E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.017 0.074 -9999.0 0.0 -0.37 14.0 14.0 KLHL20 0.011 0.065 -9999.0 0.0 -0.186 34.0 34.0 CYFIP2 -0.02 0.099 -9999.0 0.0 -0.254 75.0 75.0 Rac1/GDP 0.028 0.072 -9999.0 0.0 -0.275 23.0 23.0 ENAH 0.012 0.087 -9999.0 0.0 -0.398 18.0 18.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 32.0 32.0 RAP1A 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 CTNNB1 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 CDC42/GTP -0.012 0.052 -9999.0 0.0 -0.236 22.0 22.0 ABI1/Sra1/Nap1 -0.019 0.043 -9999.0 0.0 -0.138 49.0 49.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.04 0.033 -9999.0 0.0 -0.147 9.0 9.0 RAPGEF1 0.02 0.074 -9999.0 0.0 -0.307 21.0 21.0 CTNND1 0.001 0.073 -9999.0 0.0 -0.292 31.0 31.0 regulation of calcium-dependent cell-cell adhesion 0.015 0.076 -9999.0 0.0 -0.396 13.0 13.0 CRK 0.017 0.08 -9999.0 0.0 -0.335 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.046 -9999.0 0.0 -0.129 36.0 36.0 alphaE/beta7 Integrin 0.024 0.027 -9999.0 0.0 -0.191 7.0 7.0 IQGAP1 -0.009 0.087 -9999.0 0.0 -0.274 50.0 50.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.01 -9999.0 0.0 -0.141 2.0 2.0 DLG1 0.015 0.078 -9999.0 0.0 -0.389 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.02 0.054 -9999.0 0.0 -0.198 36.0 36.0 MLLT4 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.015 0.036 -9999.0 0.0 -0.143 24.0 24.0 PI3K -0.026 0.071 -9999.0 0.0 -0.258 36.0 36.0 ARF6 0.018 0.015 -9999.0 0.0 -0.202 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.0 99.0 99.0 E-cadherin/gamma catenin 0.016 0.039 -9999.0 0.0 -0.135 25.0 25.0 TIAM1 0.003 0.066 -9999.0 0.0 -0.23 35.0 35.0 E-cadherin(dimer)/Ca2+ 0.027 0.06 -9999.0 0.0 -0.182 34.0 34.0 AKT1 0.006 0.061 -9999.0 0.0 -0.186 38.0 38.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 CDH1 0.012 0.03 -9999.0 0.0 -0.111 29.0 29.0 RhoA/GDP 0.029 0.069 -9999.0 0.0 -0.261 23.0 23.0 actin cytoskeleton organization 0.01 0.049 -9999.0 0.0 -0.137 34.0 34.0 CDC42/GDP 0.029 0.068 -9999.0 0.0 -0.258 22.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.068 -9999.0 0.0 -0.236 33.0 33.0 ITGB7 0.018 0.01 -9999.0 0.0 -0.111 3.0 3.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.03 0.065 -9999.0 0.0 -0.194 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.025 0.033 -9999.0 0.0 -0.145 15.0 15.0 mol:GDP 0.021 0.075 -9999.0 0.0 -0.307 21.0 21.0 CDC42/GTP/IQGAP1 0.009 0.053 -9999.0 0.0 -0.161 45.0 45.0 JUP 0.008 0.037 -9999.0 0.0 -0.111 47.0 47.0 p120 catenin/RhoA/GDP 0.029 0.077 -9999.0 0.0 -0.246 33.0 33.0 RAC1/GTP/IQGAP1 0.007 0.056 -9999.0 0.0 -0.16 51.0 51.0 PIP5K1C/AP1M1 0.005 0.041 -9999.0 0.0 -0.197 20.0 20.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 CDC42 0.017 0.016 -9999.0 0.0 -0.111 8.0 8.0 CTNNA1 0.011 0.048 -9999.0 0.0 -0.292 13.0 13.0 positive regulation of S phase of mitotic cell cycle 0.0 0.054 -9999.0 0.0 -0.14 53.0 53.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 108.0 108.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.014 0.081 -9999.0 0.0 -0.385 16.0 16.0 regulation of cell-cell adhesion -0.011 0.045 -9999.0 0.0 -0.209 22.0 22.0 WASF2 -0.011 0.023 -9999.0 0.0 -0.075 49.0 49.0 Rap1/GTP 0.019 0.067 -9999.0 0.0 -0.247 25.0 25.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.049 -9999.0 0.0 -0.144 20.0 20.0 CCND1 -0.001 0.066 -9999.0 0.0 -0.172 53.0 53.0 VAV2 0.024 0.079 -9999.0 0.0 -0.401 13.0 13.0 RAP1/GDP 0.022 0.068 -9999.0 0.0 -0.267 22.0 22.0 adherens junction assembly 0.015 0.078 -9999.0 0.0 -0.373 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.008 0.055 -9999.0 0.0 -0.243 22.0 22.0 PIP5K1C 0.006 0.061 -9999.0 0.0 -0.292 20.0 20.0 regulation of heterotypic cell-cell adhesion 0.037 0.048 -9999.0 0.0 -0.198 7.0 7.0 E-cadherin/beta catenin 0.008 0.034 -9999.0 0.0 -0.151 15.0 15.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 108.0 108.0 SRC 0.017 0.074 -9999.0 0.0 -0.382 13.0 13.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.224 66.0 66.0 Rac1/GTP -0.031 0.082 -9999.0 0.0 -0.304 33.0 33.0 E-cadherin/beta catenin/alpha catenin 0.029 0.04 -9999.0 0.0 -0.173 15.0 15.0 ITGAE 0.014 0.037 -9999.0 0.0 -0.238 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.015 0.078 -9999.0 0.0 -0.405 13.0 13.0