Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.036 0.162 -9999.0 0.0 -0.432 6.0 6.0 epithelial cell differentiation -0.077 0.155 -9999.0 0.0 -0.409 10.0 10.0 CYFIP2 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 ENAH -0.026 0.199 -9999.0 0.0 -0.461 8.0 8.0 EGFR -0.106 0.26 -9999.0 0.0 -0.629 14.0 14.0 EPHA2 -0.018 0.157 -9999.0 0.0 -0.662 4.0 4.0 MYO6 -0.034 0.182 -9999.0 0.0 -0.723 2.0 2.0 CTNNB1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.025 0.079 -9999.0 0.0 -0.444 1.0 1.0 AQP5 -0.086 0.203 -9999.0 0.0 -0.93 3.0 3.0 CTNND1 -0.02 0.167 -9999.0 0.0 -0.708 4.0 4.0 mol:PI-4-5-P2 -0.028 0.164 -9999.0 0.0 -0.699 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.132 0.267 -9999.0 0.0 -0.673 10.0 10.0 EGF -0.247 0.304 -9999.0 0.0 -0.581 32.0 32.0 NCKAP1 0.005 0.089 -9999.0 0.0 -0.523 2.0 2.0 AQP3 -0.142 0.281 -9999.0 0.0 -0.823 9.0 9.0 cortical microtubule organization -0.077 0.155 -9999.0 0.0 -0.409 10.0 10.0 GO:0000145 -0.027 0.156 -9999.0 0.0 -0.663 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.041 0.175 -9999.0 0.0 -0.414 10.0 10.0 MLLT4 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 ARF6/GDP -0.126 0.238 -9999.0 0.0 -0.657 10.0 10.0 ARF6 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.053 0.25 -9999.0 0.0 -0.577 11.0 11.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.041 0.199 -9999.0 0.0 -0.567 5.0 5.0 PVRL2 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.036 0.169 -9999.0 0.0 -0.718 1.0 1.0 ARF6/GTP -0.087 0.213 -9999.0 0.0 -0.528 11.0 11.0 CDH1 -0.096 0.25 -9999.0 0.0 -0.623 13.0 13.0 EGFR/EGFR/EGF/EGF -0.24 0.268 -9999.0 0.0 -0.668 14.0 14.0 RhoA/GDP -0.076 0.147 -9999.0 0.0 -0.705 1.0 1.0 actin cytoskeleton organization -0.022 0.173 -9999.0 0.0 -0.668 2.0 2.0 IGF-1R heterotetramer 0.01 0.085 -9999.0 0.0 -0.707 1.0 1.0 GIT1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 IGF1R 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 IGF1 -0.081 0.228 -9999.0 0.0 -0.585 12.0 12.0 DIAPH1 -0.012 0.08 -9999.0 0.0 -0.631 1.0 1.0 Wnt receptor signaling pathway 0.077 0.155 0.409 10.0 -9999.0 0.0 10.0 RHOA 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 RhoA/GTP -0.13 0.238 -9999.0 0.0 -0.655 10.0 10.0 CTNNA1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.023 0.178 -9999.0 0.0 -0.693 2.0 2.0 EFNA1 -0.099 0.266 -9999.0 0.0 -0.693 12.0 12.0 LPP -0.063 0.246 -9999.0 0.0 -0.758 5.0 5.0 Ephrin A1/EPHA2 -0.143 0.259 -9999.0 0.0 -0.72 10.0 10.0 SEC6/SEC8 -0.071 0.158 -9999.0 0.0 -0.782 2.0 2.0 MGAT3 -0.135 0.274 -9999.0 0.0 -0.691 10.0 10.0 HGF/MET -0.097 0.161 -9999.0 0.0 -0.578 3.0 3.0 HGF -0.023 0.159 -9999.0 0.0 -0.597 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.037 0.163 -9999.0 0.0 -0.436 6.0 6.0 actin cable formation -0.002 0.182 -9999.0 0.0 -0.411 7.0 7.0 KIAA1543 -0.025 0.164 -9999.0 0.0 -0.67 1.0 1.0 KIFC3 -0.029 0.167 -9999.0 0.0 -0.718 1.0 1.0 NCK1 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 EXOC3 0.002 0.106 -9999.0 0.0 -0.616 2.0 2.0 ACTN1 -0.068 0.237 -9999.0 0.0 -0.75 5.0 5.0 NCK1/GIT1 0.016 0.116 -9999.0 0.0 -0.964 1.0 1.0 mol:GDP -0.077 0.155 -9999.0 0.0 -0.409 10.0 10.0 EXOC4 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.039 0.196 -9999.0 0.0 -0.725 3.0 3.0 PIP5K1C -0.029 0.167 -9999.0 0.0 -0.718 1.0 1.0 LIMA1 -0.028 0.16 -9999.0 0.0 -0.554 6.0 6.0 ABI1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.045 0.23 -9999.0 0.0 -0.538 10.0 10.0 adherens junction assembly -0.001 0.158 -9999.0 0.0 -0.615 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.117 0.193 -9999.0 0.0 -0.578 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.022 0.065 -9999.0 0.0 -0.526 1.0 1.0 MET -0.005 0.122 -9999.0 0.0 -0.585 3.0 3.0 PLEKHA7 -0.029 0.167 -9999.0 0.0 -0.718 1.0 1.0 mol:GTP -0.053 0.246 -9999.0 0.0 -0.571 11.0 11.0 establishment of epithelial cell apical/basal polarity -0.006 0.204 -9999.0 0.0 -0.778 3.0 3.0 cortical actin cytoskeleton stabilization -0.036 0.162 -9999.0 0.0 -0.432 6.0 6.0 regulation of cell-cell adhesion -0.022 0.173 -9999.0 0.0 -0.668 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.037 0.163 -9999.0 0.0 -0.436 6.0 6.0