Glucocorticoid receptor regulatory network Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PCK2 -0.013 0.131 -9999.0 0.0 -0.698 2.0 2.0 SMARCC2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMARCC1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TBX21 -0.148 0.36 -9999.0 0.0 -0.782 16.0 16.0 SUMO2 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) -0.09 0.257 -9999.0 0.0 -0.637 11.0 11.0 FKBP4 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FKBP5 -0.116 0.258 -9999.0 0.0 -0.593 16.0 16.0 GR alpha/HSP90/FKBP51/HSP90 -0.057 0.176 0.301 1.0 -0.435 6.0 7.0 PRL 0.021 0.094 -9999.0 0.0 -9999.0 0.0 0.0 cortisol/GR alpha (dimer)/TIF2 0.07 0.202 0.538 6.0 -9999.0 0.0 6.0 RELA -0.075 0.108 -9999.0 0.0 -9999.0 0.0 0.0 FGG 0.017 0.234 0.497 3.0 -0.583 1.0 4.0 GR beta/TIF2 0.036 0.096 0.315 2.0 -9999.0 0.0 2.0 IFNG -0.326 0.474 -9999.0 0.0 -1.069 14.0 14.0 apoptosis -0.05 0.209 0.522 2.0 -0.774 1.0 3.0 CREB1 0.014 0.109 -9999.0 0.0 -0.837 1.0 1.0 histone acetylation -0.013 0.111 -9999.0 0.0 -0.422 3.0 3.0 BGLAP 0.012 0.089 -9999.0 0.0 -9999.0 0.0 0.0 GR/PKAc 0.025 0.103 0.298 1.0 -9999.0 0.0 1.0 NF kappa B1 p50/RelA -0.134 0.202 -9999.0 0.0 -0.482 8.0 8.0 SMARCD1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 MDM2 0.033 0.073 0.257 2.0 -9999.0 0.0 2.0 GATA3 0.013 0.125 -9999.0 0.0 -0.502 4.0 4.0 AKT1 0.009 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CSF2 -0.006 0.092 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 NR1I3 -0.002 0.204 -9999.0 0.0 -0.624 1.0 1.0 CSN2 0.061 0.142 0.439 1.0 -9999.0 0.0 1.0 BRG1/BAF155/BAF170/BAF60A 0.041 0.063 -9999.0 0.0 -0.396 1.0 1.0 NFATC1 -0.026 0.201 -9999.0 0.0 -0.695 6.0 6.0 POU2F1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDKN1A 0.004 0.277 -9999.0 0.0 -1.6 2.0 2.0 response to stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to UV -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SFN -0.025 0.15 -9999.0 0.0 -0.523 6.0 6.0 GR alpha/HSP90/FKBP51/HSP90/14-3-3 -0.066 0.163 -9999.0 0.0 -0.414 4.0 4.0 prolactin receptor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGR1 -0.098 0.341 -9999.0 0.0 -0.892 7.0 7.0 JUN -0.118 0.246 -9999.0 0.0 -0.677 8.0 8.0 IL4 -0.029 0.175 -9999.0 0.0 -0.691 2.0 2.0 CDK5R1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortisol/GR alpha (monomer)/AP-1 -0.175 0.275 -9999.0 0.0 -0.628 14.0 14.0 GR alpha/HSP90/FKBP51/HSP90/PP5C -0.048 0.172 -9999.0 0.0 -0.455 4.0 4.0 cortisol/GR alpha (monomer) 0.072 0.237 0.628 6.0 -9999.0 0.0 6.0 NCOA2 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 response to hypoxia -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.177 0.279 -9999.0 0.0 -0.609 20.0 20.0 AP-1/NFAT1-c-4 -0.25 0.374 -9999.0 0.0 -0.892 13.0 13.0 AFP -0.077 0.251 -9999.0 0.0 -1.07 2.0 2.0 SUV420H1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRF1 -0.138 0.382 -9999.0 0.0 -0.96 11.0 11.0 TP53 0.028 0.119 -9999.0 0.0 -0.535 3.0 3.0 PPP5C 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 KRT17 -0.135 0.239 -9999.0 0.0 -0.81 5.0 5.0 KRT14 -0.003 0.077 -9999.0 0.0 -9999.0 0.0 0.0 TBP 