HIF-2-alpha transcription factor network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MMP14 -0.006 0.141 -9999.0 0.0 -0.646 20.0 20.0 oxygen homeostasis 0.005 0.021 0.047 64.0 -0.025 26.0 90.0 TCEB2 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0 TCEB1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 VHL/Elongin B/Elongin C/HIF2A 0.016 0.137 0.271 37.0 -0.239 41.0 78.0 EPO -0.032 0.202 0.399 20.0 -0.427 54.0 74.0 FIH (dimer) 0.018 0.039 0.108 19.0 -0.04 58.0 77.0 APEX1 0.017 0.041 0.101 8.0 -0.049 47.0 55.0 SERPINE1 -0.066 0.199 0.37 5.0 -0.455 73.0 78.0 FLT1 -0.007 0.144 -9999.0 0.0 -0.646 18.0 18.0 ADORA2A -0.023 0.232 0.444 35.0 -0.422 63.0 98.0 germ cell development -0.027 0.224 0.405 35.0 -0.411 67.0 102.0 SLC11A2 -0.02 0.243 0.46 33.0 -0.439 65.0 98.0 BHLHE40 -0.03 0.228 0.432 28.0 -0.424 67.0 95.0 HIF1AN 0.018 0.039 0.108 19.0 -0.04 58.0 77.0 HIF2A/ARNT/SIRT1 -0.007 0.159 0.322 23.0 -0.295 50.0 73.0 ETS1 0.046 0.032 0.117 41.0 -0.107 11.0 52.0 CITED2 -0.053 0.259 -9999.0 0.0 -0.858 41.0 41.0 KDR 0.002 0.159 -9999.0 0.0 -0.884 13.0 13.0 PGK1 -0.026 0.251 0.46 33.0 -0.447 72.0 105.0 SIRT1 0.026 0.017 -9999.0 0.0 0.0 143.0 143.0 response to hypoxia -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIF2A/ARNT -0.015 0.26 0.468 12.0 -0.477 67.0 79.0 EPAS1 0.007 0.132 0.276 47.0 -0.223 52.0 99.0 SP1 0.04 0.011 0.11 8.0 -9999.0 0.0 8.0 ABCG2 -0.033 0.251 0.444 35.0 -0.442 81.0 116.0 EFNA1 -0.028 0.238 0.413 35.0 -0.432 72.0 107.0 FXN -0.025 0.23 0.435 34.0 -0.423 64.0 98.0 POU5F1 -0.03 0.228 0.432 28.0 -0.424 67.0 95.0 neuron apoptosis 0.014 0.255 0.466 67.0 -0.461 12.0 79.0 EP300 0.033 0.011 -9999.0 0.0 0.0 49.0 49.0 EGLN3 0.02 0.039 0.11 16.0 -0.04 61.0 77.0 EGLN2 0.024 0.041 0.11 21.0 -0.039 63.0 84.0 EGLN1 0.025 0.041 0.109 21.0 -0.039 59.0 80.0 VHL/Elongin B/Elongin C 0.044 0.024 -9999.0 0.0 -0.115 9.0 9.0 VHL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARNT 0.018 0.041 0.101 8.0 -0.049 42.0 50.0 SLC2A1 -0.046 0.221 0.426 21.0 -0.437 70.0 91.0 TWIST1 -0.063 0.201 0.412 10.0 -0.417 83.0 93.0 ELK1 0.037 0.036 0.112 30.0 -0.094 25.0 55.0 HIF2A/ARNT/Cbp/p300 0.013 0.185 0.375 30.0 -0.311 48.0 78.0 VEGFA -0.03 0.228 0.432 28.0 -0.424 67.0 95.0 CREBBP 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0