Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 -0.013 0.011 0.0 211.0 -9999.0 0.0 211.0 MAP4K4 0.003 0.054 -9999.0 0.0 -0.212 11.0 11.0 BAG4 0.035 0.005 -9999.0 0.0 0.0 11.0 11.0 PKC zeta/ceramide -0.045 0.13 -9999.0 0.0 -0.233 111.0 111.0 NFKBIA 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 BIRC3 0.03 0.013 -9999.0 0.0 0.0 77.0 77.0 BAX -0.022 0.101 -9999.0 0.0 -0.35 32.0 32.0 RIPK1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 AKT1 -0.001 0.088 0.674 6.0 -9999.0 0.0 6.0 BAD -0.05 0.131 0.219 2.0 -0.239 110.0 112.0 SMPD1 -0.003 0.05 0.13 2.0 -0.173 21.0 23.0 RB1 -0.047 0.135 0.211 10.0 -0.239 110.0 120.0 FADD/Caspase 8 0.015 0.051 -9999.0 0.0 -0.223 7.0 7.0 MAP2K4 -0.051 0.127 0.186 5.0 -0.237 107.0 112.0 NSMAF 0.034 0.008 -9999.0 0.0 0.0 28.0 28.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 -0.053 0.129 0.191 9.0 -0.239 108.0 117.0 EGF 0.034 0.008 -9999.0 0.0 0.0 24.0 24.0 mol:ceramide -0.046 0.139 -9999.0 0.0 -0.248 111.0 111.0 MADD 0.035 0.006 -9999.0 0.0 0.0 13.0 13.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.013 0.011 0.0 207.0 -9999.0 0.0 207.0 ASAH1 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 negative regulation of cell cycle -0.046 0.133 0.21 10.0 -0.236 110.0 120.0 cell proliferation -0.022 0.119 0.2 5.0 -0.217 95.0 100.0 BID -0.037 0.2 -9999.0 0.0 -0.625 46.0 46.0 MAP3K1 -0.048 0.132 0.154 3.0 -0.241 108.0 111.0 EIF2A -0.053 0.12 0.189 2.0 -0.228 108.0 110.0 TRADD 0.036 0.004 -9999.0 0.0 0.0 7.0 7.0 CRADD 0.035 0.006 -9999.0 0.0 0.0 12.0 12.0 MAPK3 -0.045 0.115 0.191 9.0 -0.222 99.0 108.0 response to heat -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.054 0.126 0.187 10.0 -0.234 111.0 121.0 Cathepsin D/ceramide -0.033 0.139 -9999.0 0.0 -0.239 111.0 111.0 FADD 0.008 0.048 -9999.0 0.0 -0.214 5.0 5.0 KSR1 -0.051 0.131 -9999.0 0.0 -0.24 111.0 111.0 MAPK8 -0.084 0.16 0.161 2.0 -0.247 178.0 180.0 PRKRA -0.053 0.132 -9999.0 0.0 -0.243 111.0 111.0 PDGFA 0.021 0.018 -9999.0 0.0 0.0 201.0 201.0 TRAF2 0.035 0.006 -9999.0 0.0 0.0 14.0 14.0 IGF1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 mol:GD3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process -0.046 0.137 -9999.0 0.0 -0.246 111.0 111.0 CTSD 0.032 0.011 -9999.0 0.0 0.0 55.0 55.0 regulation of nitric oxide biosynthetic process 0.049 0.025 -9999.0 0.0 -0.141 7.0 7.0 response to radiation -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta -0.023 0.129 0.214 5.0 -0.232 95.0 100.0 PRKCD 0.034 0.01 -9999.0 0.0 0.0 36.0 36.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.013 0.011 0.0 207.0 -9999.0 0.0 207.0 RelA/NF kappa B1 0.049 0.025 -9999.0 0.0 -0.142 7.0 7.0 mol:glutathione 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR 0.035 0.006 -9999.0 0.0 0.0 13.0 13.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD 0.018 0.054 -9999.0 0.0 -0.232 6.0 6.0 TNFR1A/BAG4/TNF-alpha 0.053 0.055 -9999.0 0.0 -0.123 39.0 39.0 mol:Sphingosine-1-phosphate -0.013 0.011 0.0 211.0 -9999.0 0.0 211.0 MAP2K1 -0.057 0.123 0.176 9.0 -0.234 108.0 117.0 mol:C11AG -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.035 0.005 -9999.0 0.0 0.0 10.0 10.0 CYCS -0.013 0.085 0.13 6.0 -0.235 38.0 44.0 TNFRSF1A 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 NFKB1 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 TNFR1A/BAG4 0.034 0.054 -9999.0 0.0 -0.142 40.0 40.0 EIF2AK2 -0.056 0.126 0.197 2.0 -0.24 108.0 110.0 TNF-alpha/TNFR1A/FAN 0.047 0.066 -9999.0 0.0 -0.133 52.0 52.0 response to hydrogen peroxide 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.033 0.053 -9999.0 0.0 -0.298 5.0 5.0 MAP2K2 -0.046 0.117 0.181 21.0 -0.227 99.0 120.0 SMPD3 0.006 0.056 0.16 1.0 -0.287 7.0 8.0 TNF 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 PKC zeta/PAR4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PHOSPHOCHOLINE -0.023 0.075 0.127 7.0 -0.142 103.0 110.0 NF kappa B1/RelA/I kappa B alpha 0.07 0.045 -9999.0 0.0 -0.117 18.0 18.0 AIFM1 -0.034 0.095 0.121 2.0 -0.162 121.0 123.0 BCL2 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0