HIF-2-alpha transcription factor network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MMP14 -0.005 0.039 -9999.0 0.0 -9999.0 0.0 0.0 oxygen homeostasis -0.008 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TCEB2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCEB1 0.013 0.041 -9999.0 0.0 -0.274 10.0 10.0 VHL/Elongin B/Elongin C/HIF2A -0.029 0.108 -9999.0 0.0 -0.262 51.0 51.0 EPO -0.11 0.248 -9999.0 0.0 -0.478 124.0 124.0 FIH (dimer) 0.009 0.016 -9999.0 0.0 -9999.0 0.0 0.0 APEX1 0.003 0.039 -9999.0 0.0 -0.331 5.0 5.0 SERPINE1 -0.169 0.305 -9999.0 0.0 -0.575 153.0 153.0 FLT1 -0.003 0.043 -9999.0 0.0 -9999.0 0.0 0.0 ADORA2A -0.128 0.257 -9999.0 0.0 -0.499 132.0 132.0 germ cell development -0.13 0.256 -9999.0 0.0 -0.46 159.0 159.0 SLC11A2 -0.131 0.272 -9999.0 0.0 -0.521 132.0 132.0 BHLHE40 -0.136 0.266 -9999.0 0.0 -0.477 159.0 159.0 HIF1AN 0.009 0.016 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT/SIRT1 -0.057 0.166 -9999.0 0.0 -0.304 115.0 115.0 ETS1 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CITED2 -0.062 0.243 -9999.0 0.0 -1.094 27.0 27.0 KDR -0.03 0.169 -9999.0 0.0 -1.147 11.0 11.0 PGK1 -0.138 0.283 -9999.0 0.0 -0.538 136.0 136.0 SIRT1 0.008 0.048 -9999.0 0.0 -0.162 32.0 32.0 response to hypoxia 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT -0.135 0.327 -9999.0 0.0 -0.551 157.0 157.0 EPAS1 -0.044 0.116 -9999.0 0.0 -0.244 83.0 83.0 SP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABCG2 -0.16 0.298 -9999.0 0.0 -0.551 157.0 157.0 EFNA1 -0.137 0.28 -9999.0 0.0 -0.536 135.0 135.0 FXN -0.128 0.257 -9999.0 0.0 -0.499 132.0 132.0 POU5F1 -0.136 0.266 -9999.0 0.0 -0.477 159.0 159.0 neuron apoptosis 0.131 0.317 0.535 157.0 -9999.0 0.0 157.0 EP300 0.012 0.046 -9999.0 0.0 -0.244 15.0 15.0 EGLN3 -0.014 0.069 -9999.0 0.0 -0.171 67.0 67.0 EGLN2 0.009 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EGLN1 -0.0 0.055 -9999.0 0.0 -0.277 17.0 17.0 VHL/Elongin B/Elongin C 0.023 0.024 -9999.0 0.0 -0.157 9.0 9.0 VHL -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.006 0.022 -9999.0 0.0 -0.093 1.0 1.0 SLC2A1 -0.14 0.27 -9999.0 0.0 -0.521 137.0 137.0 TWIST1 -0.173 0.286 -9999.0 0.0 -0.506 181.0 181.0 ELK1 0.022 0.017 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT/Cbp/p300 -0.054 0.165 -9999.0 0.0 -0.307 104.0 104.0 VEGFA -0.17 0.303 -9999.0 0.0 -0.555 163.0 163.0 CREBBP 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0