S1P3 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.011 0.043 -9999.0 0.0 -0.18 21.0 21.0 mol:S1P 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P/Gi -0.048 0.142 -9999.0 0.0 -0.257 124.0 124.0 GNAO1 -0.012 0.085 -9999.0 0.0 -0.195 81.0 81.0 S1P/S1P3/G12/G13 0.012 0.045 -9999.0 0.0 -0.141 39.0 39.0 AKT1 -0.026 0.155 -9999.0 0.0 -0.603 31.0 31.0 AKT3 -0.055 0.142 -9999.0 0.0 -0.466 30.0 30.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.011 0.043 -9999.0 0.0 -0.18 21.0 21.0 GNAI2 0.002 0.074 -9999.0 0.0 -0.275 34.0 34.0 GNAI3 0.016 0.038 -9999.0 0.0 -0.291 8.0 8.0 GNAI1 -0.044 0.111 -9999.0 0.0 -0.198 157.0 157.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 S1PR3 0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 S1PR2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 0.001 0.068 -9999.0 0.0 -0.222 39.0 39.0 mol:Ca2+ -0.036 0.121 -9999.0 0.0 -0.279 73.0 73.0 MAPK3 -0.031 0.115 -9999.0 0.0 -0.309 53.0 53.0 MAPK1 -0.034 0.121 -9999.0 0.0 -0.292 67.0 67.0 JAK2 -0.04 0.126 -9999.0 0.0 -0.279 87.0 87.0 CXCR4 -0.048 0.128 -9999.0 0.0 -0.291 87.0 87.0 FLT1 0.021 0.008 -9999.0 0.0 -0.109 2.0 2.0 RhoA/GDP 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 Rac1/GDP 0.011 0.024 -9999.0 0.0 -0.197 7.0 7.0 SRC -0.031 0.115 -9999.0 0.0 -0.277 65.0 65.0 S1P/S1P3/Gi -0.037 0.122 -9999.0 0.0 -0.281 73.0 73.0 RAC1 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 RhoA/GTP -0.026 0.116 -9999.0 0.0 -0.275 65.0 65.0 VEGFA -0.065 0.129 -9999.0 0.0 -0.223 188.0 188.0 S1P/S1P2/Gi -0.04 0.121 -9999.0 0.0 -0.213 141.0 141.0 VEGFR1 homodimer/VEGFA homodimer -0.028 0.093 -9999.0 0.0 -0.189 119.0 119.0 RHOA 0.015 0.036 -9999.0 0.0 -0.292 7.0 7.0 S1P/S1P3/Gq 0.012 0.045 -9999.0 0.0 -0.165 29.0 29.0 GNAQ 0.015 0.023 -9999.0 0.0 -0.111 17.0 17.0 GNAZ -0.006 0.083 -9999.0 0.0 -0.233 56.0 56.0 G12/G13 0.009 0.059 -9999.0 0.0 -0.193 39.0 39.0 GNA14 0.015 0.022 -9999.0 0.0 -9999.0 0.0 0.0 GNA15 0.012 0.033 -9999.0 0.0 -0.125 26.0 26.0 GNA12 -0.005 0.082 -9999.0 0.0 -0.275 43.0 43.0 GNA13 0.016 0.021 -9999.0 0.0 -0.111 14.0 14.0 GNA11 0.003 0.069 -9999.0 0.0 -0.292 27.0 27.0 Rac1/GTP -0.026 0.118 -9999.0 0.0 -0.311 54.0 54.0