Fc-epsilon receptor I signaling in mast cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PPAP2A -0.068 0.235 -9999.0 0.0 -0.687 9.0 9.0 LAT2 -0.103 0.314 -9999.0 0.0 -0.817 9.0 9.0 AP1 -0.208 0.305 -9999.0 0.0 -0.654 18.0 18.0 mol:PIP3 -0.101 0.313 -9999.0 0.0 -0.764 11.0 11.0 IKBKB -0.033 0.157 -9999.0 0.0 -0.334 11.0 11.0 AKT1 -0.121 0.318 -9999.0 0.0 -0.711 13.0 13.0 IKBKG -0.033 0.157 -9999.0 0.0 -0.334 11.0 11.0 MS4A2 -0.129 0.281 -9999.0 0.0 -0.648 16.0 16.0 mol:Sphingosine-1-phosphate -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.019 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 -0.061 0.279 -9999.0 0.0 -0.689 10.0 10.0 mol:Ca2+ -0.06 0.22 -9999.0 0.0 -0.512 11.0 11.0 LYN 0.017 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CBLB -0.107 0.307 -9999.0 0.0 -0.791 10.0 10.0 SHC1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RasGAP/p62DOK -0.005 0.132 -9999.0 0.0 -0.407 7.0 7.0 positive regulation of cell migration -0.053 0.183 -9999.0 0.0 -0.538 9.0 9.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLD2 -0.183 0.401 -9999.0 0.0 -0.724 19.0 19.0 PTPN13 -0.085 0.279 -9999.0 0.0 -0.742 9.0 9.0 PTPN11 0.016 0.012 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of mast cell degranulation -0.039 0.205 -9999.0 0.0 -0.417 12.0 12.0 SYK -0.008 0.125 -9999.0 0.0 -0.601 3.0 3.0 GRB2 0.01 0.086 -9999.0 0.0 -0.712 1.0 1.0 LAT/PLCgamma1/GRB2/SLP76/GADs -0.167 0.293 -9999.0 0.0 -0.81 11.0 11.0 LAT -0.124 0.354 -9999.0 0.0 -0.952 9.0 9.0 PAK2 -0.086 0.32 -9999.0 0.0 -0.806 10.0 10.0 NFATC2 -0.058 0.169 -9999.0 0.0 -1.355 1.0 1.0 HRAS -0.117 0.381 -9999.0 0.0 -0.913 11.0 11.0 GAB2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLA2G1B 0.046 0.024 -9999.0 0.0 -9999.0 0.0 0.0 Fc epsilon R1 -0.182 0.337 -9999.0 0.0 -0.763 14.0 14.0 Antigen/IgE/Fc epsilon R1 -0.17 0.317 -9999.0 0.0 -0.714 14.0 14.0 mol:GDP -0.131 0.397 -9999.0 0.0 -0.966 11.0 11.0 JUN -0.094 0.256 -9999.0 0.0 -0.662 12.0 12.0 mol:Ca++ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.039 0.194 -9999.0 0.0 -0.68 6.0 6.0 FOS -0.157 0.289 -9999.0 0.0 -0.616 20.0 20.0 Antigen/IgE/Fc epsilon R1/LYN/SYK -0.115 0.314 -9999.0 0.0 -0.734 11.0 11.0 CHUK -0.033 0.157 -9999.0 0.0 -0.334 11.0 11.0 KLRG1 -0.112 0.302 -9999.0 0.0 -0.679 12.0 12.0 VAV1 -0.13 0.364 -9999.0 0.0 -0.876 11.0 11.0 calcium-dependent protein kinase C activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CBL -0.097 0.295 -9999.0 0.0 -0.772 9.0 9.0 negative regulation of mast cell degranulation -0.104 0.271 -9999.0 0.0 -0.617 12.0 12.0 BTK -0.142 0.41 -9999.0 0.0 -1.067 10.0 10.0 Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.162 0.391 -9999.0 0.0 -0.629 20.0 20.0 GAB2/PI3K/SHP2 -0.201 0.338 -9999.0 0.0 -0.799 14.0 14.0 Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.094 0.273 -9999.0 0.0 -0.688 10.0 10.0 RAF1 0.032 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Fc epsilon R1/FcgammaRIIB/SHIP -0.225 0.378 -9999.0 0.0 -0.697 20.0 20.0 FCER1G -0.044 0.2 -9999.0 0.0 -0.645 7.0 7.0 FCER1A -0.097 0.262 -9999.0 0.0 -0.677 12.0 12.0 Antigen/IgE/Fc epsilon R1/Fyn -0.222 0.379 -9999.0 0.0 -0.709 20.0 20.0 MAPK3 0.046 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.046 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.013 0.163 -9999.0 0.0 -0.676 3.0 3.0 DUSP1 -0.051 0.216 -9999.0 0.0 -0.708 7.0 7.0 NF-kappa-B/RelA -0.045 0.069 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton reorganization -0.089 0.283 -9999.0 0.0 -0.799 8.0 8.0 mol:Glucocorticoid Dexamethasone -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.161 0.324 -9999.0 0.0 -0.836 11.0 11.0 FER -0.097 0.295 -9999.0 0.0 -0.772 9.0 9.0 RELA 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITK -0.082 0.199 -9999.0 0.0 -0.645 7.0 7.0 SOS1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 -0.123 0.387 -9999.0 0.0 -0.942 11.0 11.0 cytokine secretion -0.033 0.05 -9999.0 0.0 -9999.0 0.0 0.0 SPHK1 -0.139 0.343 -9999.0 0.0 -0.725 14.0 14.0 PTK2 -0.097 0.308 -9999.0 0.0 -0.87 8.0 8.0 NTAL/PLCgamma1/GRB2/SLP76/GADs -0.17 0.304 -9999.0 0.0 -0.825 11.0 11.0 EDG1 -0.053 0.184 -9999.0 0.0 -0.539 9.0 9.0 mol:DAG -0.121 0.313 -9999.0 0.0 -0.675 14.0 14.0 MAP2K2 0.04 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 0.04 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K7 -0.01 0.145 -9999.0 0.0 -0.708 3.0 3.0 KLRG1/SHP2 -0.139 0.266 -9999.0 0.0 -0.705 10.0 10.0 MAP2K4 -0.017 0.219 -9999.0 0.0 -1.062 3.0 3.0 Fc epsilon R1/FcgammaRIIB -0.237 0.395 -9999.0 0.0 -0.733 20.0 20.0 mol:Choline -0.176 0.38 -9999.0 0.0 -0.695 19.0 19.0 SHC/Grb2/SOS1 -0.122 0.268 -9999.0 0.0 -0.799 8.0 8.0 FYN -0.101 0.271 -9999.0 0.0 -0.708 12.0 12.0 DOK1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PXN -0.075 0.271 -9999.0 0.0 -0.756 8.0 8.0 HCLS1 -0.144 0.381 -9999.0 0.0 -0.847 13.0 13.0 PRKCB -0.069 0.217 -9999.0 0.0 -0.486 12.0 12.0 FCGR2B -0.114 0.274 -9999.0 0.0 -0.668 14.0 14.0 IGHE -0.004 0.011 -9999.0 0.0 -9999.0 0.0 0.0 KLRG1/SHIP -0.107 0.283 -9999.0 0.0 -0.64 12.0 12.0 LCP2 -0.069 0.236 -9999.0 0.0 -0.69 9.0 9.0 PLA2G4A -0.153 0.355 -9999.0 0.0 -0.758 14.0 14.0 RASA1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Phosphatidic acid -0.176 0.38 -9999.0 0.0 -0.695 19.0 19.0 IKK complex -0.003 0.125 -9999.0 0.0 -0.25 7.0 7.0 WIPF1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0