0.034 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1 -0.005 0.084 -9999.0 0.0 -0.715 1.0 1.0 HDAC2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AP-1 -0.251 0.377 -9999.0 0.0 -0.899 13.0 13.0 MAPK14 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAPK10 -0.09 0.226 -9999.0 0.0 -0.565 13.0 13.0 MAPK11 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 KRT5 -0.13 0.223 -9999.0 0.0 -0.777 4.0 4.0 interleukin-1 receptor activity -0.003 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCOA1 0.021 0.02 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 -0.09 0.257 -9999.0 0.0 -0.637 11.0 11.0 CGA -0.018 0.199 -9999.0 0.0 -0.716 4.0 4.0 NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 -0.01 0.083 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ICAM1 -0.248 0.47 -9999.0 0.0 -1.207 12.0 12.0 NFKB1 -0.075 0.108 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.019 0.118 -9999.0 0.0 -0.374 2.0 2.0 MAPK9 -0.002 0.119 -9999.0 0.0 -0.705 2.0 2.0 cortisol/GR alpha (dimer) -0.057 0.213 0.526 2.0 -0.826 1.0 3.0 BAX 0.038 0.088 -9999.0 0.0 -9999.0 0.0 0.0 POMC -0.073 0.258 -9999.0 0.0 -1.161 2.0 2.0 EP300 -0.01 0.084 -9999.0 0.0 -0.719 1.0 1.0 cortisol/GR alpha (dimer)/p53 0.07 0.202 0.542 5.0 -9999.0 0.0 5.0 proteasomal ubiquitin-dependent protein catabolic process 0.014 0.056 -9999.0 0.0 -9999.0 0.0 0.0 SGK1 0.023 0.046 -9999.0 0.0 -9999.0 0.0 0.0 IL13 -0.078 0.179 -9999.0 0.0 -9999.0 0.0 0.0 IL6 -0.267 0.413 -9999.0 0.0 -0.865 17.0 17.0 PRKACG 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL5 -0.065 0.143 -9999.0 0.0 -9999.0 0.0 0.0 IL2 -0.159 0.318 -9999.0 0.0 -1.097 5.0 5.0 CDK5 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 PRKACB -0.02 0.149 -9999.0 0.0 -0.56 5.0 5.0 HSP90AA1 0.005 0.089 -9999.0 0.0 -0.523 2.0 2.0 IL8 -0.275 0.426 -9999.0 0.0 -0.972 15.0 15.0 CDK5R1/CDK5 0.017 0.049 -9999.0 0.0 -0.366 1.0 1.0 NF kappa B1 p50/RelA/PKAc -0.079 0.186 -9999.0 0.0 -0.522 4.0 4.0 cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 0.073 0.184 0.511 5.0 -9999.0 0.0 5.0 SMARCA4 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 chromatin remodeling 0.063 0.113 0.366 3.0 -9999.0 0.0 3.0 NF kappa B1 p50/RelA/Cbp -0.097 0.166 -9999.0 0.0 -0.508 2.0 2.0 JUN (dimer) -0.117 0.245 -9999.0 0.0 -0.674 8.0 8.0 YWHAH 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VIPR1 0.002 0.095 -9999.0 0.0 -9999.0 0.0 0.0 NR3C1 0.052 0.131 0.447 3.0 -9999.0 0.0 3.0 NR4A1 -0.046 0.181 -9999.0 0.0 -0.535 8.0 8.0 TIF2/SUV420H1 0.024 0.046 -9999.0 0.0 -0.366 1.0 1.0 MAPKKK cascade -0.05 0.209 0.522 2.0 -0.774 1.0 3.0 cortisol/GR alpha (dimer)/Src-1 0.078 0.197 0.541 5.0 -9999.0 0.0 5.0 PBX1 0.024 0.064 -9999.0 0.0 -0.512 1.0 1.0 POU1F1 0.014 0.106 -9999.0 0.0 -0.605 2.0 2.0 SELE -0.244 0.445 -9999.0 0.0 -1.097 12.0 12.0 cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.061 0.113 0.366 3.0 -9999.0 0.0 3.0 cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 0.073 0.184 0.511 5.0 -9999.0 0.0 5.0 mol:cortisol 0.031 0.137 0.355 6.0 -9999.0 0.0 6.0 MMP1 -0.27 0.496 -9999.0 0.0 -1.441 10.0 10.0