PDGFR-beta signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations S1P1/Sphingosine-1-phosphate 0.03 0.112 0.342 10.0 -0.32 21.0 31.0 PDGFB-D/PDGFRB/SLAP 0.018 0.073 -9999.0 0.0 -0.156 67.0 67.0 PDGFB-D/PDGFRB/APS/CBL 0.044 0.024 -9999.0 0.0 -0.118 8.0 8.0 AKT1 -0.022 0.095 0.235 24.0 -0.234 16.0 40.0 mol:PI-4-5-P2 -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Sphingosine-1-phosphate 0.021 0.106 0.311 9.0 -0.356 19.0 28.0 PIK3CA 0.03 0.014 -9999.0 0.0 0.0 85.0 85.0 FGR 0.004 0.096 0.269 2.0 -0.506 11.0 13.0 mol:Ca2+ 0.012 0.105 0.256 11.0 -0.38 20.0 31.0 MYC -0.003 0.256 0.383 25.0 -0.66 52.0 77.0 SHC1 0.033 0.011 -9999.0 0.0 0.0 48.0 48.0 HRAS/GDP 0.013 0.064 0.174 20.0 -0.18 13.0 33.0 LRP1/PDGFRB/PDGFB 0.047 0.056 -9999.0 0.0 -0.137 31.0 31.0 GRB10 0.022 0.018 -9999.0 0.0 0.0 185.0 185.0 PTPN11 0.036 0.005 -9999.0 0.0 0.0 9.0 9.0 GO:0007205 0.012 0.106 0.261 10.0 -0.385 20.0 30.0 PTEN 0.026 0.016 -9999.0 0.0 0.0 130.0 130.0 GRB2 0.035 0.006 -9999.0 0.0 0.0 16.0 16.0 GRB7 0.035 0.006 -9999.0 0.0 0.0 13.0 13.0 PDGFB-D/PDGFRB/SHP2 0.046 0.035 -9999.0 0.0 -0.144 14.0 14.0 PDGFB-D/PDGFRB/GRB10 0.021 0.054 -9999.0 0.0 -0.146 36.0 36.0 cell cycle arrest 0.018 0.073 -9999.0 0.0 -0.156 67.0 67.0 HRAS 0.034 0.009 -9999.0 0.0 0.0 32.0 32.0 HIF1A -0.027 0.088 0.213 24.0 -0.239 15.0 39.0 GAB1 0.009 0.125 0.292 10.0 -0.376 28.0 38.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNM2 0.01 0.123 0.304 17.0 -0.334 27.0 44.0 PDGFB-D/PDGFRB 0.054 0.053 -9999.0 0.0 -0.135 14.0 14.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB/LMW-PTP 0.043 0.041 -9999.0 0.0 -0.145 20.0 20.0 S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB 0.025 0.118 0.305 4.0 -0.281 34.0 38.0 positive regulation of MAPKKK cascade 0.046 0.035 -9999.0 0.0 -0.144 14.0 14.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 61.0 61.0 mol:IP3 0.012 0.107 0.263 10.0 -0.388 20.0 30.0 E5 -0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CSK 0.034 0.011 -9999.0 0.0 -0.01 25.0 25.0 PDGFB-D/PDGFRB/GRB7 0.049 0.024 -9999.0 0.0 -0.145 5.0 5.0 SHB 0.033 0.011 -9999.0 0.0 0.0 48.0 48.0 BLK 0.012 0.075 0.26 3.0 -0.423 7.0 10.0 PTPN2 0.033 0.015 -9999.0 0.0 -0.017 36.0 36.0 PDGFB-D/PDGFRB/SNX15 0.049 0.027 -9999.0 0.0 -0.141 8.0 8.0 BCAR1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 -0.005 0.156 0.293 14.0 -0.392 48.0 62.0 CBL 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 PDGFB-D/PDGFRB/DEP1 0.048 0.028 -9999.0 0.0 -0.143 8.0 8.0 LCK 0.014 0.063 0.255 3.0 -0.339 5.0 8.0 PDGFRB 0.031 0.021 0.061 2.0 -0.018 68.0 