Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.056 -9999.0 0.0 -0.222 20.0 20.0 epithelial cell differentiation 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 73.0 73.0 ENAH -0.034 0.078 0.251 15.0 -0.251 8.0 23.0 EGFR 0.01 0.016 -9999.0 0.0 0.0 355.0 355.0 EPHA2 0.032 0.011 -9999.0 0.0 0.0 53.0 53.0 MYO6 -0.025 0.053 0.174 14.0 -0.218 11.0 25.0 CTNNB1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 ABI1/Sra1/Nap1 0.031 0.066 -9999.0 0.0 -0.126 57.0 57.0 AQP5 -0.015 0.052 0.176 1.0 -0.282 7.0 8.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 30.0 30.0 mol:PI-4-5-P2 -0.025 0.049 0.173 13.0 -0.211 10.0 23.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.05 0.172 15.0 -0.193 7.0 22.0 EGF 0.034 0.008 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 1.0 1.0 AQP3 -0.029 0.076 -9999.0 0.0 -0.295 28.0 28.0 cortical microtubule organization 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 GO:0000145 -0.024 0.045 0.155 13.0 -0.202 10.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.069 0.051 -9999.0 0.0 -0.14 20.0 20.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ARF6/GDP -0.049 0.039 -9999.0 0.0 -0.226 10.0 10.0 ARF6 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 Ephrin A1/EPHA2/NCK1/GIT1 0.074 0.052 -9999.0 0.0 -0.129 21.0 21.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.025 0.082 0.171 8.0 -0.303 27.0 35.0 PVRL2 0.034 0.01 -9999.0 0.0 0.0 36.0 36.0 ZYX -0.019 0.047 0.174 11.0 -0.21 12.0 23.0 ARF6/GTP 0.079 0.057 -9999.0 0.0 -0.13 20.0 20.0 CDH1 0.033 0.01 -9999.0 0.0 0.0 37.0 37.0 EGFR/EGFR/EGF/EGF 0.001 0.057 -9999.0 0.0 -0.122 59.0 59.0 RhoA/GDP 0.062 0.054 -9999.0 0.0 -0.143 24.0 24.0 actin cytoskeleton organization -0.021 0.049 0.154 12.0 -0.227 11.0 23.0 IGF-1R heterotetramer 0.032 0.012 -9999.0 0.0 0.0 56.0 56.0 GIT1 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 IGF1R 0.032 0.012 -9999.0 0.0 0.0 56.0 56.0 IGF1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 DIAPH1 -0.11 0.266 -9999.0 0.0 -0.509 121.0 121.0 Wnt receptor signaling pathway -0.062 0.049 0.139 20.0 -9999.0 0.0 20.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 RhoA/GTP -0.05 0.041 -9999.0 0.0 -0.235 11.0 11.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 VCL -0.022 0.05 0.155 12.0 -0.232 11.0 23.0 EFNA1 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 LPP -0.027 0.05 0.161 9.0 -0.237 12.0 21.0 Ephrin A1/EPHA2 0.045 0.059 -9999.0 0.0 -0.136 34.0 34.0 SEC6/SEC8 -0.04 0.028 -9999.0 0.0 -0.142 21.0 21.0 MGAT3 -0.023 0.05 0.174 15.0 -0.195 7.0 22.0 HGF/MET 0.035 0.045 -9999.0 0.0 -0.138 11.0 11.0 HGF 0.024 0.017 -9999.0 0.0 0.0 157.0 157.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.056 -9999.0 0.0 -0.224 20.0 20.0 actin cable formation -0.033 0.105 0.298 12.0 -0.292 30.0 42.0 KIAA1543 -0.021 0.04 0.15 13.0 -0.18 7.0 20.0 KIFC3 -0.026 0.048 0.174 12.0 -0.195 7.0 19.0 NCK1 0.034 0.008 -9999.0 0.0 0.0 26.0 26.0 EXOC3 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 ACTN1 -0.024 0.053 0.174 11.0 -0.222 14.0 25.0 NCK1/GIT1 0.049 0.024 -9999.0 0.0 -0.142 6.0 6.0 mol:GDP 0.062 0.049 -9999.0 0.0 -0.139 20.0 20.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.03 0.055 22.0 -0.133 20.0 42.0 PIP5K1C -0.025 0.05 0.174 13.0 -0.214 10.0 23.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.016 -9999.0 0.0 0.0 126.0 126.0 ROCK1 -0.026 0.091 0.285 19.0 -0.291 5.0 24.0 adherens junction assembly -0.018 0.07 0.214 5.0 -0.3 13.0 18.0 IGF-1R heterotetramer/IGF1 0.048 0.059 -9999.0 0.0 -0.141 33.0 33.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.046 0.023 -9999.0 0.0 -0.142 3.0 3.0 MET 0.023 0.018 -9999.0 0.0 0.0 183.0 183.0 PLEKHA7 -0.026 0.03 0.055 22.0 -0.133 20.0 42.0 mol:GTP 0.071 0.05 -9999.0 0.0 -0.129 21.0 21.0 establishment of epithelial cell apical/basal polarity -0.032 0.044 0.127 20.0 -0.184 8.0 28.0 cortical actin cytoskeleton stabilization 0.009 0.056 -9999.0 0.0 -0.222 20.0 20.0 regulation of cell-cell adhesion -0.021 0.049 0.154 12.0 -0.227 11.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.056 -9999.0 0.0 -0.224 20.0 20.0