCC3(2), G6PC(2), GAA(3), GANC(1), GBA(1), GBE1(1), GCK(2), GPI(4), GUSB(3), GYS2(3), HK2(3), HK3(4), IFIH1(2), MGAM(7), MOV10L1(2), PGM3(2), PYGB(4), PYGL(1), PYGM(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SI(3), SKIV2L2(1), SMARCA2(5), SMARCA5(2), TREH(2), UGP2(1), UGT1A1(1), UGT1A10(1), UGT1A3(1), UGT1A5(2), UGT1A6(2), UGT1A9(1), UGT2A3(3), UGT2B10(1), UGT2B11(3), UGT2B17(1), UGT2B4(5), UGT2B7(3), UXS1(1) 47415617 149 71 147 56 54 22 30 26 17 0 0.78 1.00 409 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(1), ACTA2(2), ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ATF2(1), ATF4(1), ATP2A2(2), ATP2A3(4), CACNB3(1), CALCA(3), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CNN2(1), CORIN(5), CREB3(1), CRHR1(2), DGKZ(5), FOS(1), GABPA(1), GJA1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNB4(2), GNG2(1), GNGT1(1), GRK6(1), GSTO1(3), GUCA2B(1), GUCY1A3(5), IGFBP1(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(7), ITPR2(11), ITPR3(11), MIB1(2), MYL2(2), MYLK2(1), NFKB1(1), NOS1(9), NOS3(5), OXTR(2), PDE4B(1), PDE4D(3), PLCB3(5), PLCD1(1), PLCG1(3), PLCG2(11), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RAMP3(2), RGS1(1), RGS14(1), RGS2(1), RGS3(2), RGS4(2), RGS5(1), RGS6(1), RGS7(2), RGS9(2), RYR1(14), RYR3(17), SLC8A1(2), SP1(6), TNXB(6), USP5(5), YWHAB(1) 64122809 255 100 250 85 106 32 48 38 31 0 0.78 1.00 410 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), ATF2(1), DLD(1), DUSP10(1), DUSP4(3), DUSP8(1), GAB1(1), GCK(2), IL1R1(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK7(3), MAPK9(2), NFATC3(1), PAPPA(6), ZAK(1) 19763110 55 34 53 21 23 6 7 11 8 0 0.79 1.00 411 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2) 9862884 28 17 28 6 10 3 6 5 4 0 0.79 1.00 412 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADHA(1), HSD17B10(1), HSD17B4(1), MECR(2) 3446007 6 5 6 1 1 1 0 2 2 0 0.79 1.00 413 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(3), HIF1A(1), JAK2(4), NFKB1(1), NFKBIA(2) 4989920 15 9 13 3 6 2 3 3 1 0 0.79 1.00 414 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(1), MAP3K1(5), MAP3K14(2), MAP4K2(1), MAPK14(1), NFKB1(1), NFKBIA(2), RIPK1(1), TNFRSF1A(2), TRAF2(2) 9608353 26 17 25 16 6 3 5 7 5 0 0.79 1.00 415 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(2), CDT1(1), DIAPH2(3), MCM10(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), NACA(7), PCNA(1), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), PRIM1(1), RFC1(3), RFC2(1), RFC3(1), RFC4(2), RFC5(1), RPA4(2), UBA52(1), UBB(1), UBC(1) 20051853 55 32 52 22 15 3 15 5 17 0 0.79 1.00 416 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), PDE6D(1) 1564927 4 3 4 1 0 1 2 0 1 0 0.79 1.00 417 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(1) 530101 1 1 1 1 0 1 0 0 0 0 0.79 1.00 418 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1) 738713 1 1 1 0 1 0 0 0 0 0 0.79 1.00 419 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), DAXX(4), DDIT3(1), ELK1(1), HMGN1(1), MAP3K1(5), MAP3K5(1), MAP3K7(2), MAP3K9(2), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(1), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2) 14709253 38 23 38 8 10 6 5 10 5 2 0.80 1.00 420 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), BCL2(3), CBL(1), FOS(1), IL2RA(3), IL2RB(1), IRS1(4), JAK1(3), JAK3(4), MAPK1(3), MAPK3(2), PTPN6(4), RPS6KB1(1), SOCS1(1), SOS1(1), STAT5A(2), STAT5B(2), SYK(2) 12825362 39 23 38 12 10 4 11 10 4 0 0.80 1.00 421 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 851992 1 1 1 2 0 1 0 0 0 0 0.80 1.00 422 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 55 BTK(1), CAD(6), CASP8AP2(3), CD7(2), DAXX(4), DEDD2(2), DFFA(1), DIABLO(1), EPHB2(6), FAF1(3), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(1), MAPK1(3), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2), MET(5), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(3), PTPN13(4), RALBP1(3), RIPK1(1), ROCK1(3), TNFRSF6B(2), TPX2(1), TRAF2(2), TUFM(1) 26131557 85 41 84 27 24 15 19 16 11 0 0.80 1.00 423 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), GZMB(3), MAP3K1(5), MAP3K14(2), MDM2(1), NFKB1(1), NFKBIA(2), PARP1(3), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(5), TRAF1(1), TRAF2(2) 14497999 41 26 41 17 8 5 13 8 7 0 0.80 1.00 424 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(8), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), GNAS(3), MAPK1(3), MAPK14(1), MAPK3(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), SOS1(1) 9904478 31 19 31 12 11 4 5 10 1 0 0.80 1.00 425 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), CDKN1B(3), ILK(2), MAPK1(3), MAPK3(2), PTK2(2), SOS1(1) 5828210 14 10 14 3 2 3 3 4 2 0 0.80 1.00 426 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(3), ABAT(2), ACY3(1), ADSSL1(1), AGXT2(2), ASNS(1), CAD(6), DLAT(1), DLD(1), GAD1(4), GAD2(3), GOT1(1), NARS(1), NARS2(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1) 15040466 39 25 39 20 12 8 8 6 5 0 0.80 1.00 427 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(1), CALM1(1), GNAS(3), GNB1(1), GNGT1(1), NFKB1(1), NOS3(5), NR3C1(1), SYT1(1) 5500194 16 10 16 8 5 2 3 3 3 0 0.80 1.00 428 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(2), CAPN1(5), CAPNS1(1), CDK5R1(1), GSK3B(1), MAPT(1), PPP2CA(1) 3492849 12 6 12 2 5 1 3 3 0 0 0.80 1.00 429 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(3), ELK1(1), FOS(1), JAK1(3), MAP2K1(1), MAP3K1(5), MAPK3(2), PLCG1(3), PRKCA(3), SOS1(1), SRF(2), STAT1(1), STAT3(2), STAT5A(2) 11521437 30 19 30 10 10 7 4 5 4 0 0.81 1.00 430 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(1), GUSB(3), HEXA(1), LCT(8), NAGLU(1) 5692197 17 10 17 7 7 0 3 3 4 0 0.81 1.00 431 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(4), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2) 6718112 21 12 20 4 11 1 5 3 1 0 0.81 1.00 432 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 GNAQ(1), GNB1(1), GNGT1(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), PLCG1(3), PRKCA(3), PTK2(2), PTK2B(1), PXN(1) 8497039 20 14 20 9 4 2 5 7 2 0 0.81 1.00 433 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(2), GNAQ(1), GNB1(1), GNGT1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(6), PRKCA(3), ROCK1(3) 8359857 34 14 34 9 10 3 10 6 3 2 0.81 1.00 434 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1) 5466314 11 8 11 6 2 2 2 3 2 0 0.82 1.00 435 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 30 AKT1(1), APC(7), ASAH1(1), CCL13(1), CCL15(1), DAG1(2), GNA11(2), GNA15(4), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), MAPK14(1), PHKA2(4), PIK3CD(2), SRC(2) 18006951 68 31 68 19 22 12 14 14 6 0 0.82 1.00 436 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(4), EIF4B(3), EIF4E(2), EIF4G1(2), EIF4G2(2), EIF4G3(1), FKBP1A(1), MKNK1(1), PPP2CA(1), RPS6KB1(1), TSC1(4), TSC2(2) 9098958 25 14 25 4 5 