EPO signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 0.025 0.093 -9999.0 0.0 -0.37 5.0 5.0 CRKL 0.021 0.049 -9999.0 0.0 -0.13 19.0 19.0 mol:DAG 0.011 0.09 -9999.0 0.0 -0.213 59.0 59.0 HRAS 0.015 0.067 -9999.0 0.0 -0.213 27.0 27.0 MAPK8 0.012 0.054 -9999.0 0.0 -0.139 57.0 57.0 RAP1A 0.021 0.05 -9999.0 0.0 -0.167 12.0 12.0 GAB1 0.016 0.053 -9999.0 0.0 -0.149 23.0 23.0 MAPK14 0.011 0.054 -9999.0 0.0 -0.139 57.0 57.0 EPO 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.011 0.091 -9999.0 0.0 -0.217 59.0 59.0 EPOR/TRPC2/IP3 Receptors 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPO/EPOR (dimer)/SOCS3 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GAB1/SHC/GRB2/SOS1 0.019 0.064 -9999.0 0.0 -0.201 24.0 24.0 EPO/EPOR (dimer) 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IRS2 0.01 0.068 -9999.0 0.0 -0.192 40.0 40.0 STAT1 0.015 0.094 -9999.0 0.0 -0.296 25.0 25.0 STAT5B 0.016 0.09 -9999.0 0.0 -0.286 24.0 24.0 cell proliferation 0.013 0.049 -9999.0 0.0 -0.123 57.0 57.0 GAB1/SHIP/PIK3R1/SHP2/SHC 0.002 0.075 -9999.0 0.0 -0.2 45.0 45.0 TEC 0.021 0.048 -9999.0 0.0 -0.111 45.0 45.0 SOCS3 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) 0.015 0.092 -9999.0 0.0 -0.29 25.0 25.0 JAK2 0.014 0.028 -9999.0 0.0 -0.113 23.0 23.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 EPO/EPOR (dimer)/JAK2 0.044 0.061 -9999.0 0.0 -0.121 47.0 47.0 EPO/EPOR 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 LYN -0.017 0.098 -9999.0 0.0 -0.253 72.0 72.0 TEC/VAV2 0.033 0.05 -9999.0 0.0 -0.162 8.0 8.0 elevation of cytosolic calcium ion concentration 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.004 0.052 -9999.0 0.0 -0.145 48.0 48.0 EPO/EPOR (dimer)/LYN 0.022 0.068 -9999.0 0.0 -0.165 57.0 57.0 mol:IP3 0.011 0.09 -9999.0 0.0 -0.213 59.0 59.0 PI3K regualtory subunit polypeptide 1/IRS2/SHIP -0.002 0.09 -9999.0 0.0 -0.226 52.0 52.0 SH2B3 0.013 0.037 -9999.0 0.0 -0.153 20.0 20.0 NFKB1 0.01 0.057 -9999.0 0.0 -0.142 59.0 59.0 EPO/EPOR (dimer)/JAK2/SOCS3 0.031 0.052 0.203 43.0 -9999.0 0.0 43.0 PTPN6 0.018 0.048 -9999.0 0.0 -0.12 46.0 46.0 TEC/VAV2/GRB2 0.039 0.057 -9999.0 0.0 -0.222 10.0 10.0 EPOR 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.018 0.064 -9999.0 0.0 -0.203 24.0 24.0 SOS1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG2 -0.002 0.069 -9999.0 0.0 -0.191 52.0 52.0 CRKL/CBL/C3G 0.041 0.05 -9999.0 0.0 -0.171 6.0 6.0 VAV2 0.021 0.048 -9999.0 0.0 -0.13 19.0 19.0 CBL 0.021 0.048 -9999.0 0.0 -0.13 19.0 19.0 SHC/Grb2/SOS1 0.013 0.058 -9999.0 0.0 -0.201 22.0 22.0 STAT5A 0.016 0.09 -9999.0 0.0 -0.211 57.0 57.0 GRB2 0.014 0.039 -9999.0 0.0 -0.256 10.0 10.0 STAT5 (dimer) 0.036 0.089 -9999.0 0.0 -0.251 23.0 23.0 LYN/PLCgamma2 -0.009 0.095 -9999.0 0.0 -0.23 72.0 72.0 PTPN11 0.015 0.033 -9999.0 0.0 -0.266 7.0 7.0 BTK 0.02 0.05 -9999.0 0.0 -0.16 11.0 11.0 BCL2 0.027 0.092 -9999.0 0.0 -0.37 5.0 5.0