E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.071 -9999.0 0.0 -0.288 22.0 22.0 KLHL20 0.041 0.092 0.198 61.0 -0.194 21.0 82.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 73.0 73.0 Rac1/GDP 0.008 0.063 0.195 2.0 -0.242 15.0 17.0 ENAH 0.007 0.074 -9999.0 0.0 -0.309 20.0 20.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 56.0 -0.0 10.0 66.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42/GTP -0.024 0.05 0.119 11.0 -0.2 18.0 29.0 ABI1/Sra1/Nap1 -0.016 0.036 -9999.0 0.0 -0.134 32.0 32.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.081 0.038 -9999.0 0.0 -0.131 6.0 6.0 RAPGEF1 -0.005 0.073 0.185 3.0 -0.275 21.0 24.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 30.0 30.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.076 -9999.0 0.0 -0.289 23.0 23.0 CRK 0.002 0.075 0.197 1.0 -0.29 21.0 22.0 E-cadherin/gamma catenin/alpha catenin 0.061 0.035 -9999.0 0.0 -0.124 8.0 8.0 alphaE/beta7 Integrin 0.049 0.024 -9999.0 0.0 -0.142 6.0 6.0 IQGAP1 0.033 0.01 -9999.0 0.0 0.0 43.0 43.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 1.0 1.0 Rap1/GTP/I-afadin 0.042 0.015 -9999.0 0.0 -0.101 1.0 1.0 DLG1 0.006 0.075 -9999.0 0.0 -0.293 23.0 23.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.043 -9999.0 0.0 -0.175 28.0 28.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.102 23.0 23.0 PI3K -0.039 0.056 -9999.0 0.0 -0.225 28.0 28.0 ARF6 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 mol:Ca2+ 0.0 0.0 0.001 66.0 -0.0 26.0 92.0 E-cadherin/gamma catenin 0.047 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.033 0.01 -9999.0 0.0 0.0 43.0 43.0 E-cadherin(dimer)/Ca2+ 0.07 0.051 -9999.0 0.0 -0.141 20.0 20.0 AKT1 -0.017 0.057 0.137 13.0 -0.17 25.0 38.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 RhoA/GDP 0.012 0.071 0.237 3.0 -0.23 18.0 21.0 actin cytoskeleton organization 0.034 0.073 0.163 62.0 -0.143 21.0 83.0 CDC42/GDP 0.011 0.067 0.195 2.0 -0.228 16.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.048 -9999.0 0.0 -0.202 19.0 19.0 ITGB7 0.035 0.005 -9999.0 0.0 0.0 10.0 10.0 RAC1 0.027 0.016 -9999.0 0.0 0.0 123.0 123.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.075 0.055 -9999.0 0.0 -0.15 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.053 0.032 -9999.0 0.0 -0.111 9.0 9.0 mol:GDP -0.005 0.072 0.235 3.0 -0.261 16.0 19.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.115 32.0 32.0 JUP 0.032 0.011 -9999.0 0.0 0.0 50.0 50.0 p120 catenin/RhoA/GDP 0.025 0.077 0.249 3.0 -0.235 18.0 21.0 RAC1/GTP/IQGAP1 0.026 0.044 -9999.0 0.0 -0.117 32.0 32.0 PIP5K1C/AP1M1 0.018 0.031 -9999.0 0.0 -0.132 19.0 19.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 22.0 22.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 positive regulation of S phase of mitotic cell cycle 0.01 0.046 0.116 8.0 -0.118 34.0 42.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 30.0 30.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.008 0.073 -9999.0 0.0 -0.297 21.0 21.0 regulation of cell-cell adhesion -0.026 0.039 -9999.0 0.0 -0.166 22.0 22.0 WASF2 -0.009 0.02 -9999.0 0.0 -0.073 32.0 32.0 Rap1/GTP -0.022 0.058 0.151 16.0 -0.225 17.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.089 0.05 -9999.0 0.0 -0.129 12.0 12.0 CCND1 0.012 0.054 0.132 8.0 -0.144 34.0 42.0 VAV2 0.016 0.116 -9999.0 0.0 -0.526 13.0 13.0 RAP1/GDP -0.008 0.064 0.17 17.0 -0.234 15.0 32.0 adherens junction assembly 0.008 0.071 -9999.0 0.0 -0.289 21.0 21.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.016 -9999.0 0.0 0.0 126.0 126.0 PIP5K1C 0.032 0.012 -9999.0 0.0 0.0 58.0 58.0 regulation of heterotypic cell-cell adhesion 0.062 0.046 0.198 2.0 -0.136 12.0 14.0 E-cadherin/beta catenin 0.008 0.019 -9999.0 0.0 -0.096 6.0 6.0 mol:GTP 0.0 0.0 0.001 60.0 -0.0 30.0 90.0 SRC 0.006 0.072 -9999.0 0.0 -0.287 23.0 23.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 Rac1/GTP -0.009 0.077 0.16 4.0 -0.285 25.0 29.0 E-cadherin/beta catenin/alpha catenin 0.061 0.037 -9999.0 0.0 -0.134 9.0 9.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.019 0.077 -9999.0 0.0 -0.294 23.0 23.0