S1P1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.018 0.05 -9999.0 0.0 -0.183 25.0 25.0 PDGFRB 0.035 0.009 -9999.0 0.0 -0.001 26.0 26.0 SPHK1 0.018 0.021 -9999.0 0.0 -9999.0 0.0 0.0 mol:S1P 0.019 0.028 -9999.0 0.0 -9999.0 0.0 0.0 S1P1/S1P/Gi -0.005 0.14 0.239 11.0 -0.433 30.0 41.0 GNAO1 0.032 0.015 0.063 1.0 0.0 81.0 82.0 PDGFB-D/PDGFRB/PLCgamma1 0.023 0.143 0.248 21.0 -0.361 33.0 54.0 PLCG1 -0.011 0.129 0.221 13.0 -0.394 31.0 44.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.035 0.009 -9999.0 0.0 -0.001 26.0 26.0 GNAI2 0.035 0.012 -9999.0 0.0 0.0 42.0 42.0 GNAI3 0.037 0.007 -9999.0 0.0 0.0 12.0 12.0 GNAI1 0.019 0.019 -9999.0 0.0 0.0 245.0 245.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 0.011 0.072 0.118 2.0 -0.267 25.0 27.0 S1P1/S1P 0.026 0.073 0.215 3.0 -0.266 14.0 17.0 negative regulation of cAMP metabolic process -0.004 0.137 0.238 11.0 -0.421 30.0 41.0 MAPK3 -0.006 0.135 0.256 12.0 -0.421 28.0 40.0 calcium-dependent phospholipase C activity 0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.018 0.02 -9999.0 0.0 -0.132 6.0 6.0 RhoA/GDP 0.024 0.019 -9999.0 0.0 -0.132 7.0 7.0 KDR 0.028 0.033 0.091 1.0 -0.127 15.0 16.0 PLCB2 0.033 0.082 0.22 13.0 -0.249 14.0 27.0 RAC1 0.027 0.016 -9999.0 0.0 0.0 123.0 123.0 RhoA/GTP 0.018 0.063 -9999.0 0.0 -0.239 14.0 14.0 receptor internalization 0.024 0.069 0.205 3.0 -0.252 14.0 17.0 PTGS2 0.028 0.15 0.349 10.0 -0.432 20.0 30.0 Rac1/GTP 0.013 0.055 -9999.0 0.0 -0.263 9.0 9.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 VEGFA -0.001 0.021 -9999.0 0.0 -0.098 20.0 20.0 negative regulation of T cell proliferation -0.004 0.137 0.238 11.0 -0.421 30.0 41.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.032 0.015 -9999.0 0.0 0.0 79.0 79.0 MAPK1 -0.002 0.134 0.27 10.0 -0.442 24.0 34.0 S1P1/S1P/PDGFB-D/PDGFRB 0.049 0.096 0.261 7.0 -0.281 18.0 25.0 ABCC1 0.036 0.008 -9999.0 0.0 0.0 19.0 19.0