70.0 ACP1 0.034 0.008 -9999.0 0.0 0.0 28.0 28.0 HCK -0.043 0.182 -9999.0 0.0 -0.506 57.0 57.0 ABL1 0.004 0.115 0.281 9.0 -0.344 28.0 37.0 PDGFB-D/PDGFRB/CBL 0.008 0.134 0.304 6.0 -0.435 26.0 32.0 PTPN1 0.032 0.016 -9999.0 0.0 -0.013 46.0 46.0 SNX15 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 STAT3 0.033 0.01 -9999.0 0.0 0.0 37.0 37.0 STAT1 0.033 0.01 -9999.0 0.0 0.0 40.0 40.0 cell proliferation 0.005 0.235 0.364 28.0 -0.589 52.0 80.0 SLA 0.027 0.016 -9999.0 0.0 0.0 122.0 122.0 actin cytoskeleton reorganization -0.016 0.069 0.204 29.0 -0.194 7.0 36.0 SRC 0.017 0.049 0.308 1.0 -9999.0 0.0 1.0 PI3K -0.047 0.045 -9999.0 0.0 -0.177 30.0 30.0 PDGFB-D/PDGFRB/GRB7/SHC 0.06 0.037 -9999.0 0.0 -0.125 10.0 10.0 SH2B2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCgamma1/SPHK1 0.021 0.108 0.315 9.0 -0.367 19.0 28.0 LYN -0.034 0.16 0.221 2.0 -0.467 50.0 52.0 LRP1 0.031 0.013 -9999.0 0.0 0.0 68.0 68.0 SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT5B 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 STAT5A 0.036 0.004 -9999.0 0.0 0.0 6.0 6.0 NCK1-2/p130 Cas 0.065 0.065 -9999.0 0.0 -0.138 25.0 25.0 SPHK1 0.033 0.011 0.059 2.0 0.0 47.0 49.0 EDG1 0.034 0.011 0.059 2.0 0.0 38.0 40.0 mol:DAG 0.012 0.107 0.263 10.0 -0.388 20.0 30.0 PLCG1 0.011 0.109 0.279 8.0 -0.407 19.0 27.0 NHERF/PDGFRB 0.062 0.037 -9999.0 0.0 -0.124 12.0 12.0 YES1 -0.009 0.131 0.233 3.0 -0.527 24.0 27.0 cell migration 0.061 0.037 -9999.0 0.0 -0.124 12.0 12.0 SHC/Grb2/SOS1 0.067 0.06 -9999.0 0.0 -0.135 18.0 18.0 SLC9A3R2 0.036 0.004 -9999.0 0.0 0.0 5.0 5.0 SLC9A3R1 0.034 0.009 -9999.0 0.0 0.0 34.0 34.0 NHERF1-2/PDGFRB/PTEN 0.059 0.054 -9999.0 0.0 -0.115 13.0 13.0 FYN -0.053 0.187 0.222 1.0 -0.452 75.0 76.0 DOK1 -0.018 0.05 0.173 21.0 -0.129 3.0 24.0 HRAS/GTP 0.021 0.029 -9999.0 0.0 -0.132 16.0 16.0 PDGFB 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 RAC1 0.017 0.188 0.33 29.0 -0.427 51.0 80.0 PRKCD -0.015 0.051 0.175 22.0 -0.131 4.0 26.0 FER -0.016 0.051 0.175 20.0 -0.133 4.0 24.0 MAPKKK cascade -0.011 0.064 0.162 43.0 -0.172 5.0 48.0 RASA1 -0.016 0.052 0.175 21.0 -0.178 5.0 26.0 NCK1 0.034 0.008 -9999.0 0.0 0.0 26.0 26.0 NCK2 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 p62DOK/Csk -0.013 0.059 0.18 22.0 -0.196 3.0 25.0 PDGFB-D/PDGFRB/SHB 0.045 0.028 -9999.0 0.0 -0.142 6.0 6.0 chemotaxis 0.004 0.113 0.269 10.0 -0.336 28.0 38.0 STAT1-3-5/STAT1-3-5 0.06 0.072 -9999.0 0.0 -0.134 39.0 39.0 Bovine Papilomavirus E5/PDGFRB 0.02 0.026 -9999.0 0.0 -0.139 8.0 8.0 PTPRJ 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0