3 5 3 9 0 0.82 1.00 437 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(4) 3187804 5 5 3 2 0 0 0 5 0 0 0.82 1.00 438 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8) 6680545 21 11 20 10 4 4 5 3 3 2 0.82 1.00 439 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(1), GNB1(1), GNGT1(1), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), PLA2G4A(5), PLCB1(4), PRKCA(3), PTGS1(2), PTK2(2), SRC(2), SYK(2), TBXAS1(3) 9811189 34 16 34 8 11 5 5 7 2 4 0.83 1.00 440 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(7), AXIN1(2), BTRC(1), CREBBP(8), CSNK2A1(3), CTBP1(3), FZD1(1), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(6), WIF1(2) 11291036 38 19 38 10 11 4 8 9 6 0 0.83 1.00 441 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(1), LDHA(2), LDHC(1), MPST(1) 2737319 6 4 6 1 1 1 2 1 1 0 0.83 1.00 442 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(9), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), AKT1(1), AKT2(1), AKT3(1), CAMKK1(3), CAMKK2(1), CD36(2), CHUK(4), CPT1A(1), CPT1C(2), CPT2(1), G6PC(2), IKBKB(2), IRS1(4), IRS4(3), JAK1(3), JAK2(4), JAK3(4), LEPR(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PCK1(4), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKCQ(1), PTPN11(6), RXRA(3), RXRB(1), RXRG(1), SLC2A1(4), SLC2A4(3), STAT3(2), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2), TYK2(3) 32767225 117 54 112 39 42 14 23 19 19 0 0.83 1.00 443 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(8), GLI3(3), GSK3B(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), SHH(2), SMO(2), SUFU(2) 6443477 25 12 24 16 6 8 4 5 2 0 0.83 1.00 444 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 3357368 9 6 9 6 3 2 2 2 0 0 0.83 1.00 445 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), CASP1(4), GAPDH(1), INSR(5), ITCH(1), MAGI1(2), MAGI2(4), RERE(5), WWP2(2) 9532109 26 17 26 13 9 6 2 6 3 0 0.83 1.00 446 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA1(1), ACADM(2), ACADS(4), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH6A1(2), ALDH9A1(1), AOX1(7), BCAT1(1), BCKDHA(2), BCKDHB(1), DBT(1), DLD(1), ECHS1(1), EHHADH(2), HADHA(1), HIBADH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B10(1), HSD17B4(1), MCCC1(1), MCCC2(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 17450125 52 27 50 14 20 7 10 7 8 0 0.83 1.00 447 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CCNE1(1), CUL1(5) 2747020 7 5 7 4 3 1 2 0 1 0 0.83 1.00 448 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), SNCAIP(2), UBE2E2(2), UBE2L3(1) 2567484 8 4 8 2 2 0 2 2 2 0 0.84 1.00 449 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(1), AKT2(1), AKT3(1), BRD4(7), CBL(1), CDKN2A(3), FLOT1(2), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), LNPEP(2), MAPK1(3), MAPK3(2), PARD3(2), PARD6A(1), PIK3CD(2), PPYR1(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SERPINB6(1), SLC2A4(3), SORBS1(2), SOS1(1), SOS2(4), YWHAB(1), YWHAE(2) 21316006 66 34 66 31 20 8 9 14 15 0 0.84 1.00 450 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), MAP2K3(1), MAPK14(1), NFATC1(3), NFATC2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 4513284 12 8 12 9 2 0 1 5 4 0 0.84 1.00 451 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 HMGCL(1), OXCT1(1) 1377947 2 2 2 0 0 0 1 1 0 0 0.84 1.00 452 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(3), OAT(1), PRODH(1) 2059879 6 3 6 1 2 0 1 1 2 0 0.84 1.00 453 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTAP(1), MTFMT(1), MTR(2), TAT(3) 8300658 28 16 28 9 11 9 2 3 3 0 0.84 1.00 454 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2D(1), CAMK2G(4), DAG1(2), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFAT5(3), PDE6A(4), PDE6B(7), PDE6C(1), PDE6D(1), SLC6A13(2) 14093721 57 25 56 15 20 9 11 9 8 0 0.85 1.00 455 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(7), ATR(9), BRCA1(4), CDC25B(1), CDKN1A(1), CDKN2D(1), EP300(6), MDM2(1), MYT1(7), PRKDC(5) 16182349 42 22 42 9 10 8 10 6 6 2 0.85 1.00 456 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(4), BAG4(1), CASP2(1), CRADD(1), DFFA(1), DFFB(3), LMNB1(1), LMNB2(3), MADD(6), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TRAF2(2) 14743687 46 25 46 12 9 10 10 11 6 0 0.85 1.00 457 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(2), GFPT1(5), GNE(3), GNPDA1(1), HEXA(1), HK2(3), HK3(4), PGM3(2), UAP1(1) 6734770 23 12 22 3 10 2 4 4 3 0 0.85 1.00 458 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP12A(5), ATP4A(5), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(5), ATP6V0D1(3), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1G1(2), ATP6V1G2(1), ATP6V1H(1), COX10(1), COX15(1), COX7B2(1), COX8A(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA3(1), NDUFA4(2), NDUFA4L2(1), NDUFA8(1), NDUFB1(1), NDUFB7(1), NDUFS2(1), NDUFS4(1), NDUFS7(1), NDUFV1(2), NDUFV2(2), PPA1(1), PPA2(1), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRQ(2) 22312708 77 37 77 25 23 16 20 10 8 0 0.85 1.00 459 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 23 AKT1(1), APC(7), AXIN1(2), CD14(2), FZD1(1), GJA1(1), GSK3B(1), IRAK1(2), LBP(2), LEF1(1), LY96(1), NFKB1(1), PPP2CA(1), TLR4(1) 10180160 24 17 24 11 7 4 5 4 4 0 0.86 1.00 460 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(1), CALM1(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), F2(1), GNA11(2), GNB1(1), GNGT1(1), JAK2(4), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK14(1), MAPK3(2), MAPT(1), MYLK(7), PLCG1(3), PRKCA(3), PTK2B(1), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), SYT1(1) 16725683 50 29 49 20 15 6 11 14 4 0 0.86 1.00 461 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT2(1), FUT8(1), ST3GAL1(2), ST3GAL3(1) 3137179 7 5 7 1 2 2 2 0 1 0 0.86 1.00 462 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(1), CAPN1(5), CAPN10(2), CAPN11(1), CAPN2(1), CAPN3(2), CAPN5(1), CAPN6(5), CAPNS1(1), CAV1(1), CAV3(1), DOCK1(9), GIT2(2), ILK(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(2), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), ITGAD(7), ITGAE(3), ITGAL(4), ITGAM(8), ITGAV(1), ITGAX(7), ITGB2(5), ITGB3(1), ITGB4(5), ITGB5(2), ITGB6(5), ITGB7(2), ITGB8(3), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK6(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PIK3R2(5), PTK2(2), PXN(1), RAP1B(2), RHO(1), ROCK1(3), ROCK2(4), SEPP1(1), SHC3(1), SORBS1(2), SOS1(1), SRC(2), TLN1(6), TNS1(5), VASP(2), VAV2(3), VAV3(2), VCL(2), ZYX(2) 52505328 182 77 181 71 69 23 38 27 25 0 0.86 1.00 463 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(1), UQCRC1(3) 2672895 4 4 4 4 0 2 0 1 1 0 0.86 1.00 464 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(2), GNAQ(1), GNAS(3), GNB1(1), GNGT1(1), LIMK1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), NOX1(2), PLCB1(4), PPP1R12B(6), PRKCA(3), PTK2(2), ROCK2(4) 9085995 38 14 38 9 9 7 11 