rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p q 1 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTN2(2), AKT1(2), AKT2(2), ARHGAP5(1), BCAR1(2), BIRC2(2), BIRC3(1), BRAF(3), CCND2(1), CHAD(1), COL11A1(2), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), DIAPH1(1), DOCK1(1), EGF(1), EGFR(4), ERBB2(3), FARP2(2), FIGF(2), FLNA(2), FLNB(1), FLNC(3), FLT1(2), FN1(2), FYN(1), GRLF1(2), GSK3B(1), HGF(1), HRAS(2), ILK(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), JUN(1), KDR(2), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), MAPK10(1), MAPK9(1), MET(1), MYL7(1), MYL9(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PARVG(1), PDGFD(1), PDGFRA(3), PGF(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP5K1C(1), PRKCG(2), PTEN(11), PTK2(1), RELN(3), ROCK1(2), SOS1(4), SOS2(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TLN1(3), TLN2(4), TNC(2), TNN(2), TNR(3), TNXB(1), VAV1(1), VAV3(1), VCL(1), VEGFA(1), VTN(1), VWF(5) 181072482 223 145 223 95 26 61 92 10 34 0 <1.00e-15 <2.05e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2S2(1), FLT1(2), FLT4(3), HIF1A(1), HRAS(2), KDR(2), NOS3(1), PIK3CA(8), PIK3R1(2), PLCG1(1), PTK2(1), VHL(102) 16366258 131 119 100 14 7 21 31 6 66 0 <1.00e-15 <2.05e-13 3 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(2), EP300(3), HIF1A(1), JUN(1), NOS3(1), VHL(102) 8099514 111 104 80 6 2 13 26 5 65 0 <1.00e-15 <2.05e-13 4 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC4(1), CDC27(1), CUL1(2), CUL3(1), FBXW11(1), FBXW7(3), SMURF2(2), TCEB1(1), UBA1(1), UBE2E2(1), VHL(102), WWP2(1) 19910346 120 109 89 8 1 14 32 6 67 0 1.18e-14 1.45e-12 5 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTN2(2), AKT1(2), AKT2(2), ASH1L(2), CDK4(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), EPB41(1), EPB41L2(2), EPB41L3(2), EXOC4(2), F11R(1), HCLS1(1), HRAS(2), INADL(2), LLGL1(1), LLGL2(1), MAGI1(2), MAGI2(1), MAGI3(1), MLLT4(1), MPDZ(3), MRAS(1), MYH1(4), MYH10(2), MYH11(5), MYH13(2), MYH14(2), MYH2(5), MYH3(3), MYH4(2), MYH6(3), MYH7(2), MYH7B(2), MYH8(1), MYH9(2), MYL7(1), MYL9(1), PARD3(1), PARD6B(1), PPM1J(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PPP2R3A(2), PPP2R4(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PTEN(11), SPTAN1(1), TJP1(1), TJP2(1), ZAK(1) 95510705 121 100 121 61 9 38 40 6 28 0 1.19e-14 1.45e-12 6 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(2), ASH2L(1), DOT1L(2), EHMT2(2), EZH1(1), EZH2(2), FBXO11(2), HCFC1(1), HSF4(1), JMJD6(4), KDM6A(3), MLL(1), MLL2(6), MLL3(9), MLL4(2), MLL5(4), NSD1(2), OGT(3), PRDM9(2), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), RBBP5(2), SETD1A(1), SETD2(26), SETDB1(1), SETMAR(1), SUV420H1(1), SUZ12(2), WHSC1(1), WHSC1L1(4) 59129401 95 82 95 30 8 22 26 3 36 0 1.41e-14 1.45e-12 7 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(1), ACTN2(2), APC(5), APC2(3), ARHGEF7(1), ARPC2(1), ARPC3(1), BCAR1(2), BDKRB1(1), BRAF(3), CHRM2(1), CHRM5(2), CSK(1), CYFIP1(2), CYFIP2(1), DIAPH1(1), DIAPH2(1), DIAPH3(1), DOCK1(1), EGF(1), EGFR(4), F2(2), FGD1(3), FGF20(1), FGF6(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(1), FN1(2), GIT1(2), GNA13(1), GNG12(1), GRLF1(2), HRAS(2), IQGAP1(1), IQGAP2(1), IQGAP3(3), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGAE(2), ITGAL(2), ITGAX(1), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), LIMK2(1), MRAS(1), MSN(2), MYH10(2), MYH14(2), MYH9(2), MYL7(1), MYL9(1), MYLK(2), NCKAP1(1), NCKAP1L(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDGFRA(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP4K2A(2), PIP5K1C(1), PPP1R12B(1), PTK2(1), ROCK1(2), SLC9A1(1), SOS1(4), SOS2(2), SSH2(2), SSH3(1), TIAM1(2), TIAM2(2), VAV1(1), VAV3(1), VCL(1), WASL(2) 137704604 152 114 152 62 14 41 68 3 26 0 1.97e-13 1.73e-11 8 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(2), EIF4G3(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), PTEN(11), RPS6KB1(2), TSC1(2), TSC2(2) 13388837 38 37 38 11 6 12 8 2 10 0 3.76e-12 2.89e-10 9 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3C3(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(2), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PTEN(11), PTPMT1(1), SYNJ1(4) 36528872 61 53 61 23 5 18 18 1 17 2 4.55e-12 3.12e-10 10 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(2), ILK(1), PDK1(1), PIK3CA(8), PIK3CD(1), PTEN(11), PTK2B(2), RBL2(1), SOS1(4) 9973858 33 32 33 8 4 10 11 1 7 0 1.59e-11 9.04e-10 11 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(2), ILK(1), ITGB1(2), PIK3CA(8), PIK3R1(2), PTEN(11), PTK2(1), SOS1(4) 9384222 33 31 33 11 7 8 11 0 7 0 1.71e-11 9.04e-10 12 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(2), CD19(1), CDKN2A(1), GAB1(1), ITPR1(1), ITPR2(4), ITPR3(1), PDK1(1), PHF11(1), PIK3CA(8), PLCG2(1), PPP1R13B(1), PREX1(3), PTEN(11), PTPRC(4), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SAG(1), SYK(1), TEC(1), VAV1(1) 27392091 52 50 52 16 6 14 16 2 14 0 1.76e-11 9.04e-10 13 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY2(1), ADCY7(1), ADCY8(4), ADCY9(2), ADORA2A(1), ADRB2(1), ATP2A1(2), ATP2A2(2), ATP2B3(1), ATP2B4(1), AVPR1A(2), BDKRB1(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1F(3), CACNA1H(3), CACNA1I(3), CACNA1S(1), CALM2(1), CAMK2G(2), CCKAR(2), CCKBR(1), CD38(1), CHRM2(1), CHRM5(2), CHRNA7(1), DRD1(1), EGFR(4), ERBB2(3), ERBB3(3), ERBB4(3), GNAL(1), GNAS(1), GRIN1(1), GRIN2A(3), GRM1(1), GRM5(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), MYLK(2), NOS1(5), NOS3(1), NTSR1(1), P2RX1(1), PDE1B(2), PDE1C(1), PDGFRA(3), PHKA1(1), PHKB(2), PHKG1(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCG(2), PTAFR(1), PTGFR(1), PTK2B(2), RYR1(3), RYR2(3), RYR3(3), SLC25A4(1), SLC8A1(1), SLC8A3(1), SPHK2(1), TACR1(1), TACR2(1), TACR3(2), TRPC1(1), VDAC3(1) 134793666 145 121 145 59 14 44 59 5 23 0 5.01e-11 2.37e-09 14 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 ATM(8), ATR(4), BAI1(1), CASP8(1), CCNB2(2), CCNB3(2), CCND2(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK2(1), IGFBP3(1), LRDD(1), PTEN(11), RFWD2(3), RRM2(1), SERPINB5(2), THBS1(4), TP53(11), TP53I3(3), TSC2(2) 31385324 63 52 63 29 5 14 27 2 15 0 2.56e-10 1.12e-08 15 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2S2(1), EIF4E(1), GSK3B(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), PTEN(11), RPS6KB1(2) 9695885 30 29 30 11 7 7 7 0 9 0 5.08e-10 2.09e-08 16 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(2), EIF4G3(1), GHR(1), IRS1(1), PABPC1(1), PIK3CA(8), PIK3R1(2), PTEN(11), RPS6KB1(2) 13691797 35 34 35 18 6 11 8 1 9 0 5.74e-10 2.21e-08 17 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(3), AKT1(2), ATM(8), CDKN1A(1), CPB2(1), HIF1A(1), IGFBP3(1), NFKBIB(1), TP53(11) 9764779 29 25 29 12 2 7 12 0 8 0 1.08e-09 3.90e-08 18 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(2), AKT2(2), ARHGAP1(1), ARHGEF11(1), ITPR1(1), ITPR2(4), ITPR3(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPP1R13B(1), PTEN(11), RACGAP1(1), ROCK1(2), SAG(1), WASL(2) 34824775 53 53 53 16 6 13 22 2 10 0 1.91e-09 6.54e-08 19 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN2(2), ARHGAP5(1), BCAR1(2), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), CTNND1(3), F11R(1), GRLF1(2), ITGAL(2), ITGB1(2), ITK(2), MLLT4(1), MSN(2), MYL7(1), MYL9(1), NCF1(1), NOX1(1), NOX3(2), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PRKCG(2), PTK2(1), PTK2B(2), PTPN11(1), RAPGEF3(2), RAPGEF4(1), RASSF5(1), ROCK1(2), VAV1(1), VAV3(1), VCAM1(1), VCL(1) 61394465 76 59 76 28 9 19 29 2 17 0 2.16e-09 6.77e-08 20 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTN2(2), ACVR1B(3), ACVR1C(2), CDH1(2), CREBBP(3), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(3), CTNND1(3), EGFR(4), EP300(3), ERBB2(3), FARP2(2), FER(2), FGFR1(1), FYN(1), INSR(4), IQGAP1(1), LMO7(3), MAP3K7(1), MET(1), MLLT4(1), PARD3(1), PTPRB(2), PTPRF(3), PTPRJ(4), PTPRM(1), PVRL3(2), SMAD2(1), SMAD4(4), SNAI1(1), SNAI2(1), SORBS1(1), SSX2IP(1), TCF7(2), TGFBR2(2), TJP1(1), VCL(1), WASL(2) 58917089 82 69 81 29 7 26 30 6 13 0 2.20e-09 6.77e-08 21 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(2), AKT1(2), AKT2(2), ATF4(1), BRAF(3), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1F(3), CACNA1H(3), CACNA1I(3), CACNA1S(1), CACNA2D1(1), CACNB1(1), CACNG3(1), CACNG5(1), DAXX(2), DUSP10(1), DUSP3(1), DUSP8(1), ECSIT(2), EGF(1), EGFR(4), ELK4(2), FGF20(1), FGF6(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(1), FLNA(2), FLNB(1), FLNC(3), GNG12(1), HRAS(2), IL1R2(1), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(1), MAPT(1), MAX(2), MKNK2(2), MRAS(1), NF1(13), NFATC2(1), NTRK2(1), PAK1(1), PDGFRA(3), PLA2G12A(1), PLA2G6(2), PPM1A(1), PPP3CC(1), PPP5C(2), PRKACA(1), PRKACB(1), PRKCG(2), PTPN7(1), RAPGEF2(5), RASGRF1(1), RASGRF2(1), RASGRP2(2), RASGRP4(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), SOS1(4), SOS2(2), STK3(1), TAOK2(2), TAOK3(1), TGFB2(1), TGFB3(1), TGFBR2(2), TNFRSF1A(1), TP53(11), TRAF6(1), ZAK(1) 143082331 176 122 176 63 22 46 71 8 29 0 7.13e-09 2.09e-07 22 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(3), DAXX(2), HRAS(2), PAX3(1), PML(2), RARA(2), RB1(3), SIRT1(1), SP100(1), TNFRSF1A(1), TP53(11) 9260127 29 25 29 14 1 9 14 1 4 0 8.26e-09 2.27e-07 23 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), INPP4A(1), INPP4B(2), INPP5A(1), INPP5B(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), OCRL(2), PI4KA(2), PI4KB(2), PIK3C2G(1), PIK3C3(3), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PIP4K2A(2), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(1), PLCG1(1), PLCG2(1), PRKCG(2), PTEN(11), PTPMT1(1), SYNJ1(4) 62161116 77 66 77 31 8 22 26 1 18 2 8.49e-09 2.27e-07 24 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(2), AKT2(2), CDKN2A(1), GSK3A(2), GSK3B(1), IARS(1), PDK1(1), PIK3CA(8), PPP1R13B(1), PTEN(11), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SOS1(4), SOS2(2), TEC(1), YWHAE(1) 17696060 43 37 43 14 6 11 15 1 10 0 1.50e-08 3.85e-07 25 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(2), AKT1(2), AKT2(2), ATM(8), BIRC2(2), BIRC3(1), CAPN1(1), CASP10(2), CASP7(1), CASP8(1), CSF2RB(1), IL3(1), IRAK1(2), IRAK3(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPP3CC(1), PRKACA(1), PRKACB(1), RELA(1), RIPK1(1), TNFRSF10A(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1) 40823160 63 55 63 22 8 17 27 0 11 0 5.17e-08 1.27e-06 26 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 86 AGRN(2), CD44(2), CHAD(1), COL11A1(2), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), FN1(2), FNDC1(2), GP1BA(1), HSPG2(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), RELN(3), SV2C(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TNC(2), TNN(2), TNR(3), TNXB(1), VTN(1), VWF(5) 109979156 116 94 116 53 17 30 42 8 19 0 9.10e-08 2.16e-06 27 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(1), ADORA2A(1), ADRB2(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(1), CHRM2(1), CHRM5(2), CNR2(1), CRHR2(1), DRD1(1), DRD5(1), F2(2), GABBR1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(1), GABRB3(1), GABRE(3), GABRG2(2), GABRQ(3), GABRR1(2), GABRR2(2), GH2(1), GHR(1), GIPR(1), GLP2R(1), GLRA1(1), GPR35(1), GPR50(1), GPR63(1), GPR83(1), GRIA1(5), GRIA2(1), GRIA4(3), GRID2(5), GRIK1(1), GRIK2(1), GRIK3(1), GRIK5(1), GRIN1(1), GRIN2A(3), GRIN2B(4), GRIN3B(2), GRM1(1), GRM2(2), GRM3(1), GRM4(1), GRM5(1), GRM7(1), GRM8(1), GZMA(1), HRH4(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), LEPR(1), LTB4R(1), MAS1(1), MC3R(1), MCHR2(3), NMBR(1), NPFFR2(1), NPY1R(1), NTSR1(1), OPRD1(1), OPRM1(1), P2RX1(1), P2RY10(2), P2RY13(1), P2RY2(1), PARD3(1), PRLR(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1), SSTR1(2), SSTR4(1), TAAR2(1), TACR1(1), TACR2(1), TACR3(2), THRA(1), TSHR(1) 107023493 128 104 128 41 12 34 59 5 18 0 1.03e-07 2.35e-06 28 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(2), TP53(11), WT1(3) 3400893 16 13 16 6 0 5 8 0 3 0 1.90e-07 4.19e-06 29 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(4), CHEK2(1), TP53(11) 7847444 24 21 24 16 0 7 10 1 6 0 2.87e-07 6.09e-06 30 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25A(1), CDK2(1), CDK4(1), RB1(3), TP53(11), WEE1(1) 8766252 26 21 26 18 0 7 12 0 7 0 5.13e-07 0.000011 31 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(2), AKT1(2), AKT2(2), BRAF(3), BTC(1), CAMK2G(2), CBL(1), CBLB(1), CDKN1A(1), EGF(1), EGFR(4), ERBB2(3), ERBB3(3), ERBB4(3), GAB1(1), GSK3B(1), HRAS(2), JUN(1), MAP2K7(1), MAPK10(1), MAPK9(1), NRG1(3), NRG2(1), NRG3(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PRKCG(2), PTK2(1), RPS6KB1(2), SOS1(4), SOS2(2), STAT5B(1) 50497577 78 63 78 31 9 25 31 1 12 0 6.43e-07 0.000013 32 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(8), ATR(4), CCNA1(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), GSK3B(1), RB1(3), TGFB2(1), TGFB3(1), TP53(11) 14731285 36 29 36 23 1 13 14 0 8 0 7.93e-07 0.000015 33 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(8), CDK2(1), CDK4(1), CDKN1A(1), PCNA(1), RB1(3), TP53(11) 9019902 26 21 26 16 0 7 12 0 7 0 1.29e-06 0.000024 34 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(2), BRAF(3), FIGF(2), HIF1A(1), PGF(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), RHEB(1), RICTOR(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), RPS6KB1(2), TSC1(2), TSC2(2), ULK3(2), VEGFA(1) 25649478 45 40 45 13 6 13 14 2 10 0 1.40e-06 0.000025 35 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), TP53(11) 3928038 16 14 16 6 0 6 7 0 3 0 1.56e-06 0.000027 36 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(2), BRD4(4), CBL(1), CDKN2A(1), GSK3A(2), GSK3B(1), IRS1(1), LNPEP(2), PARD3(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PTEN(11), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SORBS1(1), SOS1(4), SOS2(2), YWHAE(1) 28176180 53 45 53 19 9 17 15 1 11 0 2.11e-06 0.000035 37 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), DOCK1(1), GAB1(1), HGF(1), HRAS(2), ITGA1(1), ITGB1(2), JUN(1), MAP4K1(1), MET(1), PAK1(1), PIK3CA(8), PIK3R1(2), PTEN(11), PTK2(1), PTK2B(2), PTPN11(1), SOS1(4) 22271504 42 39 42 23 9 8 18 0 7 0 2.12e-06 0.000035 38 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(2), CDK2(1), CDKN2A(1), CREB5(1), ERBB4(3), GAB1(1), GSK3A(2), GSK3B(1), IRS1(1), MET(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PARD3(1), PDK1(1), PIK3CA(8), PIK3CD(1), PPP1R13B(1), PREX1(3), PTEN(11), PTK2(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), SOS1(4), SOS2(2), TSC1(2), TSC2(2), YWHAE(1) 36771409 64 56 64 20 7 18 25 3 11 0 2.14e-06 0.000035 39 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(5), APC2(3), AXIN1(1), CACYBP(1), CAMK2G(2), CCND2(1), CHD8(1), CREBBP(3), CSNK2A2(1), CUL1(2), CXXC4(1), DKK2(1), EP300(3), FBXW11(1), FZD1(2), FZD10(1), FZD4(1), FZD5(1), GSK3B(1), JUN(1), LRP5(1), LRP6(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFAT5(1), NFATC2(1), NFATC3(2), NKD1(1), PLCB1(1), PLCB2(1), PLCB4(3), PORCN(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PPP3CC(1), PRICKLE1(1), PRKACA(1), PRKACB(1), PRKCG(2), ROCK1(2), SFRP1(2), SFRP4(1), SMAD2(1), SMAD4(4), TBL1X(1), TBL1XR1(2), TBL1Y(1), TCF7(2), TP53(11), VANGL1(1), VANGL2(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1) 78363864 92 75 90 52 1 33 37 0 21 0 2.45e-06 0.000039 40 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 