IL1-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations UBC13/UEV1A 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 PRKCZ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP2 0.008 0.057 -9999.0 0.0 -0.292 18.0 18.0 ERC1 -0.002 0.075 -9999.0 0.0 -0.242 43.0 43.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.032 0.125 -9999.0 0.0 -0.314 69.0 69.0 IRAK/TOLLIP 0.019 0.038 -9999.0 0.0 -0.147 23.0 23.0 IKBKB 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IKBKG 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R2 0.009 0.039 -9999.0 0.0 -0.135 6.0 6.0 IL1A 0.013 0.026 -9999.0 0.0 -0.111 23.0 23.0 IL1B -0.027 0.075 -9999.0 0.0 -0.184 83.0 83.0 IRAK/TRAF6/p62/Atypical PKCs 0.027 0.053 -9999.0 0.0 -0.147 38.0 38.0 IL1R2 -0.003 0.049 -9999.0 0.0 -0.111 91.0 91.0 IL1R1 0.016 0.02 -9999.0 0.0 -0.111 13.0 13.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.023 0.105 -9999.0 0.0 -0.303 47.0 47.0 TOLLIP 0.016 0.021 -9999.0 0.0 -0.111 14.0 14.0 TICAM2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K3 0.019 0.006 -9999.0 0.0 -0.111 1.0 1.0 TAK1/TAB1/TAB2 0.025 0.055 -9999.0 0.0 -0.185 31.0 31.0 IKK complex/ELKS 0.026 0.09 -9999.0 0.0 -0.286 33.0 33.0 JUN 0.021 0.05 -9999.0 0.0 -0.228 15.0 15.0 MAP3K7 0.007 0.059 -9999.0 0.0 -0.254 24.0 24.0 IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.034 0.104 -9999.0 0.0 -0.163 171.0 171.0 IL1 alpha/IL1R1/IL1RAP/MYD88 0.015 0.07 -9999.0 0.0 -0.153 61.0 61.0 PIK3R1 -0.015 0.095 -9999.0 0.0 -0.269 62.0 62.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.023 0.067 -9999.0 0.0 -0.138 61.0 61.0 IL1 beta fragment/IL1R1/IL1RAP -0.023 0.085 -9999.0 0.0 -0.168 107.0 107.0 NFKB1 0.014 0.037 -9999.0 0.0 -0.226 11.0 11.0 MAPK8 0.023 0.046 -9999.0 0.0 -0.236 10.0 10.0 IRAK1 0.015 0.027 -9999.0 0.0 -0.201 7.0 7.0 IL1RN/IL1R1 0.025 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IRAK4 0.019 0.008 -9999.0 0.0 -0.111 2.0 2.0 PRKCI 0.015 0.028 -9999.0 0.0 -0.135 15.0 15.0 TRAF6 0.018 0.019 -9999.0 0.0 -0.292 2.0 2.0 PI3K -0.016 0.093 -9999.0 0.0 -0.211 88.0 88.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.027 0.121 -9999.0 0.0 -0.298 69.0 69.0 CHUK 0.016 0.025 -9999.0 0.0 -0.147 10.0 10.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.023 0.085 -9999.0 0.0 -0.168 107.0 107.0 IL1 beta/IL1R2 -0.029 0.078 -9999.0 0.0 -0.154 118.0 118.0 IRAK/TRAF6/TAK1/TAB1/TAB2 0.035 0.063 -9999.0 0.0 -0.271 12.0 12.0 NF kappa B1 p50/RelA -0.028 0.095 -9999.0 0.0 -0.202 87.0 87.0 IRAK3 0.018 0.014 -9999.0 0.0 -0.111 6.0 6.0 IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.013 0.079 -9999.0 0.0 -0.146 107.0 107.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.004 0.076 -9999.0 0.0 -0.186 61.0 61.0 IL1 alpha/IL1R1/IL1RAP 0.014 0.055 -9999.0 0.0 -0.144 44.0 44.0 RELA 0.018 0.02 -9999.0 0.0 -0.232 3.0 3.0 MAP3K7IP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SQSTM1 0.004 0.062 -9999.0 0.0 -0.224 32.0 32.0 MYD88 -0.0 0.075 -9999.0 0.0 -0.292 33.0 33.0 IRAK/TRAF6/MEKK3 0.032 0.038 -9999.0 0.0 -0.132 25.0 25.0 IL1RAP -0.013 0.084 -9999.0 0.0 -0.198 77.0 77.0 UBE2N 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 IRAK/TRAF6 -0.03 0.06 -9999.0 0.0 -0.193 43.0 43.0 CASP1 -0.033 0.11 -9999.0 0.0 -0.236 109.0 109.0 IL1RN/IL1R2 0.012 0.036 -9999.0 0.0 -0.135 3.0 3.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.022 0.098 -9999.0 0.0 -0.174 118.0 118.0 TMEM189-UBE2V1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.002 0.099 -9999.0 0.0 -0.325 35.0 35.0 PIK3CA -0.011 0.086 -9999.0 0.0 -0.223 66.0 66.0 IL1RN 0.018 0.011 -9999.0 0.0 -0.111 4.0 4.0 TRAF6/TAK1/TAB1/TAB2 0.033 0.054 -9999.0 0.0 -0.157 34.0 34.0 MAP2K6 0.021 0.048 -9999.0 0.0 -0.252 10.0 10.0