7 2 2 0.86 1.00 465 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(3), AGTR2(1), EDNRA(1), EDNRB(1), EGF(3), FOS(1), NFKB1(1), PLCG1(3), PRKCA(3) 7219548 18 12 18 13 3 3 3 7 2 0 0.86 1.00 466 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNB1(1), CHRNG(1), MUSK(1), PTK2(2), PTK2B(1), SRC(2), TERT(8) 4859970 17 9 17 4 9 3 2 1 2 0 0.86 1.00 467 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCL2(3), BCR(1), FOS(1), JAK2(4), MAP2K1(1), MAP3K1(5), MAPK3(2), SOS1(1), STAT1(1), STAT5A(2), STAT5B(2) 9624492 24 15 23 6 8 5 5 3 3 0 0.87 1.00 468 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 74 AIFM1(4), AKT1(1), AKT2(1), AKT3(1), APAF1(1), ATM(7), BCL2(3), BIRC2(1), BIRC3(1), CAPN1(5), CAPN2(1), CASP6(1), CHUK(4), CSF2RB(4), DFFA(1), DFFB(3), IKBKB(2), IL1R1(2), IL1RAP(2), IRAK1(2), IRAK2(3), IRAK3(2), IRAK4(2), MAP3K14(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(4), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), RIPK1(1), TNFRSF10A(2), TNFRSF1A(2), TNFSF10(5), TRAF2(2) 29917791 93 45 92 29 27 14 18 24 10 0 0.87 1.00 469 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 42 CBL(1), CD28(1), DAG1(2), EPHB2(6), FBXW7(2), GRAP2(1), ITK(3), ITPKB(2), MAPK1(3), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PLCG1(3), PTPRC(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(1), SOS2(4), VAV1(6), ZAP70(5) 21037100 70 35 70 25 24 9 13 14 10 0 0.87 1.00 470 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(4), ABO(2), B3GALNT1(1), B3GALT2(1), B3GALT5(2), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(4), B4GALT2(1), B4GALT4(1), B4GALT6(1), FUT1(1), FUT5(2), FUT6(2), FUT9(1), GBGT1(2), GCNT2(1), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2), ST3GAL1(2), ST3GAL3(1), ST3GAL6(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1), UGCG(1) 18987660 70 32 70 19 22 8 21 14 5 0 0.87 1.00 471 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 79 ACVR1(3), ACVRL1(2), AKT1(1), BMPR1A(2), BMPR2(2), BUB1(4), CDKL1(3), CDS1(1), CLK2(2), CLK4(2), CSNK2A1(3), DGKB(1), DGKD(6), DGKE(2), DGKG(5), DGKH(3), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(2), INPP4A(1), INPP4B(1), INPP5A(1), INPPL1(4), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PIK3C2A(3), PIK3C2B(2), PIK3CB(2), PIM2(1), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PLCD1(1), PLCG1(3), PLCG2(11), PLK3(3), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCQ(1), PRKCZ(2), PRKD1(3), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), TGFBR1(1) 41975275 141 61 139 36 43 27 23 24 22 2 0.87 1.00 472 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 13 ERCC3(2), GTF2B(2), GTF2E1(1), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(1), NCOA3(4), NCOR2(5), POLR2A(2), RXRA(3), TBP(2) 9328188 27 14 27 7 7 2 9 2 7 0 0.87 1.00 473 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(1), EPO(1), EPOR(1), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), PLCG1(3), PTPN6(4), SOS1(1), STAT5A(2), STAT5B(2) 8596885 26 15 25 7 13 2 6 3 2 0 0.87 1.00 474 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), GCK(2), GMDS(1), GMPPA(1), HK2(3), HK3(4), MPI(1), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PMM1(1) 9558665 39 18 38 5 17 5 7 9 1 0 0.88 1.00 475 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), ATM(7), BCL2(3), CCNE1(1), CDKN1A(1), MDM2(1), PCNA(1), TIMP3(2) 6307728 17 10 17 2 3 5 4 3 2 0 0.88 1.00 476 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF1D(4), EEF2(4), EEF2K(2), EIF2AK1(2), EIF2AK2(1), EIF2AK3(1), EIF2B2(2), EIF2B3(1), EIF2B4(1), EIF2S2(1), EIF2S3(3), EIF4A1(4), EIF4E(2), EIF4G1(2), EIF4G3(1), EIF5A(1), EIF5B(3), ETF1(1), GSPT2(1), KIAA0664(4), PABPC3(2) 17275881 45 23 43 13 10 5 7 17 6 0 0.88 1.00 477 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(1), AKT2(1), AKT3(1), ASAH1(1), DAG1(2), DRD2(1), EPHB2(6), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), PIK3CB(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), SOS1(1), SOS2(4), SRC(2), STAT3(2), TERF2IP(3) 21593417 83 35 82 19 27 20 16 9 9 2 0.88 1.00 478 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25B(1), CDKN1A(1), NEK1(2) 2383928 4 3 4 1 0 1 2 1 0 0 0.88 1.00 479 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST12(1), CHST13(1), PAPSS2(1), SULT1E1(1), SULT2A1(1), SUOX(4) 3705994 11 6 11 5 4 1 2 3 1 0 0.88 1.00 480 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(4), CASP6(1), DAXX(4), DFFA(1), DFFB(3), FAF1(3), LMNB1(1), LMNB2(3), MAP3K1(5), MAP3K7(2), PAK1(2), PRKDC(5), PTPN13(4), RIPK2(1), SPTAN1(6) 15563846 45 24 45 11 5 10 10 13 7 0 0.88 1.00 481 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), PAK1(2) 3001382 7 4 7 1 1 1 1 1 3 0 0.88 1.00 482 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(7), APC2(2), AXIN1(2), AXIN2(1), BTRC(1), CACYBP(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CCND2(1), CHD8(9), CREBBP(8), CSNK2A1(3), CTBP1(3), CTBP2(4), CUL1(5), CXXC4(2), DAAM1(1), DAAM2(1), DKK1(1), DKK2(3), DVL2(2), EP300(6), FBXW11(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD4(3), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LEF1(1), LRP5(3), LRP6(4), MAP3K7(2), MAPK9(2), MMP7(2), NFAT5(3), NFATC1(3), NFATC2(1), NFATC3(1), NFATC4(2), NKD2(2), PLCB1(4), PLCB2(5), PLCB3(5), PLCB4(3), PORCN(2), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CB(1), PPP3R1(1), PPP3R2(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), PRKX(2), RHOA(1), ROCK1(3), ROCK2(4), RUVBL1(1), SENP2(2), SFRP1(2), SFRP5(1), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(1), TBL1Y(1), TCF7(3), TCF7L2(3), VANGL1(2), VANGL2(1), WIF1(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4) 62353562 217 86 213 70 64 25 53 40 31 4 0.88 1.00 483 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(6), NCOA1(3), NCOA2(1), RXRA(3) 7314514 21 10 21 5 3 4 7 2 3 2 0.89 1.00 484 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(1), FUT5(2), FUT6(2), ST3GAL3(1) 1913974 8 3 8 5 5 1 1 1 0 0 0.89 1.00 485 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), FTCD(3), GART(3), MTFMT(1), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1) 7607519 21 12 21 9 5 4 5 3 4 0 0.89 1.00 486 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF2S2(1), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1R(2), INPPL1(4), PPP2CA(1), RPS6KB1(1) 6051096 16 9 16 3 3 3 2 4 4 0 0.89 1.00 487 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(2), DOLPP1(1), DPAGT1(1), FUT8(1), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), RFT1(1), RPN1(1), ST6GAL1(4) 16795454 44 24 44 15 13 7 8 10 6 0 0.89 1.00 488 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(1), ATM(7), ATR(9), BAI1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(3), DDB2(1), GADD45B(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(2), PERP(3), PPM1D(1), RFWD2(2), RPRM(1), SERPINB5(2), SERPINE1(1), SESN1(2), SESN2(1), SESN3(4), STEAP3(2), THBS1(3), TP53I3(2), TP73(1), TSC2(2) 