AKT1(2), AKT2(2), ARHGEF7(1), BCAR1(2), BRAF(3), CDKN2A(1), CSE1L(1), DOCK1(1), EPHB2(1), FYN(1), GRB7(1), GRLF1(2), ILK(1), ITGA1(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PIK3CA(8), PIK3CB(1), PLCG1(1), PLCG2(1), PTEN(11), PTK2(1), ROCK1(2), SOS1(4), SOS2(2), TLN1(3), TLN2(4) 60131238 81 64 81 34 8 23 35 2 13 0 4.93e-06 0.000076 41 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(3), AKT1(2), AURKB(1), BMPR2(2), BUB1(1), CDKL2(1), CDS2(1), CLK2(1), CLK4(1), CSNK2A2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), INPP4A(1), INPP4B(2), INPP5A(1), ITPKA(1), ITPKB(1), MAP3K10(1), NEK3(2), OCRL(2), PAK4(2), PIK3C2G(1), PIK3CA(8), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2) 56129176 74 62 74 20 8 23 24 2 17 0 5.83e-06 0.000088 42 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(1), CADM1(1), CD22(2), CD274(1), CD34(1), CD4(1), CDH1(2), CDH2(1), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN2(2), CLDN4(1), CNTN1(3), CNTNAP1(3), CNTNAP2(3), F11R(1), GLG1(2), HLA-B(1), HLA-C(1), HLA-DMB(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(3), HLA-E(1), HLA-F(1), ITGA6(2), ITGA8(1), ITGA9(2), ITGAL(2), ITGB1(2), ITGB7(1), L1CAM(1), MPZL1(1), NCAM2(2), NEGR1(2), NEO1(1), NFASC(3), NRXN1(5), NRXN2(1), NRXN3(2), PTPRC(4), PTPRF(3), PTPRM(1), PVRL3(2), SELE(3), SELP(1), SELPLG(3), VCAM1(1), VCAN(2) 71331516 94 78 94 36 14 25 35 9 11 0 9.22e-06 0.00014 43 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(2), GOT2(3), TYR(2) 2303193 9 9 9 0 1 2 2 1 3 0 0.000012 0.00017 44 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), AGMAT(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH4A1(1), AOC2(1), ARG1(1), CPS1(5), DAO(1), GATM(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), NOS1(5), NOS3(1), P4HA1(2), P4HA2(1), SMS(1) 21376576 38 35 38 10 3 9 16 3 7 0 0.000015 0.00021 45 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC2(1), ARPC3(1), PAK1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), WASL(2) 6603789 18 18 18 9 3 6 6 0 3 0 0.000021 0.00029 46 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1B(1), ADHFE1(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOX1(5), DBH(2), DCT(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), TH(1), TPO(1), TYR(2) 15283136 30 27 30 6 4 4 10 6 6 0 0.000023 0.00031 47 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), ATM(8), CASP7(1), PTK2(1), STAT1(3), TLN1(3), TP53(11) 13620350 29 25 29 15 1 9 14 0 5 0 0.000024 0.00032 48 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNGR1(1), IFNGR2(1), JAK2(2), RB1(3), RELA(1), TNFRSF1A(1), TP53(11), WT1(3) 8869567 23 20 23 14 0 8 12 0 3 0 0.000036 0.00046 49 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CDK2(1), CDK4(1), CDKN1A(1), HRAS(2), PAK1(1), PIK3CA(8), PIK3R1(2), RB1(3), RELA(1) 10015364 22 22 22 12 3 10 6 0 3 0 0.000037 0.00046 50 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), GOT1(2), GOT2(3), LDHB(1), LDHC(1), MPST(1) 3269686 10 10 10 1 1 2 3 0 4 0 0.000046 0.00056 51 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC1(3), ANAPC4(1), ATM(8), ATR(4), BUB1(1), CCNA1(2), CCNB2(2), CCNB3(2), CCND2(1), CDC14A(2), CDC25A(1), CDC27(1), CDC6(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), CHEK2(1), CREBBP(3), CUL1(2), EP300(3), ESPL1(3), GSK3B(1), MAD2L1(1), MCM2(3), MCM6(2), MCM7(1), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(1), PRKDC(2), RB1(3), RBL2(1), SMAD2(1), SMAD4(4), SMC1A(1), SMC1B(1), TGFB2(1), TGFB3(1), TP53(11), WEE1(1), YWHAE(1) 67464805 87 66 87 49 5 25 34 4 19 0 0.000055 0.00066 52 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(4), BRCA1(1), CDC25A(1), CDKN1A(1), CHEK2(1), EP300(3), PRKDC(2), RPS6KA1(1), TP53(11), WEE1(1) 21282878 34 31 34 22 0 11 14 1 8 0 0.000059 0.00070 53 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(8), BRCA1(1), CDKN1A(1), CHEK2(1), JUN(1), RAD50(4), RELA(1), TP53(11) 14500017 28 25 28 18 0 6 15 1 6 0 0.000073 0.00085 54 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY8(4), ATF4(1), BRAF(3), CACNA1C(5), CALM2(1), CAMK2G(2), CREBBP(3), EP300(3), GRIA1(5), GRIA2(1), GRIN1(1), GRIN2A(3), GRIN2B(4), GRM1(1), GRM5(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), PLCB1(1), PLCB2(1), PLCB4(3), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCG(2), RAPGEF3(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3) 50350448 64 58 64 26 4 22 23 2 13 0 0.000077 0.00088 55 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), CACNA1C(5), CACNA1D(4), CACNA1F(3), CACNA1S(1), CALM2(1), CAMK2G(2), EGFR(4), GNAS(1), GNRH2(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K3(1), MAP3K4(3), MAPK10(1), MAPK9(1), PLA2G12A(1), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB4(3), PLD1(1), PLD2(1), PRKACA(1), PRKACB(1), PRKCD(2), PTK2B(2), SOS1(4), SOS2(2) 63917816 75 65 75 23 5 21 35 1 13 0 0.000082 0.00092 56 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(5), AXIN1(1), FZD1(2), GSK3B(1), IRAK1(2), LBP(2), PIK3CA(8), PIK3R1(2), PPP2CA(2), RELA(1), TLR4(1) 14626234 29 28 29 15 4 10 11 0 4 0 0.00011 0.0012 57 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 CHAD(1), COL11A1(2), COL17A1(1), COL1A2(6), COL2A1(3), COL4A1(1), COL4A4(2), COL4A6(2), COL5A1(2), COL5A2(1), COL5A3(2), COL6A3(5), COL6A6(5), DSC2(1), DSC3(1), DSG1(2), DSG2(1), DSG3(1), DSG4(1), FN1(2), GJA4(1), GJA8(1), GJB6(1), GJC2(1), GJD2(1), GJD4(1), ITGA6(2), KRT1(4), KRT12(1), KRT13(1), KRT15(2), KRT16(1), KRT18(1), KRT2(1), KRT28(1), KRT31(1), KRT33A(1), KRT35(1), KRT36(2), KRT4(2), KRT6B(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT78(1), KRT79(2), KRT82(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(3), LAMA2(5), LAMA3(1), LAMA4(3), LAMA5(4), LAMB1(3), LAMB2(1), LAMB4(4), LAMC2(3), LAMC3(3), LMNB1(1), RELN(3), THBS1(4), THBS2(1), THBS3(1), THBS4(1), TNC(2), TNN(2), TNR(3), TNXB(1), VTN(1), VWF(5) 120220440 138 98 136 55 18 33 52 8 27 0 0.00011 0.0012 58 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 145 AKT1(2), AKT2(2), CBL(1), CBLB(1), CCND2(1), CREBBP(3), CSF2RB(1), CSF3R(1), EP300(3), GH2(1), GHR(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL19(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL2RB(1), IL3(1), IL4R(1), IL6R(1), IL6ST(2), IRF9(1), JAK1(2), JAK2(2), JAK3(1), LEPR(1), LIFR(1), PIAS1(2), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PRLR(1), PTPN11(1), SOS1(4), SOS2(2), SPRED1(2), SPRY2(1), STAM(1), STAT1(3), STAT2(1), STAT4(2), STAT5B(1), STAT6(2), TPO(1), TYK2(2) 69514730 88 72 88 31 11 36 30 2 9 0 0.00012 0.0013 59 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(4), POLR2A(4), PPP2CA(2), RB1(3), TERT(1), TNKS(1), TP53(11), XRCC5(1) 13830155 29 24 29 13 2 11 11 0 5 0 0.00012 0.0013 60 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CREBBP(3), ELSPBP1(1), F2(2), GATA4(1), GSK3B(1), HRAS(2), MYH2(5), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PPP3CC(1), PRKACB(1), RPS6KB1(2) 24527285 38 37 38 14 5 12 13 0 8 0 0.00014 0.0015 61 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(1), PIK3CA(8), PIK3R1(2), POLR1A(1), POLR1C(1), RB1(3), TP53(11) 9750464 27 21 27 16 3 12 8 0 4 0 0.00016 0.0016 62 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 HLA-DRA(1), HLA-DRB1(3), ITK(2), PIK3CA(8), PIK3R1(2), PTPN11(1) 6139444 17 15 17 8 3 7 3 1 3 0 0.00017 0.0017 63 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GBA3(1), GGT1(2), SHMT1(1), SHMT2(2) 2824354 8 8 8 2 0 1 4 1 2 0 0.00017 0.0017 64 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ACY1(1), AGMAT(2), ALDH18A1(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), ARG1(1), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(1), SAT1(1), SAT2(1), SMS(1) 14578957 26 26 26 8 1 6 14 3 2 0 0.00018 0.0017 65 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(1), FUCA2(1), GBA(2), GLB1(3), GNS(1), GUSB(2), HEXA(1), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(1), MAN2B2(2), MAN2C1(4), NAGLU(1), SPAM1(2) 16850879 31 27 31 6 3 10 10 3 5 0 0.00019 0.0018 66 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), DAXX(2), HRAS(2), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K6(1), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(2), MAP4K5(3), MAPK10(1), MAPK4(1), MAPK9(1), MAPKAPK5(1), MAX(2), MEF2A(1), MKNK2(2), PAK1(1), RELA(1), RIPK1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KB1(2), STAT1(3), TGFB2(1), TGFB3(1), TRADD(1) 47551987 54 47 54 14 7 13 20 0 14 0 0.00021 0.0020 67 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), DPM2(1), HRAS(2), KLK2(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4) 7666611 21 19 21 6 4 10 6 0 1 0 0.00021 0.0020 68 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1B(1), ADH5(1), ADHFE1(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOX1(5), DBH(2), DCT(1), DDC(2), GOT1(2), GOT2(3), LCMT2(1), MAOA(1), MAOB(1), MYST3(4), PNPLA3(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TH(1), TPO(1), TYR(2), TYRP1(1) 28874502 43 37 43 9 6 7 17 6 7 0 0.00024 0.0021 69 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CARS2(1), GOT1(2), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(1), MPST(1), SULT4A1(1) 6120236 13 13 13 1 1 2 4 0 6 0 0.00025 0.0022 70 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), MPO(3), PRDX1(1), PRDX5(1), TPO(1) 10813926 22 19 22 2 2 5 8 4 3 0 0.00026 0.0023 71 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(2), GSK3A(2), GSK3B(1), IL4R(1), IRS1(1), JAK1(2), JAK3(1), MAP4K1(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PPP1R13B(1), SOS1(4), SOS2(2), STAT6(2) 17350469 34 30 34 7 7 10 12 1 4 0 0.00027 0.0023 72 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(8), BUB1(1), CCNA1(2), CCNB2(2), CCNB3(2), CCND2(1), CDAN1(1), CDC14A(2), CDC25A(1), CDC6(1), CDH1(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK2(1), DTX4(1), EP300(3), ESPL1(3), GSK3B(1), HDAC4(1), MAD2L1(1), MCM2(3), MCM6(2), MCM7(1), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(1), PRKDC(2), PTPRA(1), RB1(3), SMAD4(4), TBC1D8(1), TP53(11), WEE1(1) 55165539 72 57 72 43 4 19 31 3 15 0 0.00027 0.0023 73 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ASS1(1), CPS1(5), DAO(1), EPRS(1), GATM(2), GOT1(2), GOT2(3), LAP3(2), NOS1(5), NOS3(1), P4HA1(2), P4HA2(1), PARS2(1) 17335384 29 27 29 10 2 8 13 0 6 0 0.00028 0.0024 74 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(3), CACNA1A(1), GNA13(1), GNAO1(1), GNAS(1), GNAZ(1), GRIA1(5), GRIA2(1), GRID2(5), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), HRAS(2), ITPR1(1), ITPR2(4), ITPR3(1), NOS1(5), NOS3(1), NPR1(3), NPR2(1), PLA2G12A(1), PLA2G6(2), PLCB1(1), PLCB2(1), PLCB4(3), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(3) 54982218 64 58 64 34 4 23 25 2 10 0 0.00029 0.0024 75 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP6(1), BMP7(1), BMP8B(1), CSNK1G1(1), CSNK1G2(1), FBXW11(1), GLI2(3), GLI3(2), GSK3B(1), HHIP(2), LRP2(7), PRKACA(1), PRKACB(1), PTCH1(2), PTCH2(1), SMO(2), STK36(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1) 29022754 35 35 35 14 0 12 18 2 3 0 0.00030 0.0025 76 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BIRC2(2), BIRC3(1), CASP2(1), CASP7(1), CASP8(1), JUN(1), MAP3K1(1), MAPK10(1), PARP1(2), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1) 18248756 27 25 27 9 3 5 12 1 6 0 0.00038 0.0031 77 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 HRAS(2), JAK1(2), JUN(1), MAP3K1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3) 17090651 27 26 27 14 4 10 7 0 6 0 0.00039 0.0031 78 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(3) 1287858 5 5 5 0 1 1 1 0 2 0 0.00041 0.0031 79 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(2), CDKN1A(1), HRAS(2), PIK3CA(8), PIK3CD(1), SOS1(4) 7972438 20 19 20 2 2 10 7 0 1 0 0.00041 0.0031 80 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(4), BRCA1(1), BRCA2(2), CHEK2(1), FANCE(3), FANCF(1), FANCG(1), RAD50(4), TP53(11) 21731805 36 32 36 19 0 11 17 1 7 0 0.00041 0.0031 81 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(1), EIF2S2(1), RELA(1), TP53(11) 5017925 14 12 14 4 1 3 8 0 2 0 0.00042 0.0031 82 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GLB1(3), GNS(1), GUSB(2), HEXA(1), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(1), NAGLU(1), SPAM1(2) 10147121 22 20 22 3 3 7 5 3 4 0 0.00042 0.0031 83 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), EGFR(4), ERBB2(3), ERBB4(3), ETV6(1), FMN2(7), NOTCH1(6), NOTCH2(2), NOTCH3(2), PIWIL2(1), SOS1(4), SOS2(2), SPIRE1(1), SPIRE2(1) 24526885 40 37 40 18 2 11 18 1 8 0 0.00046 0.0034 84 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(8), CCNA1(2), CCND2(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), GBA2(3), MCM2(3), MCM6(2), MCM7(1), MNAT1(1), NACA(2), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), POLE(1), POLE2(1), RB1(3), RPA3(1), TFDP2(3), TNXB(1), TP53(11), WEE1(1) 36743213 55 45 55 30 4 16 24 1 10 0 0.00047 0.0035 85 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), PTPRU(2), STAT1(3), STAT2(1), TYK2(2) 6164882 12 12 12 3 1 5 2 1 3 0 0.00051 0.0036 86 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(2), INPP5A(1), ITPKA(1), ITPKB(1), MIOX(1), OCRL(2), PIK3C2G(1), PIK3CA(8), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(1), PLCB4(3), PLCD1(1), PLCG1(1), PLCG2(1) 22215854 31 27 31 10 2 12 8 0 9 0 0.00051 0.0036 87 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CCND2(1), CDK4(1), EGR1(1), GJA4(1), MLH1(1), NCOR1(2), NRIP1(4), PGR(1), PRLR(1), PTGER2(1), SMPD1(1), VDR(1) 16906629 25 24 25 7 0 7 11 2 5 0 0.00052 0.0037 88 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(2), CARD11(3), CBL(1), CBLB(1), CD4(1), CDK4(1), FYN(1), HRAS(2), ITK(2), JUN(1), MALT1(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PPP3CC(1), PRKCQ(2), PTPRC(4), SOS1(4), SOS2(2), TEC(1), VAV1(1), VAV3(1), ZAP70(1) 49632734 63 56 63 21 7 26 23 1 6 0 0.00057 0.0040 89 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(3), AKT1(2), AKT2(2), BRAF(3), CALM2(1), CBL(1), CBLB(1), FBP1(1), GSK3B(1), GYS1(2), GYS2(1), HRAS(2), INSR(4), IRS1(1), LIPE(2), MAPK10(1), MAPK9(1), MKNK2(2), PCK1(2), PDE3A(2), PDE3B(1), PFKM(2), PHKA1(1), PHKB(2), PHKG1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PPARGC1A(3), PPP1R3A(1), PPP1R3D(1), PRKACA(1), PRKACB(1), PRKAG1(2), PRKAG2(1), PRKCI(1), PRKCZ(1), PTPRF(3), RHEB(1), RPS6KB1(2), SORBS1(1), SOS1(4), SOS2(2), TSC1(2), TSC2(2) 77264356 87 73 87 32 10 31 32 3 11 0 0.00061 0.0042 90 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(1), GGT1(2), SHMT1(1), SHMT2(2) 2108602 6 6 6 0 0 0 3 1 2 0 0.00061 0.0042 91 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(2), GHR(1), HRAS(2), PIK3CA(8), PIK3R1(2) 6466242 17 16 17 5 3 8 5 0 1 0 0.00073 0.0049 92 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(5), GLS(1), GOT1(2) 3745761 9 9 9 0 0 3 3 0 3 0 0.00081 0.0054 93 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1B(3), ACVR1C(2), ACVR2A(1), AMHR2(2), BMP2(1), BMP4(1), BMP6(1), BMP7(1), BMP8B(1), BMPR1B(1), BMPR2(2), CHRD(1), CREBBP(3), CUL1(2), DCN(2), EP300(3), INHBE(1), LTBP1(1), PPP2CA(2), PPP2R1A(1), PPP2R2B(1), RBL2(1), ROCK1(2), RPS6KB1(2), SMAD2(1), SMAD4(4), SMAD9(2), SMURF2(2), TGFB2(1), TGFB3(1), TGFBR2(2), THBS1(4), THBS2(1), THBS3(1), THBS4(1), ZFYVE16(2), ZFYVE9(3) 48527294 64 55 64 17 8 19 22 3 12 0 0.00084 0.0056 94 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(8), PIK3R1(2), PLCB1(1), PLCG1(1), VAV1(1) 6355990 15 15 15 7 3 6 4 0 2 0 0.00093 0.0061 95 