Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.178 0.239 -9999.0 0.0 -0.536 12.0 12.0 IHH -0.14 0.232 -9999.0 0.0 -0.529 18.0 18.0 SHH Np/Cholesterol/GAS1 0.007 0.099 -9999.0 0.0 -0.407 2.0 2.0 LRPAP1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.007 0.098 0.404 2.0 -9999.0 0.0 2.0 SMO/beta Arrestin2 -0.102 0.174 -9999.0 0.0 -0.575 3.0 3.0 SMO -0.118 0.182 -9999.0 0.0 -0.576 4.0 4.0 AKT1 -0.063 0.176 -9999.0 0.0 -0.618 5.0 5.0 ARRB2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.0 0.12 -9999.0 0.0 -0.708 2.0 2.0 ADRBK1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.117 0.18 -9999.0 0.0 -0.567 4.0 4.0 STIL -0.065 0.133 -9999.0 0.0 -0.454 2.0 2.0 DHH N/PTCH2 0.014 0.091 -9999.0 0.0 -0.526 2.0 2.0 DHH N/PTCH1 -0.106 0.16 -9999.0 0.0 -0.584 2.0 2.0 PIK3CA 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.0 0.12 -9999.0 0.0 -0.708 2.0 2.0 PTHLH -0.31 0.428 -9999.0 0.0 -0.967 17.0 17.0 determination of left/right symmetry -0.117 0.18 -9999.0 0.0 -0.567 4.0 4.0 PIK3R1 -0.038 0.194 -9999.0 0.0 -0.677 6.0 6.0 skeletal system development -0.306 0.421 -9999.0 0.0 -0.951 17.0 17.0 IHH N/Hhip -0.131 0.219 -9999.0 0.0 -0.486 16.0 16.0 DHH N/Hhip -0.048 0.199 -9999.0 0.0 -0.477 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.117 0.18 -9999.0 0.0 -0.567 4.0 4.0 pancreas development -0.068 0.209 -9999.0 0.0 -0.556 11.0 11.0 HHAT 0.002 0.106 -9999.0 0.0 -0.616 2.0 2.0 PI3K -0.014 0.147 -9999.0 0.0 -0.499 6.0 6.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.136 -9999.0 0.0 -0.57 4.0 4.0 somite specification -0.117 0.18 -9999.0 0.0 -0.567 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.079 0.14 -9999.0 0.0 -0.486 2.0 2.0 SHH Np/Cholesterol/PTCH2 0.026 0.063 -9999.0 0.0 -0.406 1.0 1.0 SHH Np/Cholesterol/Megalin -0.065 0.206 -9999.0 0.0 -0.452 15.0 15.0 SHH 0.02 0.08 -9999.0 0.0 -0.446 2.0 2.0 catabolic process -0.12 0.165 -9999.0 0.0 -0.441 6.0 6.0 SMO/Vitamin D3 -0.094 0.157 -9999.0 0.0 -0.5 3.0 3.0 SHH Np/Cholesterol/Hhip -0.025 0.132 -9999.0 0.0 -0.407 3.0 3.0 LRP2 -0.132 0.296 -9999.0 0.0 -0.708 15.0 15.0 receptor-mediated endocytosis -0.136 0.231 -9999.0 0.0 -0.601 9.0 9.0 SHH Np/Cholesterol/BOC 0.014 0.095 -9999.0 0.0 -0.407 3.0 3.0 SHH Np/Cholesterol/CDO -0.033 0.181 -9999.0 0.0 -0.482 9.0 9.0 mesenchymal cell differentiation 0.025 0.132 0.404 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.078 0.142 -9999.0 0.0 -0.489 2.0 2.0 IHH N/PTCH2 -0.064 0.143 -9999.0 0.0 -0.375 6.0 6.0 CDON -0.079 0.246 -9999.0 0.0 -0.689 10.0 10.0 IHH N/PTCH1 -0.12 0.167 -9999.0 0.0 -0.446 6.0 6.0 Megalin/LRPAP1 -0.086 0.226 -9999.0 0.0 -0.526 15.0 15.0 PTCH2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.059 -9999.0 0.0 -0.35 2.0 2.0 PTCH1 -0.12 0.166 -9999.0 0.0 -0.442 6.0 6.0 HHIP -0.068 0.209 -9999.0 0.0 -0.557 11.0 11.0