24296544 63 36 63 27 13 17 12 9 10 2 0.89 1.00 489 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(8), MPI(1), PYGL(1), PYGM(2), TREH(2) 5368237 14 8 14 9 8 1 2 2 1 0 0.89 1.00 490 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), BTRC(1), CDC20(2), CDC23(1), CDC27(3), CUL1(5), CUL2(4), CUL3(1), FBXW11(2), FBXW7(2), ITCH(1), SMURF1(6), TCEB2(1), UBE2E2(2), VHL(1), WWP2(2) 16014634 46 23 46 10 11 4 9 12 10 0 0.90 1.00 491 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), GH1(1), GHR(3), IGF1R(2), SOD3(1) 3770785 8 7 8 4 3 3 1 1 0 0 0.90 1.00 492 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(7), AXIN1(2), CCND2(1), DVL2(2), FZD1(1), FZD10(4), FZD2(1), FZD3(4), FZD5(2), FZD6(2), FZD7(1), FZD8(1), FZD9(6), GSK3B(1), LDLR(4), MAPK9(2), PLAU(2), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), RHOA(1), TCF7(3), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT4(3), WNT5A(1) 22842777 77 38 74 26 24 6 18 14 15 0 0.90 1.00 493 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(1), MAPK3(2), OPRK1(1), POLR2A(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 5009356 9 7 9 3 4 1 1 2 1 0 0.90 1.00 494 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(7), ASAH1(1), CAV3(1), DAG1(2), DLG4(2), EPHB2(6), GNAQ(1), ITPR1(7), ITPR2(11), ITPR3(11), KCNJ3(2), KCNJ5(3), MAPK1(3), RHO(1), RYR1(14) 18204668 74 32 74 23 30 13 13 13 5 0 0.90 1.00 495 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2) 1481400 2 2 2 4 2 0 0 0 0 0 0.91 1.00 496 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(7), AXIN1(2), BTRC(1), FZD1(1), GSK3B(1), NOTCH1(4) 7699463 16 11 14 8 3 0 4 8 1 0 0.91 1.00 497 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(3) 3347164 11 4 11 5 2 1 2 3 1 2 0.91 1.00 498 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(1), ATM(7), ATR(9), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), DHFR(1), GSK3B(1), HDAC1(1), TGFB1(1), TGFB2(1) 11044664 32 16 32 9 6 8 6 4 8 0 0.91 1.00 499 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(1), RANGAP1(1) 3294692 3 3 3 2 1 0 1 1 0 0 0.91 1.00 500 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), PER1(3) 3359241 10 5 10 4 2 1 3 1 3 0 0.91 1.00 501 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT2(1), B3GALT5(2), B3GNT5(1), FUT1(1), ST3GAL3(1) 2868757 8 4 8 6 4 1 2 1 0 0 0.91 1.00 502 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(3), ALG10B(4), ALG12(1), ALG3(2), ALG8(1), ALG9(1), B3GNT1(2), B3GNT2(3), B3GNT7(3), B4GALT2(1), B4GALT4(1), B4GALT7(1), C1GALT1C1(3), CHST1(2), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST2(3), CHST3(1), CHST6(1), CHST7(2), CHSY1(1), DDOST(2), DPAGT1(1), EXT2(5), EXTL1(1), EXTL2(2), EXTL3(4), FUT8(1), GALNT1(3), GALNT10(3), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(2), GALNT2(4), GALNT5(1), GALNT6(3), GALNT7(1), GALNT8(3), GALNT9(3), GALNTL1(2), GALNTL2(2), GALNTL4(1), GALNTL5(3), GCNT3(2), GCNT4(1), HS2ST1(2), HS3ST1(1), HS3ST3A1(3), HS3ST5(2), HS6ST2(3), HS6ST3(3), MAN1A1(3), MAN1A2(1), MAN1C1(1), MAN2A1(2), MGAT1(1), MGAT2(2), MGAT3(3), MGAT4A(2), MGAT5B(4), NDST1(2), NDST2(2), NDST3(2), NDST4(5), OGT(3), RPN1(1), ST3GAL1(2), ST3GAL3(1), ST6GAL1(4), ST6GALNAC1(2), UST(2), WBSCR17(7), XYLT1(3), XYLT2(1) 43749781 164 66 164 50 60 23 32 24 25 0 0.91 1.00 503 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(2), DIAPH1(2), GSN(2), ITGA1(1), MAP2K1(1), MAPK1(3), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), ROCK1(3), SRC(2), TLN1(6) 13637503 36 20 36 9 14 4 7 5 6 0 0.92 1.00 504 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 53 BMP5(3), BMP6(3), BTRC(1), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(2), GLI1(4), GLI2(8), GLI3(3), GSK3B(1), HHIP(4), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(2), SHH(2), SMO(2), STK36(2), SUFU(2), WNT10A(1), WNT11(1), WNT16(1), WNT2B(1), WNT3(3), WNT3A(1), WNT4(3), WNT5A(1), WNT8A(1), WNT8B(3), WNT9A(3), WNT9B(4), ZIC2(1) 19604888 76 35 75 40 23 20 15 9 9 0 0.92 1.00 505 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(1), ADH1A(4), ADH1B(3), ADH1C(3), ADH6(2), ADH7(1), AKR1B10(2), AKR1C4(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(1), RDH13(1), SOAT1(2), SOAT2(2) 12781541 37 20 37 9 17 7 8 5 0 0 0.92 1.00 506 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 3 PLCD1(1), PRKCA(3) 1488258 4 2 4 2 1 0 2 1 0 0 0.92 1.00 507 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC3(1), PSMD14(1), RPN1(1), UBE2A(1), UBE3A(5) 5186159 15 6 15 3 1 2 3 5 2 2 0.92 1.00 508 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(3), GSK3B(1) 4666550 8 5 8 2 1 1 1 2 3 0 0.92 1.00 509 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(2), DHRS7(1), PON1(4), PON3(2), RDH13(1) 3385089 10 5 10 3 4 1 3 2 0 0 0.93 1.00 510 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(2), BMPR1B(1), BMPR2(2) 2548853 6 3 6 1 0 2 1 3 0 0 0.93 1.00 511 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(7), CCNA1(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREB3(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F2(3), E2F3(2), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MYT1(7), NACA(7), PCNA(1), POLA2(3), POLE(4), POLE2(2), PRIM1(1), RBL1(3), TFDP2(1), TNXB(6) 28571523 82 38 79 28 26 13 19 9 15 0 0.93 1.00 512 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(1), B4GALT7(1), CHST11(1), CHST12(1), CHST13(1), CHST14(1), CHST3(1), CHST7(2), CHSY1(1), UST(2), XYLT1(3), XYLT2(1) 5485838 17 10 17 6 7 1 5 1 3 0 0.93 1.00 513 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(4), GLB1(1), HEXA(1), LCT(8), ST3GAL1(2), ST6GALNAC3(4), ST6GALNAC5(2), ST6GALNAC6(1) 6634452 23 11 23 9 13 1 4 3 2 0 0.93 1.00 514 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(2), ACO2(1), IDH2(2), MDH2(1), SUCLA2(1) 3264809 7 5 7 7 2 1 4 0 0 0 0.93 1.00 515 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 40 ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(1), ARHGEF11(3), BTK(1), CFL2(1), INPPL1(4), ITPR1(7), ITPR2(11), ITPR3(11), LIMK1(1), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CD(2), RACGAP1(1), RHO(1), ROCK1(3), ROCK2(4), RPS4X(1), WASF1(1) 24953553 77 38 77 23 28 10 17 9 13 0 0.93 1.00 516 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB3(1), CREB5(1), DUSP4(3), DUSP9(1), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NFKB1(1), RPS6KA2(2), RPS6KA3(5), SOS1(1), SOS2(4), TRAF3(3) 11251091 34 17 33 9 11 3 7 11 2 0 0.93 1.00 517 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25B(1), PRKCA(3), PTPRA(4), SRC(2) 3687886 10 5 10 2 4 1 2 1 2 0 0.93 1.00 518 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), RDH13(1) 1922363 5 3 5 0 4 0 1 0 0 0 0.93 1.00 519 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(1), CTH(1), GGT1(2), MARS(1), MAT1A(2), PAPSS2(1), SCLY(1), SEPHS1(1) 