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(2), CALM2(1), GNAS(1), GNB1(2), NOS3(1), PIK3CA(8), PIK3R1(2), RELA(1) 8618018 19 19 19 7 3 9 6 0 1 0 0.00095 0.0061 96 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(2), STAT1(3), STAT2(1), TYK2(2) 5284693 10 10 10 3 0 4 2 1 3 0 0.00099 0.0064 97 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(2), IARS(1), IL4R(1), JAK1(2), JAK2(2), JAK3(1), PIK3CA(8), PPP1R13B(1), RPS6KB1(2), SERPINA4(1), SOS1(4), SOS2(2), STAT6(2), TYK2(2) 18184542 33 28 33 6 4 11 11 1 6 0 0.0011 0.0068 98 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), FBP1(1), GOT1(2), GOT2(3), GPT2(1), MDH1(1), ME1(1), ME2(1), ME3(1), PGK1(3) 8643968 15 15 15 3 2 4 4 2 3 0 0.0011 0.0071 99 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(3), CALM2(1), CDKN1A(1), CREBBP(3), EGR2(1), EGR3(1), EP300(3), GATA4(1), GRLF1(2), GSK3A(2), GSK3B(1), HRAS(2), IFNB1(1), IL3(1), ITK(2), JUNB(2), MAP2K7(1), MAPK9(1), MEF2A(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), NPPB(1), NUP214(1), OPRD1(1), PAK1(1), PPP3CC(1), PTPRC(4), RELA(1), TRPV6(1), VAV1(1), VAV3(1), XPO5(1) 44261565 49 47 49 19 6 16 20 1 6 0 0.0011 0.0072 100 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(2), CR2(2), HLA-DRA(1), HLA-DRB1(3), ITGAL(2), PTPRC(4) 7337450 14 13 14 5 2 2 5 1 4 0 0.0013 0.0077 101 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), HRAS(2), JAK2(2), JUN(1), MAP3K1(1), PIK3CA(8), PIK3R1(2), SOS1(4), STAT1(3), STAT5B(1) 13510281 26 25 26 7 4 12 8 0 2 0 0.0014 0.0082 102 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(2), AKT2(2), CASP8(1), CXCL11(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IRAK1(2), JUN(1), LBP(2), MAP2K3(2), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK9(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), RELA(1), RIPK1(1), STAT1(3), TICAM1(2), TICAM2(1), TLR1(1), TLR4(1), TLR6(1), TLR7(1), TLR8(2), TRAF3(1), TRAF6(1) 43683662 55 49 55 16 8 21 17 0 9 0 0.0014 0.0085 103 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), FBP1(1), GOT1(2), GOT2(3), GPT2(1), MDH1(1), ME1(1), ME3(1), PGK1(3), TKTL2(2) 9676635 16 16 16 4 2 4 5 2 3 0 0.0014 0.0085 104 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), HRAS(2), JUN(1), KLK2(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4) 9282291 20 19 20 5 4 9 6 0 1 0 0.0015 0.0087 105 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), GHR(1), PIK3CA(8), PIK3R1(2), PPP2CA(2), RELA(1) 6958353 16 16 16 4 3 8 3 0 2 0 0.0016 0.0094 106 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(3), PTPRC(4), ZAP70(1) 4341535 11 10 11 5 1 4 3 1 2 0 0.0018 0.011 107 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), ITGB1(2), KLRC1(1), PAK1(1), PIK3CA(8), PIK3R1(2), PTK2B(2), SYK(1), VAV1(1) 9192726 19 19 19 6 4 7 4 0 4 0 0.0019 0.011 108 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), CBL(1), HRAS(2), IL2RB(1), IRS1(1), JAK1(2), JAK3(1), PIK3CA(8), PIK3R1(2), RPS6KB1(2), SOS1(4), STAT5B(1), SYK(1) 17458648 28 27 28 10 5 10 7 0 6 0 0.0021 0.012 109 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), MPO(3), MYST3(4), PNPLA3(1), TPO(1) 16770427 25 22 25 4 2 7 9 4 3 0 0.0022 0.012 110 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(1), EGFR(4), ERBB3(3), NRG1(3) 5030470 11 11 11 2 2 3 4 0 2 0 0.0022 0.012 111 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), C1QA(1), C1QC(1), C1S(1), C3(4), C3AR1(1), C4BPA(1), C5(4), C6(2), C7(2), C8A(1), C9(1), CD55(1), CFB(1), CFH(2), CPB2(1), CR1(2), CR2(2), F12(1), F13A1(1), F2(2), F5(3), F8(1), FGA(1), MASP2(1), PLAT(2), PLAU(3), PLG(1), PROC(2), SERPINA1(1), SERPIND1(1), SERPINF2(1), SERPING1(2), TFPI(1), VWF(5) 44176232 61 51 61 20 2 22 28 1 8 0 0.0022 0.012 112 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(3), EP300(3), FYN(1), JAK1(2), JAK3(1), PIK3CA(8), PIK3R1(2), PTK2B(2), STAT5B(1) 13838858 23 22 23 12 4 7 7 0 5 0 0.0023 0.013 113 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ADRB2(1), ANXA6(2), ATP1A4(2), ATP2A2(2), ATP2B3(1), CACNA1A(1), CACNA1C(5), CACNA1D(4), CACNA1E(1), CACNA1S(1), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2G(2), CASQ1(1), CASQ2(1), CHRM2(1), CHRM5(2), GJA4(1), GJB6(1), GNAO1(1), GNAZ(1), GNB1(2), GNG12(1), GNG3(1), GRK6(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), MYCBP(1), PKIA(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), RGS17(1), RGS18(1), RGS2(1), RGS3(3), RGS9(1), RYR1(3), RYR2(3), RYR3(3), SLC8A1(1), SLC8A3(1) 94915598 95 79 95 33 8 31 35 2 19 0 0.0023 0.013 114 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADSL(1), AK2(1), AK5(1), ALLC(1), AMPD3(1), ATP5A1(1), ATP5G2(1), ENPP3(2), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), IMPDH1(1), IMPDH2(2), NPR1(3), NPR2(1), PAPSS2(1), PDE4A(2), PDE4C(4), PDE5A(1), PDE6C(2), PDE8A(1), PFAS(1), POLD1(2), POLE(1), POLL(1), POLQ(3), POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2(1) 63445862 63 55 63 11 11 15 20 3 14 0 0.0024 0.013 115 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ATF4(1), ATF5(1), ATP2A2(2), CALM2(1), CAMK2G(2), CNN2(1), DGKZ(1), GABPA(1), GBA2(3), GNB1(2), GNG12(1), GNG3(1), GRK6(1), GUCA2A(1), GUCY1A3(2), IGFBP3(1), ITPR1(1), ITPR2(4), ITPR3(1), JUN(1), NOS1(5), NOS3(1), PKIA(1), PLCD1(1), PLCG1(1), PLCG2(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCH(2), PRKCQ(2), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP3(1), RGS17(1), RGS18(1), RGS2(1), RGS3(3), RGS9(1), RLN1(1), RYR1(3), RYR2(3), RYR3(3), SLC8A1(1), TNXB(1) 85419334 84 72 84 28 10 22 40 1 11 0 0.0025 0.013 116 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(2), CARD11(3), CD19(1), CD22(2), CR2(2), GSK3B(1), HRAS(2), JUN(1), LILRB3(3), MALT1(1), NFAT5(1), NFATC2(1), NFATC3(2), NFKBIB(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG2(1), PPP3CC(1), SYK(1), VAV1(1), VAV3(1) 36383678 46 40 46 16 5 19 14 0 8 0 0.0025 0.013 117 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), MUSK(1), PIK3CA(8), PIK3R1(2), PTK2(1), PTK2B(2), TERT(1) 8189082 17 17 17 7 3 8 4 0 2 0 0.0026 0.013 118 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(4), GNAS(1), GNB1(2), HRAS(2), ITGB1(2), KLK2(1), MKNK2(2), PDGFRA(3), PPP2CA(2), RPS6KA1(1), SOS1(4) 16247220 25 24 25 8 3 8 11 0 3 0 0.0027 0.014 119 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CREBBP(3), EP300(3), HSD17B4(1), JUN(1), ME1(1), NCOA1(1), NCOR1(2), NCOR2(3), NR1H3(1), NRIP1(4), PIK3CA(8), PIK3R1(2), PRKACB(1), PTGS2(2), RB1(3), RELA(1), STAT5B(1) 30400235 38 36 38 20 3 13 17 0 5 0 0.0029 0.015 120 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(1), EGFR(4), HRAS(2), JAK1(2), JUN(1), MAP3K1(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3) 18379052 29 27 29 11 5 12 7 0 5 0 0.0030 0.015 121 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(5), AXIN1(1), DLL1(1), FZD1(2), GSK3B(1), NOTCH1(6) 9575567 16 16 16 10 1 3 9 0 3 0 0.0030 0.015 122 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), AXIN1(1), CCND2(1), FZD1(2), FZD10(1), FZD5(1), GSK3B(1), JUN(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(3), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(3), SFRP4(1), TCF7(2), WNT5B(1), WNT7B(1) 28540264 37 34 36 22 2 14 15 0 6 0 0.0031 0.016 123 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1) 6324134 14 13 14 0 0 3 9 1 1 0 0.0034 0.017 124 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), CES1(3) 2863414 8 8 8 1 1 2 2 3 0 0 0.0034 0.017 125 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(2), FYN(1), GAB2(1), HRAS(2), IL3(1), MAP2K3(2), MAP2K7(1), MAPK10(1), MAPK9(1), PDK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLA2G12A(1), PLA2G6(2), PLCG1(1), PLCG2(1), PRKCD(2), SOS1(4), SOS2(2), SYK(1), VAV1(1), VAV3(1) 35248653 47 39 47 16 7 13 20 1 6 0 0.0034 0.017 126 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), MPO(3), PRDX1(1), PRDX5(1), SHMT1(1), SHMT2(2), TPO(1) 5834910 12 12 12 0 1 2 8 0 1 0 0.0034 0.017 127 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CHN1(2), MAP3K1(1), MYLK(2), PAK1(1), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLD1(1), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(1), VAV1(1) 17220568 27 26 27 10 6 7 6 1 7 0 0.0035 0.017 128 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(2), ANKRD6(1), APC(5), AXIN1(1), DACT1(2), DKK2(1), FSTL1(1), GSK3A(2), GSK3B(1), LRP1(5), MVP(1), NKD1(1), PTPRA(1), SFRP1(2) 19769296 28 26 27 13 2 7 12 1 6 0 0.0037 0.018 129 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(5), AR(1), BRAF(3), EGFR(4), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), MAPK10(1), PIK3CA(8), PIK3CD(1), PIK3R1(2) 26491684 39 34 39 20 5 15 11 1 7 0 0.0041 0.020 130 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), MAP2K3(2), MAP3K1(1), PIK3CA(8), PIK3R1(2), RB1(3), RELA(1) 9680783 19 17 19 11 4 8 4 0 3 0 0.0043 0.020 131 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), HRAS(2), MEF2A(1), PIK3CA(8), PIK3R1(2), PLCG1(1), RPS6KA1(1) 9593470 17 17 17 5 3 7 5 0 2 0 0.0050 0.024 132 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), DRD1(1), EGF(1), EGFR(4), GJD2(1), GNAS(1), GRM1(1), GRM5(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), HRAS(2), HTR2A(1), HTR2C(1), ITPR1(1), ITPR2(4), ITPR3(1), NPR1(3), NPR2(1), PDGFD(1), PDGFRA(3), PLCB1(1), PLCB2(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(4), SOS2(2), TJP1(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1) 65019970 68 60 68 29 8 22 25 1 12 0 0.0051 0.024 133 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), HRAS(2), IRS1(1), PIK3CA(8), PIK3R1(2), SOS1(4) 9128234 19 18 19 7 4 8 6 0 1 0 0.0051 0.024 134 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CDH1(2), CREBBP(3), EP300(3), MAP3K7(1), SKIL(1), TGFB2(1), TGFB3(1), TGFBR2(2) 12682942 19 19 19 13 3 4 8 0 4 0 0.0055 0.025 135 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), DLAT(2), FBP1(1), GAPDHS(2), GOT1(2), GOT2(3), GPI(1), HK1(3), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PCK1(2), PDHX(1), PFKM(2), PGAM1(1), PGK1(3) 20479664 28 25 28 6 1 7 9 4 7 0 0.0057 0.026 136 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(1), ADRB2(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CCKAR(2), CCKBR(1), CHML(1), CHRM2(1), CHRM5(2), CMKLR1(1), CNR2(1), DRD1(1), DRD5(1), GPR17(1), GPR173(2), GPR174(3), GPR35(1), GPR50(1), GPR63(1), GPR83(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1), LTB4R(1), MAS1(1), MC3R(1), NMBR(1), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(1), OPRM1(1), OR12D3(1), OR1F1(1), OR5V1(1), OR7A5(1), OR8B8(1), P2RY10(2), P2RY13(1), P2RY2(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1), SSTR1(2), SSTR4(1) 57449655 58 54 58 16 4 16 30 1 7 0 0.0059 0.027 137 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(3) 1043406 5 4 5 3 0 2 1 1 1 0 0.0060 0.027 138 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1D(1), EIF2AK1(3), EIF2AK2(2), EIF2AK3(1), EIF2B1(2), EIF2B2(1), EIF2S2(1), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G3(1), EIF5(2), EIF5A(1), ETF1(3), KIAA0664(2), PABPC1(1), PABPC3(3), SLC35A4(2) 21641122 31 29 31 12 6 9 9 2 5 0 0.0061 0.027 139 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), BRAF(3), CREB5(1), CREBBP(3), EGR1(1), EGR2(1), EGR3(1), FRS2(2), JUN(1), MAP1B(1), MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), PIK3C2G(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PTPN11(1), RPS6KA3(1), TH(1) 25106623 36 34 36 16 5 11 14 1 5 0 0.0063 0.028 140 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 F2(2), GNA13(1), GNB1(2), MAP3K7(1), PIK3CA(8), PIK3R1(2), PLCB1(1), PPP1R12B(1), PTK2B(2), ROCK1(2) 12669992 22 22 22 6 4 9 4 0 5 0 0.0063 0.028 141 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1) 8609056 16 15 16 1 0 3 11 1 1 0 0.0067 0.029 142 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(4), C5(4), C6(2), C7(2), ITGAL(2), ITGB1(2), SELP(1), SELPLG(3), VCAM1(1) 12196641 21 20 21 3 1 3 13 2 2 0 0.0069 0.030 143 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), DUSP10(1), DUSP8(1), GAB1(1), JUN(1), MAP2K7(1), MAP3K1(1), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K3(1), MAP3K4(3), MAP3K5(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFATC3(2), NR2C2(1), TP53(11), TRAF6(1), ZAK(1) 24567523 36 31 36 9 3 13 12 0 8 0 0.0069 0.030 144 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(3), G6PD(1), GGT1(2), GPX3(3), GSS(1), IDH1(1), IDH2(1), OPLAH(1), TXNDC12(1) 10517621 14 14 14 5 1 4 6 0 3 0 0.0070 0.030 145 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(2), GCA(1), ITGA9(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), PAK1(1), PDE3A(2), PDE3B(1), PIK3C2G(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), RIPK3(1) 24375423 30 29 30 9 4 11 10 1 4 0 0.0075 0.032 146 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(1), NDUFA13(3) 2046493 6 6 6 0 0 0 5 1 0 0 0.0076 0.032 147 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 AKT1(2), GNB1(2), PDGFRA(3), PIK3CA(8), PIK3R1(2), PLCB1(1), PTK2(1), SMPD1(1) 13385405 20 20 20 16 3 7 6 0 4 0 0.0081 0.034 148 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CD4(1), CD74(1), CIITA(1), CTSB(2), CTSL1(1), HLA-B(1), HLA-C(1), HLA-DMB(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(3), HLA-E(1), HLA-F(1), HSP90AA1(3), HSP90AB1(1), HSPA5(2), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), KLRC1(1), TAP1(1), TAP2(1) 21291644 32 29 32 12 5 12 8 3 4 0 0.0083 0.035 149 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(2), HRAS(2), HSPB2(1), MAP3K1(1), MAP3K5(1), MAP3K7(1), MAPKAPK5(1), MAX(2), MEF2A(1), RIPK1(1), STAT1(3), TGFB2(1), TGFB3(1), TRADD(1) 18158506 19 19 19 2 3 7 3 0 6 0 0.0084 0.035 150 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), IFNGR2(1), JAK1(2), JAK2(2), STAT1(3) 4048587 9 8 9 1 0 5 2 0 2 0 0.0085 0.035 151 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), MPO(3), MTHFR(1), SHMT1(1), SHMT2(2), TPO(1) 5734934 11 11 11 0 1 2 7 0 1 0 0.0086 0.035 152 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDK2(1), CUL1(2), FBXW7(3), RB1(3) 4196502 9 8 9 8 0 2 4 0 3 0 0.0090 0.036 153 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), AKAP10(1), AKAP11(1), AKAP7(1), AKAP9(4), CALM2(1), CHMP1B(1), GNA13(1), GNAL(1), GNAO1(1), GNAZ(1), GNB1(2), GNG12(1), GNG3(1), HRAS(2), IL18BP(1), ITPR1(1), KCNJ3(3), PDE1B(2), PDE1C(1), PDE4A(2), PDE4C(4), PDE8A(1), PPP3CC(1), PRKACA(1), PRKACB(1), PRKCD(2), PRKCG(2), PRKCH(2), PRKCI(1), PRKCQ(2), PRKCZ(1), PRKD1(3), PRKD3(2), SLC9A1(1) 57930118 64 56 64 25 8 18 25 2 11 0 0.0090 0.036 154 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 HRAS(2), INSR(4), IRS1(1), JUN(1), PIK3CA(8), PIK3R1(2), PTPN11(1), SOS1(4) 12349616 23 21 23 8 4 9 8 1 1 0 0.0094 0.038 155 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), HRAS(2), INSR(4), IRS1(1), JAK2(2), PIK3CA(8), PIK3R1(2), PLCG1(1), RPS6KA1(1), SOS1(4), STAT5B(1) 16067800 27 25 27 9 4 11 10 1 1 0 0.0099 0.039 156 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD4(1), CREBBP(3), CSK(1), GNAS(1), GNB1(2), HLA-DRA(1), HLA-DRB1(3), PRKACB(1), PTPRC(4), ZAP70(1) 11034545 18 16 18 7 1 6 8 1 2 0 0.010 0.040 157 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD4(1), CREBBP(3), CSK(1), GNAS(1), GNB1(2), HLA-DRA(1), HLA-DRB1(3), PRKACB(1), PTPRC(4), ZAP70(1) 11034545 18 16 18 7 1 6 8 1 2 0 0.010 0.040 158 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CDK2(1), CUL1(2), RB1(3) 4308009 8 8 8 6 0 3 2 0 3 0 0.010 0.041 159 