Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.006 0.106 -9999.0 0.0 -0.248 65.0 65.0 epithelial cell differentiation 0.024 0.059 -9999.0 0.0 -0.18 34.0 34.0 CYFIP2 -0.02 0.099 -9999.0 0.0 -0.254 75.0 75.0 ENAH 0.014 0.069 -9999.0 0.0 -0.201 35.0 35.0 EGFR -0.08 0.116 -9999.0 0.0 -0.177 267.0 267.0 EPHA2 0.008 0.036 -9999.0 0.0 -0.111 45.0 45.0 MYO6 0.011 0.065 -9999.0 0.0 -0.2 36.0 36.0 CTNNB1 0.017 0.023 -9999.0 0.0 -0.292 3.0 3.0 ABI1/Sra1/Nap1 0.009 0.072 -9999.0 0.0 -0.166 70.0 70.0 AQP5 0.017 0.089 -9999.0 0.0 -0.383 20.0 20.0 CTNND1 0.001 0.073 -9999.0 0.0 -0.292 31.0 31.0 mol:PI-4-5-P2 0.01 0.068 -9999.0 0.0 -0.207 39.0 39.0 regulation of calcium-dependent cell-cell adhesion 0.015 0.052 -9999.0 0.0 -0.166 34.0 34.0 EGF 0.014 0.025 -9999.0 0.0 -0.111 21.0 21.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.016 0.09 -9999.0 0.0 -0.385 20.0 20.0 cortical microtubule organization 0.024 0.059 -9999.0 0.0 -0.18 34.0 34.0 GO:0000145 0.005 0.064 -9999.0 0.0 -0.198 39.0 39.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.06 -9999.0 0.0 -0.182 34.0 34.0 MLLT4 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.018 0.054 -9999.0 0.0 -0.21 27.0 27.0 ARF6 0.018 0.015 -9999.0 0.0 -0.202 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.053 -9999.0 0.0 -0.147 31.0 31.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.129 -9999.0 0.0 -0.324 63.0 63.0 PVRL2 0.016 0.026 -9999.0 0.0 -0.189 7.0 7.0 ZYX 0.002 0.078 -9999.0 0.0 -0.231 44.0 44.0 ARF6/GTP 0.033 0.052 -9999.0 0.0 -0.137 31.0 31.0 CDH1 0.012 0.03 -9999.0 0.0 -0.111 29.0 29.0 EGFR/EGFR/EGF/EGF -0.024 0.078 -9999.0 0.0 -0.143 113.0 113.0 RhoA/GDP 0.024 0.06 -9999.0 0.0 -0.171 38.0 38.0 actin cytoskeleton organization 0.012 0.065 -9999.0 0.0 -0.2 36.0 36.0 IGF-1R heterotetramer -0.001 0.07 -9999.0 0.0 -0.209 46.0 46.0 GIT1 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 IGF1R -0.001 0.07 -9999.0 0.0 -0.209 46.0 46.0 IGF1 0.014 0.025 -9999.0 0.0 -0.111 21.0 21.0 DIAPH1 -0.035 0.21 -9999.0 0.0 -0.573 69.0 69.0 Wnt receptor signaling pathway -0.024 0.059 0.18 34.0 -9999.0 0.0 34.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 RhoA/GTP -0.019 0.057 -9999.0 0.0 -0.217 28.0 28.0 CTNNA1 0.011 0.048 -9999.0 0.0 -0.292 13.0 13.0 VCL 0.012 0.066 -9999.0 0.0 -0.204 36.0 36.0 EFNA1 -0.001 0.07 -9999.0 0.0 -0.209 46.0 46.0 LPP 0.004 0.076 -9999.0 0.0 -0.245 36.0 36.0 Ephrin A1/EPHA2 0.009 0.066 -9999.0 0.0 -0.15 59.0 59.0 SEC6/SEC8 -0.011 0.043 -9999.0 0.0 -0.221 16.0 16.0 MGAT3 0.015 0.053 -9999.0 0.0 -0.168 34.0 34.0 HGF/MET 0.016 0.055 -9999.0 0.0 -0.162 34.0 34.0 HGF 0.016 0.02 -9999.0 0.0 -0.111 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.006 0.106 -9999.0 0.0 -0.25 65.0 65.0 actin cable formation -0.006 0.112 -9999.0 0.0 -0.269 61.0 61.0 KIAA1543 0.003 0.048 -9999.0 0.0 -0.165 34.0 34.0 KIFC3 0.015 0.053 -9999.0 0.0 -0.168 34.0 34.0 NCK1 0.014 0.036 -9999.0 0.0 -0.189 14.0 14.0 EXOC3 0.017 0.021 -9999.0 0.0 -0.202 4.0 4.0 ACTN1 0.003 0.073 -9999.0 0.0 -0.239 36.0 36.0 NCK1/GIT1 0.024 0.026 -9999.0 0.0 -0.191 6.0 6.0 mol:GDP 0.024 0.059 -9999.0 0.0 -0.18 34.0 34.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.013 0.064 -9999.0 0.0 -0.201 35.0 35.0 PIP5K1C 0.01 0.069 -9999.0 0.0 -0.21 39.0 39.0 LIMA1 -0.013 0.09 -9999.0 0.0 -0.24 66.0 66.0 ABI1 0.008 0.055 -9999.0 0.0 -0.243 22.0 22.0 ROCK1 0.017 0.066 -9999.0 0.0 -0.201 29.0 29.0 adherens junction assembly 0.007 0.089 -9999.0 0.0 -0.343 27.0 27.0 IGF-1R heterotetramer/IGF1 0.011 0.066 -9999.0 0.0 -0.165 50.0 50.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.026 0.018 -9999.0 0.0 -0.191 3.0 3.0 MET 0.008 0.037 -9999.0 0.0 -0.111 47.0 47.0 PLEKHA7 0.004 0.051 -9999.0 0.0 -0.172 34.0 34.0 mol:GTP 0.026 0.052 -9999.0 0.0 -0.146 31.0 31.0 establishment of epithelial cell apical/basal polarity 0.022 0.06 -9999.0 0.0 -0.253 18.0 18.0 cortical actin cytoskeleton stabilization -0.006 0.106 -9999.0 0.0 -0.248 65.0 65.0 regulation of cell-cell adhesion 0.012 0.065 -9999.0 0.0 -0.2 36.0 36.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.006 0.106 -9999.0 0.0 -0.25 65.0 65.0