4922070 11 7 11 7 5 2 2 2 0 0 0.94 1.00 520 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(2), ACO2(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), PC(3), PCK1(4), SUCLA2(1), SUCLG1(2) 7900909 21 12 21 14 3 5 9 4 0 0 0.94 1.00 521 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(4), BTK(1), EEA1(2), GRASP(2), GSK3B(1), LYN(1), PFKM(3), PFKP(6), PLCG1(3), PRKCE(1), PRKCZ(2), RPS6KB1(1), VAV2(3) 9711807 33 15 33 11 9 8 4 5 7 0 0.94 1.00 522 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(1), FOS(1), IL2(1), IL2RA(3), IL2RB(1), JAK1(3), JAK3(4), MAP2K1(1), MAPK3(2), SOS1(1), STAT5A(2), STAT5B(2), SYK(2) 9381702 27 14 26 12 9 2 7 6 3 0 0.94 1.00 523 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(1), SOS1(1), SRC(2) 3530468 4 4 4 4 1 1 1 1 0 0 0.94 1.00 524 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAP2K1(1), MAPK1(3), MAPK3(2), NFKB1(1), NFKBIA(2), PLCB1(4), PRKCA(3) 6221687 17 8 17 9 3 3 3 4 2 2 0.94 1.00 525 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(1), ABL2(1), AKT1(1), AKT2(1), AKT3(1), ARAF(1), AREG(1), CAMK2B(1), CAMK2D(1), CAMK2G(4), CBL(1), CBLB(1), CBLC(1), CDKN1A(1), CDKN1B(3), EGF(3), ELK1(1), ERBB2(7), ERBB3(4), ERBB4(1), GAB1(1), GSK3B(1), KRAS(1), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(3), MAPK3(2), MAPK9(2), NRAS(1), NRG1(4), NRG2(1), NRG3(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PLCG1(3), PLCG2(11), PRKCA(3), PRKCG(1), PTK2(2), RPS6KB1(1), SHC3(1), SHC4(1), SOS1(1), SOS2(4), SRC(2), STAT5A(2), STAT5B(2), TGFA(2) 36809261 111 54 109 37 40 11 20 25 15 0 0.94 1.00 526 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(3), PGAP1(3), PIGA(1), PIGG(3), PIGH(1), PIGK(3), PIGM(1), PIGO(6), PIGQ(3), PIGS(1), PIGT(1), PIGV(2) 9471806 30 14 30 4 8 4 10 4 2 2 0.94 1.00 527 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(1), CBX3(1), CLDN5(2), CLOCK(1), CRY1(3), CRY2(2), DAZAP2(1), EIF4G2(2), GFRA1(1), GSTM3(1), GSTP1(1), HERPUD1(1), KLF9(1), NCKAP1(2), NCOA4(3), PER1(3), PER2(2), PPP1R3C(1), PURA(1), SF3A3(2), TOB1(2), TUBB3(1), UCP3(2), UGP2(1), ZFR(1) 14458089 39 20 38 11 10 2 12 8 7 0 0.94 1.00 528 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(1), GNGT1(1), HTR2C(2), PLCB1(4) 2874536 9 3 9 7 2 1 1 3 0 2 0.95 1.00 529 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(7), AXIN1(2), CREBBP(8), EP300(6), FZD1(1), GSK3B(1), HDAC1(1), LDB1(1), LEF1(1), TRRAP(8) 12947179 36 20 36 17 10 4 13 4 3 2 0.95 1.00 530 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), GNB1(1), GNGT1(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3) 3641689 11 5 11 8 4 0 3 4 0 0 0.95 1.00 531 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(1), ALDOC(3) 1572725 7 2 7 1 3 2 1 1 0 0 0.95 1.00 532 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), BIRC5(1), BNIP3L(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GZMB(3), IKBKB(2), IRF2(1), IRF4(2), IRF6(6), MAP3K1(5), MDM2(1), NFKB1(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), PLEKHG5(2), PRF1(3), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF25(1), TNFSF10(5), TP73(1), TRAF1(1), TRAF2(2), TRAF3(3) 21748899 71 32 70 32 15 11 18 17 10 0 0.95 1.00 533 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GGT1(2), SHMT2(1) 2166090 4 3 4 1 2 0 1 0 1 0 0.95 1.00 534 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(1), BCL2(3), CASP8AP2(3), CES1(2) 3968535 9 5 9 0 2 1 3 1 2 0 0.95 1.00 535 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMB8(1) 3478665 7 4 7 1 1 1 1 3 1 0 0.95 1.00 536 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(1), CBS(1), CTH(1), MUT(2) 1933650 6 2 6 4 4 0 1 0 1 0 0.95 1.00 537 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), AKT1(1), AKT2(1), AKT3(1), ASH1L(3), CASK(2), CGN(3), CLDN14(1), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(1), CLDN23(2), CLDN4(1), CLDN5(2), CLDN6(1), CLDN7(1), CLDN8(1), CRB3(1), CSDA(1), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41(2), EPB41L1(2), EPB41L2(2), EPB41L3(7), EXOC3(3), EXOC4(1), F11R(1), GNAI2(1), HCLS1(5), INADL(3), JAM2(1), JAM3(1), KRAS(1), LLGL1(1), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(2), MLLT4(5), MPDZ(5), MPP5(1), MYH1(3), MYH10(3), MYH11(7), MYH13(11), MYH14(6), MYH15(3), MYH2(13), MYH3(6), MYH4(6), MYH6(5), MYH7(3), MYH7B(9), MYH8(8), MYH9(8), MYL2(2), MYLPF(1), NRAS(1), OCLN(1), PARD3(2), PARD6A(1), PARD6B(3), PPP2CA(1), PPP2R1A(1), PPP2R1B(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(3), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), RHOA(1), RRAS2(3), SPTAN1(6), SRC(2), SYMPK(4), TJP1(2), TJP2(3), TJP3(6), ZAK(1) 75573368 251 99 247 107 110 31 46 35 29 0 0.95 1.00 538 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 64 ACAA1(1), ACADM(2), ACOX1(2), ACOX3(1), ACSL3(3), ACSL4(2), ACSL5(2), ACSL6(4), APOA2(1), APOA5(1), AQP7(2), CD36(2), CPT1A(1), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A11(3), CYP4A22(4), CYP8B1(2), EHHADH(2), FADS2(1), GK(1), GK2(2), HMGCS2(3), ILK(2), ME1(4), NR1H3(1), OLR1(3), PCK1(4), PCK2(1), PLTP(1), PPARA(1), RXRA(3), RXRB(1), RXRG(1), SCD(2), SLC27A1(3), SLC27A4(2), SLC27A6(4), SORBS1(2), UBC(1), UCP1(1) 25503182 83 39 81 30 23 11 14 18 17 0 0.95 1.00 539 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), DPYD(2), DPYS(2), ENPP3(1), PANK3(1), PANK4(2), PPCS(1), UPB1(1) 6826923 11 8 11 7 2 2 2 3 2 0 0.95 1.00 540 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(3), ELK1(1), FOS(1), MAP2K1(1), MAPK3(2), NGFR(1), PLCG1(3), SOS1(1) 6141192 13 8 13 5 5 2 2 2 2 0 0.95 1.00 541 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 56 AANAT(1), ABP1(9), ACMSD(1), AFMID(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), AOC2(2), AOC3(2), AOX1(7), CARM1(1), CYP1A1(1), CYP1B1(4), DDC(1), ECHS1(1), EHHADH(2), HAAO(1), HADHA(1), HSD17B10(1), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), MAOB(1), NFX1(3), OGDH(1), OGDHL(5), PRMT7(2), PRMT8(1), TDO2(2), TPH1(3) 23868039 70 37 68 25 33 8 12 12 5 0 0.95 1.00 542 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(7), ATR(9), BRCA1(4), BRCA2(7), FANCA(4), FANCC(2), FANCD2(4), FANCG(1), MRE11A(3), RAD1(1), RAD17(3), RAD50(2), RAD9A(1) 17216522 48 20 48 8 11 8 6 13 8 2 0.96 1.00 543 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(1) 2926677 6 4 6 3 2 0 2 1 1 0 0.96 1.00 544 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), FOS(1), HDAC2(3), HDAC5(4), NCOR2(5), RBL1(3), RBL2(1), SIN3A(2), SIN3B(6) 10170982 28 14 28 7 9 4 8 3 4 0 0.96 1.00 545 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(2), ACO1(2), ACO2(1), CLYBL(3), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), OGDHL(5), PC(3), PCK1(4), PCK2(1), SUCLA2(1), SUCLG1(2) 11623506 33 17 33 17 8 6 12 6 1 0 0.96 1.00 546 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1) 5295093 9 7 9 4 4 0 3 1 1 0 0.96 1.00 547 