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), AKT1(2), AKT2(2), CAMKK1(1), CAMKK2(2), IRS1(1), JAK1(2), JAK2(2), JAK3(1), LEPR(1), MAPK10(1), MAPK9(1), NFKBIB(1), NPY(1), PCK1(2), POMC(1), PPARGC1A(3), PRKAG1(2), PRKAG2(1), PRKCQ(2), PTPN11(1), RELA(1), RXRB(1), RXRG(2), TNFRSF1A(1), TRADD(1), TYK2(2) 39820344 43 41 43 17 4 14 18 2 5 0 0.011 0.043 160 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(3), ACSS1(2), ACSS2(2), IDH1(1), IDH2(1), MDH1(1) 6525575 13 12 13 7 1 2 8 0 2 0 0.012 0.047 161 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 HRAS(2), JAK2(2), JUN(1), PIK3CA(8), PIK3R1(2), PLCG1(1), SOS1(4), STAT1(3), STAT5B(1) 14736662 24 23 24 9 4 11 8 0 1 0 0.012 0.047 162 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(2), DMD(6), MYBPC1(1), MYBPC2(1), MYBPC3(2), MYH3(3), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL9(1), MYOM1(3), NEB(7), TMOD1(1), TNNT1(1), TNNT2(1), TNNT3(1), TTN(39) 69036756 77 64 77 24 15 27 25 1 9 0 0.013 0.050 163 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), FPGS(2) 3096940 8 7 8 3 0 1 5 1 1 0 0.014 0.051 164 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), LDHB(1), LDHC(1), NCL(3) 4342884 9 9 9 3 2 2 2 1 2 0 0.014 0.051 165 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PDXP(1) 2380775 6 6 6 0 1 1 2 1 1 0 0.014 0.052 166 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), GNB1(2), HRAS(2), PIK3C2G(1), PIK3CA(8), PIK3R1(2), PLCG1(1), PTK2(1), PTK2B(2), RELA(1) 13763386 22 21 22 10 3 7 9 0 3 0 0.015 0.054 167 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 GOT1(2), GOT2(3), PAH(1), YARS2(1) 4268604 7 7 7 0 1 2 2 0 2 0 0.015 0.055 168 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(3), CALM2(1), CAMK1(1), INSR(4), MEF2A(1), NFATC2(1), PIK3CA(8), PIK3R1(2), PPP3CC(1) 16796439 24 24 24 7 3 10 5 2 4 0 0.016 0.057 169 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 GBA3(1), MPO(3), PRDX1(1), PRDX5(1), TPO(1), TYR(2) 4776007 9 9 9 0 0 2 5 1 1 0 0.016 0.060 170 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), ADSL(1), AK2(1), AK5(1), ALLC(1), AMPD3(1), ENPP3(2), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY2C(2), GUCY2F(1), IMPDH1(1), IMPDH2(2), NPR1(3), NPR2(1), NT5C1B(1), NT5C3(1), NUDT9(1), PAPSS2(1), PDE11A(2), PDE1C(1), PDE2A(2), PDE3B(1), PDE4A(2), PDE4C(4), PDE5A(1), PDE8A(1), PFAS(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1), PRIM2(1), PRPS1L1(1), PRPS2(1), PRUNE(1), RRM2(1), XDH(2) 81223845 80 68 78 16 10 22 28 3 17 0 0.017 0.060 171 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), HLA-DRB1(3), IL3(1) 1328354 5 4 5 2 1 1 1 1 1 0 0.017 0.060 172 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MAPKAPK5(1), NFKBIB(1), NFKBIL2(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), TRAF3(1), TRAF5(1), TRAF6(1) 15783568 22 22 22 10 5 8 5 0 4 0 0.017 0.060 173 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), HRAS(2), PIK3CA(8), PIK3R1(2), RALBP1(1), RELA(1) 9432966 16 16 16 5 3 7 4 0 2 0 0.017 0.060 174 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 AKT1(2), CAMK2G(2), GNAS(1), HRAS(2), PIK3CA(8), PIK3R1(2), PRKACB(1), RPS6KA1(1), SOS1(4) 14167132 23 22 23 9 4 9 9 0 1 0 0.017 0.060 175 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(1), F2(2), FGA(1), PLAT(2), PLAU(3), PLG(1) 6608056 11 11 11 6 1 4 2 0 4 0 0.017 0.060 176 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), DIAPH1(1), FYN(1), HRAS(2), ITGA1(1), ITGB1(2), MYLK(2), PIK3CA(8), PIK3R1(2), PTK2(1), ROCK1(2), TLN1(3) 18634320 26 26 26 10 4 10 9 1 2 0 0.018 0.061 177 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(2), ALOX5(1), GGT1(2), LTA4H(1), PLA2G6(2), PTGDS(1), PTGS2(2) 7375888 11 11 11 2 0 5 3 0 3 0 0.018 0.061 178 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HBXIP(1), HRAS(2), PTK2B(2), SOS1(4) 4312977 9 9 9 0 1 3 4 0 1 0 0.018 0.062 179 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ADCY8(4), CACNA1A(1), GNAS(1), GNB1(2), GNG3(1), GRM4(1), ITPR3(1), PLCB2(1), PRKACA(1), PRKACB(1), SCNN1A(2), SCNN1G(1), TAS1R2(3), TAS2R3(1), TAS2R38(1), TAS2R46(2), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(2) 27822259 30 29 30 11 3 10 12 0 5 0 0.019 0.065 180 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1), MASP2(1) 10519915 17 16 17 3 0 4 11 1 1 0 0.019 0.066 181 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(2), BCAR1(2), CSK(1), CTNNA1(2), CTNNA2(4), PTK2(1), VCL(1) 9824853 13 12 13 5 3 4 2 1 3 0 0.020 0.067 182 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(2), EGF(1), EGFR(4), HRAS(2), JUN(1), MAP2K3(2), MAP2K7(1), MAP3K1(1), MAP3K5(1), PPP2CA(2), PRKCD(2), PRKCG(2), PRKCH(2), PRKCQ(2), RELA(1), RIPK1(1), TNFRSF1A(1) 24032454 28 26 28 12 5 8 9 0 6 0 0.020 0.069 183 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(2), CD19(1), CD22(2), CR2(2), CSK(1), GSK3A(2), GSK3B(1), ITPR1(1), ITPR2(4), ITPR3(1), MAP4K1(1), NFATC2(1), PDK1(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), PPP3CC(1), PTPRC(4), SOS1(4), SOS2(2), SYK(1), VAV1(1) 36106397 48 41 48 10 7 16 16 1 8 0 0.021 0.071 184 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(3), G6PD(1), GGT1(2), GPX3(3), GSS(1), IDH1(1), IDH2(1) 8825515 12 12 12 6 1 3 6 0 2 0 0.024 0.079 185 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(2), BIRC3(1), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(1) 3973275 7 7 6 2 0 2 4 0 1 0 0.024 0.080 186 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BIRC2(2), BIRC3(1), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), HELLS(1), JUN(1), MAP3K1(1), MAPK10(1), NFKBIB(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(11), TRADD(1), TRAF3(1) 27753187 32 30 32 13 5 7 14 0 6 0 0.025 0.082 187 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(2), JAK2(2), PTPRU(2), STAT1(3) 5666393 10 9 10 1 1 6 1 0 2 0 0.025 0.083 188 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 BRAF(3), FYN(1), HLA-B(1), HLA-C(1), HLA-E(1), HRAS(2), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), ITGAL(2), KLRC1(1), MICB(1), NFAT5(1), NFATC2(1), NFATC3(2), PAK1(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLCG1(1), PLCG2(1), PPP3CC(1), PRKCG(2), PTK2B(2), PTPN11(1), SH3BP2(1), SOS1(4), SOS2(2), SYK(1), TNFRSF10A(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(1), VAV3(1), ZAP70(1) 55038056 65 54 65 29 7 26 22 0 10 0 0.025 0.083 189 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(2), HRAS(2), KDR(2), NFAT5(1), NFATC2(1), NFATC3(2), NOS3(1), PIK3CA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R1(2), PLA2G12A(1), PLA2G6(2), PLCG1(1), PLCG2(1), PPP3CC(1), PRKCG(2), PTGS2(2), PTK2(1), SPHK2(1), VEGFA(1) 35009255 42 36 42 20 4 16 15 0 7 0 0.026 0.083 190 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1S(1), C3(4), C5(4), C6(2), C7(2), C8A(1), C9(1) 10221977 16 15 16 1 0 3 11 1 1 0 0.027 0.087 191 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), CD38(1), ENPP3(2), NNT(4) 7197618 12 12 12 0 2 3 3 2 2 0 0.027 0.087 192 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(1), CBR1(1), CYP4F2(1), GGT1(2), LTA4H(1), MPO(3), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS2(2), TPO(1) 13668371 17 17 17 3 0 6 8 0 3 0 0.027 0.087 193 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(1), AGXT2(1), AKR1B10(2), ALAS2(1), AOC2(1), CHDH(2), DAO(1), DMGDH(1), GATM(2), MAOA(1), MAOB(1), PHGDH(1), RDH13(1), SARDH(1), SARS(2), SHMT1(1), SHMT2(2), TARS(1), TARS2(2) 21206867 29 26 29 6 3 9 11 3 3 0 0.028 0.088 194 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), C1GALT1C1(1), GALNT1(1), GALNT11(1), GALNT2(1), GALNT5(3), GALNT7(3), GALNTL2(1), GALNTL4(1), GCNT1(2), OGT(3), WBSCR17(1) 15859519 19 19 19 9 3 6 5 0 5 0 0.028 0.088 195 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(4), ABCA10(3), ABCA12(4), ABCA13(5), ABCA2(1), ABCA4(2), ABCA5(3), ABCA6(1), ABCA7(4), ABCA8(2), ABCA9(2), ABCB1(3), ABCB11(2), ABCB4(1), ABCC1(1), ABCC10(1), ABCC11(1), ABCC12(2), ABCC3(3), ABCC4(3), ABCC5(1), ABCC6(1), ABCC8(1), ABCC9(3), ABCD2(1), ABCD3(1), ABCD4(3), ABCG1(1), ABCG4(2), ABCG5(1), CFTR(3), TAP1(1), TAP2(1) 57591290 68 56 68 29 4 25 29 4 6 0 0.029 0.091 196 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(2), B3GALT4(1), FAU(1), IL6ST(2), PIGK(1), RPL15(1), RPL19(1), RPL22(1), RPL27(1), RPL30(1), RPL31(1), RPL34(1), RPL4(1), RPL5(1), RPL7(1), RPLP0(1), RPS13(1), RPS26(1), RPS29(1), RPS3A(1), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), RPS6KA6(3), RPS6KB1(2), SLC36A2(1), TSPAN9(1) 25573777 32 29 32 7 3 10 13 1 5 0 0.030 0.094 197 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), CALM2(1), CHRNA1(1), FLT1(2), FLT4(3), KDR(2), NOS3(1), PDE2A(2), PDE3A(2), PDE3B(1), PRKACB(1), PRKG1(1), PRKG2(1), RYR2(3) 20010945 24 24 24 8 6 6 8 1 3 0 0.030 0.095 198 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 GOT1(2), GOT2(3), PAH(1) 4059837 6 6 6 0 1 1 2 0 2 0 0.031 0.095 199 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCND2(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(1), CDKN2C(1), RB1(3) 7818193 12 11 12 9 0 6 4 0 2 0 0.032 0.098 200 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(2), ALOX5(1), CBR1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2J2(1), CYP4A11(2), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(3), LTA4H(1), PLA2G12A(1), PLA2G6(2), PTGDS(1), PTGS2(2) 19256833 27 24 27 7 3 6 13 1 4 0 0.033 0.10 201 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4R(1), IRS1(1), JAK1(2), JAK3(1), RPS6KB1(2), STAT6(2) 7150692 11 10 11 2 2 2 3 0 4 0 0.035 0.11 202 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(2), BRAF(3), EGFR(4), EPHB2(1), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(1), PLCB4(3), SOS1(4), SOS2(2) 29039649 36 33 36 14 2 14 14 1 5 0 0.036 0.11 203 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(1), AGXT2(1), ALAS2(1), AOC2(1), CHDH(2), DAO(1), DMGDH(1), GATM(2), MAOA(1), MAOB(1), PLCB2(1), PLCG1(1), PLCG2(1), SARDH(1), SARS(2), SHMT1(1), SHMT2(2), TARS(1) 20779099 26 25 26 6 1 8 11 3 3 0 0.036 0.11 204 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CSK(1), EPHB2(1), FBXW7(3), ITK(2), ITPKA(1), ITPKB(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PLCG1(1), PTPRC(4), RASGRP2(2), RASGRP4(2), SOS1(4), SOS2(2), VAV1(1), ZAP70(1) 27286173 35 32 35 11 4 12 16 0 3 0 0.036 0.11 205 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GLB1(3), GNS(1), GUSB(2), HEXA(1), IDS(2), IDUA(1), LCT(1), NAGLU(1) 7108167 13 11 13 3 1 4 4 1 3 0 0.038 0.11 206 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(2), CASP2(1), CASP8(1), JUN(1), LMNB1(1), MADD(2), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(2), RB1(3), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TRADD(1) 19552017 20 20 19 13 0 6 9 0 5 0 0.038 0.11 207 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(6) 3935694 7 7 7 2 1 1 4 0 1 0 0.039 0.11 208 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 GTF2E2(2), GTF2H1(2), GTF2H2(2), ILK(1), MNAT1(1), POLR1A(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3B(5), POLR3H(1), TAF13(1), TAF5(3) 17252534 25 24 23 11 2 12 8 0 3 0 0.039 0.11 209 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(2), ABCB4(1), ABCC1(1), ABCC3(3) 7150579 10 10 10 0 0 6 2 1 1 0 0.040 0.12 210 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), HARS(1), MAOA(1), MAOB(1), PRPS2(1) 12024157 17 16 17 3 2 2 8 4 1 0 0.041 0.12 211 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADS(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOX1(5), BCAT1(1), ECHS1(1), HADHA(1), HADHB(2), IVD(1), MCCC2(3), MCEE(1), OXCT1(1), PCCA(1), PCCB(1) 17749922 24 24 24 7 6 6 8 1 3 0 0.043 0.12 212 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(1), WEE1(1) 6831521 10 9 10 9 0 2 5 0 3 0 0.043 0.12 213 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), CD38(1), ENPP3(2), NNT(4), NT5C1B(1), NT5C3(1), NUDT12(1) 10657174 15 15 15 3 2 4 5 2 2 0 0.044 0.13 214 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 JUN(1), KEAP1(2), NFE2L2(4) 4243937 7 7 7 5 0 1 4 1 1 0 0.045 0.13 215 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 AKT1(2), CSF2RB(1), IL3(1), KITLG(1), PIK3CA(8), PIK3R1(2), PRKACB(1) 10269441 16 16 16 7 4 8 3 0 1 0 0.049 0.14 216 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CALM2(1), CAMK2G(2), F2(2), FYN(1), GNB1(2), HRAS(2), JAK2(2), MAPT(1), MYLK(2), PLCG1(1), PTK2B(2), SOS1(4), STAT1(3) 20609579 25 25 25 7 1 7 13 2 2 0 0.049 0.14 217 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 HRAS(2), IRS1(1), JUN(1), PIK3CA(8), PIK3R1(2), PTPN11(1), SOS1(4) 11977908 19 18 19 9 4 7 7 0 1 0 0.049 0.14 218 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), HLA-DRA(1), HLA-DRB1(3) 1828206 5 4 5 3 0 2 1 1 1 0 0.050 0.14 219 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 GBA(2), GBA3(1), MPO(3), TPO(1) 4168251 7 7 7 2 0 3 3 1 0 0 0.050 0.14 220 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(5), AXIN1(1), BMP2(1), BMP4(1), BMP7(1), BMPR2(2), CHRD(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(1), NPPB(1), RFC1(1), TGFB2(1), TGFB3(1), TGFBR2(2) 17503505 24 21 24 11 6 5 8 0 5 0 0.057 0.16 221 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASDHPPT(1), AASS(1), KARS(1) 3427954 5 5 5 1 0 2 0 0 3 0 0.058 0.16 222 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(2), CD19(1), CSK(1), EPHB2(1), ITPKA(1), ITPKB(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PIK3CA(8), PIK3CD(1), PIK3R1(2), PLCG2(1), PPP1R13B(1), SERPINA4(1), SOS1(4), SOS2(2), SYK(1), VAV1(1) 25331626 34 31 34 9 5 14 11 0 4 0 0.059 0.16 223 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 HRAS(2), IL6R(1), IL6ST(2), JAK1(2), JAK2(2), JAK3(1), JUN(1), PTPN11(1), SOS1(4) 11734328 16 15 16 5 3 4 6 0 3 0 0.062 0.17 224 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 CASP10(2), CASP8(1), DAXX(2), DEDD(2), EGFR(4), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1), MET(1), NFAT5(1), NFKBIB(1), NFKBIL2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TP53(11) 35829560 41 35 41 17 6 13 15 0 7 0 0.063 0.17 225 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(2), BIRC2(2), BIRC3(1), CASP8(1), JUN(1), MAP3K3(1), MAP3K7(1), NFKBIB(1), NFKBIL2(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1) 12878207 16 16 15 8 2 5 6 0 3 0 0.064 0.17 226 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 748503 2 2 2 1 0 1 1 0 0 0 0.064 0.18 227 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CUL1(2), RB1(3) 4269289 6 6 6 5 0 2 1 0 3 0 0.067 0.18 228 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2E2(2), GTF2H1(2), GTF2H2(2), GTF2I(1), TAF1(2), TAF13(1), TAF1L(2), TAF4B(2), TAF5(3), TAF5L(1), TAF7L(2) 17607334 21 21 21 5 1 7 11 1 1 0 0.068 0.18 229 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV2(1) 3436193 6 6 6 2 1 2 3 0 0 0 0.070 0.19 230 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), CLOCK(1), EIF4G2(2), ETV6(1), HERPUD1(1), HSPA8(4), MYF6(1), NCKAP1(1), NCOA4(2), PER1(2), PER2(1), PSMA4(1), UGP2(1), ZFR(3) 17955631 22 21 22 7 1 7 9 1 4 0 0.070 0.19 231 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(1), EGFR(4), MAP3K1(1), NCOR2(3), RARA(2), THRA(1) 8436214 12 12 12 0 1 4 4 0 3 0 0.072 0.19 232 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK1(2), JAK2(2), JAK3(1), STAT1(3), STAT5B(1), TYK2(2) 9052577 12 11 12 6 1 4 4 1 2 0 0.075 0.20 233 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 CALM2(1), HRAS(2), JUN(1), MAP2K7(1), MAP3K1(1), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PLCG1(1), PPP3CC(1), SOS1(4), SYK(1), VAV1(1) 