Angiopoietin receptor Tie2-mediated signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.224 0.409 -9999.0 0.0 -0.832 132.0 132.0 NCK1/PAK1/Dok-R -0.122 0.168 -9999.0 0.0 -0.387 122.0 122.0 NCK1/Dok-R -0.13 0.352 -9999.0 0.0 -0.857 89.0 89.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 mol:beta2-estradiol 0.029 0.096 0.226 89.0 -9999.0 0.0 89.0 RELA 0.035 0.005 -9999.0 0.0 0.0 10.0 10.0 SHC1 0.032 0.011 -9999.0 0.0 0.0 48.0 48.0 Rac/GDP 0.018 0.02 -9999.0 0.0 -0.132 6.0 6.0 F2 0.051 0.111 0.274 82.0 -0.109 7.0 89.0 TNIP2 0.035 0.006 -9999.0 0.0 0.0 13.0 13.0 NF kappa B/RelA -0.107 0.354 -9999.0 0.0 -0.829 89.0 89.0 FN1 0.034 0.009 -9999.0 0.0 0.0 29.0 29.0 PLD2 -0.145 0.358 -9999.0 0.0 -0.89 89.0 89.0 PTPN11 0.036 0.005 -9999.0 0.0 0.0 9.0 9.0 GRB14 0.031 0.013 -9999.0 0.0 0.0 67.0 67.0 ELK1 -0.138 0.33 -9999.0 0.0 -0.821 89.0 89.0 GRB7 0.035 0.006 -9999.0 0.0 0.0 13.0 13.0 PAK1 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 Tie2/Ang1/alpha5/beta1 Integrin -0.129 0.36 -9999.0 0.0 -0.865 89.0 89.0 CDKN1A -0.188 0.356 -9999.0 0.0 -0.694 139.0 139.0 ITGA5 0.032 0.012 -9999.0 0.0 0.0 56.0 56.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RasGAP/Dok-R -0.134 0.354 -9999.0 0.0 -0.863 89.0 89.0 CRK 0.035 0.008 -9999.0 0.0 0.0 23.0 23.0 mol:NO -0.131 0.32 0.404 4.0 -0.597 130.0 134.0 PLG -0.146 0.357 -9999.0 0.0 -0.889 89.0 89.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 chemokinesis -0.172 0.363 -9999.0 0.0 -0.757 116.0 116.0 GRB2 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 PIK3R1 0.031 0.012 -9999.0 0.0 0.0 61.0 61.0 ANGPT2 -0.223 0.453 -9999.0 0.0 -1.01 107.0 107.0 BMX -0.145 0.358 -9999.0 0.0 -0.889 89.0 89.0 ANGPT1 -0.157 0.422 -9999.0 0.0 -1.036 89.0 89.0 tube development -0.206 0.361 -9999.0 0.0 -0.701 155.0 155.0 ANGPT4 0.023 0.028 -9999.0 0.0 -0.029 104.0 104.0 response to hypoxia -0.012 0.026 0.034 1.0 -0.063 89.0 90.0 Tie2/Ang1/GRB14 -0.136 0.367 -9999.0 0.0 -0.895 89.0 89.0 alpha5/beta1 Integrin 0.03 0.043 -9999.0 0.0 -0.139 20.0 20.0 FGF2 0.035 0.016 -9999.0 0.0 -0.011 41.0 41.0 STAT5A (dimer) -0.231 0.446 -9999.0 0.0 -0.823 159.0 159.0 mol:L-citrulline -0.131 0.32 0.404 4.0 -0.597 130.0 134.0 AGTR1 0.021 0.034 -9999.0 0.0 -0.047 88.0 88.0 MAPK14 -0.151 0.373 -9999.0 0.0 -0.9 90.0 90.0 Tie2/SHP2 -0.071 0.231 -9999.0 0.0 -0.824 29.0 29.0 TEK -0.082 0.241 -9999.0 0.0 -0.951 26.0 26.0 RPS6KB1 -0.199 0.374 -9999.0 0.0 -0.776 126.0 126.0 Angiotensin II/AT1 0.014 0.036 0.078 2.0 -0.056 85.0 87.0 Tie2/Ang1/GRB2 -0.136 0.372 -9999.0 0.0 -0.905 89.0 89.0 MAPK3 -0.146 0.335 -9999.0 0.0 -0.841 89.0 89.0 MAPK1 -0.144 0.334 -9999.0 0.0 -0.838 89.0 89.0 Tie2/Ang1/GRB7 -0.135 0.373 -9999.0 0.0 -0.907 89.0 89.0 NFKB1 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 MAPK8 -0.148 0.354 -9999.0 0.0 -0.887 89.0 89.0 PI3K -0.235 0.438 -9999.0 0.0 -0.918 124.0 124.0 FES -0.153 0.375 -9999.0 0.0 -0.905 90.0 90.0 Crk/Dok-R -0.132 0.355 -9999.0 0.0 -0.864 89.0 89.0 Tie2/Ang1/ABIN2 -0.136 0.373 -9999.0 0.0 -0.906 89.0 89.0 blood circulation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of caspase activity -0.197 0.366 -9999.0 0.0 -0.737 134.0 134.0 STAT5A 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 mol:ROS -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 -0.199 0.373 -9999.0 0.0 -0.777 125.0 125.0 Tie2/Ang2 -0.285 0.507 -9999.0 0.0 -0.982 151.0 151.0 Tie2/Ang1 -0.147 0.378 -9999.0 0.0 -0.934 89.0 89.0 FOXO1 -0.217 0.392 -9999.0 0.0 -0.751 156.0 156.0 ELF1 0.028 0.036 0.102 3.0 -0.045 76.0 79.0 ELF2 -0.135 0.352 -9999.0 0.0 -0.867 89.0 89.0 mol:Choline -0.14 0.347 -9999.0 0.0 -0.862 89.0 89.0 cell migration -0.065 0.097 -9999.0 0.0 -0.216 125.0 125.0 FYN -0.242 0.414 -9999.0 0.0 -0.812 154.0 154.0 DOK2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of cell cycle -0.164 0.322 0.385 2.0 -0.621 139.0 141.0 ETS1 -0.0 0.117 -9999.0 0.0 -0.246 86.0 86.0 PXN -0.169 0.314 -9999.0 0.0 -0.652 125.0 125.0 ITGB1 0.027 0.016 -9999.0 0.0 0.0 118.0 118.0 NOS3 -0.159 0.355 0.421 3.0 -0.683 128.0 131.0 RAC1 0.027 0.016 -9999.0 0.0 0.0 123.0 123.0 TNF -0.001 0.117 -9999.0 0.0 -0.251 84.0 84.0 MAPKKK cascade -0.14 0.347 -9999.0 0.0 -0.862 89.0 89.0 RASA1 0.034 0.009 -9999.0 0.0 0.0 30.0 30.0 Tie2/Ang1/Shc -0.14 0.37 -9999.0 0.0 -0.904 89.0 89.0 NCK1 0.034 0.008 -9999.0 0.0 0.0 26.0 26.0 vasculogenesis -0.113 0.292 0.387 5.0 -0.536 130.0 135.0 mol:Phosphatidic acid -0.14 0.347 -9999.0 0.0 -0.862 89.0 89.0 mol:Angiotensin II -0.004 0.013 0.021 1.0 -0.032 72.0 73.0 mol:NADP -0.131 0.32 0.404 4.0 -0.597 130.0 134.0 Rac1/GTP -0.173 0.342 -9999.0 0.0 -0.716 119.0 119.0 MMP2 -0.146 0.363 -9999.0 0.0 -0.898 89.0 89.0