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), CYP2C9(2), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2) 12265492 30 18 30 10 7 5 6 6 6 0 0.96 1.00 548 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), NCKAP1(2), NTRK1(4), WASF1(1), WASF2(1) 6163897 14 8 14 7 3 2 2 4 3 0 0.96 1.00 549 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 APAF1(1), ARHGDIB(4), BAG4(1), BCL2(3), BIRC2(1), BIRC3(1), CASP2(1), CASP6(1), CHUK(4), CRADD(1), DAXX(4), DFFA(1), DFFB(3), GSN(2), LMNB1(1), LMNB2(3), MAP2K7(1), MAP3K1(5), MAP3K14(2), MAP3K5(1), MDM2(1), NFKB1(1), NFKBIA(2), NUMA1(4), PRKCD(5), PRKDC(5), PSEN2(1), PTK2(2), RIPK1(1), SPTAN1(6), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2) 26678168 76 38 75 25 15 11 22 16 12 0 0.96 1.00 550 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 FOS(1), MAPK1(3), MAPK14(1), NFE2L2(1), PRKCA(3) 3445740 9 4 9 4 2 2 1 4 0 0 0.96 1.00 551 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOA(1), ALDOB(1), ALDOC(3), FBP1(2), FBP2(4), FPGT(1), FUK(1), GMDS(1), GMPPA(1), HK2(3), HK3(4), LHPP(1), MPI(1), MTMR1(2), MTMR2(3), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKM(3), PFKP(6), PGM2(2), PMM1(1), RDH13(1) 14689970 50 23 49 6 21 6 10 10 3 0 0.97 1.00 552 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(2), ATIC(1), DHFR(1), GART(3), MTHFD1L(1), MTHFR(3), MTR(2), SHMT2(1) 7282297 17 10 17 9 4 4 5 1 3 0 0.97 1.00 553 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), AK1(1), ALLC(3), AMPD1(7), AMPD3(4), APRT(3), ATIC(1), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP5H(1), ATP5I(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), GART(3), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NPR1(6), NPR2(1), NUDT2(1), PAPSS2(1), PDE1A(1), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6B(7), PDE6C(1), PDE7B(1), PDE8A(3), PDE9A(2), PFAS(5), PKLR(4), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2) 51133096 153 70 144 55 59 14 32 24 22 2 0.97 1.00 554 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(1), CDKN2A(3), MDM2(1), POLR1A(3), POLR1B(1), POLR1C(1), TBX2(1) 5445052 11 6 11 10 1 4 3 1 2 0 0.97 1.00 555 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), CRY1(3), CRY2(2), NPAS2(1), NR1D1(3), PER1(3), PER2(2), PER3(1) 6718626 17 10 16 8 5 2 3 4 3 0 0.97 1.00 556 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(2), ACO1(2), ACO2(1), ACSS2(2), IDH2(2), MDH2(1), SUCLA2(1) 5050395 11 7 11 7 4 1 5 1 0 0 0.97 1.00 557 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 16 ABCB1(4), AKT1(1), ATM(7), CDKN1A(1), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MDM2(1), NFKBIB(1) 7719882 19 10 19 4 6 7 1 3 2 0 0.97 1.00 558 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(1), ACTA2(2), ACTN3(1), ACTN4(4), DES(3), DMD(11), FAM48A(5), MYBPC1(2), MYBPC2(1), MYBPC3(3), MYH3(6), MYH6(5), MYH7(3), MYH8(8), MYL2(2), MYOM1(3), NEB(11), TNNI1(2), TNNT1(2), TNNT2(1), TPM1(1), TPM3(1), TPM4(1), VIM(1) 23852628 80 35 80 32 32 14 17 11 6 0 0.97 1.00 559 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 33 AKT1(1), AKT2(1), AKT3(1), ARHGEF11(3), BCL2(3), DLG4(2), LPA(6), MAP3K1(5), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PHKA2(4), PIK3CB(2), PLD2(1), PTK2(2), ROCK1(3), ROCK2(4), SRF(2) 18693986 48 26 48 17 15 9 10 6 8 0 0.97 1.00 560 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), CHUK(4), DAXX(4), ELK1(1), FOS(1), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(5), MAP3K13(2), MAP3K14(2), MAP3K2(1), MAP3K3(4), MAP3K4(2), MAP3K5(1), MAP3K6(5), MAP3K7(2), MAP3K9(2), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(5), MAPK1(3), MAPK13(1), MAPK14(1), MAPK3(2), MAPK6(1), MAPK7(3), MAPK9(2), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(1), MEF2D(1), MKNK1(1), NFKB1(1), NFKBIA(2), PAK1(2), RIPK1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SP1(6), STAT1(1), TGFB1(1), TGFB2(1), TGFBR1(1), TRAF2(2) 37099530 107 51 105 38 32 12 15 27 21 0 0.97 1.00 561 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2), SHMT2(1) 1612285 3 2 3 0 2 0 1 0 0 0 0.97 1.00 562 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(3), CBS(1), CTH(1), DNMT1(5), DNMT3A(3), DNMT3B(3), MARS(1), MAT1A(2), MTR(2) 7027617 22 11 22 9 9 6 2 3 2 0 0.97 1.00 563 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2(3), BCL2A1(1), CASP1(4), CASP2(1), CASP4(1), CASP6(1), CRADD(1), DAXX(4), DFFA(1), DFFB(3), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(4), RIPK1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF1(1), TRAF2(2), TRAF3(3) 17487405 45 25 45 16 10 7 12 11 5 0 0.97 1.00 564 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS7(1), ESCO1(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2) 6448451 14 8 14 4 2 2 3 3 4 0 0.97 1.00 565 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2) 2219692 2 2 2 1 1 0 1 0 0 0 0.97 1.00 566 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(2), FN3K(1), HADHA(1), ITGB1BP3(2), MYST3(4), MYST4(4), PNPLA3(1), SH3GLB1(2), YOD1(2) 10227781 23 13 23 7 4 5 3 5 6 0 0.98 1.00 567 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), DFFA(1), DFFB(3), DIABLO(1) 5274802 12 8 12 2 3 0 5 3 1 0 0.98 1.00 568 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(1), BCL2(3), BIRC2(1), BIRC3(1), CASP6(1), CHUK(4), DFFA(1), DFFB(3), GAS2(1), MAP3K14(2), NFKB1(1), NFKBIA(2), RIPK1(1), SPTAN1(6), TNFRSF10A(2), TNFRSF25(1), TNFSF10(5), TRAF2(2) 13210098 38 18 37 13 8 1 14 11 4 0 0.98 1.00 569 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), MAP2(3), PPP2CA(1), PRKACG(1), PRKAG1(2), PRKAR2A(1), PRKAR2B(1), PRKCE(1) 7405607 14 8 14 9 2 5 2 3 2 0 0.98 1.00 570 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(2), ALPPL2(2), ASCC3(4), ATP13A2(8), DDX18(1), DDX23(3), DDX4(1), DDX41(1), DDX47(2), DDX54(1), DDX56(2), DHFR(1), DHX58(2), EP400(15), ERCC2(1), ERCC3(2), FPGS(2), IFIH1(2), MOV10L1(2), RAD54B(3), RAD54L(2), RUVBL2(4), SETX(4), SKIV2L2(1), SMARCA2(5), SMARCA5(2) 24991247 79 37 79 26 25 13 18 14 9 0 0.98 1.00 571 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB3(1), CREB5(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(1), IL1R1(2), MAP2K3(1), MAP3K10(3), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK1(3), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(1), NFKB1(1), SRF(2) 13300265 30 18 30 9 10 4 1 11 4 0 0.98 1.00 572 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), GPI(4), PKLR(4) 3384490 9 4 9 2 5 0 1 1 2 0 0.98 1.00 573 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(2), ARPC1B(1), ARPC2(1), ARPC4(1), WASF1(1) 3282209 7 3 7 1 1 1 1 1 3 0 0.98 1.00 574 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(3), APC(7), ATF2(1), AXIN1(2), BMP10(2), BMP5(3), BMPR1A(2), BMPR2(2), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(2), MEF2C(1), MYL2(2), RFC1(3), TGFB1(1), TGFB2(1), TGFBR1(1), TGFBR2(5), TGFBR3(2) 14155219 