20719458 27 26 27 11 5 10 8 0 4 0 0.079 0.21 234 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGAL(2), ITGB1(2), SELE(3) 6346170 9 9 9 4 1 2 5 0 1 0 0.079 0.21 235 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(2), BIRC3(1), CASP10(2), CASP7(1), CASP8(1), SCAP(1), SREBF2(3) 8808028 11 11 11 3 4 1 4 0 2 0 0.086 0.22 236 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), AR(1), ESRRA(1), NR1H2(2), NR1H3(1), NR1I2(1), NR2C2(1), NR2F2(1), NR5A2(2), PGR(1), RARA(2), RARB(1), RORA(1), RORC(1), RXRB(1), RXRG(2), THRA(1), VDR(1) 20251673 22 21 21 8 3 7 5 2 5 0 0.086 0.23 237 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), GAA(2), GALE(1), GALK1(1), GALK2(1), GLB1(3), HK1(3), LALBA(1), LCT(1), MGAM(2), PFKM(2), RDH13(1), UGP2(1) 18848844 21 20 21 3 1 6 7 2 5 0 0.088 0.23 238 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(1), CREBBP(3), EP300(3), FZD1(2), GSK3B(1), TRRAP(2) 15946260 17 17 17 15 0 3 11 0 3 0 0.089 0.23 239 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), FYN(1), HRAS(2), JUN(1), MAP3K1(1), NFATC2(1), NFATC3(2), PIK3CA(8), PIK3R1(2), PLCG1(1), PPP3CC(1), PTPN7(1), RELA(1), SOS1(4), VAV1(1), ZAP70(1) 23244961 29 28 29 15 4 12 10 0 3 0 0.089 0.23 240 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(1), THBS1(4) 3591166 6 6 6 2 0 1 4 1 0 0 0.090 0.23 241 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(1), EGF(1), EGFR(4), MET(1), PDGFRA(3) 9609009 11 11 11 8 2 3 3 0 3 0 0.091 0.23 242 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG1(1), CPS1(5), GATM(2), SMS(1) 8493042 11 11 11 5 0 4 5 0 2 0 0.097 0.25 243 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(1), RDH13(1) 2364724 4 4 4 0 1 0 2 0 1 0 0.097 0.25 244 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD4(1), ITGAL(2), PTPRC(4) 5512508 7 7 7 3 1 2 3 0 1 0 0.099 0.25 245 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GABBR1(1), GPRC5A(1), GPRC5C(1), GRM1(1), GRM2(2), GRM3(1), GRM4(1), GRM5(1), GRM7(1), GRM8(1) 9761324 12 12 12 2 3 3 5 0 1 0 0.10 0.26 246 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1) 11422889 16 15 14 2 1 8 4 0 3 0 0.10 0.26 247 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1) 6443467 7 6 7 2 0 1 3 0 3 0 0.10 0.26 248 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(1), KARS(1) 2333393 3 3 3 1 0 1 0 0 2 0 0.11 0.26 249 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 HRAS(2), IL2RB(1), JAK1(2), JAK3(1), JUN(1), SOS1(4), STAT5B(1), SYK(1) 11540060 13 13 13 3 2 3 5 0 3 0 0.11 0.26 250 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(5), AXIN1(1), CREBBP(3), FZD1(2), GSK3B(1), MAP3K7(1), PPP2CA(2) 14204951 15 15 15 12 0 3 8 0 4 0 0.11 0.26 251 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(1), GALNT7(3), GCNT1(2), WBSCR17(1) 7055661 8 8 8 3 1 2 2 0 3 0 0.11 0.26 252 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(3), DLL1(1), DLL4(1), DTX3(2), DTX3L(1), DTX4(1), EP300(3), JAG1(1), MAML1(2), MAML2(1), MAML3(1), NCOR2(3), NCSTN(1), NOTCH1(6), NOTCH2(2), NOTCH3(2), NUMB(2), PSEN2(1), RBPJL(1) 32576394 35 31 35 17 4 6 16 1 6 2 0.11 0.26 253 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(3), CLYBL(1), CS(1), IDH1(1), IDH2(1), MDH1(1), OGDH(2), OGDHL(1), PCK1(2), SDHA(1), SDHD(1), SUCLG1(2), SUCLG2(1) 14727273 21 18 21 9 1 9 8 0 3 0 0.11 0.26 254 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 BAG4(2), BIRC2(2), BIRC3(1), CASP2(1), CASP7(1), CASP8(1), DAXX(2), LMNB1(1), MAP2K7(1), MAP3K1(1), MAP3K5(1), PRKCD(2), PRKDC(2), PSEN2(1), PTK2(1), RB1(3), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF1A(1), TRADD(1) 34282887 28 27 27 17 4 8 11 0 5 0 0.11 0.27 255 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(1), CPS1(5), EPRS(1), GAD1(1), GFPT1(1), GLS(1), GLS2(1), GOT1(2), GOT2(3), GPT2(1), GSS(1) 16220031 18 17 18 6 2 8 5 0 3 0 0.11 0.27 256 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(1), CAPN3(1), CAPN7(1), CAPN9(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA11(2), ITGA3(2), ITGA6(2), ITGA8(1), ITGA9(2), ITGAE(2), ITGAL(2), ITGAX(1), ITGB1(2), ITGB5(3), ITGB6(2), ITGB7(1), MAP2K3(2), MAPK10(1), MAPK4(1), PAK1(1), PAK4(2), PAK6(1), PTK2(1), ROCK1(2), SDCCAG8(1), SORBS1(1), SOS1(4), TLN1(3), TNS1(3), VAV3(1), VCL(1) 66784386 61 56 61 18 4 18 32 0 7 0 0.11 0.27 257 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F12(1), F2(2), F5(3), F8(1), FGA(1), PLAT(2), PLAU(3), PLG(1), SERPINF2(1), VWF(5) 17065317 20 19 20 11 0 8 8 0 4 0 0.11 0.27 258 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(3), GLI3(2), GSK3B(1), PRKACB(1), SMO(2) 7807771 10 10 10 3 0 3 6 1 0 0 0.11 0.27 259 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(1), EGFR(4), HRAS(2), PTPRB(2), SOS1(4), SPRY2(1) 12052154 15 15 15 5 2 6 4 1 2 0 0.12 0.28 260 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(3), ACSS1(2), ACSS2(2), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), PCCA(1), PCCB(1), SUCLG1(2), SUCLG2(1) 19481375 22 22 22 10 2 7 7 1 5 0 0.12 0.28 261 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(3), EP300(3), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1) 10891870 11 11 11 6 0 1 7 0 3 0 0.12 0.28 262 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), GRIN1(1), GRIN2A(3), GRIN2B(4), NOS1(5), PPP3CC(1), PRKACB(1) 12465844 16 16 16 7 1 5 9 0 1 0 0.12 0.28 263 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(2), JAK2(2), TYK2(2) 5132519 7 6 7 3 0 2 2 1 2 0 0.12 0.28 264 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(1), JAK1(2), JAK2(2), TYK2(2) 5132519 7 6 7 3 0 2 2 1 2 0 0.12 0.28 265 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), CREB5(1), EPHB2(1), ITPKA(1), ITPKB(1), JUN(1), MAP2K7(1), MAPK10(1), MAPK8IP1(1), MAPK8IP3(1), MAPK9(1) 13528521 15 15 15 13 1 5 6 0 3 0 0.13 0.29 266 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1) 3887372 6 6 6 2 2 1 2 1 0 0 0.13 0.29 267 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), CS(1), IDH1(1), IDH2(1), MDH1(1), PCK1(2), SDHA(1), SUCLG1(2), SUCLG2(1) 10188980 13 13 13 7 0 6 4 0 3 0 0.13 0.30 268 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), LUM(1) 1784260 3 3 3 0 0 1 1 0 1 0 0.13 0.30 269 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA2(1), GLB1(3), HEXA(1), LCT(1), MAN2C1(4) 7953557 10 9 10 3 0 4 4 1 1 0 0.13 0.30 270 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(1), HLA-DRA(1), HLA-DRB1(3) 2492016 5 4 5 4 0 2 1 1 1 0 0.13 0.30 271 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(1), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), BBOX1(1), DOT1L(2), ECHS1(1), EHMT2(2), HADH(1), HADHA(1), HSD17B4(1), NSD1(2), OGDH(2), OGDHL(1), PLOD2(1), PLOD3(1), RDH13(1), SETD1A(1), SETDB1(1), SHMT1(1), SHMT2(2) 28031433 29 29 29 6 2 7 14 1 5 0 0.13 0.30 272 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(5), EPHB2(1), ITPR1(1), ITPR2(4), ITPR3(1), KCNJ3(3), KCNJ5(1), RYR1(3) 22957004 21 21 21 16 0 7 9 1 4 0 0.13 0.30 273 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG10(1), ALG10B(1), ALG13(1), ALG3(1), ALG8(1), B3GNT6(1), B3GNT7(1), B4GALT4(2), C1GALT1C1(1), CHST1(1), DPAGT1(1), EXT1(1), EXTL3(1), FUT11(1), GALNT1(1), GALNT11(1), GALNT2(1), GALNT5(3), GALNT7(3), GALNTL2(1), GALNTL4(1), GCNT1(2), HS6ST3(1), MAN1A2(1), MAN2A1(1), MGAT3(1), MGAT4A(1), MGAT5(1), NDST4(1), OGT(3), RPN1(2), RPN2(1), ST3GAL3(1), STT3B(1), WBSCR17(1), XYLT1(1), XYLT2(1) 53571744 47 43 47 19 4 14 17 1 11 0 0.13 0.30 274 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), CES1(3), CES7(1), MYST3(4), PNPLA3(1) 12415482 15 14 15 4 1 4 7 3 0 0 0.14 0.30 275 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 GPI(1), HK1(3), PGAM1(1), PGK1(3) 4267803 8 6 8 2 0 2 5 1 0 0 0.14 0.30 276 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), DDC(2), HARS(1), HARS2(1), LCMT2(1), MAOA(1), MAOB(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), PRPS2(1), UROC1(1) 19387189 24 20 24 4 2 3 13 4 2 0 0.14 0.30 277 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GGT1(2) 2829117 3 3 3 1 0 0 2 0 1 0 0.14 0.31 278 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CHIT1(1), CTBS(1), CYB5R1(2), GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), MTMR1(2), MTMR2(1), NANS(1), RENBP(2) 14081415 18 17 18 2 1 5 10 1 1 0 0.14 0.32 279 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), ASCC3(2), ATP13A2(4), DDX18(2), DDX50(2), DDX56(1), DHX58(1), EP400(1), FPGS(2), IFIH1(2), RAD54L(1), SKIV2L2(1), SMARCA2(4), SMARCA5(2) 30961716 31 28 31 12 0 9 16 1 5 0 0.14 0.32 280 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(2), PTPRC(4) 5218168 6 6 6 2 1 1 3 0 1 0 0.14 0.32 281 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 CASP1(1), CASP7(1), CASP8(1), INSR(4), MAGI1(2), MAGI2(1), RERE(2), WWP2(1) 11513864 13 13 13 4 1 5 4 1 2 0 0.14 0.32 282 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), LTB4R(1), P2RY2(1) 2696735 3 3 3 2 0 0 2 0 1 0 0.14 0.32 283 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(2), ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GAPDHS(2), GPI(1), HK1(3), LDHAL6B(1), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3) 28165196 31 28 31 7 3 4 13 4 7 0 0.15 0.32 284 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(1), TH(1) 2859292 4 4 4 1 0 0 3 1 0 0 0.15 0.32 285 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA4(1), PSMA6(1), RPN1(2), RPN2(1), UBE2A(1) 6432172 7 7 7 3 1 0 3 2 1 0 0.15 0.33 286 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR2(1), DNMT1(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(1) 5361002 7 7 7 1 0 3 3 0 1 0 0.15 0.33 287 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(2), SELE(3) 5605345 7 7 7 4 0 2 4 0 1 0 0.15 0.33 288 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(1), HRAS(2), IL3(1), JAK2(2), SOS1(4), STAT5B(1) 8336733 11 11 11 1 2 4 5 0 0 0 0.16 0.34 289 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSL(1), AGXT(1), AGXT2(1), ASNS(1), DARS(1), GAD1(1), GOT1(2), GOT2(3), GPT2(1) 12801712 12 12 12 4 1 3 4 0 4 0 0.16 0.34 290 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM2(1), HRAS(2), JUN(1), MAP2K3(2), MAP3K1(1), PAK1(1), PLCG1(1), PTK2B(2), SOS1(4) 13925154 17 16 17 7 2 3 9 0 3 0 0.16 0.34 291 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY2(1), ADCY5(3), ADCY7(1), ADCY8(4), ADCY9(2), CALM2(1), CAMK2G(2), CREBBP(3), DCT(1), EP300(3), FZD1(2), FZD10(1), FZD4(1), FZD5(1), GNAO1(1), GNAS(1), GSK3B(1), HRAS(2), KITLG(1), MITF(1), PLCB1(1), PLCB2(1), PLCB4(3), POMC(1), PRKACA(1), PRKACB(1), PRKCG(2), TCF7(2), TYR(2), TYRP1(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT9A(1) 52988976 52 48 51 33 1 17 28 0 6 0 0.16 0.34 292 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(1), THTPA(1), TPK1(1) 3141313 5 5 5 1 0 3 2 0 0 0 0.16 0.34 293 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 AKT1(2), FLNA(2), FLNC(3), FSCN1(2), MYH2(5), MYLK(2), PAK1(1), PAK4(2), PAK6(1), PAK7(1), ROCK1(2), WASL(2) 23076020 25 23 25 5 1 8 12 1 3 0 0.16 0.34 294 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(3), EP300(3), NCOA3(3), PRKACB(1), RARA(2) 10035320 12 12 12 4 0 4 7 0 1 0 0.16 0.34 295 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGAL(2), ITGB1(2), SELE(3), SELP(1) 8328406 10 10 10 5 1 2 6 0 1 0 0.16 0.34 296 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ECHS1(1), HADHA(1) 2649293 4 4 4 3 0 1 3 0 0 0 0.16 0.34 297 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), HLA-DRA(1), HLA-DRB1(3), IFNB1(1), IL3(1), TGFB2(1), TGFB3(1) 6360873 9 8 9 5 2 3 2 1 1 0 0.17 0.34 298 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 ABP1(4), ALDH1B1(2), ALDH3A2(1), AOC2(1), AOX1(5), CAT(2), CYP1A1(1), DDC(2), ECHS1(1), HADH(1), HADHA(1), HSD17B4(1), LCMT2(1), MAOA(1), MAOB(1), OGDH(2), OGDHL(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), TPH2(2) 29445365 35 30 35 8 4 9 15 5 2 0 0.17 0.35 299 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), IDH2(1), MDH1(1), OGDH(2), SDHA(1) 4644957 6 6 6 1 0 2 3 0 1 0 0.17 0.35 300 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(1), CARS(2), CARS2(1), DARS(1), EPRS(1), HARS(1), HARS2(1), IARS(1), IARS2(2), KARS(1), MARS(1), NARS2(1), PARS2(1), SARS(2), TARS(1), TARS2(2), VARS2(4), YARS2(1) 25902714 25 25 25 8 4 6 10 0 5 0 0.17 0.35 301 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GAA(2), GALE(1), GALK1(1), GALK2(1), GLB1(3), HK1(3), LALBA(1), LCT(1), MGAM(2), PFKM(2) 15995501 17 16 17 3 0 5 6 2 4 0 0.17 0.35 302 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), IDH1(1), IDH2(1), MDH1(1) 4389294 6 6 6 3 0 2 3 0 1 0 0.17 0.35 303 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK2G(2), CAMKK1(1), CAMKK2(2) 5731873 7 7 7 1 0 1 4 1 1 0 0.18 0.36 304 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACADS(2), ALDH1B1(2), ALDH3A2(1), AOX1(5), BCAT1(1), ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), IVD(1), MCCC2(3), MCEE(1), OXCT1(1), PCCA(1), PCCB(1) 21299672 25 24 25 7 5 8 8 1 3 0 0.18 0.36 305 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1), TUB(1) 3496315 5 5 5 0 0 2 2 0 1 0 0.18 0.36 306 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(1), HRAS(2), KLK2(1) 3984279 5 5 5 1 0 3 1 1 0 0 0.18 0.36 307 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD4(1), IL12RB1(1), IL12RB2(1), JAK2(2), STAT4(2), TYK2(2) 7207181 9 9 9 4 1 4 2 1 1 0 0.18 0.36 308 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 354468 1 1 1 0 0 1 0 0 0 0 0.18 0.36 309 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 CREM(1), FHL5(2), GNAS(1), XPO1(2) 4562040 6 6 6 1 0 3 2 1 0 0 0.18 0.36 310 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2A1(2), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), DAXX(2), PTPN13(1), RIPK1(1), SFRS2IP(1), TFG(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1) 21618286 19 19 19 3 3 2 10 0 4 0 0.19 0.37 311 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), ARF1(1), EEA1(1), GSK3A(2), GSK3B(1), PFKM(2), PLCG1(1), PRKCZ(1), RAB5A(1), RPS6KB1(2) 12465674 14 14 14 3 2 4 5 0 3 0 0.19 0.37 312 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASDHPPT(1), AASS(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), BBOX1(1), DOT1L(2), ECHS1(1), EHMT2(2), HADHA(1), PLOD2(1), PLOD3(1), SHMT1(1), SHMT2(2) 17622460 20 19 20 2 1 5 9 1 4 0 0.19 0.37 313 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP7(1), CASP8(1), DAXX(2), JUN(1), LMNB1(1), MAP3K1(1), MAP3K7(1), PAK1(1), PRKDC(2), PTPN13(1), RB1(3), RIPK2(1), SPTAN1(1) 21115404 19 19 19 12 3 3 8 0 5 0 0.19 0.37 314 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), CREB5(1), DUSP10(1), EIF4E(1), MAP2K3(2), MAP3K10(1), MAP3K4(3), MAP3K5(1), MAP3K7(1), MAPKAPK5(1), MKNK2(2), NR2C2(1), TRAF6(1) 16402798 18 16 18 4 3 4 8 0 3 0 0.19 0.37 315 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(2), JAK3(1), TYK2(2) 5821323 7 6 7 5 1 1 2 1 2 0 0.19 0.38 316 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 HLA-DRA(1), HLA-DRB1(3), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL4R(1) 6138997 9 8 9 3 1 4 2 1 1 0 0.19 0.38 317 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA2(1), GLB1(3), HEXA(1), LCT(1), MAN2B2(2), MAN2C1(4) 9810644 12 10 12 3 0 5 5 1 1 0 0.19 0.38 318 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB1A(1), RAB5A(1), RAB9A(1) 2127794 4 4 4 1 2 0 2 0 0 0 0.20 0.38 319 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1) 4127532 7 6 7 1 2 3 2 0 0 0 0.20 0.38 320 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(2), CYP11A1(1), HPGD(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGFR(1), PTGS2(2) 