E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.035 0.208 -9999.0 0.0 -0.589 7.0 7.0 KLHL20 -0.069 0.118 -9999.0 0.0 -0.317 10.0 10.0 CYFIP2 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 Rac1/GDP 0.004 0.163 -9999.0 0.0 -0.595 2.0 2.0 ENAH -0.041 0.216 -9999.0 0.0 -0.583 8.0 8.0 AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 RAP1A 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 CTNNB1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.058 0.125 -9999.0 0.0 -0.545 3.0 3.0 ABI1/Sra1/Nap1 -0.046 0.073 -9999.0 0.0 -0.208 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.022 0.163 -9999.0 0.0 -0.436 7.0 7.0 RAPGEF1 -0.022 0.204 -9999.0 0.0 -0.527 8.0 8.0 CTNND1 -0.021 0.167 -9999.0 0.0 -0.708 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.212 -9999.0 0.0 -0.617 7.0 7.0 CRK -0.032 0.207 -9999.0 0.0 -0.545 8.0 8.0 E-cadherin/gamma catenin/alpha catenin -0.041 0.184 -9999.0 0.0 -0.504 7.0 7.0 alphaE/beta7 Integrin 0.024 0.046 -9999.0 0.0 -0.366 1.0 1.0 IQGAP1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.005 0.089 -9999.0 0.0 -0.523 2.0 2.0 Rap1/GTP/I-afadin 0.02 0.111 -9999.0 0.0 -0.608 2.0 2.0 DLG1 -0.035 0.208 -9999.0 0.0 -0.589 7.0 7.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.053 0.101 -9999.0 0.0 -0.309 7.0 7.0 MLLT4 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.02 0.089 -9999.0 0.0 -0.408 3.0 3.0 PI3K -0.07 0.137 -9999.0 0.0 -0.421 7.0 7.0 ARF6 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.063 0.209 -9999.0 0.0 -0.486 13.0 13.0 TIAM1 -0.01 0.145 -9999.0 0.0 -0.708 3.0 3.0 E-cadherin(dimer)/Ca2+ -0.045 0.175 -9999.0 0.0 -0.415 10.0 10.0 AKT1 -0.037 0.07 -9999.0 0.0 -0.272 2.0 2.0 PIK3R1 -0.038 0.194 -9999.0 0.0 -0.677 6.0 6.0 CDH1 -0.096 0.25 -9999.0 0.0 -0.623 13.0 13.0 RhoA/GDP 0.001 0.171 -9999.0 0.0 -0.566 3.0 3.0 actin cytoskeleton organization -0.001 0.113 -9999.0 0.0 -0.223 10.0 10.0 CDC42/GDP 0.005 0.162 -9999.0 0.0 -0.592 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.164 -9999.0 0.0 -0.385 10.0 10.0 ITGB7 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.046 0.185 -9999.0 0.0 -0.437 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.033 0.14 -9999.0 0.0 -0.386 7.0 7.0 mol:GDP -0.012 0.19 -9999.0 0.0 -0.757 2.0 2.0 CDC42/GTP/IQGAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 p120 catenin/RhoA/GDP -0.07 0.162 -9999.0 0.0 -0.661 3.0 3.0 RAC1/GTP/IQGAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 CDC42 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.025 0.131 -9999.0 0.0 -0.262 16.0 16.0 NME1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.035 0.208 -9999.0 0.0 -0.589 7.0 7.0 regulation of cell-cell adhesion -0.051 0.107 -9999.0 0.0 -0.457 3.0 3.0 WASF2 -0.023 0.037 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.069 0.15 -9999.0 0.0 -0.659 3.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.015 0.173 -9999.0 0.0 -0.458 7.0 7.0 CCND1 -0.036 0.164 -9999.0 0.0 -0.333 16.0 16.0 VAV2 -0.02 0.194 -9999.0 0.0 -0.527 7.0 7.0 RAP1/GDP -0.006 0.176 -9999.0 0.0 -0.628 3.0 3.0 adherens junction assembly -0.033 0.199 -9999.0 0.0 -0.564 7.0 7.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.004 0.167 -9999.0 0.0 -0.66 2.0 2.0 E-cadherin/beta catenin -0.062 0.139 -9999.0 0.0 -0.444 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.04 0.207 -9999.0 0.0 -0.591 7.0 7.0 PIK3CA 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.115 0.2 -9999.0 0.0 -0.541 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.039 0.162 -9999.0 0.0 -0.444 7.0 7.0 ITGAE 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.09 0.203 -9999.0 0.0 -0.637 7.0 7.0