Ephrin B reverse signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations EFNB2 0.028 0.015 -9999.0 0.0 0.0 110.0 110.0 EPHB2 0.034 0.01 -9999.0 0.0 0.0 35.0 35.0 EFNB1 -0.018 0.015 0.023 53.0 -9999.0 0.0 53.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.052 0.054 -9999.0 0.0 -0.15 9.0 9.0 Ephrin B2/EPHB1-2 0.031 0.056 -9999.0 0.0 -0.105 51.0 51.0 neuron projection morphogenesis 0.035 0.042 -9999.0 0.0 -0.127 13.0 13.0 Ephrin B1/EPHB1-2/Tiam1 0.056 0.049 -9999.0 0.0 -0.104 26.0 26.0 DNM1 0.035 0.008 -9999.0 0.0 0.0 23.0 23.0 cell-cell signaling -0.0 0.003 0.023 1.0 -9999.0 0.0 1.0 MAP2K4 -0.053 0.158 0.202 1.0 -0.52 48.0 49.0 YES1 -0.054 0.234 -9999.0 0.0 -0.745 49.0 49.0 Ephrin B1/EPHB1-2/NCK2 0.06 0.043 -9999.0 0.0 -0.101 19.0 19.0 PI3K -0.021 0.189 -9999.0 0.0 -0.558 49.0 49.0 mol:GDP 0.054 0.048 -9999.0 0.0 -0.102 27.0 27.0 ITGA2B 0.036 0.003 -9999.0 0.0 0.0 3.0 3.0 endothelial cell proliferation 0.016 0.048 -9999.0 0.0 -0.114 46.0 46.0 FYN -0.065 0.239 -9999.0 0.0 -0.765 49.0 49.0 MAP3K7 -0.05 0.163 -9999.0 0.0 -0.54 47.0 47.0 FGR -0.05 0.224 -9999.0 0.0 -0.722 48.0 48.0 TIAM1 0.033 0.01 -9999.0 0.0 0.0 43.0 43.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 RGS3 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 cell adhesion -0.033 0.174 -9999.0 0.0 -0.536 48.0 48.0 LYN -0.059 0.228 -9999.0 0.0 -0.734 48.0 48.0 Ephrin B1/EPHB1-2/Src Family Kinases -0.055 0.209 -9999.0 0.0 -0.677 49.0 49.0 Ephrin B1/EPHB1-2 -0.046 0.174 -9999.0 0.0 -0.574 47.0 47.0 SRC -0.049 0.225 -9999.0 0.0 -0.716 49.0 49.0 ITGB3 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0 EPHB1 0.03 0.014 -9999.0 0.0 0.0 87.0 87.0 EPHB4 0.026 0.016 -9999.0 0.0 0.0 141.0 141.0 RAC1 0.027 0.016 -9999.0 0.0 0.0 123.0 123.0 Ephrin B2/EPHB4 0.016 0.048 -9999.0 0.0 -0.114 46.0 46.0 alphaIIb/beta3 Integrin 0.053 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BLK -0.051 0.226 -9999.0 0.0 -0.719 49.0 49.0 HCK -0.063 0.23 -9999.0 0.0 -0.733 49.0 49.0 regulation of stress fiber formation -0.058 0.042 0.101 19.0 -9999.0 0.0 19.0 MAPK8 -0.056 0.15 -9999.0 0.0 -0.493 49.0 49.0 Ephrin B1/EPHB1-2/RGS3 0.065 0.033 -9999.0 0.0 -0.111 6.0 6.0 endothelial cell migration 0.002 0.17 0.196 112.0 -0.447 44.0 156.0 NCK2 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 PTPN13 0.034 0.013 -9999.0 0.0 0.0 56.0 56.0 regulation of focal adhesion formation -0.058 0.042 0.101 19.0 -9999.0 0.0 19.0 chemotaxis -0.063 0.032 0.111 6.0 -9999.0 0.0 6.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 Rac1/GTP 0.045 0.048 -9999.0 0.0 -0.136 11.0 11.0 angiogenesis -0.045 0.173 -9999.0 0.0 -0.571 47.0 47.0 LCK -0.048 0.223 -9999.0 0.0 -0.718 48.0 48.0