Caspase cascade in apoptosis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TOP1 0.027 0.14 0.266 1.0 -0.407 2.0 3.0 ACTA1 0.011 0.164 0.312 4.0 -0.439 2.0 6.0 NUMA1 0.026 0.14 0.266 1.0 -0.407 2.0 3.0 SPTAN1 0.02 0.165 -9999.0 0.0 -0.436 2.0 2.0 LIMK1 0.003 0.193 -9999.0 0.0 -0.518 4.0 4.0 BIRC3 -0.162 0.306 -9999.0 0.0 -0.669 19.0 19.0 BIRC2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP10 -0.041 0.185 -9999.0 0.0 -0.557 5.0 5.0 CRMA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 0.027 0.14 0.266 1.0 -0.407 2.0 3.0 DIABLO 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptotic nuclear changes 0.021 0.164 0.311 3.0 -0.429 2.0 5.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.012 0.064 -9999.0 0.0 -0.524 1.0 1.0 GSN 0.001 0.177 -9999.0 0.0 -0.405 4.0 4.0 MADD 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TFAP2A 0.004 0.157 -9999.0 0.0 -1.227 1.0 1.0 BID -0.026 0.142 -9999.0 0.0 -0.382 7.0 7.0 MAP3K1 0.015 0.127 -9999.0 0.0 -0.868 1.0 1.0 TRADD 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 APAF-1/Pro-Caspase 9 0.03 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Activated DNA -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARHGDIB -0.01 0.191 -9999.0 0.0 -0.616 3.0 3.0 CASP9 0.02 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DNA repair -0.051 0.097 0.22 1.0 -0.242 11.0 12.0 neuron apoptosis -0.044 0.217 -9999.0 0.0 -0.65 8.0 8.0 mol:NAD -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA fragmentation during apoptosis 0.032 0.154 -9999.0 0.0 -0.417 2.0 2.0 APAF1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP6 0.024 0.109 -9999.0 0.0 -0.587 1.0 1.0 TRAF2 0.005 0.089 -9999.0 0.0 -0.523 2.0 2.0 ICAD/CAD 0.033 0.156 -9999.0 0.0 -0.437 1.0 1.0 CASP7 0.084 0.141 0.32 18.0 -9999.0 0.0 18.0 KRT18 -0.011 0.146 -9999.0 0.0 -0.594 4.0 4.0 apoptosis -0.001 0.144 -9999.0 0.0 -0.44 3.0 3.0 DFFA 0.024 0.162 -9999.0 0.0 -0.436 2.0 2.0 DFFB 0.024 0.162 0.312 3.0 -0.436 2.0 5.0 PARP1 0.051 0.097 0.242 11.0 -0.221 1.0 12.0 actin filament polymerization 0.01 0.188 0.585 3.0 -9999.0 0.0 3.0 TNF 0.002 0.106 -9999.0 0.0 -0.616 2.0 2.0 CYCS -0.035 0.123 -9999.0 0.0 -0.288 9.0 9.0 SATB1 0.001 0.141 -9999.0 0.0 -0.554 2.0 2.0 SLK 0.024 0.162 0.31 4.0 -0.436 2.0 6.0 p15 BID/BAX -0.013 0.13 -9999.0 0.0 -0.441 4.0 4.0 CASP2 -0.031 0.204 -9999.0 0.0 -0.561 7.0 7.0 JNK cascade -0.015 0.126 0.857 1.0 -9999.0 0.0 1.0 CASP3 0.015 0.173 0.325 4.0 -0.47 2.0 6.0 LMNB2 0.009 0.131 -9999.0 0.0 -0.592 2.0 2.0 RIPK1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP4 -0.041 0.201 -9999.0 0.0 -0.708 6.0 6.0 Mammalian IAPs/DIABLO -0.071 0.186 -9999.0 0.0 -0.408 15.0 15.0 negative regulation of DNA binding 0.004 0.154 -9999.0 0.0 -1.193 1.0 1.0 stress fiber formation 0.024 0.161 0.309 4.0 -0.429 2.0 6.0 GZMB -0.057 0.191 -9999.0 0.0 -0.435 14.0 14.0 CASP1 -0.091 0.3 -9999.0 0.0 -0.738 11.0 11.0 LMNB1 -0.02 0.188 -9999.0 0.0 -0.643 5.0 5.0 APP -0.045 0.22 -9999.0 0.0 -0.659 8.0 8.0 TNFRSF1A -0.061 0.229 -9999.0 0.0 -0.708 8.0 8.0 response to stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VIM -0.009 0.145 -9999.0 0.0 -0.431 4.0 4.0 LMNA -0.032 0.232 -9999.0 0.0 -0.618 8.0 8.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD -0.044 0.216 -9999.0 0.0 -0.603 7.0 7.0 LRDD 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 SREBF1 0.016 0.162 -9999.0 0.0 -0.436 2.0 2.0 APAF-1/Caspase 9 0.023 0.057 -9999.0 0.0 -9999.0 0.0 0.0 nuclear fragmentation during apoptosis 0.026 0.139 0.265 1.0 -0.401 2.0 3.0 CFL2 -0.011 0.193 -9999.0 0.0 -0.607 3.0 3.0 GAS2 -0.091 0.211 -9999.0 0.0 -0.494 10.0 10.0 positive regulation of apoptosis -0.018 0.191 -9999.0 0.0 -0.495 8.0 8.0 PRF1 -0.048 0.18 -9999.0 0.0 -0.523 9.0 9.0