p75(NTR)-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Sortilin/TRAF6 0.025 0.026 -9999.0 0.0 -0.191 7.0 7.0 Necdin/E2F1 -0.059 0.096 -9999.0 0.0 -0.191 168.0 168.0 proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.025 0.048 -9999.0 0.0 -0.135 29.0 29.0 NGF (dimer)/p75(NTR)/BEX1 -0.023 0.073 -9999.0 0.0 -0.155 111.0 111.0 NT-4/5 (dimer)/p75(NTR) 0.003 0.028 -9999.0 0.0 -0.07 70.0 70.0 IKBKB 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.016 0.08 -9999.0 0.0 -0.163 95.0 95.0 IKBKG 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BDNF 0.004 0.042 -9999.0 0.0 -0.111 62.0 62.0 MGDIs/NGR/p75(NTR)/LINGO1 0.004 0.023 -9999.0 0.0 -0.056 70.0 70.0 FURIN 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 proBDNF (dimer)/p75(NTR)/Sortilin 0.017 0.044 -9999.0 0.0 -0.125 20.0 20.0 LINGO1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Sortilin/TRAF6/NRIF -0.016 0.059 -9999.0 0.0 -0.297 15.0 15.0 proBDNF (dimer) 0.004 0.042 -9999.0 0.0 -0.111 62.0 62.0 NTRK1 0.018 0.011 -9999.0 0.0 -0.111 4.0 4.0 RTN4R 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neuron apoptosis -0.006 0.115 -9999.0 0.0 -0.398 32.0 32.0 IRAK1 0.008 0.057 -9999.0 0.0 -0.274 20.0 20.0 SHC1 0.004 0.029 -9999.0 0.0 -0.11 6.0 6.0 ARHGDIA 0.015 0.022 -9999.0 0.0 -0.111 15.0 15.0 RhoA/GTP 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 Gamma Secretase 0.041 0.063 -9999.0 0.0 -0.174 33.0 33.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.005 0.06 -9999.0 0.0 -0.136 69.0 69.0 MAGEH1 -0.018 0.098 -9999.0 0.0 -0.254 72.0 72.0 proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.043 0.078 -9999.0 0.0 -0.139 188.0 188.0 Mammalian IAPs/DIABLO 0.023 0.037 -9999.0 0.0 -0.207 6.0 6.0 proNGF (dimer) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAGED1 0.004 0.066 -9999.0 0.0 -0.285 26.0 26.0 APP 0.013 0.042 -9999.0 0.0 -0.292 10.0 10.0 NT-4/5 (dimer) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZNF274 0.0 0.072 -9999.0 0.0 -0.257 36.0 36.0 RhoA/GDP/RHOGDI 0.018 0.031 -9999.0 0.0 -0.109 14.0 14.0 NGF 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell cycle arrest 0.023 0.047 0.109 95.0 -0.103 12.0 107.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.006 0.067 -9999.0 0.0 -0.194 46.0 46.0 NT-4/5 (dimer)/p75(NTR)/TRAF6 0.015 0.028 -9999.0 0.0 -0.157 2.0 2.0 NCSTN 0.008 0.056 -9999.0 0.0 -0.265 20.0 20.0 mol:GTP 0.003 0.05 -9999.0 0.0 -0.155 35.0 35.0 PSENEN 0.013 0.041 -9999.0 0.0 -0.274 10.0 10.0 mol:ceramide 0.013 0.027 -9999.0 0.0 -0.129 7.0 7.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.01 0.061 -9999.0 0.0 -0.193 35.0 35.0 p75(NTR)/beta APP 0.012 0.042 -9999.0 0.0 -0.191 10.0 10.0 BEX1 -0.047 0.124 -9999.0 0.0 -0.262 125.0 125.0 mol:GDP -0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 NGF (dimer) 0.017 0.034 -9999.0 0.0 -0.093 1.0 1.0 MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.014 0.027 -9999.0 0.0 -0.098 7.0 7.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 RAC1/GTP 0.012 0.027 -9999.0 0.0 -0.131 7.0 7.0 MYD88 -0.0 0.075 -9999.0 0.0 -0.292 33.0 33.0 CHUK 0.016 0.025 -9999.0 0.0 -0.147 10.0 10.0 NGF (dimer)/p75(NTR)/PKA 0.004 0.05 -9999.0 0.0 -0.156 35.0 35.0 RHOB -0.012 0.087 -9999.0 0.0 -0.229 66.0 66.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 MAGE-G1/E2F1 0.014 0.004 -9999.0 0.0 -0.07 1.0 1.0 NT3 (dimer) 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 TP53 0.004 0.054 -9999.0 0.0 -0.144 41.0 41.0 PRDM4 0.013 0.027 -9999.0 0.0 -0.13 7.0 7.0 BDNF (dimer) 0.017 0.045 -9999.0 0.0 -0.14 4.0 4.