Signaling events mediated by VEGFR1 and VEGFR2 Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations alphaV beta3 Integrin 0.016 0.048 -9999.0 0.0 -0.191 25.0 25.0 AKT1 -0.081 0.207 -9999.0 0.0 -0.446 93.0 93.0 PTK2B -0.033 0.114 -9999.0 0.0 -0.29 55.0 55.0 VEGFR2 homodimer/Frs2 0.006 0.089 -9999.0 0.0 -0.344 22.0 22.0 CAV1 -0.071 0.129 -9999.0 0.0 -0.224 197.0 197.0 CALM1 0.007 0.056 -9999.0 0.0 -0.214 28.0 28.0 VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.034 0.12 -9999.0 0.0 -0.317 46.0 46.0 endothelial cell proliferation -0.049 0.167 -9999.0 0.0 -0.366 79.0 79.0 mol:Ca2+ -0.041 0.13 -9999.0 0.0 -0.336 56.0 56.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.035 0.133 -9999.0 0.0 -0.312 63.0 63.0 RP11-342D11.1 -0.048 0.126 -9999.0 0.0 -0.337 55.0 55.0 CDH5 -0.016 0.088 -9999.0 0.0 -0.199 84.0 84.0 VEGFA homodimer -0.017 0.079 -9999.0 0.0 -0.15 122.0 122.0 SHC1 0.004 0.052 -9999.0 0.0 -0.145 48.0 48.0 SHC2 0.001 0.071 -9999.0 0.0 -0.256 35.0 35.0 HRAS/GDP -0.06 0.114 -9999.0 0.0 -0.317 63.0 63.0 SH2D2A 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.027 0.145 -9999.0 0.0 -0.385 47.0 47.0 VEGFR2 homodimer/VEGFA homodimer/TsAd -0.033 0.12 -9999.0 0.0 -0.318 46.0 46.0 VEGFR1 homodimer 0.019 0.008 -9999.0 0.0 -0.111 2.0 2.0 SHC/GRB2/SOS1 -0.033 0.137 -9999.0 0.0 -0.327 61.0 61.0 GRB10 -0.057 0.157 -9999.0 0.0 -0.407 67.0 67.0 PTPN11 0.015 0.033 -9999.0 0.0 -0.266 7.0 7.0 GRB2 0.014 0.039 -9999.0 0.0 -0.256 10.0 10.0 PAK1 0.017 0.017 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.04 0.144 -9999.0 0.0 -0.325 70.0 70.0 HRAS 0.009 0.055 -9999.0 0.0 -0.282 18.0 18.0 VEGF/Rho/ROCK1/Integrin Complex -0.032 0.136 -9999.0 0.0 -0.349 50.0 50.0 HIF1A 0.011 0.047 -9999.0 0.0 -0.266 14.0 14.0 FRS2 0.018 0.013 -9999.0 0.0 -0.111 5.0 5.0 oxygen and reactive oxygen species metabolic process -0.035 0.131 -9999.0 0.0 -0.308 63.0 63.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FLT4 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 Nck/Pak 0.023 0.029 -9999.0 0.0 -0.177 8.0 8.0 VEGFR2 homodimer/VEGFA homodimer/Fyn -0.051 0.144 -9999.0 0.0 -0.35 64.0 64.0 mol:GDP -0.038 0.129 -9999.0 0.0 -0.319 61.0 61.0 mol:NADP -0.027 0.125 -9999.0 0.0 -0.347 43.0 43.0 eNOS/Hsp90 -0.018 0.123 -9999.0 0.0 -0.354 36.0 36.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 mol:IP3 -0.042 0.131 -9999.0 0.0 -0.339 56.0 56.0 HIF1A/ARNT 0.023 0.033 -9999.0 0.0 -0.191 12.0 12.0 SHB 0.016 0.02 -9999.0 0.0 -0.111 13.0 13.0 VEGFA -0.072 0.131 -9999.0 0.0 -0.232 188.0 188.0 VEGFC 0.01 0.033 -9999.0 0.0 -0.111 37.0 37.0 FAK1/Vinculin -0.045 0.168 -9999.0 0.0 -0.4 63.0 63.0 mol:Ca ++ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.027 0.128 -9999.0 0.0 -0.306 56.0 56.0 PTPN6 0.005 0.057 -9999.0 0.0 -0.199 33.0 33.0 EPAS1 0.003 0.076 -9999.0 0.0 -0.28 28.0 28.0 mol:L-citrulline -0.027 0.125 -9999.0 0.0 -0.347 43.0 43.0 ITGAV 0.003 0.067 -9999.0 0.0 -0.253 32.0 32.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.223 66.0 66.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 -0.023 0.121 -9999.0 0.0 -0.306 48.0 48.0 VEGFR2 homodimer/VEGFA homodimer -0.04 0.146 -9999.0 0.0 -0.366 55.0 55.0 VEGFR2/3 heterodimer 0.006 0.089 -9999.0 0.0 -0.372 19.0 19.0 VEGFB 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 MAPK11 -0.046 0.135 -9999.0 0.0 -0.359 53.0 53.0 VEGFR2 homodimer -0.003 0.101 -9999.0 0.0 -0.378 25.0 25.0 FLT1 0.019 0.008 -9999.0 0.0 -0.111 2.0 2.0 NEDD4 0.009 0.033 -9999.0 0.0 -0.117 25.0 25.0 MAPK3 -0.037 0.116 -9999.0 0.0 -0.304 56.0 56.0 MAPK1 -0.039 0.118 -9999.0 0.0 -0.308 57.0 57.0 VEGFA145/NRP2 -0.037 0.093 -9999.0 0.0 -0.192 125.0 125.0 VEGFR1/2 heterodimer 0.006 0.089 -9999.0 0.0 -0.352 21.0 21.0 KDR -0.003 0.101 -9999.0 0.0 -0.379 25.0 25.0 VEGFA165/NRP1/VEGFR2 homodimer -0.031 0.133 -9999.0 0.0 -0.336 53.0 53.0 SRC 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 platelet activating factor biosynthetic process -0.038 0.12 -9999.0 0.0 -0.315 56.0 56.0 PI3K -0.06 0.182 -9999.0 0.0 -0.398 84.0 84.0 VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.036 0.123 -9999.0 0.0 -0.321 49.0 49.0 FES -0.042 0.132 -9999.0 0.0 -0.349 53.0 53.0 GAB1 -0.063 0.168 -9999.0 0.0 -0.392 76.0 76.0 VEGFR2 homodimer/VEGFA homodimer/Src -0.033 0.12 -9999.0 0.0 -0.317 46.0 46.0 CTNNB1 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 eNOS/Caveolin-1 -0.043 0.139 -9999.0 0.0 -0.337 61.0 61.0 VEGFR2 homodimer/VEGFA homodimer/Yes -0.04 0.127 -9999.0 0.0 -0.312 58.0 58.0 PI3K/GAB1 -0.076 0.202 -9999.0 0.0 -0.431 95.0 95.0 VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.015 0.118 -9999.0 0.0 -0.291 47.0 47.0 PRKACA 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VEGFR2/3 heterodimer/VEGFC homodimer 0.014 0.088 -9999.0 0.0 -0.321 23.0 23.0 HSP90AA1 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 CDC42 -0.042 0.132 -9999.0 0.0 -0.348 53.0 53.0 actin cytoskeleton reorganization -0.033 0.119 -9999.0 0.0 -0.316 46.0 46.0 PTK2 -0.056 0.176 -9999.0 0.0 -0.433 61.0 61.0 EDG1 -0.048 0.147 -9999.0 0.0 -0.357 70.0 70.0 mol:DAG -0.042 0.131 -9999.0 0.0 -0.339 56.0 56.0 CaM/Ca2+ -0.036 0.133 -9999.0 0.0 -0.336 57.0 57.0 MAP2K3 -0.037 0.124 -9999.0 0.0 -0.327 53.0 53.0 VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.047 0.167 -9999.0 0.0 -0.414 67.0 67.0 PLCG1 -0.042 0.132 -9999.0 0.0 -0.343 56.0 56.0 VEGFR2 homodimer/VEGFA homodimer/Src/Shb -0.021 0.118 -9999.0 0.0 -0.298 46.0 46.0 IQGAP1 -0.009 0.087 -9999.0 0.0 -0.274 50.0 50.0 YES1 0.005 0.061 -9999.0 0.0 -0.24 28.0 28.0 VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.035 0.123 -9999.0 0.0 -0.328 47.0 47.0 VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.04 0.123 -9999.0 0.0 -0.308 54.0 54.0 cell migration -0.047 0.175 -9999.0 0.0 -0.407 68.0 68.0 mol:PI-3-4-5-P3 -0.056 0.17 -9999.0 0.0 -0.371 84.0 84.0 FYN -0.019 0.101 -9999.0 0.0 -0.279 68.0 68.0 VEGFB/NRP1 -0.038 0.123 -9999.0 0.0 -0.324 53.0 53.0 mol:NO -0.027 0.125 -9999.0 0.0 -0.347 43.0 43.0 PXN 0.018 0.011 -9999.0 0.0 -0.111 4.0 4.0 HRAS/GTP -0.062 0.112 -9999.0 0.0 -0.315 63.0 63.0 VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.05 0.164 -9999.0 0.0 -0.413 67.0 67.0 VHL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITGB3 0.019 0.008 -9999.0 0.0 -0.111 2.0 2.0 NOS3 -0.032 0.138 -9999.0 0.0 -0.388 43.0 43.0 VEGFR2 homodimer/VEGFA homodimer/Sck -0.041 0.136 -9999.0 0.0 -0.35 53.0 53.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 PRKCA -0.036 0.122 -9999.0 0.0 -0.315 56.0 56.0 PRKCB -0.042 0.121 -9999.0 0.0 -0.319 56.0 56.0 VCL 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 VEGFA165/NRP1 -0.044 0.131 -9999.0 0.0 -0.34 55.0 55.0 VEGFR1/2 heterodimer/VEGFA homodimer -0.033 0.12 -9999.0 0.0 -0.315 47.0 47.0 VEGFA165/NRP2 -0.037 0.093 -9999.0 0.0 -0.192 125.0 125.0 MAPKKK cascade -0.041 0.154 -9999.0 0.0 -0.389 64.0 64.0 NRP2 0.017 0.016 -9999.0 0.0 -0.111 8.0 8.0 VEGFC homodimer 0.01 0.033 -9999.0 0.0 -0.111 37.0 37.0 NCK1 0.014 0.036 -9999.0 0.0 -0.189 14.0 14.0 ROCK1 0.016 0.031 -9999.0 0.0 -0.262 6.0 6.0 FAK1/Paxillin -0.045 0.167 -9999.0 0.0 -0.402 61.0 61.0 MAP3K13 -0.041 0.131 -9999.0 0.0 -0.346 53.0 53.0 PDPK1 -0.052 0.153 -9999.0 0.0 -0.334 83.0 83.0