Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer -0.045 0.096 -9999.0 0.0 -0.196 132.0 132.0 alphaV beta3 Integrin 0.025 0.049 -9999.0 0.0 -0.157 31.0 31.0 PTK2 -0.031 0.139 -9999.0 0.0 -0.241 136.0 136.0 IGF1R -0.001 0.07 -9999.0 0.0 -0.209 46.0 46.0 PI4KB 0.018 0.017 -9999.0 0.0 -0.156 4.0 4.0 MFGE8 0.016 0.025 -9999.0 0.0 -0.292 2.0 2.0 SRC 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1B 0.003 0.092 -9999.0 0.0 -0.361 29.0 29.0 VEGFA -0.068 0.128 -9999.0 0.0 -0.225 188.0 188.0 ILK 0.013 0.07 -9999.0 0.0 -0.368 15.0 15.0 ROCK1 0.016 0.031 -9999.0 0.0 -0.262 6.0 6.0 AKT1 0.012 0.076 -9999.0 0.0 -0.378 17.0 17.0 PTK2B -0.025 0.075 -9999.0 0.0 -0.137 136.0 136.0 alphaV/beta3 Integrin/JAM-A 0.03 0.054 -9999.0 0.0 -0.147 35.0 35.0 CBL 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 0.028 0.042 -9999.0 0.0 -0.152 25.0 25.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.021 0.065 -9999.0 0.0 -0.143 59.0 59.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.021 0.105 -9999.0 0.0 -0.321 29.0 29.0 alphaV/beta3 Integrin/Syndecan-1 0.017 0.052 -9999.0 0.0 -0.163 28.0 28.0 PI4KA -0.007 0.083 -9999.0 0.0 -0.259 49.0 49.0 IGF-1R heterotetramer/IGF1/IRS1 0.009 0.076 -9999.0 0.0 -0.235 29.0 29.0 PI4 Kinase 0.009 0.061 -9999.0 0.0 -0.195 40.0 40.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.223 66.0 66.0 alphaV/beta3 Integrin/Osteopontin 0.011 0.076 -9999.0 0.0 -0.184 63.0 63.0 RPS6KB1 0.005 0.071 -9999.0 0.0 -0.227 28.0 28.0 TLN1 -0.003 0.065 -9999.0 0.0 -0.162 64.0 64.0 MAPK3 0.008 0.101 -9999.0 0.0 -0.386 28.0 28.0 GPR124 0.014 0.024 -9999.0 0.0 -0.111 19.0 19.0 MAPK1 0.004 0.106 -9999.0 0.0 -0.405 28.0 28.0 PXN 0.018 0.011 -9999.0 0.0 -0.111 4.0 4.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 alphaV/beta3 Integrin/Tumstatin 0.028 0.042 -9999.0 0.0 -0.152 25.0 25.0 cell adhesion 0.027 0.053 -9999.0 0.0 -0.167 33.0 33.0 ANGPTL3 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/Src -0.025 0.083 -9999.0 0.0 -0.156 132.0 132.0 IGF-1R heterotetramer -0.001 0.07 -9999.0 0.0 -0.209 46.0 46.0 Rac1/GDP 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 TGFBR2 0.013 0.035 -9999.0 0.0 -0.145 21.0 21.0 ITGB3 0.019 0.008 -9999.0 0.0 -0.111 2.0 2.0 IGF1 0.014 0.025 -9999.0 0.0 -0.111 21.0 21.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 regulation of cell-matrix adhesion 0.025 0.043 -9999.0 0.0 -0.151 25.0 25.0 apoptosis 0.003 0.067 -9999.0 0.0 -0.252 32.0 32.0 CD47 0.012 0.043 -9999.0 0.0 -0.213 16.0 16.0 alphaV/beta3 Integrin/CD47 0.024 0.051 -9999.0 0.0 -0.165 32.0 32.0 VCL 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 alphaV/beta3 Integrin/Del1 0.028 0.042 -9999.0 0.0 -0.152 25.0 25.0 CSF1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3C2A 0.013 0.023 -9999.0 0.0 -0.128 4.0 4.0 PI4 Kinase/Pyk2 -0.035 0.069 -9999.0 0.0 -0.205 49.0 49.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.021 0.089 -9999.0 0.0 -0.147 148.0 148.0 FAK1/Vinculin -0.016 0.119 -9999.0 0.0 -0.256 61.0 61.0 alphaV beta3/Integrin/ppsTEM5 0.025 0.044 -9999.0 0.0 -0.152 25.0 25.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 VTN 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 BCAR1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FGF2 0.013 0.036 -9999.0 0.0 -0.292 5.0 5.0 F11R 0.007 0.044 -9999.0 0.0 -0.21 14.0 14.0 alphaV/beta3 Integrin/Lactadherin 0.027 0.045 -9999.0 0.0 -0.158 27.0 27.0 alphaV/beta3 Integrin/TGFBR2 0.024 0.047 -9999.0 0.0 -0.149 32.0 32.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.028 0.037 -9999.0 0.0 -0.135 25.0 25.0 HSP90AA1 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 alphaV/beta3 Integrin/Talin 0.015 0.053 -9999.0 0.0 -0.141 44.0 44.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 0.001 0.071 -9999.0 0.0 -0.26 34.0 34.0 alphaV/beta3 Integrin/Pyk2 -0.018 0.081 -9999.0 0.0 -0.137 136.0 136.0 SDC1 0.0 0.046 -9999.0 0.0 -0.111 77.0 77.0 VAV3 0.009 0.044 -9999.0 0.0 -0.149 28.0 28.0 PTPN11 0.015 0.033 -9999.0 0.0 -0.266 7.0 7.0 IRS1 -0.002 0.07 -9999.0 0.0 -0.193 53.0 53.0 FAK1/Paxillin -0.016 0.118 -9999.0 0.0 -0.254 60.0 60.0 cell migration -0.011 0.11 -9999.0 0.0 -0.231 61.0 61.0 ITGAV 0.003 0.067 -9999.0 0.0 -0.253 32.0 32.0 PI3K 0.011 0.091 -9999.0 0.0 -0.222 46.0 46.0 SPP1 -0.011 0.092 -9999.0 0.0 -0.292 51.0 51.0 KDR 0.001 0.057 -9999.0 0.0 -0.145 59.0 59.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.003 0.067 -9999.0 0.0 -0.252 32.0 32.0 COL4A3 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 angiogenesis 0.008 0.109 -9999.0 0.0 -0.423 28.0 28.0 Rac1/GTP 0.008 0.058 -9999.0 0.0 -0.128 65.0 65.0 EDIL3 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation 0.024 0.047 -9999.0 0.0 -0.149 32.0 32.0