Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) -0.035 0.17 -9999.0 0.0 -0.462 64.0 64.0 HDAC1 0.026 0.034 0.08 55.0 -0.038 83.0 138.0 AES 0.033 0.013 0.068 9.0 -0.002 50.0 59.0 FBXW11 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 DTX1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRP6/FZD1 0.033 0.027 -9999.0 0.0 -0.141 1.0 1.0 TLE1 0.034 0.011 0.067 10.0 -0.006 26.0 36.0 AP1 -0.012 0.077 -9999.0 0.0 -0.206 58.0 58.0 NCSTN 0.034 0.008 -9999.0 0.0 0.0 28.0 28.0 ADAM10 0.032 0.012 -9999.0 0.0 0.0 57.0 57.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.008 0.127 -9999.0 0.0 -0.457 13.0 13.0 NICD/RBPSUH -0.041 0.167 -9999.0 0.0 -0.462 64.0 64.0 WIF1 0.028 0.015 -9999.0 0.0 0.0 106.0 106.0 NOTCH1 -0.037 0.177 -9999.0 0.0 -0.489 63.0 63.0 PSENEN 0.034 0.009 -9999.0 0.0 0.0 33.0 33.0 KREMEN2 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0 DKK1 0.018 0.018 -9999.0 0.0 0.0 240.0 240.0 beta catenin/beta TrCP1 0.057 0.093 0.232 18.0 -0.288 9.0 27.0 APH1B 0.035 0.006 -9999.0 0.0 0.0 14.0 14.0 APH1A 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 AXIN1 0.01 0.069 0.25 1.0 -0.368 1.0 2.0 CtBP/CBP/TCF1/TLE1/AES 0.013 0.073 0.172 49.0 -0.199 10.0 59.0 PSEN1 0.033 0.01 -9999.0 0.0 0.0 41.0 41.0 FOS 0.025 0.017 -9999.0 0.0 0.0 147.0 147.0 JUN 0.033 0.01 -9999.0 0.0 0.0 39.0 39.0 MAP3K7 0.032 0.017 0.062 9.0 -0.01 55.0 64.0 CTNNB1 0.044 0.088 0.215 26.0 -0.307 5.0 31.0 MAPK3 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 DKK2/LRP6/Kremen 2 0.064 0.026 -9999.0 0.0 -0.123 1.0 1.0 HNF1A 0.0 0.006 0.032 10.0 -9999.0 0.0 10.0 CTBP1 0.034 0.012 0.069 8.0 -0.005 28.0 36.0 MYC -0.08 0.364 -9999.0 0.0 -1.153 49.0 49.0 NKD1 -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 FZD1 0.025 0.017 -9999.0 0.0 0.0 155.0 155.0 NOTCH1 precursor/Deltex homolog 1 -0.041 0.167 -9999.0 0.0 -0.462 64.0 64.0 apoptosis -0.013 0.077 -9999.0 0.0 -0.204 59.0 59.0 Delta 1/NOTCHprecursor -0.041 0.167 -9999.0 0.0 -0.462 64.0 64.0 DLL1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPARD 0.02 0.066 -9999.0 0.0 -0.678 3.0 3.0 Gamma Secretase 0.076 0.073 -9999.0 0.0 -0.153 29.0 29.0 APC -0.022 0.164 -9999.0 0.0 -0.653 25.0 25.0 DVL1 0.016 0.091 -9999.0 0.0 -0.344 21.0 21.0 CSNK2A1 0.034 0.01 -9999.0 0.0 -0.001 32.0 32.0 MAP3K7IP1 0.032 0.017 0.062 10.0 -0.01 48.0 58.0 DKK1/LRP6/Kremen 2 0.033 0.037 -9999.0 0.0 -9999.0 0.0 0.0 LRP6 0.033 0.01 -9999.0 0.0 0.0 37.0 37.0 CSNK1A1 0.035 0.007 -9999.0 0.0 -0.002 13.0 13.0 NLK 0.01 0.053 0.13 1.0 -0.206 22.0 23.0 CCND1 -0.054 0.344 -9999.0 0.0 -1.129 42.0 42.0 WNT1 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 Axin1/APC/beta catenin 0.011 0.135 0.294 4.0 -0.429 26.0 30.0 DKK2 0.034 0.009 -9999.0 0.0 0.0 29.0 29.0 NOTCH1 precursor/DVL1 -0.018 0.19 -9999.0 0.0 -0.486 54.0 54.0 GSK3B 0.034 0.01 -9999.0 0.0 0.0 35.0 35.0 FRAT1 0.027 0.016 -9999.0 0.0 0.0 130.0 130.0 NOTCH/Deltex homolog 1 -0.035 0.17 -9999.0 0.0 -0.462 64.0 64.0 PPP2R5D 0.025 0.037 -9999.0 0.0 -0.25 4.0 4.0 MAPK1 0.033 0.011 -9999.0 0.0 0.0 48.0 48.0 WNT1/LRP6/FZD1 0.058 0.044 -9999.0 0.0 -9999.0 0.0 0.0 RBPJ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.032 0.021 0.07 7.0 -0.016 70.0 77.0