Signaling events mediated by HDAC Class III Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations EP300 0.012 0.046 -9999.0 0.0 -0.244 15.0 15.0 HDAC4 0.007 0.056 -9999.0 0.0 -0.218 27.0 27.0 induction of apoptosis -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of S phase of mitotic cell cycle -0.015 0.045 0.2 6.0 -0.132 41.0 47.0 CDKN1A -0.052 0.171 -9999.0 0.0 -0.515 62.0 62.0 KAT2B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.014 0.035 -9999.0 0.0 -0.171 15.0 15.0 FOXO3 -0.007 0.042 0.291 5.0 -0.162 18.0 23.0 FOXO1 -0.012 0.088 -9999.0 0.0 -0.23 67.0 67.0 FOXO4 0.017 0.032 -9999.0 0.0 -0.2 11.0 11.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 TAT 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Lysophosphatidic acid -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYOD1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPARGC1A -0.006 0.067 -9999.0 0.0 -0.154 76.0 76.0 FHL2 -0.027 0.088 -9999.0 0.0 -0.161 134.0 134.0 response to nutrient levels 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU70/SIRT1 0.031 0.048 0.143 41.0 -0.219 7.0 48.0 HIST2H4A 0.015 0.045 0.132 41.0 -0.2 6.0 47.0 SIRT1/FOXO3a 0.013 0.051 0.141 45.0 -0.125 18.0 63.0 SIRT1 0.024 0.063 0.182 41.0 -0.17 20.0 61.0 response to hypoxia -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/MEF2D/HDAC4 0.035 0.054 0.143 37.0 -0.167 21.0 58.0 SIRT1/Histone H1b 0.03 0.049 0.147 38.0 -0.19 10.0 48.0 apoptosis -0.037 0.047 0.168 11.0 -0.141 41.0 52.0 SIRT1/PGC1A 0.015 0.053 0.129 32.0 -0.149 22.0 54.0 p53/SIRT1 0.031 0.11 0.335 48.0 -0.191 28.0 76.0 SIRT1/FOXO4 0.032 0.048 0.147 40.0 -0.185 10.0 50.0 FOXO1/FHL2/SIRT1 -0.003 0.073 0.135 18.0 -0.152 70.0 88.0 HIST1H1E 0.015 0.033 -9999.0 0.0 -0.204 11.0 11.0 SIRT1/p300 0.027 0.056 0.143 40.0 -0.2 17.0 57.0 muscle cell differentiation -0.022 0.039 0.159 6.0 -0.126 41.0 47.0 TP53 0.012 0.083 0.179 47.0 -0.187 47.0 94.0 KU70/SIRT1/BAX 0.038 0.048 0.143 41.0 -0.168 11.0 52.0 CREBBP 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MEF2D 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIV-1 Tat/SIRT1 0.032 0.044 0.143 41.0 -0.194 6.0 47.0 ACSS2 0.015 0.045 0.132 41.0 -0.2 6.0 47.0 SIRT1/PCAF/MYOD 0.022 0.039 0.127 41.0 -0.16 6.0 47.0