44 18 44 13 9 6 13 10 6 0 0.98 1.00 575 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(1), ACTN1(1), ACTR3(2), AKT1(1), AKT2(1), AKT3(1), ANGPTL2(2), ARHGEF7(1), CAV1(1), CDKN2A(3), CSE1L(2), DOCK1(9), EPHB2(6), GRB7(1), GRLF1(4), ILK(2), ITGA1(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA3(2), ITGA4(7), ITGA5(1), ITGA6(2), ITGA7(3), ITGA8(7), ITGA9(1), MAP2K7(1), MAPK1(3), MAPK8IP1(3), MAPK8IP3(5), MAPK9(2), MYLK(7), MYLK2(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PIK3CB(2), PKLR(4), PLCG1(3), PLCG2(11), PTK2(2), RALA(1), RHO(1), ROCK1(3), ROCK2(4), SOS1(1), SOS2(4), SRC(2), TERF2IP(3), TLN1(6), TLN2(5), VASP(2), ZYX(2) 46055594 157 64 157 56 58 24 30 27 18 0 0.98 1.00 576 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(3), FOS(1), JAK2(4), MAP2K1(1), MAPK3(2), MPL(2), PLCG1(3), PRKCA(3), SOS1(1), STAT1(1), STAT3(2), STAT5A(2), STAT5B(2), THPO(1) 10511170 28 14 27 7 12 4 6 4 2 0 0.98 1.00 577 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 125 ACACA(8), ACACB(9), AKT1(1), AKT2(1), AKT3(1), ARAF(1), CALM1(1), CBL(1), CBLB(1), CBLC(1), ELK1(1), EXOC7(2), FASN(7), FBP1(2), FBP2(4), FLOT1(2), FOXO1(1), G6PC(2), GCK(2), GSK3B(1), GYS2(3), IKBKB(2), INPP5D(6), INSR(5), IRS1(4), IRS4(3), KRAS(1), LIPE(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MAPK9(2), MKNK1(1), NRAS(1), PCK1(4), PCK2(1), PDE3A(1), PDE3B(4), PFKM(3), PFKP(6), PHKA1(3), PHKA2(4), PHKB(2), PIK3CB(2), PIK3CD(2), PIK3R2(5), PIK3R5(2), PKLR(4), PPARGC1A(2), PPP1CB(1), PPP1CC(1), PPP1R3C(1), PPP1R3D(2), PRKAA2(1), PRKACG(1), PRKAG1(2), PRKAG2(5), PRKAG3(3), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(2), PRKX(2), PTPN1(1), PTPRF(4), PYGB(4), PYGL(1), PYGM(2), RHOQ(3), RPS6KB1(1), SH2B2(3), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS4(2), SORBS1(2), SOS1(1), SOS2(4), SREBF1(2), TRIP10(4), TSC1(4), TSC2(2) 58283711 201 79 201 62 76 26 37 35 27 0 0.98 1.00 578 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(1), AKT2(1), AKT3(1), CDKN1B(3), CDKN2A(3), CREB3(1), CREB5(1), ERBB4(1), GAB1(1), GSK3B(1), IGFBP1(1), INPPL1(4), IRS1(4), IRS4(3), MET(5), NOLC1(1), PAK1(2), PAK3(2), PAK6(1), PAK7(3), PARD3(2), PARD6A(1), PIK3CD(2), PREX1(9), PTK2(2), PTPN1(1), RPS6KA2(2), RPS6KA3(5), RPS6KB1(1), SLC2A4(3), SOS1(1), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAE(2) 28824124 82 38 82 26 25 9 13 16 19 0 0.98 1.00 579 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ITPA(1), NUDT2(1), POLD1(3), POLE(4), POLG(4), POLL(2), POLQ(8), POLR1B(1), POLR2A(2), POLR2B(4), POLR2D(1), POLRMT(1), RRM1(2), TK2(1), TXNRD1(1), UPB1(1), UPP1(2) 22781723 59 30 58 26 15 9 19 7 7 2 0.98 1.00 580 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 35 CCNH(2), ERCC3(2), GTF2B(2), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(2), POLR1A(3), POLR1B(1), POLR2A(2), POLR2B(4), POLR3B(4), POLR3D(1), TAF5(2), TAF6(3), TAF7(2), TAF9(1), TBP(2) 14056316 36 17 35 6 7 5 13 5 6 0 0.98 1.00 581 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AICDA(3), CAD(6), CANT1(2), CTPS(3), DCK(1), DCTD(1), DHODH(2), DPYD(2), DPYS(2), ENTPD1(1), ENTPD3(1), ITPA(1), NME7(3), NT5C1B(3), NT5C2(2), NUDT2(1), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), TXNRD2(3), UPB1(1), UPP1(2), UPP2(1), ZNRD1(1) 32129500 89 44 89 36 28 12 26 11 12 0 0.98 1.00 582 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(1), BIRC2(1), BIRC3(1), MAP3K3(4), MAP3K7(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), RALBP1(3), RIPK1(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2) 10020470 27 12 27 13 9 3 5 7 3 0 0.98 1.00 583 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLG(4), POLH(2), POLI(2), POLK(1), POLL(2), POLM(1), POLQ(8), PRIM1(1), REV1(1), REV3L(6), RFC5(1) 16146761 47 19 46 16 11 7 15 7 5 2 0.99 1.00 584 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 15 CARM1(1), LCMT1(1), PCYT1A(1), PCYT1B(2), PRMT7(2), PRMT8(1) 5326483 8 6 8 5 3 0 3 1 1 0 0.99 1.00 585 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(3), CARS2(3), EARS2(2), EPRS(2), FARSA(1), FARSB(1), HARS(3), HARS2(1), IARS(4), IARS2(1), KARS(4), LARS(3), LARS2(1), MARS(1), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(1), VARS(3), VARS2(5), YARS(2), YARS2(2) 21945440 59 29 58 22 16 9 13 13 8 0 0.99 1.00 586 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(2), ARHGAP1(1), ARHGAP4(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), ARPC4(1), DIAPH1(2), GSN(2), LIMK1(1), MYL2(2), MYLK(7), OPHN1(1), PIP5K1B(2), PPP1R12B(6), ROCK1(3), SRC(2), TLN1(6), VCL(2) 18138147 52 23 52 15 21 7 8 6 10 0 0.99 1.00 587 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(1), GNAS(3), GNB1(1), GNGT1(1), IGF1R(2), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), MKNK1(1), NGFR(1), PPP2CA(1), PTPRR(2), SOS1(1), SRC(2), STAT3(2) 11268813 25 16 25 10 12 5 3 4 1 0 0.99 1.00 588 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), ZNRD1(1) 9520788 23 12 23 3 8 4 5 3 3 0 0.99 1.00 589 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25B(1), SHH(2), XPO1(2) 3517835 7 3 7 0 0 2 3 2 0 0 0.99 1.00 590 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), DLD(1), DLST(2), IDH2(2), IDH3G(2), MDH2(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(1), PDK3(1), PDK4(2), PDP2(1), SUCLA2(1), SUCLG1(2) 11406070 26 14 26 17 7 6 7 4 2 0 0.99 1.00 591 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 15 ALOX15(2), ALOX15B(1), ALOX5(1), GGT1(2), LTA4H(1), PLA2G6(3), PTGIS(1), PTGS1(2), TBXAS1(3) 5517115 16 7 16 7 7 3 1 2 3 0 0.99 1.00 592 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), ADSSL1(1), AK1(1), AK7(2), ALLC(3), AMPD1(7), AMPD3(4), APRT(3), ATIC(1), CANT1(2), DCK(1), ENPP3(1), ENTPD1(1), ENTPD3(1), GART(3), GMPR(1), GMPR2(1), GMPS(1), GUCY1A2(1), GUCY1A3(5), GUCY2C(2), GUCY2D(2), GUCY2F(1), IMPDH1(2), IMPDH2(1), ITPA(1), NME7(3), NPR1(6), NPR2(1), NT5C1B(3), NT5C2(2), NUDT2(1), PAPSS2(1), PDE11A(2), PDE1A(1), PDE1C(4), PDE2A(3), PDE3B(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE5A(2), PDE6D(1), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PNPT1(1), POLA1(3), POLA2(3), POLD1(3), POLD4(1), POLE(4), POLE2(2), POLE3(2), POLR1A(3), POLR1B(1), POLR1C(1), POLR2A(2), POLR2B(4), POLR2D(1), POLR3A(3), POLR3B(4), POLR3G(2), POLR3GL(1), PRIM1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(1), RRM1(2), XDH(8), ZNRD1(1) 65244203 199 81 192 69 71 28 43 27 30 0 0.99 1.00 593 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 1626459 1 1 1 0 0 0 0 1 0 0 0.99 1.00 594 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(1), NRG2(1), NRG3(1), PRKCA(3) 3608656 6 3 6 4 3 0 1 1 1 0 0.99 1.00 595 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN3(1), CAPN1(5), CAPNS1(1), ITGA1(1), ITGB3(1), PTK2(2), PXN(1), SPTAN1(6), SRC(2), TLN1(6) 11191079 28 13 28 10 13 2 4 7 2 0 0.99 1.00 596 