Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.064 0.171 0.414 13.0 -9999.0 0.0 13.0 KIRREL -0.015 0.125 -9999.0 0.0 -0.739 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.064 0.172 -9999.0 0.0 -0.415 13.0 13.0 PLCG1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 Nephrin/NEPH1/podocin/CD2AP -0.052 0.166 -9999.0 0.0 -0.439 6.0 6.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.017 0.131 -9999.0 0.0 -0.661 1.0 1.0 FYN -0.093 0.2 -9999.0 0.0 -0.416 16.0 16.0 mol:Ca2+ -0.08 0.141 -9999.0 0.0 -0.45 5.0 5.0 mol:DAG -0.08 0.142 -9999.0 0.0 -0.452 5.0 5.0 NPHS2 -0.039 0.16 -9999.0 0.0 -0.566 6.0 6.0 mol:IP3 -0.08 0.142 -9999.0 0.0 -0.452 5.0 5.0 regulation of endocytosis -0.075 0.19 -9999.0 0.0 -0.473 8.0 8.0 Nephrin/NEPH1/podocin/Cholesterol -0.061 0.161 -9999.0 0.0 -0.424 8.0 8.0 establishment of cell polarity -0.064 0.171 -9999.0 0.0 -0.414 13.0 13.0 Nephrin/NEPH1/podocin/NCK1-2 -0.036 0.17 -9999.0 0.0 -0.588 3.0 3.0 Nephrin/NEPH1/beta Arrestin2 -0.075 0.193 -9999.0 0.0 -0.48 8.0 8.0 NPHS1 -0.075 0.201 -9999.0 0.0 -0.542 11.0 11.0 Nephrin/NEPH1/podocin -0.092 0.202 -9999.0 0.0 -0.416 16.0 16.0 TJP1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 NCK2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.048 0.162 -9999.0 0.0 -0.454 5.0 5.0 CD2AP 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.053 0.183 -9999.0 0.0 -0.536 5.0 5.0 GRB2 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.096 0.203 -9999.0 0.0 -0.468 11.0 11.0 cytoskeleton organization -0.028 0.182 -9999.0 0.0 -0.628 3.0 3.0 Nephrin/NEPH1 -0.042 0.124 -9999.0 0.0 -0.367 5.0 5.0 Nephrin/NEPH1/ZO-1 -0.035 0.14 -9999.0 0.0 -0.4 5.0 5.0