Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) -0.099 0.259 -9999.0 0.0 -0.744 9.0 9.0 HDAC1 0.015 0.085 -9999.0 0.0 -0.673 1.0 1.0 AES 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRP6/FZD1 -0.055 0.2 -9999.0 0.0 -0.527 11.0 11.0 TLE1 0.005 0.103 -9999.0 0.0 -0.6 2.0 2.0 AP1 -0.066 0.166 -9999.0 0.0 -0.385 11.0 11.0 NCSTN 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 0.002 0.105 -9999.0 0.0 -0.615 2.0 2.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.032 0.194 -9999.0 0.0 -0.633 4.0 4.0 NICD/RBPSUH -0.059 0.268 -9999.0 0.0 -0.745 9.0 9.0 WIF1 0.005 0.089 -9999.0 0.0 -0.524 2.0 2.0 NOTCH1 -0.102 0.252 -9999.0 0.0 -0.752 9.0 9.0 PSENEN 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KREMEN2 -0.013 0.136 -9999.0 0.0 -0.57 4.0 4.0 DKK1 -0.043 0.179 -9999.0 0.0 -0.547 8.0 8.0 beta catenin/beta TrCP1 0.028 0.057 -9999.0 0.0 -9999.0 0.0 0.0 APH1B 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 APH1A -0.021 0.167 -9999.0 0.0 -0.708 4.0 4.0 AXIN1 -0.015 0.08 0.23 1.0 -0.267 1.0 2.0 CtBP/CBP/TCF1/TLE1/AES 0.05 0.095 0.306 4.0 -9999.0 0.0 4.0 PSEN1 0.01 0.085 -9999.0 0.0 -0.709 1.0 1.0 FOS -0.157 0.289 -9999.0 0.0 -0.616 20.0 20.0 JUN -0.094 0.256 -9999.0 0.0 -0.662 12.0 12.0 MAP3K7 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.016 0.06 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 0.015 0.095 -9999.0 0.0 -0.444 1.0 1.0 HNF1A -0.015 0.153 -9999.0 0.0 -0.642 4.0 4.0 CTBP1 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.157 0.515 -9999.0 0.0 -1.611 8.0 8.0 NKD1 0.013 0.064 -9999.0 0.0 -0.525 1.0 1.0 FZD1 -0.091 0.262 -9999.0 0.0 -0.709 11.0 11.0 NOTCH1 precursor/Deltex homolog 1 -0.054 0.253 -9999.0 0.0 -0.704 9.0 9.0 apoptosis -0.066 0.165 -9999.0 0.0 -0.383 11.0 11.0 Delta 1/NOTCHprecursor -0.059 0.273 -9999.0 0.0 -0.741 9.0 9.0 DLL1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 PPARD 0.013 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.017 0.117 -9999.0 0.0 -9999.0 0.0 0.0 APC -0.037 0.181 -9999.0 0.0 -0.929 2.0 2.0 DVL1 -0.01 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CSNK2A1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.012 0.086 -9999.0 0.0 -0.711 1.0 1.0 DKK1/LRP6/Kremen 2 -0.02 0.137 -9999.0 0.0 -0.444 2.0 2.0 LRP6 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.019 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NLK 0.037 0.056 -9999.0 0.0 -0.395 1.0 1.0 CCND1 -0.323 0.671 -9999.0 0.0 -1.578 16.0 16.0 WNT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/beta catenin 0.005 0.146 -9999.0 0.0 -0.802 1.0 1.0 DKK2 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 NOTCH1 precursor/DVL1 -0.088 0.228 -9999.0 0.0 -0.676 9.0 9.0 GSK3B 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.006 0.089 -9999.0 0.0 -0.518 2.0 2.0 NOTCH/Deltex homolog 1 -0.094 0.238 -9999.0 0.0 -0.708 9.0 9.0 PPP2R5D -0.006 0.042 0.27 1.0 -9999.0 0.0 1.0 MAPK1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WNT1/LRP6/FZD1 -0.029 0.166 -9999.0 0.0 -0.4 11.0 11.0 RBPJ 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 CREBBP 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0