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(1), APAF1(1), ATM(7), BCL2(3), CASP6(1), PRKCA(3), PTK2(2), PXN(1), STAT1(1), TLN1(6) 10587692 26 12 26 4 8 4 5 6 3 0 0.99 1.00 597 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 ADRBK1(2), AKT1(1), AKT2(1), AKT3(1), DAG1(2), GNAQ(1), ITPKB(2), ITPR1(7), ITPR2(11), ITPR3(11), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PHKA2(4), PIK3CB(2), PLD2(1), VN1R1(1) 16789819 54 22 54 12 17 9 9 9 10 0 0.99 1.00 598 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN3(1), BCR(1), CAPN1(5), CAPNS1(1), CAV1(1), ITGA1(1), MAP2K1(1), MAP2K2(1), MAPK1(3), MAPK3(2), PPP1R12B(6), PTK2(2), PXN(1), ROCK1(3), SOS1(1), SRC(2), TLN1(6), VCL(2), ZYX(2) 18381154 44 22 44 14 16 6 6 11 5 0 0.99 1.00 599 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN3(1), CTNNA1(1), CTNNA2(2), PECAM1(2), PTK2(2), PXN(1), SRC(2), VCL(2) 7930015 14 9 14 6 5 2 3 2 2 0 1.00 1.00 600 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 53 ASH1L(3), ASH2L(1), CARM1(1), CTCFL(3), EED(2), EHMT1(3), EHMT2(2), EZH1(2), EZH2(2), FBXO11(3), HCFC1(3), HSF4(1), JMJD4(2), KDM6A(2), MEN1(2), MLL(3), MLL2(7), MLL3(12), MLL4(7), MLL5(3), NSD1(7), OGT(3), PPP1CB(1), PPP1CC(1), PRDM2(2), PRDM7(1), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(9), SETD7(2), SETD8(1), SETDB2(3), SMYD3(1), SUV39H2(3), SUV420H1(1), SUV420H2(3), SUZ12(1), WHSC1(4), WHSC1L1(7) 45951361 121 53 120 38 25 20 31 21 24 0 1.00 1.00 601 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA5(1), PSMB1(1), PSMB4(1), PSMC2(1), PSMC3(1), PSMD11(1), PSMD12(3) 6453136 12 5 12 3 1 1 2 4 4 0 1.00 1.00 602 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1) 1723510 2 1 2 0 1 0 0 1 0 0 1.00 1.00 603 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(1), ANAPC1(4), ANAPC10(2), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ATM(7), ATR(9), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDC20(2), CDC23(1), CDC25B(1), CDC27(3), CDC7(2), CDKN1A(1), CDKN1B(3), CDKN2A(3), CDKN2B(1), CDKN2D(1), CREBBP(8), CUL1(5), E2F2(3), E2F3(2), EP300(6), ESPL1(8), GADD45B(1), GSK3B(1), HDAC1(1), HDAC2(3), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), PCNA(1), PKMYT1(1), PLK1(1), PRKDC(5), PTTG2(2), RBL1(3), RBL2(1), SMAD3(1), SMAD4(1), SMC1A(7), SMC1B(3), TGFB1(1), TGFB2(1), YWHAB(1), YWHAE(2) 52835399 143 60 142 40 28 29 39 17 28 2 1.00 1.00 604 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(1), ATM(7), BUB1(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND2(1), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(5), CDC20(2), CDC25B(1), CDC7(2), CDH1(3), CDKN1A(1), CDKN2A(3), E2F2(3), E2F3(2), EP300(6), ESPL1(8), GSK3B(1), HDAC1(1), HDAC2(3), HDAC3(1), HDAC4(1), HDAC5(4), HDAC6(3), HDAC8(1), MAD1L1(1), MCM2(3), MCM3(3), MCM4(3), MCM5(1), MCM6(1), MCM7(2), MDM2(1), MPL(2), PCNA(1), PLK1(1), PRKDC(5), PTPRA(4), PTTG2(2), RBL1(3), SMAD4(1), TBC1D8(4), TGFB1(1) 42619691 110 50 109 39 26 22 30 12 18 2 1.00 1.00 605 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(1), ATM(7), BRCA1(4), CDKN1A(1), MDM2(1), MRE11A(3), NFKB1(1), NFKBIA(2), RAD50(2), RBBP8(2), TP73(1) 11257255 25 11 25 8 5 8 3 6 3 0 1.00 1.00 606 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTB(1), ACTN1(1), ACTN3(1), ACTN4(4), ACVR1C(2), CDH1(3), CREBBP(8), CSNK2A1(3), CTNNA1(1), CTNNA2(2), CTNNA3(1), EP300(6), ERBB2(7), FARP2(2), FGFR1(3), IGF1R(2), INSR(5), IQGAP1(2), LEF1(1), LMO7(2), MAP3K7(2), MAPK1(3), MAPK3(2), MET(5), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(4), PTPRF(4), PTPRJ(3), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(5), RHOA(1), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(1), SORBS1(2), SRC(2), SSX2IP(1), TCF7(3), TCF7L2(3), TGFBR1(1), TGFBR2(5), TJP1(2), VCL(2), WASF1(1), WASF2(1) 46520680 131 59 127 38 41 22 29 21 14 4 1.00 1.00 607 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGAP3(1), ARFGEF2(2), COPA(2), GBF1(5), GPLD1(3), KDELR1(1), KDELR2(1) 6465040 16 6 16 6 5 2 3 4 0 2 1.00 1.00 608 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), EPRS(2), HARS(3), IARS(4), KARS(4), LARS(3), LARS2(1), MARS(1), NARS(1), QARS(3), TARS(2), YARS(2) 13075913 29 14 29 11 8 6 5 5 5 0 1.00 1.00 609 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), IDH2(2), OGDH(1), SUCLA2(1) 3806392 5 3 5 9 2 1 2 0 0 0 1.00 1.00 610 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), DRD1(2), DRD2(1), GRM1(1), PLCB1(4), PPP2CA(1), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 6247312 13 5 13 11 4 2 1 3 1 2 1.00 1.00 611 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASS(3), ALDH1A1(4), ALDH1A2(3), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), PLOD1(2), PLOD3(1), SDS(4), SHMT2(1), TMLHE(1) 14665322 40 17 40 9 7 12 9 6 6 0 1.00 1.00 612 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(1), CARM1(1), CBS(1), CTH(1), GGT1(2), LCMT1(1), MARS(1), MAT1A(2), PAPSS2(1), PRMT7(2), PRMT8(1), SCLY(1), SEPHS1(1) 9615700 16 10 16 12 8 2 3 3 0 0 1.00 1.00 613 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(8), ADCY2(3), ADCY3(3), ADCY4(2), ADCY5(3), ADCY6(2), ADCY7(3), ADCY8(4), ADCY9(5), AKAP10(4), AKAP11(3), AKAP12(1), AKAP3(2), AKAP4(2), AKAP5(2), AKAP6(5), AKAP7(1), AKAP8(3), AKAP9(4), ARHGEF1(2), CALM1(1), GNA11(2), GNA12(2), GNA15(4), GNAI2(1), GNAL(1), GNAO1(1), GNAQ(1), GNB1(1), GNB2(1), GNB3(1), GNGT1(1), GNGT2(1), ITPR1(7), KCNJ3(2), KRAS(1), NRAS(1), PDE1A(1), PDE1C(4), PDE4B(1), PDE4C(1), PDE4D(3), PDE7A(2), PDE7B(1), PDE8A(3), PDE8B(3), PLCB3(5), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCA(3), PRKCD(5), PRKCE(1), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), PRKCZ(2), PRKD1(3), PRKD3(6), RHOA(1), SLC9A1(3), USP5(5) 46657373 152 58 151 47 51 24 33 24 20 0 1.00 1.00 614 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), DHRS7(1), LCMT1(1), PRMT7(2), PRMT8(1) 5440284 6 4 6 7 3 0 2 1 0 0 1.00 1.00 615 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(3), AKR1B10(2), ALDH1A3(1), ALDH2(2), ALDH3A1(3), ALDH3A2(1), ALDH9A1(1), DLST(2), ECHS1(1), EHHADH(2), EHMT1(3), EHMT2(2), HADHA(1), HSD17B10(1), HSD17B4(1), NSD1(7), OGDH(1), OGDHL(5), PIPOX(2), PLOD1(2), PLOD3(1), RDH13(1), SETD1A(1), SETD7(2), SHMT2(1), SUV39H2(3), TMLHE(1) 23173273 53 23 53 14 17 8 14 8 6 0 1.00 1.00 616 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CLK2(2), CLK4(2), COL2A1(2), CPSF1(4), CPSF3(1), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDIT3(1), DHX15(1), DHX16(4), DHX38(4), DHX8(4), DHX9(2), DICER1(4), FUS(1), GIPC1(2), NCBP2(1), NONO(3), NUDT21(2), NXF1(1), PABPN1(2), PHF5A(1), POLR2A(2), PRPF3(1), PRPF4(1), PRPF4B(1), PRPF8(9), PSKH1(1), PTBP1(2), PTBP2(1), RBM17(1), RNGTT(1), SF3A1(2), SF3A3(2), SF3B1(2), SF3B2(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SRPK1(2), SRPK2(3), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF2(2), XRN2(2) 41964994 94 40 94 19 28 9 22 14 21 0 1.00 1.00