Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.033 0.03 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.051 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.017 0.027 -9999.0 0.0 -0.11 15.0 15.0 LRPAP1 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 dorsoventral neural tube patterning -0.017 0.027 0.109 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.078 0.055 0.25 5.0 -9999.0 0.0 5.0 SMO 0.027 0.031 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.014 0.136 -9999.0 0.0 -0.472 28.0 28.0 ARRB2 0.034 0.008 -9999.0 0.0 0.0 27.0 27.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.035 0.006 -9999.0 0.0 0.0 14.0 14.0 heart looping 0.027 0.031 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.031 0.079 0.182 89.0 -9999.0 0.0 89.0 DHH N/PTCH2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.016 0.019 0.111 19.0 -9999.0 0.0 19.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.027 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 skeletal system development 0.03 0.033 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.027 0.031 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 PI3K 0.016 0.075 -9999.0 0.0 -0.155 73.0 73.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.03 0.014 -9999.0 0.0 0.0 83.0 83.0 somite specification 0.027 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.021 0.027 0.162 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol/PTCH2 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.017 0.01 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.02 0.025 0.136 21.0 -9999.0 0.0 21.0 SMO/Vitamin D3 0.023 0.035 0.185 12.0 -9999.0 0.0 12.0 SHH Np/Cholesterol/Hhip -0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.035 0.006 -9999.0 0.0 0.0 12.0 12.0 receptor-mediated endocytosis 0.024 0.038 0.177 14.0 -9999.0 0.0 14.0 SHH Np/Cholesterol/BOC -0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.055 0.074 0.192 102.0 -9999.0 0.0 102.0 IHH N/PTCH2 0.06 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 IHH N/PTCH1 0.046 0.027 0.166 19.0 -9999.0 0.0 19.0 Megalin/LRPAP1 0.048 0.028 -9999.0 0.0 -0.142 9.0 9.0 PTCH2 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0 SHH Np/Cholesterol 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.025 0.136 21.0 -9999.0 0.0 21.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0