10086362 12 12 12 4 0 6 3 0 3 0 0.20 0.38 321 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 DBH(2), DDC(2), GAD1(1), MAOA(1), PAH(1), TH(1) 7000508 8 8 8 4 1 1 4 2 0 0 0.20 0.38 322 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), JAK1(2), STAT1(3) 5907858 6 6 6 4 0 4 0 0 2 0 0.20 0.38 323 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), HADH(1), HADHA(1), HSD17B4(1), SIRT1(1), SIRT5(1) 5762755 6 6 6 0 0 4 1 0 1 0 0.20 0.39 324 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(4), ALDH1B1(2), ALDH3A2(1), AOC2(1), DPYS(1), ECHS1(1), GAD1(1), HADHA(1), MLYCD(1), SMS(1) 13188242 14 14 14 6 0 1 9 3 1 0 0.20 0.39 325 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), JUN(1), POLR2A(4), PRKACB(1) 6231588 7 6 7 0 0 2 4 0 1 0 0.21 0.39 326 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN2(2), BCAR1(2), CAPN1(1), CSK(1), FYN(1), HRAS(2), ITGA1(1), ITGB1(2), JUN(1), PPP1R12B(1), PTK2(1), ROCK1(2), SOS1(4), TLN1(3), VCL(1) 23124901 26 23 26 9 4 8 11 0 3 0 0.21 0.40 327 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(1), CPO(1), FECH(1), HBB(2) 4040289 5 5 5 2 2 1 0 0 2 0 0.22 0.41 328 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(1), GNB1(2), PPP2CA(2), PRKACB(1), PRKAG1(2), PRKAG2(1) 7378253 9 9 9 1 1 3 4 0 1 0 0.22 0.41 329 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), CS(1), MDH1(1), MTHFD1(2), MTHFD1L(1) 6313760 8 8 8 2 1 2 5 0 0 0 0.22 0.42 330 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), B4GALT6(1), ENPP7(3), GAL3ST1(1), GBA(2), GLB1(3), LCT(1), PPAP2C(1), SGPP2(1), SMPD1(1), SPHK2(1), UGT8(2) 16946269 19 18 18 11 1 9 5 1 3 0 0.22 0.42 331 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1), PTK2B(2) 3302272 4 4 4 2 0 1 2 0 1 0 0.22 0.42 332 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CDK2(1), CDK4(1), CDKN2A(1) 4271198 5 5 5 3 0 2 2 0 1 0 0.23 0.42 333 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ENPP3(2), FLAD1(1), MTMR1(2), MTMR2(1), TYR(2) 7398735 9 9 9 0 1 1 5 1 1 0 0.23 0.42 334 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2A1(1), NCOA1(1), NCOA2(1), NCOA3(3), NCOR2(3), POLR2A(4), RARA(2) 12323664 15 12 15 8 1 4 9 0 1 0 0.23 0.42 335 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), DPYS(1), ECHS1(1), GAD1(1), HADHA(1), MLYCD(1), SMS(1) 14198337 15 15 15 7 1 1 9 3 1 0 0.23 0.42 336 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ABP1(4), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), AOC2(1), AOX1(5), CAT(2), CYP19A1(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), CYP2J2(1), CYP4B1(1), DDC(2), ECHS1(1), HADHA(1), MAOA(1), MAOB(1) 26774162 31 27 31 8 5 4 14 7 1 0 0.23 0.42 337 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(1), ACVR1B(3), ACVR2A(1), AMHR2(2), BMP2(1), BMP7(1), BMPR1B(1), BMPR2(2), CCL2(1), CSF1R(1), CSF2RB(1), CSF3R(1), CXCL11(1), EDA(1), EGF(1), EGFR(4), FLT1(2), FLT3(1), FLT4(3), GH2(1), GHR(1), HGF(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNB1(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL17RB(1), IL19(1), IL1R2(1), IL21(1), IL21R(1), IL22RA1(1), IL23A(1), IL25(1), IL2RB(1), IL3(1), IL4R(1), IL6R(1), IL6ST(2), INHBE(1), KDR(2), KITLG(1), LEPR(1), LIFR(1), MET(1), PDGFRA(3), PF4(1), PLEKHO2(1), PRLR(1), TGFB2(1), TGFB3(1), TGFBR2(2), TNFRSF10A(1), TNFRSF11B(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF9(1), TPO(1), VEGFA(1), XCL1(1) 85021508 83 73 83 32 15 28 30 2 8 0 0.23 0.42 338 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(1), EGF(1), EGFR(4), HRAS(2), ITGA1(1), ITGB1(2), MYLK(2), PRKACB(1), PTK2(1), TLN1(3) 16353942 19 18 19 5 3 4 9 1 2 0 0.23 0.42 339 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1B(1), BMPR2(2) 3044412 4 4 4 0 1 1 0 0 2 0 0.24 0.43 340 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ENPP3(2), FLAD1(1), TYR(2) 4791318 6 6 6 0 1 0 3 1 1 0 0.24 0.44 341 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), FBP1(1), G6PD(1), GPI(1), PFKM(2), PRPS1L1(1), PRPS2(1), TALDO1(3) 9949466 11 11 11 6 1 2 6 1 1 0 0.24 0.44 342 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 GGT1(2), LCMT2(1), MARS(1), PAPSS2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), SEPHS2(1) 12156958 11 11 11 4 1 3 4 1 2 0 0.25 0.44 343 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(1), MDH1(1), ME1(1) 4534099 6 6 6 3 0 1 5 0 0 0 0.25 0.44 344 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADRB2(1), CFTR(3), GNAS(1), PRKACB(1) 6212768 6 6 6 3 0 2 3 0 1 0 0.25 0.44 345 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(2), AKT2(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PIK3CB(1), PLD1(1), PLD2(1), PLD3(1) 21894326 20 20 20 4 1 7 8 1 3 0 0.25 0.44 346 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), FBP1(1), G6PD(1), GPI(1), PFKM(2), PRPS1L1(1), PRPS2(1), TALDO1(3), TKTL2(2) 11846628 13 13 13 7 2 2 7 1 1 0 0.25 0.44 347 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(3), NRG2(1), NRG3(2) 4419237 6 6 6 5 0 2 2 1 1 0 0.25 0.44 348 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 CALM2(1), EGFR(4), HRAS(2), JUN(1), MAP3K1(1), MEF2A(1), PAK1(1), PTK2(1), PTK2B(2), SOS1(4) 16739717 18 18 18 8 2 5 8 0 3 0 0.25 0.44 349 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(2), JAK3(1), PIAS1(2), PTPRU(2) 6880358 9 7 9 2 2 3 2 0 2 0 0.25 0.44 350 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CREBBP(3), EP300(3), GTF2A1(1), HDAC4(1), NCOR2(3), NRIP1(4), POLR2A(4) 23237069 20 18 20 16 0 5 12 0 3 0 0.25 0.44 351 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(1), CASP1(1), CASP10(2), CASP8(1), JUN(1) 6305637 6 6 6 0 1 0 3 0 2 0 0.25 0.44 352 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 NAT1(1), NAT2(2), XDH(2) 3923609 5 5 5 2 2 0 3 0 0 0 0.26 0.45 353 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), MST1(2), MST1R(1) 2938899 4 4 4 0 0 1 3 0 0 0 0.26 0.45 354 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(3), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), PCCA(1), PCCB(1), SUCLG1(2), SUCLG2(1) 16259033 18 18 18 8 2 7 5 1 3 0 0.26 0.45 355 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), CS(1), MDH1(1), MTHFD1(2), MTHFD1L(1) 6623274 8 8 8 2 1 2 5 0 0 0 0.26 0.45 356 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA3(2), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(1) 5923064 7 7 7 1 2 1 3 1 0 0 0.27 0.46 357 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(1), GNB1(2), PRKACA(1) 3105255 4 4 4 1 0 2 2 0 0 0 0.27 0.46 358 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(3), PIK3R4(3), ULK3(2) 10173933 13 12 13 3 2 7 3 0 1 0 0.27 0.46 359 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), SLC23A1(1), SLC23A2(1), SLC2A3(2) 12745592 14 14 14 6 1 6 5 2 0 0 0.27 0.46 360 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST6GALNAC2(2), ST8SIA1(1) 2764393 4 4 4 1 1 2 1 0 0 0 0.27 0.46 361 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), GNA13(1), GNB1(2), MYLK(2), PLCB1(1), PPP1R12B(1), ROCK1(2) 10219794 10 10 10 2 1 3 3 1 2 0 0.27 0.47 362 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF5(2), GSK3B(1) 5656518 7 7 7 2 1 3 2 0 1 0 0.28 0.47 363 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(2), ABLIM2(1), DCC(2), DPYSL2(1), EFNB2(1), EPHA1(1), EPHA4(1), EPHA5(1), EPHA8(2), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(4), FES(2), FYN(1), GSK3B(1), HRAS(2), ITGB1(2), L1CAM(1), LIMK2(1), MET(1), NFAT5(1), NFATC2(1), NFATC3(2), NGEF(1), NTN4(1), PAK1(1), PAK4(2), PAK6(1), PAK7(1), PLXNA2(2), PLXNA3(1), PLXNB1(3), PLXNC1(2), PPP3CC(1), PTK2(1), RGS3(3), RND1(1), ROBO1(2), ROBO2(2), ROBO3(1), ROCK1(2), SEMA3A(1), SEMA3C(1), SEMA3D(3), SEMA3E(1), SEMA4A(1), SEMA4D(1), SEMA4F(1), SEMA4G(1), SEMA6C(1), SEMA6D(1), SLIT1(3), SLIT2(1), SLIT3(3), SRGAP1(1), SRGAP2(1), UNC5A(1), UNC5B(1), UNC5C(1), UNC5D(2) 95824475 89 75 89 41 5 35 37 3 9 0 0.28 0.47 364 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(1), FYN(1), ITGA1(1), ITGB1(2), L1CAM(1), SELP(1) 7734869 9 9 9 5 2 0 7 0 0 0 0.28 0.47 365 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 JUN(1), MAP3K1(1), MAP3K5(1), MAP4K5(3), RELA(1), TNFRSF9(1), TNFSF9(1) 9737473 9 9 9 2 1 2 4 0 2 0 0.29 0.48 366 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(3) 3283960 3 3 3 7 0 2 0 0 1 0 0.29 0.48 367 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLAT(2), IDH2(1), MDH1(1), OGDH(2), PDHX(1), PDK1(1), PDK3(1), PDP2(1), SDHA(1), SDHD(1), SUCLG1(2), SUCLG2(1) 14060874 16 15 16 6 0 8 4 2 2 0 0.29 0.49 368 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 EGF(1), EGFR(4), HRAS(2), JUN(1), PLCG1(1), RELA(1) 10055215 10 10 10 5 1 3 5 0 1 0 0.29 0.49 369 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL3(1), KITLG(1), TGFB2(1), TGFB3(1) 4157404 5 5 5 1 2 2 1 0 0 0 0.29 0.49 370 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), MAP3K1(1), NSMAF(2), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1) 10095378 9 9 9 5 0 1 5 0 3 0 0.30 0.49 371 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ARPC2(1), ARPC3(1), WASL(2) 4028140 5 5 5 2 1 1 3 0 0 0 0.30 0.49 372 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(1), CPS1(5), EPRS(1), GAD1(1), GFPT1(1), GLS(1), GLS2(1), GOT1(2), GOT2(3), GPT2(1), GSS(1) 19339213 18 17 18 7 2 8 5 0 3 0 0.30 0.50 373 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA5B(1), CA9(1), CPS1(5), GLS(1), GLS2(1) 9233145 10 10 10 1 0 6 4 0 0 0 0.30 0.50 374 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(1), ADSL(1), AGXT(1), AGXT2(1), ASNS(1), ASS1(1), DARS(1), DLAT(2), GAD1(1), GOT1(2), GOT2(3), GPT2(1), NARS2(1) 18623928 17 15 17 6 2 3 5 1 6 0 0.30 0.50 375 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC2(2), BIRC3(1), CASP1(1), CASP10(2), CASP2(1), CASP4(1), CASP7(1), CASP8(1), LMNB1(1) 9445671 11 11 11 4 3 3 4 0 1 0 0.31 0.50 376 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 886309 1 1 1 0 0 0 1 0 0 0 0.31 0.50 377 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), UGP2(1), UXS1(1) 2499944 3 3 3 1 0 2 0 1 0 0 0.31 0.50 378 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), ATP7B(2), COX6A2(1), COX7A2(1), NDUFA10(1), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFV2(1), PPA2(2), SDHA(1), SHMT1(1) 18211634 21 20 21 8 7 5 7 0 2 0 0.31 0.50 379 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(1) 2682479 3 3 3 1 0 2 0 0 1 0 0.31 0.50 380 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 TGFB2(1), TGFB3(1), TGFBR2(2), TOB2(2) 5263043 6 6 6 2 3 2 0 1 0 0 0.31 0.50 381 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 HRAS(2), JAK2(2), JUN(1), PLCG1(1), SOS1(4), STAT5B(1) 10648180 11 11 11 2 1 3 7 0 0 0 0.31 0.51 382 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(3), FGA(1), PROC(2), TFPI(1) 7922110 9 9 9 3 0 5 3 0 1 0 0.31 0.51 383 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), GRIN1(1), HIF1A(1), JAK2(2), RELA(1) 6289138 7 7 7 0 1 2 4 0 0 0 0.31 0.51 384 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(1), ASCC3(2), ATP13A2(4), DDX18(2), DDX50(2), DDX56(1), DHX58(1), ENPP3(2), EP400(1), GAA(2), GBA(2), GBA3(1), GPI(1), GUSB(2), GYS1(2), GYS2(1), HK1(3), IFIH1(2), MGAM(2), RAD54L(1), SI(3), SKIV2L2(1), SMARCA2(4), SMARCA5(2), UGP2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1), UXS1(1) 60334316 57 47 57 23 4 16 23 5 9 0 0.32 0.51 385 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(4), HMGCR(1), LIPC(1), LRP1(5), SCARB1(2) 12763083 13 13 13 5 2 6 2 2 1 0 0.32 0.51 386 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), GSK3B(1), MAPT(1), PPP2CA(2) 4631579 5 5 5 0 0 1 1 1 2 0 0.32 0.52 387 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B2(1), CYP19A1(1), HSD17B1(1), HSD17B2(1), HSD17B8(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1), STS(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1) 23525307 24 24 24 8 2 6 12 2 2 0 0.33 0.52 388 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(3), CREB5(1), SNX13(3) 5738631 7 6 7 6 0 3 3 0 1 0 0.33 0.52 389 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(1), SCAP(1), SREBF2(3) 5716128 5 5 5 2 1 1 2 0 1 0 0.33 0.52 390 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(1), ARSE(1), GAL3ST1(1), GBA(2), GLB1(3), LCT(1), PPAP2C(1), SMPD1(1) 11522198 12 11 12 9 0 5 4 1 2 0 0.33 0.53 391 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDK2(1), DIAPH2(1), MCM2(3), MCM6(2), MCM7(1), NACA(2), ORC1L(1), ORC4L(1), ORC5L(1), PCNA(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), RFC1(1), RFC2(1), RPA3(1), RPA4(1) 24938612 24 24 24 12 5 4 8 0 7 0 0.34 0.53 392 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), DPAGT1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RPN1(2), RPN2(1) 9452406 8 8 8 4 0 1 4 1 2 0 0.34 0.54 393 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(1), JAK1(2), JAK2(2), JAK3(1), PTPRU(2) 7589078 8 7 8 4 2 2 1 0 3 0 0.35 0.55 394 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), CYP19A1(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), CYP2J2(1), CYP4B1(1) 14358228 16 14 16 6 2 1 10 2 1 0 0.35 0.55 395 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 6913934 7 7 7 2 1 1 3 0 2 0 0.35 0.55 396 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), ANGPTL4(1), APOA5(1), AQP7(1), CYP4A11(2), CYP4A22(1), CYP8B1(2), DBI(1), FADS2(1), GK(1), ILK(1), ME1(1), NR1H3(1), PCK1(2), PLTP(1), RXRB(1), RXRG(2), SCP2(2), SLC27A1(2), SLC27A6(1), SORBS1(1), UCP1(1) 31653372 32 29 32 12 5 12 11 0 4 0 0.35 0.55 397 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB5(1), EIF4E(1), MKNK2(2), RPS6KA1(1), RPS6KA2(1), RPS6KA3(1), SOS1(4), SOS2(2), TRAF3(1) 14641693 17 15 17 7 3 4 8 0 2 0 0.36 0.55 398 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(4), PPP2CA(2), PRKACB(1), PRKAG1(2) 8972421 9 9 9 3 0 3 4 0 2 0 0.36 0.55 399 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), CEL(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), GK(1), GLB1(3), LCT(1), LIPC(1), LIPF(1), PNLIP(2), PNLIPRP2(1), PPAP2C(1) 23466314 22 20 22 7 3 2 11 2 4 0 0.36 0.56 400 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD4(1), IL3(1), KITLG(1) 3117195 4 4 4 2 1 3 0 0 0 0 0.36 0.56 401 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC4(1) 3607442 3 3 3 3 1 1 0 0 1 0 0.36 0.56 402 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOA(1), FBP1(1), FPGT(1), HK1(3), KHK(2), MPI(1), MTMR1(2), MTMR2(1), PFKM(2), PGM2(1), RDH13(1) 18400760 18 17 18 6 1 5 8 2 2 0 0.37 0.56 403 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BIRC2(2), BIRC3(1), CASP10(2), CASP7(1), CASP8(1), GAS2(1), RELA(1), RIPK1(1), SPTAN1(1), TNFRSF10A(1), TNFSF10(1), TRADD(1) 16548992 14 14 14 3 4 1 6 0 3 0 0.37 0.56 404 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), JUN(1), MAP2K3(2), MAP3K1(1), MAP4K2(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1) 11885639 11 10 11 4 2 1 6 0 2 0 0.37 0.56 405 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 IL12RB1(1), IL12RB2(1), JAK2(2), JUN(1), STAT4(2), TYK2(2) 9126453 9 9 9 4 1 3 3 1 1 0 0.37 0.56 406 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NOX1(1), RELA(1), XDH(2) 4846850 5 5 5 1 0 1 4 0 0 0 0.37 0.57 407 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), JUN(1), PLCG1(1), PTK2B(2) 6583910 6 6 6 4 0 1 4 0 1 0 0.38 0.58 408 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLD1(2), POLD3(1), POLE(1), POLE2(1), POLG2(3), POLH(2), POLI(2), POLL(1), POLM(1), POLQ(3), PRIM2(1), REV3L(4) 20602122 22 20 