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.223 66.0 66.0 SORT1 0.016 0.031 -9999.0 0.0 -0.24 7.0 7.0 activation of caspase activity 0.022 0.046 -9999.0 0.0 -0.134 29.0 29.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.024 0.033 -9999.0 0.0 -0.132 9.0 9.0 RHOC 0.012 0.045 -9999.0 0.0 -0.277 12.0 12.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.004 0.099 -9999.0 0.0 -0.278 44.0 44.0 DIABLO 0.016 0.028 -9999.0 0.0 -0.292 4.0 4.0 SMPD2 0.013 0.027 -9999.0 0.0 -0.13 7.0 7.0 APH1B 0.018 0.02 -9999.0 0.0 -0.232 3.0 3.0 APH1A 0.015 0.036 -9999.0 0.0 -0.27 8.0 8.0 proNGF (dimer)/p75(NTR)/Sortilin 0.014 0.032 -9999.0 0.0 -0.152 7.0 7.0 PSEN1 0.011 0.047 -9999.0 0.0 -0.256 15.0 15.0 APAF-1/Pro-Caspase 9 0.025 0.02 -9999.0 0.0 -0.191 2.0 2.0 NT3 (dimer)/p75(NTR) 0.016 0.032 -9999.0 0.0 -0.135 1.0 1.0 MAPK8 0.016 0.06 -9999.0 0.0 -0.221 19.0 19.0 MAPK9 0.015 0.065 -9999.0 0.0 -0.232 23.0 23.0 APAF1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NTF3 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 NTF4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDN -0.105 0.137 -9999.0 0.0 -0.224 269.0 269.0 RAC1/GDP 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 RhoA-B-C/GDP 0.005 0.075 -9999.0 0.0 -0.17 65.0 65.0 p75 CTF/Sortilin/TRAF6/NRIF 0.035 0.048 -9999.0 0.0 -0.136 35.0 35.0 RhoA-B-C/GTP 0.003 0.049 -9999.0 0.0 -0.155 35.0 35.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.024 0.057 -9999.0 0.0 -0.132 35.0 35.0 proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.027 0.044 -9999.0 0.0 -0.16 7.0 7.0 PRKACB -0.002 0.076 -9999.0 0.0 -0.264 39.0 39.0 proBDNF (dimer)/p75 ECD 0.017 0.032 -9999.0 0.0 -0.135 3.0 3.0 ChemicalAbstracts:86-01-1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.0 0.046 -9999.0 0.0 -9999.0 0.0 0.0 BIRC2 0.016 0.03 -9999.0 0.0 -0.292 5.0 5.0 neuron projection morphogenesis -0.033 0.075 0.109 48.0 -0.167 67.0 115.0 BAD 0.01 0.08 -9999.0 0.0 -0.264 28.0 28.0 RIPK2 0.017 0.021 -9999.0 0.0 -0.183 5.0 5.0 NGFR 0.002 0.044 -9999.0 0.0 -0.111 70.0 70.0 CYCS 0.01 0.042 -9999.0 0.0 -0.132 31.0 31.0 ADAM17 0.017 0.015 -9999.0 0.0 -0.111 7.0 7.0 NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.025 0.03 -9999.0 0.0 -0.135 4.0 4.0 BCL2L11 0.011 0.078 -9999.0 0.0 -0.262 27.0 27.0 BDNF (dimer)/p75(NTR) 0.006 0.043 -9999.0 0.0 -0.135 13.0 13.0 PI3K -0.008 0.074 -9999.0 0.0 -0.15 94.0 94.0 proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.014 0.029 -9999.0 0.0 -0.135 7.0 7.0 NDNL2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.011 0.045 -9999.0 0.0 -0.206 19.0 19.0 PRKCI 0.015 0.028 -9999.0 0.0 -0.135 15.0 15.0 NGF (dimer)/p75(NTR) 0.003 0.028 -9999.0 0.0 -0.07 70.0 70.0 ChemicalAbstracts:146-91-8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.017 0.048 -9999.0 0.0 -0.144 30.0 30.0 TRAF6 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 PRKCZ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 oligodendrocyte cell fate commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 0.012 0.035 -9999.0 0.0 -0.189 6.0 6.0 SQSTM1 0.004 0.062 -9999.0 0.0 -0.224 32.0 32.0 NGFRAP1 0.011 0.048 -9999.0 0.0 -0.292 13.0 13.0 CASP3 0.01 0.078 -9999.0 0.0 -0.251 29.0 29.0 E2F1 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 CASP9 0.014 0.029 -9999.0 0.0 -0.131 18.0 18.0 IKK complex 0.031 0.054 -9999.0 0.0 -0.244 12.0 12.0 NGF (dimer)/TRKA 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MMP7 -0.014 0.057 -9999.0 0.0 -0.111 135.0 135.0 proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.023 0.049 -9999.0 0.0 -0.128 35.0 35.0 MMP3 0.015 0.022 -9999.0 0.0 -0.111 15.0 15.0 APAF-1/Caspase 9 -0.009 0.036 -9999.0 0.0 -0.164 20.0 20.0