HIF-1-alpha transcription factor network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PKM2 -0.322 0.524 -9999.0 0.0 -0.874 204.0 204.0 HDAC7 -0.003 0.006 -9999.0 0.0 -9999.0 0.0 0.0 HIF1A/ARNT/Cbp/p300/Src-1 -0.223 0.454 -9999.0 0.0 -0.764 174.0 174.0 SMAD4 -0.003 0.079 -9999.0 0.0 -0.258 44.0 44.0 ID2 -0.323 0.527 -9999.0 0.0 -0.884 202.0 202.0 AP1 -0.029 0.107 -9999.0 0.0 -0.239 93.0 93.0 ABCG2 -0.34 0.535 -9999.0 0.0 -0.885 213.0 213.0 HIF1A -0.04 0.095 -9999.0 0.0 -0.137 186.0 186.0 TFF3 -0.32 0.52 -9999.0 0.0 -0.877 201.0 201.0 GATA2 0.019 0.012 -9999.0 0.0 -0.111 4.0 4.0 AKT1 -0.043 0.108 -9999.0 0.0 -0.188 109.0 109.0 response to hypoxia -0.043 0.072 -9999.0 0.0 -0.123 185.0 185.0 MCL1 -0.318 0.518 -9999.0 0.0 -0.873 201.0 201.0 NDRG1 -0.34 0.537 -9999.0 0.0 -0.884 214.0 214.0 SERPINE1 -0.351 0.542 -9999.0 0.0 -0.892 217.0 217.0 FECH -0.318 0.518 -9999.0 0.0 -0.874 201.0 201.0 FURIN -0.317 0.517 -9999.0 0.0 -0.872 201.0 201.0 NCOA2 0.02 0.01 -9999.0 0.0 -0.11 3.0 3.0 EP300 -0.038 0.124 -9999.0 0.0 -0.373 32.0 32.0 HMOX1 -0.346 0.54 -9999.0 0.0 -0.9 211.0 211.0 BHLHE40 -0.326 0.513 -9999.0 0.0 -0.847 212.0 212.0 BHLHE41 -0.326 0.513 -9999.0 0.0 -0.847 212.0 212.0 HIF1A/ARNT/SMAD3/SMAD4/SP1 -0.015 0.129 -9999.0 0.0 -0.198 88.0 88.0 ENG -0.028 0.104 -9999.0 0.0 -0.208 59.0 59.0 JUN -0.001 0.077 -9999.0 0.0 -0.278 37.0 37.0 RORA -0.326 0.525 -9999.0 0.0 -0.881 204.0 204.0 ABCB1 -0.157 0.336 -9999.0 0.0 -1.183 45.0 45.0 TFRC -0.328 0.528 -9999.0 0.0 -0.883 205.0 205.0 CXCR4 -0.336 0.534 -9999.0 0.0 -0.889 209.0 209.0 TF -0.368 0.534 -9999.0 0.0 -0.87 229.0 229.0 CITED2 -0.326 0.525 -9999.0 0.0 -0.885 202.0 202.0 HIF1A/ARNT -0.348 0.702 -9999.0 0.0 -1.133 178.0 178.0 LDHA -0.109 0.315 -9999.0 0.0 -1.21 38.0 38.0 ETS1 -0.317 0.517 -9999.0 0.0 -0.871 201.0 201.0 PGK1 -0.325 0.527 -9999.0 0.0 -0.879 205.0 205.0 NOS2 -0.326 0.513 -9999.0 0.0 -0.847 212.0 212.0 ITGB2 -0.336 0.535 -9999.0 0.0 -0.901 205.0 205.0 ALDOA -0.319 0.521 -9999.0 0.0 -0.876 201.0 201.0 Cbp/p300/CITED2 -0.323 0.547 -9999.0 0.0 -0.942 190.0 190.0 FOS -0.046 0.115 -9999.0 0.0 -0.217 146.0 146.0 HK2 -0.319 0.52 -9999.0 0.0 -0.875 201.0 201.0 SP1 0.019 0.021 -9999.0 0.0 -9999.0 0.0 0.0 GCK -0.047 0.156 -9999.0 0.0 -0.533 15.0 15.0 HK1 -0.32 0.522 -9999.0 0.0 -0.878 201.0 201.0 NPM1 -0.319 0.521 -9999.0 0.0 -0.864 206.0 206.0 EGLN1 -0.32 0.522 -9999.0 0.0 -0.874 203.0 203.0 CREB1 0.019 0.038 -9999.0 0.0 -0.268 7.0 7.0 PGM1 -0.319 0.522 -9999.0 0.0 -0.874 202.0 202.0 SMAD3 0.019 0.006 -9999.0 0.0 -0.11 1.0 1.0 EDN1 -0.048 0.169 -9999.0 0.0 -0.628 22.0 22.0 IGFBP1 -0.32 0.517 -9999.0 0.0 -0.872 202.0 202.0 VEGFA -0.256 0.405 -9999.0 0.0 -0.686 208.0 208.0 HIF1A/JAB1 -0.013 0.074 -9999.0 0.0 -0.162 43.0 43.0 CP -0.349 0.536 -9999.0 0.0 -0.9 210.0 210.0 CXCL12 -0.325 0.518 -9999.0 0.0 -0.869 205.0 205.0 COPS5 0.017 0.03 -9999.0 0.0 -0.292 5.0 5.0 SMAD3/SMAD4 0.013 0.056 -9999.0 0.0 -0.189 36.0 36.0 BNIP3 -0.325 0.527 -9999.0 0.0 -0.884 203.0 203.0 EGLN3 -0.326 0.522 -9999.0 0.0 -0.865 209.0 209.0 CA9 -0.325 0.517 -9999.0 0.0 -0.854 211.0 211.0 TERT -0.317 0.517 -9999.0 0.0 -0.871 201.0 201.0 ENO1 -0.321 0.522 -9999.0 0.0 -0.878 202.0 202.0 PFKL -0.319 0.52 -9999.0 0.0 -0.875 201.0 201.0 NCOA1 -0.005 0.084 -9999.0 0.0 -0.284 43.0 43.0 ADM -0.351 0.543 -9999.0 0.0 -0.891 218.0 218.0 ARNT -0.033 0.075 -9999.0 0.0 -0.125 135.0 135.0 HNF4A 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADFP -0.346 0.539 -9999.0 0.0 -0.898 212.0 212.0 SLC2A1 -0.232 0.387 -9999.0 0.0 -0.657 199.0 199.0 LEP -0.317 0.517 -9999.0 0.0 -0.871 201.0 201.0 HIF1A/ARNT/Cbp/p300 -0.233 0.459 -9999.0 0.0 -0.766 180.0 180.0 EPO -0.137 0.301 -9999.0 0.0 -0.556 121.0 121.0 CREBBP -0.032 0.107 -9999.0 0.0 -0.324 26.0 26.0 HIF1A/ARNT/Cbp/p300/HDAC7 -0.25 0.476 -9999.0 0.0 -0.793 183.0 183.0 PFKFB3 -0.33 0.533 -9999.0 0.0 -0.886 206.0 206.0 NT5E -0.344 0.533 -9999.0 0.0 -0.869 218.0 218.0