Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 -0.022 0.079 -9999.0 0.0 -0.191 87.0 87.0 MAP4K4 0.015 0.061 -9999.0 0.0 -0.249 12.0 12.0 BAG4 0.018 0.011 -9999.0 0.0 -0.111 4.0 4.0 PKC zeta/ceramide 0.011 0.03 0.075 87.0 -9999.0 0.0 87.0 NFKBIA 0.002 0.067 -9999.0 0.0 -0.239 34.0 34.0 BIRC3 -0.0 0.046 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.011 0.042 -9999.0 0.0 -0.38 5.0 5.0 RIPK1 0.016 0.019 -9999.0 0.0 -0.111 11.0 11.0 AKT1 -0.004 0.058 -9999.0 0.0 -0.238 28.0 28.0 BAD 0.014 0.036 0.085 85.0 -0.139 5.0 90.0 SMPD1 0.008 0.043 -9999.0 0.0 -0.116 50.0 50.0 RB1 0.015 0.034 0.085 85.0 -0.139 2.0 87.0 FADD/Caspase 8 0.028 0.05 -9999.0 0.0 -0.182 4.0 4.0 MAP2K4 0.017 0.035 0.086 81.0 -0.12 4.0 85.0 NSMAF 0.006 0.063 -9999.0 0.0 -0.277 24.0 24.0 response to UV -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 0.016 0.037 0.086 78.0 -0.129 11.0 89.0 EGF 0.014 0.025 -9999.0 0.0 -0.111 21.0 21.0 mol:ceramide 0.013 0.035 0.087 87.0 -9999.0 0.0 87.0 MADD 0.018 0.015 -9999.0 0.0 -0.202 2.0 2.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.021 0.078 -9999.0 0.0 -0.191 84.0 84.0 ASAH1 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 negative regulation of cell cycle 0.015 0.034 0.085 85.0 -0.138 2.0 87.0 cell proliferation 0.034 0.038 -9999.0 0.0 -0.096 14.0 14.0 BID -0.006 0.148 -9999.0 0.0 -0.611 27.0 27.0 MAP3K1 0.015 0.034 0.085 86.0 -0.067 2.0 88.0 EIF2A 0.014 0.037 0.082 80.0 -0.12 14.0 94.0 TRADD 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.017 0.015 -9999.0 0.0 -0.111 7.0 7.0 MAPK3 0.022 0.037 0.09 77.0 -0.114 14.0 91.0 response to heat -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.019 0.048 0.09 69.0 -0.17 18.0 87.0 Cathepsin D/ceramide 0.019 0.034 0.088 78.0 -0.051 29.0 107.0 FADD 0.021 0.049 -9999.0 0.0 -0.158 9.0 9.0 KSR1 0.016 0.032 0.085 87.0 -9999.0 0.0 87.0 MAPK8 0.02 0.032 0.087 81.0 -0.08 3.0 84.0 PRKRA 0.012 0.041 0.085 82.0 -0.137 14.0 96.0 PDGFA -0.045 0.116 -9999.0 0.0 -0.223 141.0 141.0 TRAF2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.025 -9999.0 0.0 -0.111 21.0 21.0 mol:GD3 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process 0.013 0.035 0.087 87.0 -9999.0 0.0 87.0 CTSD 0.005 0.053 -9999.0 0.0 -0.157 43.0 43.0 regulation of nitric oxide biosynthetic process 0.024 0.03 -9999.0 0.0 -0.191 9.0 9.0 response to radiation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta 0.037 0.04 -9999.0 0.0 -0.101 14.0 14.0 PRKCD 0.012 0.029 -9999.0 0.0 -0.111 27.0 27.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.021 0.078 -9999.0 0.0 -0.191 84.0 84.0 RelA/NF kappa B1 0.024 0.03 -9999.0 0.0 -0.191 9.0 9.0 mol:glutathione 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.019 0.051 -9999.0 0.0 -0.165 8.0 8.0 TNFR1A/BAG4/TNF-alpha 0.02 0.057 -9999.0 0.0 -0.155 50.0 50.0 mol:Sphingosine-1-phosphate -0.022 0.079 -9999.0 0.0 -0.191 87.0 87.0 MAP2K1 0.017 0.039 0.087 77.0 -0.126 16.0 93.0 mol:C11AG 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.018 0.02 -9999.0 0.0 -0.232 3.0 3.0 CYCS 0.011 0.033 -9999.0 0.0 -0.159 9.0 9.0 TNFRSF1A -0.01 0.091 -9999.0 0.0 -0.292 50.0 50.0 NFKB1 0.014 0.037 -9999.0 0.0 -0.226 11.0 11.0 TNFR1A/BAG4 0.007 0.065 -9999.0 0.0 -0.194 50.0 50.0 EIF2AK2 0.015 0.039 0.086 80.0 -0.126 14.0 94.0 TNF-alpha/TNFR1A/FAN 0.013 0.071 -9999.0 0.0 -0.17 65.0 65.0 response to hydrogen peroxide -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.027 0.045 -9999.0 0.0 -0.33 2.0 2.0 MAP2K2 0.019 0.037 0.087 78.0 -0.124 12.0 90.0 SMPD3 0.011 0.047 -9999.0 0.0 -0.151 15.0 15.0 TNF 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 PKC zeta/PAR4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PHOSPHOCHOLINE 0.01 0.033 0.088 52.0 -9999.0 0.0 52.0 NF kappa B1/RelA/I kappa B alpha 0.033 0.044 -9999.0 0.0 -0.135 30.0 30.0 AIFM1 0.01 0.034 -9999.0 0.0 -0.181 7.0 7.0 BCL2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0