22 5 4 4 8 1 5 0 0.38 0.58 409 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), LCMT2(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(1) 7021984 7 7 7 1 1 2 3 0 1 0 0.39 0.58 410 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), EIF4E(1), IFRD1(1), NR4A3(1), WDR1(1) 5400923 6 6 6 1 1 1 3 0 1 0 0.39 0.59 411 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(1), EGF(1), EGFR(4), RAB5A(1) 6276884 7 7 7 0 2 3 1 0 1 0 0.39 0.59 412 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(3), GZMA(1), HMGB2(1) 5262970 5 5 5 2 0 0 3 1 1 0 0.40 0.60 413 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(2), DHRS2(1), RDH13(1) 4130052 4 4 4 0 1 1 1 0 1 0 0.40 0.60 414 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT4(2), CHST1(1), ST3GAL3(1) 5736792 5 5 5 2 0 1 1 0 3 0 0.41 0.60 415 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(1), ENPP3(2), GAA(2), GBA3(1), GPI(1), GUSB(2), GYS1(2), GYS2(1), HK1(3), MGAM(2), SI(3), UCHL3(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1), UXS1(1) 27566105 27 25 27 11 4 5 8 5 5 0 0.41 0.60 416 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), GREB1(2), HSPB2(1), MTA3(1) 5154148 5 5 5 1 1 0 3 1 0 0 0.41 0.60 417 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 CCKBR(1), CELSR1(3), CELSR3(1), CHRM2(1), EMR3(4), GPR116(1), GPR133(3), GPR17(1), GPR84(2), GRM1(1), HRH4(1), LGR6(2), LPHN3(3), NTSR1(1), OR8G2(1), P2RY13(1), PTGFR(1), SMO(2), TSHR(1) 31849963 31 28 31 8 2 9 16 1 3 0 0.41 0.61 418 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(3), ACSS1(2), ACSS2(2), ALDH1B1(2), ALDH3A2(1), DLAT(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(1), ME3(1), PCK1(2) 22788407 22 20 22 8 3 3 7 3 6 0 0.42 0.61 419 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), UXS1(1) 1987535 2 2 2 1 0 1 0 1 0 0 0.42 0.61 420 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GPI(1), HK1(3), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3) 23773969 24 21 24 6 2 4 10 3 5 0 0.42 0.61 421 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOA(1), DLAT(2), FBP1(1), GPI(1), HK1(3), LDHB(1), LDHC(1), PFKM(2), PGAM1(1), PGK1(3) 23773969 24 21 24 6 2 4 10 3 5 0 0.42 0.61 422 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH3A2(1), MIOX(1) 4166374 4 4 4 0 0 0 3 0 1 0 0.42 0.62 423 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT6(1), ST3GAL3(1) 2302256 2 2 2 1 0 0 1 0 1 0 0.42 0.62 424 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 986886 1 1 1 0 0 0 0 1 0 0 0.43 0.62 425 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(5) 4065861 5 5 5 0 0 3 1 1 0 0 0.43 0.62 426 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), PER1(2) 4198038 4 4 4 2 0 2 1 0 1 0 0.43 0.62 427 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 JUNB(2), MAP2K3(2), NFATC2(1), PRKACB(1) 5522879 6 5 6 3 1 0 4 0 1 0 0.43 0.62 428 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA5B(1), CA9(1), CPS1(5), GLS(1), GLS2(1) 10330878 10 10 10 1 0 6 4 0 0 0 0.43 0.62 429 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRB2(1), CHRM2(1), CHRM5(2), DRD1(1), DRD5(1), HTR1A(1), HTR2A(1), HTR2C(1), HTR5A(1), HTR6(1), HTR7(1) 12206396 12 12 12 3 1 6 3 1 1 0 0.44 0.62 430 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(1), ATP5A1(1), ATP5G2(1), ATP6AP1(1), ATP6V0A4(1), ATP6V0D2(1), ATP6V1B1(1), ATP6V1B2(1), COX15(1), COX6A2(1), COX7A2(1), NDUFA10(1), NDUFA13(3), NDUFB6(1), NDUFS1(2), NDUFS2(1), NDUFS5(1), NDUFV2(1), PPA2(2), SDHA(1), SDHD(1), UQCRC2(1) 27603400 29 27 29 14 7 8 12 0 2 0 0.44 0.62 431 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(1), MNAT1(1), XPO1(2) 4251172 4 4 4 1 1 0 2 1 0 0 0.44 0.62 432 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGP2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1) 12253964 13 13 13 2 2 4 4 1 2 0 0.44 0.63 433 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNB1(2), HRAS(2), ITGA1(1), ITGB1(2), PLCB1(1), PTK2(1), SYK(1) 11956135 12 11 12 6 1 1 7 0 3 0 0.44 0.63 434 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(3), LEPR(1), PRKAG1(2), PRKAG2(1) 7140097 7 7 7 0 2 1 2 1 1 0 0.44 0.63 435 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(1), FYN(1), LRP8(1), RELN(3), VLDLR(2) 6826972 8 7 8 6 1 4 3 0 0 0 0.44 0.63 436 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(3), ADH5(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), DLAT(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(1), ME3(1), PCK1(2) 17986634 19 17 19 6 4 3 5 3 4 0 0.45 0.63 437 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN2(2), CAPN1(1), ITGA1(1), ITGB1(2), PTK2(1), SPTAN1(1), TLN1(3) 14281837 12 12 12 8 2 2 6 0 2 0 0.45 0.63 438 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), GNB1(2), HRAS(2), MAP2K3(2), MAP3K1(1), NCF1(1), NFATC2(1), NFATC3(2), PAK1(1), PIK3C2G(1), PLCB1(1), PPP3CC(1), RELA(1) 18855704 18 17 18 5 1 4 9 0 4 0 0.45 0.63 439 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(1), SHMT1(1), SHMT2(2) 8840957 8 8 8 1 1 1 5 0 1 0 0.45 0.63 440 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1B(1), ADH5(1), ADHFE1(1), AGK(3), ALDH1B1(2), ALDH3A2(1), CEL(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), GK(1), GLB1(3), LCT(1), LIPC(1), LIPF(1), PNLIP(2), PNLIPRP2(1), PNPLA3(1), PPAP2C(1) 28674109 26 23 26 6 4 4 12 2 4 0 0.45 0.63 441 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), F12(1), F2(2), F5(3), F8(1), FGA(1), PROC(2), SERPING1(2) 22068126 22 21 22 11 1 9 10 1 1 0 0.46 0.63 442 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 GGT1(2), MARS(1), PAPSS2(1) 6052156 4 4 4 3 0 1 1 1 1 0 0.46 0.63 443 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), HADHA(1) 5997941 6 6 6 1 1 1 4 0 0 0 0.46 0.63 444 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), ANPEP(3), ENPEP(1), LNPEP(2), MAS1(1), MME(1), REN(1) 10314524 10 10 10 5 4 3 2 0 1 0 0.46 0.63 445 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IRAK1(2), MAP3K1(1), MAP3K7(1), RELA(1), RIPK1(1), TLR4(1), TNFRSF1A(1), TRADD(1), TRAF6(1) 11860348 10 9 10 6 1 0 5 0 4 0 0.46 0.63 446 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CTPS(1), DCTD(1), DPYS(1), POLD1(2), POLE(1), POLL(1), POLQ(3), POLR2A(4), POLR2B(1), POLR2I(1), POLRMT(1), RRM2(1), TK2(1), UNG(2) 28285743 21 20 21 7 3 3 8 1 6 0 0.46 0.64 447 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(1), SDHD(1) 3201878 3 3 3 0 1 1 0 0 1 0 0.47 0.64 448 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), RPL19(1), RPL27(1), RPL30(1), RPL31(1), RPL34(1), RPL7(1), RPS13(1), RPS26(1), RPS29(1), RPS3A(1) 10851359 11 10 11 4 0 5 5 0 1 0 0.47 0.64 449 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT3(1), B3GNT5(1), B4GALT4(2), FUT6(1), GCNT2(1), ST3GAL6(1), ST8SIA1(1) 7359256 8 7 8 2 1 3 2 1 1 0 0.47 0.64 450 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(1), ARSE(1), CYP11B2(1), HSD17B2(1), HSD17B8(1), STS(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1) 12758150 12 12 12 5 1 3 5 1 2 0 0.47 0.65 451 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1), B3GNT5(1), ST3GAL3(1) 3498397 3 3 3 1 0 0 1 1 1 0 0.48 0.65 452 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(3), HEXA(1), LCT(1), SLC33A1(2), ST8SIA1(1) 8074688 9 8 9 6 1 4 2 1 1 0 0.48 0.65 453 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), HADHA(1) 2398269 2 2 2 0 0 1 1 0 0 0 0.48 0.65 454 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), IARS2(2), VARS2(4) 8400540 8 8 8 3 1 2 4 0 1 0 0.48 0.65 455 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1) 1597225 1 1 1 1 0 0 0 0 1 0 0.49 0.66 456 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2J2(1), PLA2G12A(1), PLA2G6(2), RDH13(1) 11771519 11 11 11 1 3 1 5 1 1 0 0.49 0.66 457 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1B1(2), ALDH3A2(1) 3929942 4 4 4 1 1 0 3 0 0 0 0.49 0.66 458 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1B1(2), ALDH3A2(1) 3929942 4 4 4 1 1 0 3 0 0 0 0.49 0.66 459 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS2(1), SULT1A2(1), SUOX(1) 2978406 3 3 3 2 0 2 0 1 0 0 0.49 0.66 460 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), EP300(3), NCOA1(1), NCOA2(1) 9063247 8 8 8 6 1 1 5 0 1 0 0.49 0.66 461 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1), RDH5(1) 1902186 2 2 2 2 1 0 1 0 0 0 0.49 0.66 462 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ITPKA(1), PDE1B(2), PLCB1(1), PLCB2(1) 5458098 5 5 5 2 1 1 1 0 2 0 0.49 0.66 463 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(1), HADHA(1), HADHB(2) 4127565 4 4 4 1 2 1 1 0 0 0 0.49 0.66 464 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADS(2), ACSL1(1), ACSL3(1), ACSL5(1), ACSL6(2), ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1), CYP4A11(2), CYP4A22(1), ECHS1(1), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1) 24016108 23 23 23 11 6 4 11 0 2 0 0.50 0.67 465 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), MYST3(4), PNPLA3(1) 7809532 6 6 6 2 0 3 3 0 0 0 0.51 0.67 466 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 GART(1), MTHFD1(2), MTHFD1L(1), MTHFR(1), SHMT1(1), SHMT2(2) 9294309 8 8 8 1 1 1 5 0 1 0 0.51 0.68 467 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), HRAS(2), JUN(1), PLCB1(1), RELA(1) 7475440 6 6 6 3 1 1 3 0 1 0 0.52 0.68 468 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UCHL3(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1) 7945896 8 8 8 3 2 2 1 1 2 0 0.52 0.69 469 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(1), MPI(1) 6668597 7 6 7 3 0 3 3 1 0 0 0.52 0.69 470 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(1), NR1H4(1) 2623419 2 2 2 3 0 0 1 1 0 0 0.52 0.69 471 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(1), HMGCR(1), PMVK(1), VKORC1(1) 5481897 5 5 5 0 0 2 3 0 0 0 0.53 0.69 472 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1) 2118540 2 2 2 0 0 2 0 0 0 0 0.53 0.69 473 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), FBP1(1), FPGT(1), HK1(3), KHK(2), MPI(1), PFKM(2) 11887077 11 10 11 6 0 4 4 2 1 0 0.53 0.70 474 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(1), GNB1(2), PRKACB(1) 4611498 4 4 4 4 0 1 3 0 0 0 0.54 0.70 475 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), CD44(2), IL6R(1), TGFB2(1), TNFRSF1A(1) 6677849 6 6 6 5 2 0 2 0 2 0 0.54 0.70 476 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 CALM2(1), HRAS(2), JUN(1), MAP3K1(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1), SOS1(4), SYK(1), VAV1(1) 18528652 16 16 16 10 1 5 7 0 3 0 0.55 0.70 477 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(1), COX15(1), CP(1), EPRS(1), FECH(1), FTMT(2), GUSB(2), HMOX1(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1) 19666031 20 19 20 5 6 4 5 1 4 0 0.55 0.70 478 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 CALM2(1), GNAS(1), GNB1(2), HRAS(2), JUN(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1), PRKACB(1), RPS6KA3(1) 16651595 14 14 14 6 1 5 7 0 1 0 0.55 0.70 479 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), PER1(2), PER2(1), PER3(2) 8363050 7 7 7 2 0 3 2 0 2 0 0.55 0.70 480 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(1), POLL(1), POLQ(3) 8338612 7 7 7 2 2 1 2 0 2 0 0.55 0.70 481 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 PTGS2(2) 2589307 2 2 2 2 0 1 0 0 1 0 0.55 0.70 482 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), EP300(3) 7476649 6 6 6 6 0 1 4 0 1 0 0.55 0.70 483 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 1656909 1 1 1 1 0 0 0 0 1 0 0.56 0.71 484 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI2(1) 2173785 2 2 2 0 0 1 1 0 0 0 0.56 0.72 485 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDKN1A(1), WEE1(1) 3712484 3 3 3 1 0 2 1 0 0 0 0.57 0.72 486 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP5(1), ALPI(1), ALPL(2), ALPP(2), ALPPL2(1), DHRS2(1) 8505842 8 7 8 4 0 2 5 0 1 0 0.57 0.73 487 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYS(1), ENPP3(2), PANK2(2) 6682716 7 6 7 1 1 1 4 1 0 0 0.57 0.73 488 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(1), ADH5(1), ADHFE1(1), ALDH1B1(2), ALDH3A2(1) 6580023 6 6 6 2 2 0 3 0 1 0 0.58 0.73 489 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 1499385 1 1 1 1 0 0 1 0 0 0 0.58 0.73 490 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(1), ALG13(1), ALG3(1), ALG8(1), DOLPP1(1), DPAGT1(1), MAN1A2(1), MAN2A1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RFT1(1), RPN1(2), RPN2(1), STT3B(1) 20673936 17 16 17 5 0 4 9 1 3 0 0.58 0.73 491 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 EPHB2(1), F2(2), JUN(1), PLD1(1), PLD2(1), PLD3(1), PTK2(1), RASAL1(1), TEC(1), VAV1(1) 13680040 11 11 11 9 0 1 8 0 2 0 0.58 0.73 492 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(1), AVPR1A(2), BDKRB1(1), C3AR1(1), CCKAR(2), CCKBR(1), MC3R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(1), OPRM1(1), SSTR1(2), SSTR4(1), TACR1(1), TACR2(1), TACR3(2), TSHR(1) 24748948 22 21 22 9 2 6 12 0 2 0 0.58 0.73 493 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 FADS2(1), PLA2G12A(1), PLA2G6(2) 5086502 4 4 4 0 0 0 4 0 0 0 0.58 0.73 494 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), GRM1(1), PLCB1(1), PPP2CA(2), PRKACB(1) 7761224 6 6 6 0 0 1 3 0 2 0 0.59 0.73 495 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), ITGAL(2) 4112732 3 3 3 1 0 0 2 0 1 0 0.60 0.74 496 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACSL1(1), ACSL3(1), HADHA(1), PECR(1), SCP2(2) 8243036 8 8 8 7 1 3 4 0 0 0 0.60 0.75 497 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1) 1852755 1 1 1 1 0 0 0 1 0 0 0.60 0.75 498 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(1), MEF2A(1) 4121456 3 3 3 1 1 0 0 0 2 0 0.60 0.75 499 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKACB(1), PRKAG1(2) 4969151 4 4 4 1 0 2 2 0 0 0 0.60 0.75 500 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL16(2), IL3(1) 4730628 4 4 4 3 1 1 2 0 0 0 0.61 0.75 501 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), IFNB1(1), RELA(1), TRAF6(1) 5365496 4 4 4 2 0 1 2 0 1 0 0.61 0.75 502 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ADH1B(1), ADH5(1), ADHFE1(1), DHRS2(1), MYST3(4), PNPLA3(1) 11968492 9 9 9 4 2 3 3 0 1 0 0.61 0.75 503 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ALDH1B1(2), ALDH3A2(1), CYP2C19(1), DHRS2(1), ECHS1(1), HADHA(1), MYST3(4), PNPLA3(1) 14912116 12 11 12 2 0 4 7 1 0 0 0.61 0.75 504 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1B(1), ADH5(1), ADHFE1(1), AKR1C1(1), ALDH3B1(1), ALDH3B2(1), CYP1A1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2F1(1), DHDH(2), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2A1(1), UGT2A3(2), UGT2B11(1), UGT2B15(1), UGT2B28(1) 27113692 24 22 24 7 6 3 8 3 4 0 0.62 0.75 505 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1) 1645680 1 1 1 0 0 0 1 0 0 0 0.62 0.75 506 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), IMPDH1(1), POLD1(2), PRPS2(1) 6298961 5 5 5 2 1 1 3 0 0 0 0.62 0.76 507 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 HRAS(2), JUN(1), MAP3K1(1), MAPK8IP3(1), RPS6KA1(1), RPS6KA3(1), SOS1(4), SYK(1), VAV1(1), VAV3(1) 15453816 14 13 14 3 2 3 7 0 2 0 0.62 0.76 508 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(1) 1831849 1 1 1 1 0 1 0 0 0 0 0.62 0.76 509 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 XYLT1(1), XYLT2(1) 3182878 2 2 2 1 0 1 1 0 0 0 0.63 0.76 510 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 XYLT1(1), XYLT2(1) 3182878 2 2 2 1 0 1 1 0 0 0 0.63 0.76 511 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(1), ADHFE1(1) 2757591 2 2 2 2 1 0 0 0 1 0 0.63 0.76 512 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), GNAS(1), GNB1(2), HRAS(2), PRKACB(1), RPS6KA1(1) 9923836 8 8 8 3 1 2 5 0 0 0 0.63 0.76 513 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 CALM2(1), CAMK2G(2), CLCA4(1), CNGA4(1), GNAL(1), GUCA1B(1), PDE1C(1), PRKACA(1), PRKACB(1), PRKG1(1), PRKG2(1) 15177282 12 12 12 5 2 1 6 2 1 0 0.63 0.76 514 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(1), HMGCR(1), PMVK(1), SC4MOL(1) 6541540 5 5 5 0 0 1 3 0 1 0 0.63 0.76 515 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IRAK1(2), IRAK3(1), JUN(1), MAP2K3(2), MAP3K1(1), MAP3K7(1), RELA(1), TGFB2(1), TGFB3(1), TRAF6(1) 14495990 13 11 13 2 2 1 7 0 3 0 0.64 0.76 516 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B1(1), HSD17B2(1), HSD17B4(1) 3943716 3 3 3 2 0 1 1 1 0 0 0.65 0.77 517 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HEXA(1), HK1(3), RENBP(2) 8352039 8 7 8 1 0 4 3 1 0 0 0.65 0.78 518 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CLK2(1), CLK4(1), COL2A1(3), CPSF1(2), CPSF2(1), CPSF3(1), CSTF2T(1), CSTF3(3), DHX15(2), DHX8(1), DHX9(1), LSM7(1), METTL3(1), NONO(2), POLR2A(4), PRPF8(6), SF3A2(1), SF3B1(2), SF3B2(2), SFRS12(2), SRPK2(1), SRRM1(1), SUPT5H(2), XRN2(2) 51502543 44 41 44 11 7 15 14 3 5 0 0.66 0.78 519 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CD4(1), IFNGR1(1), IFNGR2(1), IL12RB1(1), IL12RB2(1), IL4R(1), TGFB2(1), TGFB3(1) 9682820 8 8 8 2 2 5 1 0 0 0 0.66 0.78 520 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), IFNB1(1), IL3(1), ITGAX(1), TLR4(1), TLR7(1) 9114542 8 8 8 4 3 1 4 0 0 0 0.66 0.78 521 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD4(1) 1438965 1 1 1 1 0 1 0 0 0 0 0.66 0.78 522 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 CARS(2), DARS(1), EPRS(1), HARS(1), IARS(1), KARS(1), MARS(1), SARS(2), TARS(1) 15693646 11 11 11 7 1 2 6 0 2 0 0.66 0.78 523 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(1), CLTA(1), COPA(1), GBF1(2), KDELR2(1) 7965354 7 7 7 2 1 3 2 0 1 0 0.67 0.79 524 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA4(1), PSMA6(1) 4108699 3 3 3 1 1 0 1 1 0 0 0.67 0.79 525 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 SNAP23(1), STX10(1), STX7(1), STX8(1), TSNARE1(1) 8015575 5 5 5 2 1 1 2 0 1 0 0.67 0.79 526 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK2G(2), ESRRA(1), MEF2A(1), PPP3CC(1) 10231760 7 7 7 1 0 1 3 0 3 0 0.68 0.79 527 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(1), ITPR2(4), ITPR3(1), NFAT5(1), PDE6C(2) 17830422 13 13 13 4 0 6 6 0 1 0 0.68 0.79 528 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 COL4A1(1), COL4A3(1), COL4A4(2), COL4A5(4), COL4A6(2), REN(1) 12783227 11 11 11 5 2 4 4 1 0 0 0.68 0.79 529 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1B(1), ADHFE1(1), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), CEL(1), HADHB(2), SOAT2(1) 11495128 10 10 10 5 5 0 3 0 2 0 0.68 0.79 530 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), DAXX(2), HSPB2(1) 5439787 4 4 4 0 3 0 1 0 0 0 0.69 0.80 531 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CALM2(1), EP300(3), NFATC2(1), PPP3CC(1) 11543941 9 9 9 7 0 3 3 1 2 0 0.69 0.80 532 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACADS(2), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), BDH1(1), ECHS1(1), GAD1(1), HADH(1), HADHA(1), HSD17B4(1), OXCT1(1), RDH13(1) 20122395 16 16 16 7 2 3 9 0 2 0 0.69 0.80 533 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACADS(2), ALDH1A2(1), ALDH1B1(2), ALDH3A2(1), ECHS1(1), GAD1(1), HADHA(1), OXCT1(1) 12688083 10 10 10 4 1 1 7 0 1 0 0.70 0.80 534 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(1), CALM2(1), PPP3CC(1), SYNJ1(4) 11127707 7 7 7 6 0 2 3 0 2 0 0.70 0.81 535 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 GNAS(1), GNB1(2), HRAS(2), NOX1(1), PIK3C2G(1), PLCB1(1), PPP1R12B(1), PTK2(1) 12524412 10 10 10 5 1 2 6 0 1 0 0.71 0.82 536 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(1) 3378168 2 2 2 1 0 1 1 0 0 0 0.71 0.82 537 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 DHRS2(1), ECHS1(1), HADHA(1), MYST3(4), PNPLA3(1) 12436744 8 8 8 2 0 4 4 0 0 0 0.72 0.83 538 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ARPC2(1), ARPC3(1), NCKAP1(1), WASL(2) 7609349 6 6 6 2 1 2 3 0 0 0 0.72 0.83 539 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), EGR2(1), EGR3(1), MAP3K1(1), NFATC2(1), PLCG1(1), PPP3CC(1), PRKACB(1), RELA(1) 13247491 9 9 9 1 0 2 5 0 2 0 0.73 0.83 540 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(3), EP300(3), MAP2K3(2), MAP3K7(1), RELA(1), TGFBR2(2) 14552743 12 11 12 4 3 1 6 0 2 0 0.73 0.84 541 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), FDPS(1), HMGCR(1), IDI2(1), PMVK(1), SC4MOL(1), VKORC1(1) 9544279 7 7 7 1 0 3 3 0 1 0 0.73 0.84 542 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 CHPT1(1), PAFAH1B1(1), PLA2G12A(1), PLA2G6(2), PLD1(1), PLD2(1), PPAP2C(1) 11433514 8 8 8 2 0 1 6 0 1 0 0.74 0.84 543 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADRB2(1), GNAS(1), PLCE1(1), PRKACB(1), RAP2B(1) 7019869 5 5 5 2 0 3 1 0 1 0 0.74 0.84 544 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CD97(1), CRHR2(1), ELTD1(1), GIPR(1), GLP2R(1), LPHN1(1), LPHN3(3) 13618233 11 10 11 2 1 3 6 0 1 0 0.74 0.84 545 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(1), EPRS(1), FECH(1), GUSB(2), HMOX1(1), UGT1A1(1), UGT1A7(2), UGT1A8(1), UGT2B15(1) 12759751 11 11 11 4 5 2 1 1 2 0 0.74 0.84 546 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2) 3710742 2 2 2 0 0 1 1 0 0 0 0.74 0.84 547 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 PAPSS2(1), SULT1A2(1), SUOX(1) 4452086 3 3 3 3 0 2 0 1 0 0 0.75 0.84 548 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(1), FECH(1) 3797446 2 2 2 2 1 0 0 0 1 0 0.75 0.84 549 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), MAP3K1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1) 11081882 6 6 6 2 0 2 2 0 2 0 0.75 0.84 550 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 SNCAIP(1), UBE2E2(1) 3102891 2 2 2 1 1 1 0 0 0 0 0.75 0.84 551 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 GCNT2(1), ST8SIA1(1) 2939076 2 2 2 2 1 0 1 0 0 0 0.75 0.84 552 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1) 1862712 1 1 1 0 0 0 1 0 0 0 0.75 0.84 553 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ITPKA(1), ITPKB(1) 2855343 2 2 2 1 0 2 0 0 0 0 0.76 0.84 554 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1) 2601171 1 1 1 2 0 0 1 0 0 0 0.76 0.84 555 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 GPR45(1), GPR65(1), GPR81(1) 4848662 3 3 3 2 0 1 2 0 0 0 0.76 0.85 556 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CSK(1), PTPRA(1) 4568919 3 3 3 3 0 1 2 0 0 0 0.76 0.85 557 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), IL3(1) 3068160 2 2 2 2 1 1 0 0 0 0 0.77 0.85 558 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH1B(1), ADH5(1), ADHFE1(1), AKR1B10(2), ALDH1B1(2), ALDH3A2(1), CEL(1), HADHB(2), RDH13(1), SOAT2(1) 15762123 13 12 13 4 6 0 4 0 3 0 0.77 0.85 559 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(1), NFATC2(1), NFATC3(2), PLCG1(1), PPP3CC(1) 9931680 7 7 7 6 0 4 2 0 1 0 0.77 0.85 560 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), HRAS(2), JUN(1), NCOR2(3), RBL2(1), SIN3A(1) 12945129 9 9 9 1 2 1 6 0 0 0 0.77 0.85 561 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), OXCT1(1) 3554023 2 2 2 1 1 0 0 0 1 0 0.77 0.85 562 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYS(1), ENPP3(2), PANK2(2) 8385050 7 6 7 2 1 1 4 1 0 0 0.77 0.85 563 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BIRC2(2), BIRC3(1), CASP7(1), CASP8(1) 6680587 5 5 5 2 2 1 2 0 0 0 0.77 0.85 564 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 PLCB1(1), RELA(1) 4051481 2 2 2 2 0 0 1 0 1 0 0.78 0.85 565 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(1), HADHA(1) 3853368 2 2 2 0 0 1 1 0 0 0 0.78 0.85 566 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP5(1), ARHGEF11(1), ARHGEF5(2), ARPC2(1), ARPC3(1), DIAPH1(1), MYLK(2), PPP1R12B(1), ROCK1(2), TLN1(3), VCL(1) 22850648 17 16 17 3 3 5 7 1 1 0 0.79 0.86 567 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(2), ARHGEF11(1), GNA13(1), MAP3K1(1), MAP3K5(1), NFKBIB(1), NFKBIL2(1), PDK1(1), PIK3CB(1), PLD1(1), PLD2(1), PLD3(1), PTK2(1), ROCK1(2), SERPINA4(1) 23773686 19 18 19 6 1 7 8 1 2 0 0.79 0.86 568 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(3), CD19(1), CD1B(1), CD22(2), CD34(1), CD38(1), CD4(1), CD44(2), CD55(1), CR1(2), CR2(2), CSF1R(1), CSF3R(1), FLT3(1), GP1BA(1), HLA-DRA(1), HLA-DRB1(3), IL1R2(1), IL3(1), IL4R(1), IL6R(1), ITGA1(1), ITGA3(2), ITGA6(2), KITLG(1), MME(1), TPO(1) 39789370 37 31 37 19 5 12 12 1 7 0 0.80 0.86 569 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), NOS3(1), REN(1) 4732682 3 3 3 2 2 1 0 0 0 0 0.80 0.87 570 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT2(1), B3GALT4(1), B3GNT3(1), B3GNT5(1), B4GALT4(2), B4GALT6(1), FUT6(1), GCNT2(1), PIGG(1), PIGK(1), PIGM(1), PIGN(1), PIGO(1), PIGQ(2), PIGU(1), ST3GAL3(1), ST3GAL6(1), ST8SIA1(1) 23661756 20 18 20 5 3 6 6 1 4 0 0.80 0.87 571 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT2(1), DSE(1), XYLT1(1), XYLT2(1) 6781104 4 4 4 3 0 2 2 0 0 0 0.81 0.87 572 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 RELA(1), TRAF3(1), TRAF5(1), TRAF6(1) 7233248 4 4 4 2 0 1 2 0 1 0 0.82 0.88 573 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ATP6AP1(1), ATP6V0A4(1), ATP6V0D2(1), ATP6V1B1(1), ATP6V1B2(1), CSK(1), EGFR(4), F11R(1), GIT1(2), JUN(1), MAPK10(1), MAPK9(1), MET(1), NOD1(1), PAK1(1), PLCG1(1), PLCG2(1), PTPN11(1), PTPRZ1(3), RELA(1), TJP1(1) 34666598 28 26 28 10 3 10 13 0 2 0 0.82 0.89 574 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CTPS(1), DCTD(1), DPYS(1), NT5C1B(1), NT5C3(1), POLD1(2), POLD3(1), POLE(1), POLE2(1), POLR1A(1), POLR1C(1), POLR2A(4), POLR2B(1), POLR2I(1), POLR3A(1), POLR3B(5), POLR3G(1), POLR3H(1), PRIM2(1), RRM2(1), TK2(1), UPP2(1), UPRT(1) 40406257 32 30 30 11 3 10 12 1 6 0 0.83 0.89 575 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ELOVL2(1), FADS2(1), HADHA(1), PECR(1) 6478509 4 4 4 0 0 2 2 0 0 0 0.83 0.89 576 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP72(2) 3688758 2 2 2 2 0 1 1 0 0 0 0.83 0.89 577 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 CDH1(2), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(3), ROCK1(2), TLR4(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1), WASL(2) 25174071 20 19 20 16 3 7 7 1 2 0 0.84 0.89 578 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 CDH1(2), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCL(3), ROCK1(2), TLR4(1), TUBA3C(1), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB1(1), WASL(2) 25174071 20 19 20 16 3 7 7 1 2 0 0.84 0.89 579 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), FDXR(1), SHMT1(1) 7926774 6 5 6 4 0 2 3 0 1 0 0.84 0.90 580 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), MAP3K1(1), RELA(1), TRAF3(1), TRAF6(1) 9029476 5 5 5 2 0 2 1 0 2 0 0.85 0.90 581 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(1) 4354661 2 2 2 1 0 1 1 0 0 0 0.85 0.90 582 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(1) 4354661 2 2 2 1 0 1 1 0 0 0 0.85 0.90 583 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), CES1(3), CES2(1), UGT1A1(1), UGT1A7(2), UGT1A8(1) 11174776 9 8 9 3 2 3 2 1 1 0 0.86 0.91 584 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 DNMT1(2), DNMT3A(2), MARS(1) 8578032 5 5 5 4 0 3 2 0 0 0 0.86 0.91 585 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), HMGB2(1), TOP2A(1) 5126406 3 3 3 1 1 1 0 0 1 0 0.88 0.92 586 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA4(1), PSMA6(1), PSMD1(1), PSMD11(1), PSMD2(1) 7882835 6 5 6 3 1 0 3 2 0 0 0.88 0.92 587 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 DNMT1(2), DNMT3A(2), MARS(1), MTAP(1) 10229229 6 6 6 5 0 4 2 0 0 0 0.89 0.93 588 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3) 4975759 3 2 3 0 0 1 1 1 0 0 0.89 0.94 589 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(3), OLAH(1) 7200836 4 4 4 1 2 0 0 1 1 0 0.90 0.94 590 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1) 4924924 2 2 2 1 0 0 2 0 0 0 0.90 0.94 591 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 ST3GAL3(1) 3812383 1 1 1 1 0 0 0 0 1 0 0.91 0.94 592 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1) 2469991 1 1 1 3 0 0 1 0 0 0 0.91 0.95 593 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(1) 5114696 2 2 2 0 0 0 2 0 0 0 0.92 0.95 594 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1) 7491671 5 4 5 4 0 2 2 0 1 0 0.92 0.95 595 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1) 7491671 5 4 5 4 0 2 2 0 1 0 0.92 0.95 596 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(1), ATP6V1B1(1), ATP6V1B2(1), SHMT1(1) 7491671 5 4 5 4 0 2 2 0 1 0 0.92 0.95 597 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY9(2), ARF1(1), ATP6V0A4(1), ATP6V0D2(1), ERO1L(1), GNAS(1), PLCG1(1), PLCG2(1), SEC61B(1), TRIM23(1) 18073423 11 11 11 9 0 5 6 0 0 0 0.93 0.96 598 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3) 5623104 3 2 3 0 0 1 1 1 0 0 0.93 0.96 599 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 CES1(3) 5632490 3 3 3 3 1 2 0 0 0 0 0.94 0.96 600 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 HEXA(1), ST8SIA1(1) 4825521 2 2 2 2 1 1 0 0 0 0 0.95 0.97 601 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGG(1), PIGK(1), PIGM(1), PIGN(1), PIGO(1), PIGQ(2), PIGU(1) 12115980 8 7 8 1 2 3 2 0 1 0 0.96 0.98 602 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 HEXA(1), ST8SIA1(1) 5125130 2 2 2 2 1 1 0 0 0 0 0.96 0.98 603 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 IRAK1(2), JUN(1), MAP2K3(2), MAP3K1(1), MAP3K7(1), RELA(1), TLR10(1), TLR4(1), TLR6(1), TLR7(1), TRAF6(1) 17920265 13 10 13 4 3 0 6 1 3 0 0.97 0.99 604 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXTL3(1), GLCE(1), HS6ST3(1), NDST4(1) 10206650 5 5 5 1 1 1 3 0 0 0 0.97 0.99 605 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 CDS2(1), CHPT1(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), MYST3(4), PLA2G12A(1), PLA2G6(2), PLD1(1), PLD2(1), PNPLA3(1), PPAP2C(1) 32286546 17 16 17 6 1 4 11 0 1 0 0.98 1.00 606 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 CDS2(1), DGKB(1), DGKH(1), DGKQ(1), DGKZ(1), PAFAH1B1(1), PLA2G6(2), PLCB2(1), PLCG1(1), PLCG2(1), PPAP2C(1) 24464749 12 12 12 3 1 2 8 0 1 0 0.99 1.00 607 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 3461122 0 0 0 2 0 0 0 0 0 0 1.00 1.00 608 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 770288 0 0 0 0 0 0 0 0 0 0 1.00 1.00 609 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 247866 0 0 0 1 0 0 0 0 0 0 1.00 1.00 610 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 906038 0 0 0 1 0 0 0 0 0 0 1.00 1.00 611 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 1054317 0 0 0 1 0 0 0 0 0 0 1.00 1.00 612 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1533192 0 0 0 1 0 0 0 0 0 0 1.00 1.00 613 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 2372078 0 0 0 0 0 0 0 0 0 0 1.00 1.00 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 830307 0 0 0 0 0 0 0 0 0 0 1.00 1.00 615 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 568246 0 0 0 0 0 0 0 0 0 0 1.00 1.00 616 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 2713275 0 0 0 1 0 0 0 0 0 0 1.00 1.00